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Protein

Nucleoside diphosphate kinase

Gene

NME1-NME2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinaseUniRule annotation (EC:2.7.4.6UniRule annotation)
Gene namesi
Name:NME1-NME2Imported
ORF Names:hCG_2001850Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000011052.21
HGNCiHGNC:33531 NME1-NME2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000011052

PTM / Processingi

Proteomic databases

EPDiQ32Q12
MaxQBiQ32Q12
PRIDEiQ32Q12

Expressioni

Gene expression databases

BgeeiENSG00000011052 Expressed in 91 organ(s), highest expression level in putamen
ExpressionAtlasiQ32Q12 baseline and differential

Interactioni

Protein-protein interaction databases

IntActiQ32Q12, 2 interactors
STRINGi9606.ENSP00000376889

Structurei

3D structure databases

SMRiQ32Q12
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 143NDKInterPro annotationAdd BLAST115
Domaini144 – 281NDKInterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the NDK family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0888 Eukaryota
COG0105 LUCA
GeneTreeiENSGT00760000119146
HOGENOMiHOG000224564
OMAiDGLVQYM
OrthoDBiEOG091G0PLD

Family and domain databases

Gene3Di3.30.70.141, 2 hits
HAMAPiMF_00451 NDP_kinase, 1 hit
InterProiView protein in InterPro
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR001564 Nucleoside_diP_kinase
IPR023005 Nucleoside_diP_kinase_AS
PfamiView protein in Pfam
PF00334 NDK, 2 hits
PRINTSiPR01243 NUCDPKINASE
SMARTiView protein in SMART
SM00562 NDK, 2 hits
SUPFAMiSSF54919 SSF54919, 2 hits
PROSITEiView protein in PROSITE
PS00469 NDP_KINASES, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

Q32Q12-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLLSTLGIV FQGEGPPISS CDTGTMANCE RTFIAIKPDG VQRGLVGEII
60 70 80 90 100
KRFEQKGFRL VGLKFMQASE DLLKEHYVDL KDRPFFAGLV KYMHSGPVVA
110 120 130 140 150
MVWEGLNVVK TGRVMLGETN PADSKPGTIR GDFCIQVGRT MANLERTFIA
160 170 180 190 200
IKPDGVQRGL VGEIIKRFEQ KGFRLVAMKF LRASEEHLKQ HYIDLKDRPF
210 220 230 240 250
FPGLVKYMNS GPVVAMVWEG LNVVKTGRVM LGETNPADSK PGTIRGDFCI
260 270 280 290
QVGRNIIHGS DSVKSAEKEI SLWFKPEELV DYKSCAHDWV YE
Length:292
Mass (Da):32,642
Last modified:December 6, 2005 - v1
Checksum:i9D9E1393214E3CEE
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P22392NDKB_HUMAN
Nucleoside diphosphate kinase B
NME2 NM23B
152Annotation score:
F6XY72F6XY72_HUMAN
HCG2001850, isoform CRA_c
NME2 hCG_2001850
82Annotation score:
J3KPD9J3KPD9_HUMAN
NME1-NME2 readthrough
NME1-NME2
197Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005839 Genomic DNA No translation available.
BC107894 mRNA Translation: AAI07895.1
CH471109 Genomic DNA Translation: EAW94563.1
UniGeneiHs.463456

Genome annotation databases

EnsembliENST00000555572; ENSP00000451932; ENSG00000011052
UCSCiuc002itk.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005839 Genomic DNA No translation available.
BC107894 mRNA Translation: AAI07895.1
CH471109 Genomic DNA Translation: EAW94563.1
UniGeneiHs.463456

3D structure databases

SMRiQ32Q12
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ32Q12, 2 interactors
STRINGi9606.ENSP00000376889

Proteomic databases

EPDiQ32Q12
MaxQBiQ32Q12
PRIDEiQ32Q12

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000555572; ENSP00000451932; ENSG00000011052
UCSCiuc002itk.4 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000011052.21
GeneCardsiNME1-NME2
HGNCiHGNC:33531 NME1-NME2
OpenTargetsiENSG00000011052
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0888 Eukaryota
COG0105 LUCA
GeneTreeiENSGT00760000119146
HOGENOMiHOG000224564
OMAiDGLVQYM
OrthoDBiEOG091G0PLD

Miscellaneous databases

ChiTaRSiNME1-NME2 human

Gene expression databases

BgeeiENSG00000011052 Expressed in 91 organ(s), highest expression level in putamen
ExpressionAtlasiQ32Q12 baseline and differential

Family and domain databases

Gene3Di3.30.70.141, 2 hits
HAMAPiMF_00451 NDP_kinase, 1 hit
InterProiView protein in InterPro
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR001564 Nucleoside_diP_kinase
IPR023005 Nucleoside_diP_kinase_AS
PfamiView protein in Pfam
PF00334 NDK, 2 hits
PRINTSiPR01243 NUCDPKINASE
SMARTiView protein in SMART
SM00562 NDK, 2 hits
SUPFAMiSSF54919 SSF54919, 2 hits
PROSITEiView protein in PROSITE
PS00469 NDP_KINASES, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ32Q12_HUMAN
AccessioniPrimary (citable) accession number: Q32Q12
Entry historyiIntegrated into UniProtKB/TrEMBL: December 6, 2005
Last sequence update: December 6, 2005
Last modified: September 12, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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