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Protein

14 kDa phosphohistidine phosphatase

Gene

PHPT1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Exhibits phosphohistidine phosphatase activity.By similarity

Catalytic activityi

A [protein]-N-phospho-L-histidine + H2O = a [protein]-L-histidine + phosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei21SubstrateBy similarity1
Active sitei53Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
14 kDa phosphohistidine phosphatase (EC:3.9.1.3By similarity)
Alternative name(s):
Phosphohistidine phosphatase 1
Short name:
PHPT1
Protein histidine phosphatase
Short name:
PHP
Gene namesi
Name:PHPT1
Synonyms:PHP14
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 11

Organism-specific databases

VGNCiVGNC:32846 PHPT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002536312 – 12514 kDa phosphohistidine phosphataseAdd BLAST124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ32PA4
PeptideAtlasiQ32PA4
PRIDEiQ32PA4

Expressioni

Gene expression databases

BgeeiENSBTAG00000021549 Expressed in 9 organ(s), highest expression level in heart

Interactioni

Subunit structurei

Monomer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028712

Structurei

3D structure databases

ProteinModelPortaliQ32PA4
SMRiQ32PA4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni94 – 96Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the janus family.Curated

Phylogenomic databases

eggNOGiENOG410IZ5G Eukaryota
ENOG4111SA6 LUCA
GeneTreeiENSGT00390000002738
HOGENOMiHOG000231559
HOVERGENiHBG053589
InParanoidiQ32PA4
KOiK01112
OMAiGWAEYHA
OrthoDBiEOG091G10Y7
TreeFamiTF315158

Family and domain databases

Gene3Di3.50.20.20, 1 hit
InterProiView protein in InterPro
IPR007702 Janus
IPR038596 Janus_sf
IPR028441 PHPT1
PANTHERiPTHR12258 PTHR12258, 1 hit
PTHR12258:SF10 PTHR12258:SF10, 1 hit
PfamiView protein in Pfam
PF05005 Ocnus, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q32PA4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAGLAQIP DVDIDSDGVF KYVLIRVYAA PPSGDPAVET KEIVRGYKWA
60 70 80 90 100
EYHADIYDKV SGEIQKKGYD CECLGGGRIS HQSQDRKIHV YGYSMGYGRA
110 120
QHSVSTEKIK AKYPDYEVTW ADDGY
Length:125
Mass (Da):13,931
Last modified:December 6, 2005 - v1
Checksum:i06102DE495483FAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC108196 mRNA Translation: AAI08197.1
RefSeqiNP_001069984.1, NM_001076516.2
UniGeneiBt.53499

Genome annotation databases

EnsembliENSBTAT00000028712; ENSBTAP00000028712; ENSBTAG00000021549
GeneIDi618691
KEGGibta:618691

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC108196 mRNA Translation: AAI08197.1
RefSeqiNP_001069984.1, NM_001076516.2
UniGeneiBt.53499

3D structure databases

ProteinModelPortaliQ32PA4
SMRiQ32PA4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028712

Proteomic databases

PaxDbiQ32PA4
PeptideAtlasiQ32PA4
PRIDEiQ32PA4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000028712; ENSBTAP00000028712; ENSBTAG00000021549
GeneIDi618691
KEGGibta:618691

Organism-specific databases

CTDi29085
VGNCiVGNC:32846 PHPT1

Phylogenomic databases

eggNOGiENOG410IZ5G Eukaryota
ENOG4111SA6 LUCA
GeneTreeiENSGT00390000002738
HOGENOMiHOG000231559
HOVERGENiHBG053589
InParanoidiQ32PA4
KOiK01112
OMAiGWAEYHA
OrthoDBiEOG091G10Y7
TreeFamiTF315158

Gene expression databases

BgeeiENSBTAG00000021549 Expressed in 9 organ(s), highest expression level in heart

Family and domain databases

Gene3Di3.50.20.20, 1 hit
InterProiView protein in InterPro
IPR007702 Janus
IPR038596 Janus_sf
IPR028441 PHPT1
PANTHERiPTHR12258 PTHR12258, 1 hit
PTHR12258:SF10 PTHR12258:SF10, 1 hit
PfamiView protein in Pfam
PF05005 Ocnus, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPHP14_BOVIN
AccessioniPrimary (citable) accession number: Q32PA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 6, 2005
Last modified: September 12, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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