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UniProtKB - Q32ZL2 (PLPR5_HUMAN)
Protein
Phospholipid phosphatase-related protein type 5
Gene
PLPPR5
Organism
Homo sapiens (Human)
Status
Functioni
Induces filopodia formation and promotes neurite growth in a CDC42-independent manner; impedes neurite growth inhibitory-mediated axonal retraction.
By similarityCaution
Has most probably no lipid phosphatase activity (By similarity). Critical residues that support the reaction mechanism in active members of that protein family, including the residues of the active site acting respectively as proton donor and nucleophile, are not conserved.By similarityCurated
GO - Molecular functioni
- lipid phosphatase activity Source: GO_Central
- phosphatidate phosphatase activity Source: GO_Central
GO - Biological processi
- phospholipid dephosphorylation Source: GO_Central
- phospholipid metabolic process Source: GO_Central
- positive regulation of filopodium assembly Source: UniProtKB
- positive regulation of neuron projection development Source: UniProtKB
- signal transduction Source: GO_Central
Enzyme and pathway databases
BRENDAi | 3.1.3.4, 2681 |
PathwayCommonsi | Q32ZL2 |
Reactomei | R-HSA-419408, Lysosphingolipid and LPA receptors |
Names & Taxonomyi
Protein namesi | Recommended name: Phospholipid phosphatase-related protein type 5CuratedAlternative name(s): Lipid phosphate phosphatase-related protein type 5Curated Phosphatidic acid phosphatase type 2d1 Publication Plasticity-related gene 5 protein1 Publication Short name: PRG-5 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:31703, PLPPR5 |
neXtProti | NX_Q32ZL2 |
VEuPathDBi | HostDB:ENSG00000117598 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 10 – 30 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 62 – 82 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 122 – 142 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 196 – 213 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 225 – 245 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 252 – 272 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 163404 |
OpenTargetsi | ENSG00000117598 |
Miscellaneous databases
Pharosi | Q32ZL2, Tdark |
Genetic variation databases
BioMutai | PLPPR5 |
DMDMi | 172046620 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000321933 | 1 – 321 | Phospholipid phosphatase-related protein type 5Add BLAST | 321 |
Proteomic databases
PaxDbi | Q32ZL2 |
PeptideAtlasi | Q32ZL2 |
PRIDEi | Q32ZL2 |
ProteomicsDBi | 61633 [Q32ZL2-1] |
PTM databases
DEPODi | PLPPR5 |
iPTMneti | Q32ZL2 |
PhosphoSitePlusi | Q32ZL2 |
Expressioni
Tissue specificityi
Isoform 1 is expressed in brain, lung, kidney and colon. Isoform 2 is expressed in placenta, skeletal muscle and kidney.1 Publication
Gene expression databases
Bgeei | ENSG00000117598, Expressed in neocortex and 83 other tissues |
Genevisiblei | Q32ZL2, HS |
Organism-specific databases
HPAi | ENSG00000117598, Tissue enhanced (brain, retina, testis) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000263177 |
Miscellaneous databases
RNActi | Q32ZL2, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q32ZL2 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the PA-phosphatase related phosphoesterase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3030, Eukaryota |
GeneTreei | ENSGT00940000158610 |
InParanoidi | Q32ZL2 |
OMAi | TAYTKPY |
OrthoDBi | 1621899at2759 |
PhylomeDBi | Q32ZL2 |
Family and domain databases
InterProi | View protein in InterPro IPR028680, LPPR5 IPR036938, P_Acid_Pase_2/haloperoxi_sf IPR000326, P_Acid_Pase_2/haloperoxidase IPR043216, PA_PP_rel |
PANTHERi | PTHR10165, PTHR10165, 1 hit PTHR10165:SF17, PTHR10165:SF17, 1 hit |
Pfami | View protein in Pfam PF01569, PAP2, 1 hit |
SMARTi | View protein in SMART SM00014, acidPPc, 1 hit |
SUPFAMi | SSF48317, SSF48317, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q32ZL2-1) [UniParc]FASTAAdd to basket
Also known as: PAP2d_v1
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPLLPAALTS SMLYFQMVIM AGTVMLAYYF EYTDTFTVNV QGFFCHDSAY
60 70 80 90 100
RKPYPGPEDS SAVPPVLLYS LAAGVPVLVI IVGETAVFCL QLATRDFENQ
110 120 130 140 150
EKTILTGDCC YINPLVRRTV RFLGIYTFGL FATDIFVNAG QVVTGNLAPH
160 170 180 190 200
FLALCKPNYT ALGCQQYTQF ISGEEACTGN PDLIMRARKT FPSKEAALSV
210 220 230 240 250
YAAMYLTMYI TNTIKAKGTR LAKPVLCLGL MCLAFLTGLN RVAEYRNHWS
260 270 280 290 300
DVIAGFLVGI SIAVFLVVCV VNNFKGRQAE NEHIHMDNLA QMPMISIPRV
310 320
ESPLEKVTSV QNHITAFAEV T
