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Protein

Heterogeneous nuclear ribonucleoprotein A1-like 2

Gene

HNRNPA1L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing, mRNA transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein A1-like 2
Short name:
hnRNP A1-like 2
Alternative name(s):
hnRNP core protein A1-like 2
Gene namesi
Name:HNRNPA1L2
Synonyms:HNRNPA1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000139675.11
HGNCiHGNC:27067 HNRNPA1L2
neXtProtiNX_Q32P51

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164720701

Polymorphism and mutation databases

BioMutaiHNRNPA1L2
DMDMi190356061

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003188481 – 320Heterogeneous nuclear ribonucleoprotein A1-like 2Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineBy similarity1
Modified residuei22PhosphoserineBy similarity1
Modified residuei194Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei194Omega-N-methylarginine; alternateBy similarity1
Modified residuei206Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei206Omega-N-methylarginine; alternateBy similarity1
Modified residuei218Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei218Omega-N-methylarginine; alternateBy similarity1
Modified residuei225Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei225Omega-N-methylarginine; alternateBy similarity1
Modified residuei284Omega-N-methylarginineBy similarity1
Modified residuei298N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ32P51
MaxQBiQ32P51
PaxDbiQ32P51
PeptideAtlasiQ32P51
PRIDEiQ32P51
ProteomicsDBi61627

PTM databases

iPTMnetiQ32P51
PhosphoSitePlusiQ32P51
SwissPalmiQ32P51

Expressioni

Gene expression databases

BgeeiENSG00000139675
ExpressionAtlasiQ32P51 baseline and differential
GenevisibleiQ32P51 HS

Interactioni

Protein-protein interaction databases

BioGridi126887, 36 interactors
IntActiQ32P51, 21 interactors
MINTiQ32P51
STRINGi9606.ENSP00000341285

Structurei

3D structure databases

ProteinModelPortaliQ32P51
SMRiQ32P51
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 97RRM 1PROSITE-ProRule annotationAdd BLAST84
Domaini105 – 184RRM 2PROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni4 – 94Globular A domainAdd BLAST91
Regioni95 – 185Globular B domainAdd BLAST91
Regioni218 – 240RNA-binding RGG-boxAdd BLAST23
Regioni268 – 305Nuclear targeting sequenceBy similarityAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi195 – 317Gly-richAdd BLAST123

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00900000140828
HOGENOMiHOG000234442
InParanoidiQ32P51
KOiK12741
OMAiVTDVAIM
OrthoDBiEOG091G1CPI
PhylomeDBiQ32P51
TreeFamiTF351342

Family and domain databases

CDDicd12580 RRM2_hnRNPA1, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR021662 HnRNPA1
IPR034803 hnRNPA1_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF11627 HnRNPA1, 1 hit
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequencei

Sequence statusi: Complete.

Q32P51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSASPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN
60 70 80 90 100
TKRSRGFGFV TYATVEEVDA AMNTTPHKVD GRVVEPKRAV SREDSQRPGA
110 120 130 140 150
HLTVKKIFVG GIKEDTEEHH LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF
160 170 180 190 200
VTFDDHDSVD KIVIQKYHTV KGHNCEVRKA LPKQEMASAS SSQRGRRGSG
210 220 230 240 250
NFGGGRGDGF GGNDNFGRGG NFSGRGGFGG SCGGGGYGGS GDGYNGFGND
260 270 280 290 300
GSNFGGGGSY NDFGNYNNQS SNFGPMKGGN FGGRSSGPYG GGGQYFAKPQ
310 320
NQGGYGVSSS SSSYGSGRRF
Length:320
Mass (Da):34,225
Last modified:February 26, 2008 - v2
Checksum:i002EE1547DAC04A2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti289Y → C in AAI08267 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038904215N → D. Corresponds to variant dbSNP:rs9536212Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK123159 mRNA No translation available.
AL137058 Genomic DNA No translation available.
CH471124 Genomic DNA Translation: EAW52041.1
BC108266 mRNA Translation: AAI08267.1
CCDSiCCDS31980.1
RefSeqiNP_001011724.1, NM_001011724.1
NP_001011725.1, NM_001011725.1
UniGeneiHs.447506

Genome annotation databases

EnsembliENST00000357495; ENSP00000350090; ENSG00000139675
GeneIDi144983
KEGGihsa:144983
UCSCiuc021rjy.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRA1L2_HUMAN
AccessioniPrimary (citable) accession number: Q32P51
Secondary accession number(s): Q5TBS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: June 20, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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