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A5F9ZI76 | A0A5F9ZI76_HUMAN | Phospholipid phosphatase-related pr... | PLPPR5 | 379 | Annotation score: |
Sequence cautioni
The sequence AAH40174 differs from that shown. Reason: Erroneous initiation.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031828 | 307 – 311 | Missing in isoform 2. 2 Publications | 5 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY574039 mRNA Translation: AAS76645.1 AY634620 mRNA Translation: AAT64918.1 FJ472844 mRNA Translation: ACJ60628.1 AL445433 Genomic DNA No translation available. AL590110 Genomic DNA No translation available. AL161744 Genomic DNA No translation available. CH471097 Genomic DNA Translation: EAW72994.1 BC040174 mRNA Translation: AAH40174.1 Different initiation. BC136350 mRNA Translation: AAI36351.1 BC144000 mRNA Translation: AAI44001.1 |
CCDSi | CCDS30778.1 [Q32ZL2-1] CCDS30779.1 [Q32ZL2-2] |
RefSeqi | NP_001010861.1, NM_001010861.2 [Q32ZL2-2] NP_001032394.1, NM_001037317.1 [Q32ZL2-1] |
Genome annotation databases
Ensembli | ENST00000263177.5; ENSP00000263177.4; ENSG00000117598.13 ENST00000370188.7; ENSP00000359207.3; ENSG00000117598.13 [Q32ZL2-2] |
GeneIDi | 163404 |
KEGGi | hsa:163404 |
MANE-Selecti | ENST00000263177.5; ENSP00000263177.4; NM_001037317.2; NP_001032394.1 |
UCSCi | uc001dsb.4, human [Q32ZL2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY574039 mRNA Translation: AAS76645.1 AY634620 mRNA Translation: AAT64918.1 FJ472844 mRNA Translation: ACJ60628.1 AL445433 Genomic DNA No translation available. AL590110 Genomic DNA No translation available. AL161744 Genomic DNA No translation available. CH471097 Genomic DNA Translation: EAW72994.1 BC040174 mRNA Translation: AAH40174.1 Different initiation. BC136350 mRNA Translation: AAI36351.1 BC144000 mRNA Translation: AAI44001.1 |
CCDSi | CCDS30778.1 [Q32ZL2-1] CCDS30779.1 [Q32ZL2-2] |
RefSeqi | NP_001010861.1, NM_001010861.2 [Q32ZL2-2] NP_001032394.1, NM_001037317.1 [Q32ZL2-1] |
3D structure databases
AlphaFoldDBi | Q32ZL2 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000263177 |
PTM databases
DEPODi | PLPPR5 |
iPTMneti | Q32ZL2 |
PhosphoSitePlusi | Q32ZL2 |
Genetic variation databases
BioMutai | PLPPR5 |
DMDMi | 172046620 |
Proteomic databases
PaxDbi | Q32ZL2 |
PeptideAtlasi | Q32ZL2 |
PRIDEi | Q32ZL2 |
ProteomicsDBi | 61633 [Q32ZL2-1] |
Protocols and materials databases
Antibodypediai | 19967, 119 antibodies from 18 providers |
DNASUi | 163404 |
Genome annotation databases
Ensembli | ENST00000263177.5; ENSP00000263177.4; ENSG00000117598.13 ENST00000370188.7; ENSP00000359207.3; ENSG00000117598.13 [Q32ZL2-2] |
GeneIDi | 163404 |
KEGGi | hsa:163404 |
MANE-Selecti | ENST00000263177.5; ENSP00000263177.4; NM_001037317.2; NP_001032394.1 |
UCSCi | uc001dsb.4, human [Q32ZL2-1] |
Organism-specific databases
CTDi | 163404 |
DisGeNETi | 163404 |
GeneCardsi | PLPPR5 |
HGNCi | HGNC:31703, PLPPR5 |
HPAi | ENSG00000117598, Tissue enhanced (brain, retina, testis) |
neXtProti | NX_Q32ZL2 |
OpenTargetsi | ENSG00000117598 |
VEuPathDBi | HostDB:ENSG00000117598 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3030, Eukaryota |
GeneTreei | ENSGT00940000158610 |
InParanoidi | Q32ZL2 |
OMAi | TAYTKPY |
OrthoDBi | 1621899at2759 |
PhylomeDBi | Q32ZL2 |
Enzyme and pathway databases
BRENDAi | 3.1.3.4, 2681 |
PathwayCommonsi | Q32ZL2 |
Reactomei | R-HSA-419408, Lysosphingolipid and LPA receptors |
Miscellaneous databases
BioGRID-ORCSi | 163404, 10 hits in 1030 CRISPR screens |
ChiTaRSi | PLPPR5, human |
GenomeRNAii | 163404 |
Pharosi | Q32ZL2, Tdark |
PROi | PR:Q32ZL2 |
RNActi | Q32ZL2, protein |
Gene expression databases
Bgeei | ENSG00000117598, Expressed in neocortex and 83 other tissues |
Genevisiblei | Q32ZL2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028680, LPPR5 IPR036938, P_Acid_Pase_2/haloperoxi_sf IPR000326, P_Acid_Pase_2/haloperoxidase IPR043216, PA_PP_rel |
PANTHERi | PTHR10165, PTHR10165, 1 hit PTHR10165:SF17, PTHR10165:SF17, 1 hit |
Pfami | View protein in Pfam PF01569, PAP2, 1 hit |
SMARTi | View protein in SMART SM00014, acidPPc, 1 hit |
SUPFAMi | SSF48317, SSF48317, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PLPR5_HUMAN | |
Accessioni | Q32ZL2Primary (citable) accession number: Q32ZL2 Secondary accession number(s): A8MPX4 Q3ZCU7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | February 26, 2008 | |
Last modified: | May 25, 2022 | |
This is version 114 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families