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Entry version 126 (29 Sep 2021)
Sequence version 2 (17 Apr 2007)
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Protein

tRNA (guanine(37)-N1)-methyltransferase

Gene

TRMT5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in mitochondrial tRNA methylation (PubMed:26189817).

Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei289S-adenosyl-L-methionineUniRule annotation1
Binding sitei387S-adenosyl-L-methionineUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.1.1.228, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q32P41

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6782861, Synthesis of wybutosine at G37 of tRNA(Phe)

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q32P41

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
tRNA (guanine(37)-N1)-methyltransferaseUniRule annotation (EC:2.1.1.228UniRule annotation)
Alternative name(s):
M1G-methyltransferaseUniRule annotation
tRNA [GM37] methyltransferaseUniRule annotation
tRNA methyltransferase 5 homologUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRMT5UniRule annotation
Synonyms:KIAA1393, TRM5UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23141, TRMT5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611023, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q32P41

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000126814

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Combined oxidative phosphorylation deficiency 26 (COXPD26)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA mitochondrial disorder characterized by lactic acidosis, multiple mitochondrial respiratory-chain-complex deficiencies in skeletal muscle, and additional variable features including hypertrophic cardiomyopathy, exercise intolerance, and failure to thrive.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075655291R → H in COXPD26; decreased mitochondrial tRNA methylation. 1 PublicationCorresponds to variant dbSNP:rs746738473EnsemblClinVar.1
Natural variantiVAR_075656386M → V in COXPD26; decreased mitochondrial tRNA methylation. 1 PublicationCorresponds to variant dbSNP:rs1057517685EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...
DisGeNETi
57570

MalaCards human disease database

More...
MalaCardsi
TRMT5
MIMi616539, phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
477684, Combined oxidative phosphorylation defect type 26

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134952106

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q32P41, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRMT5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
145559536

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002565131 – 509tRNA (guanine(37)-N1)-methyltransferaseAdd BLAST509

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q32P41

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q32P41

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q32P41

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q32P41

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q32P41

PeptideAtlas

More...
PeptideAtlasi
Q32P41

PRoteomics IDEntifications database

More...
PRIDEi
Q32P41

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61623

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q32P41

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q32P41

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000126814, Expressed in sperm and 196 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q32P41, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q32P41, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000126814, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

UniRule annotation1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121623, 23 interactors

Protein interaction database and analysis system

More...
IntActi
Q32P41, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000261249

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q32P41, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni327 – 328S-adenosyl-L-methionine bindingUniRule annotation2
Regioni355 – 356S-adenosyl-L-methionine bindingUniRule annotation2
Regioni478 – 509DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi479 – 498Basic and acidic residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2078, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_022610_2_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q32P41

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q32P41

TreeFam database of animal gene trees

More...
TreeFami
TF315073

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_03152, TRM5, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030382, MeTrfase_TRM5/TYW2
IPR029063, SAM-dependent_MTases
IPR025792, tRNA_Gua_MeTrfase_euk

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02475, Met_10, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335, SSF53335, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51684, SAM_MT_TRM5_TYW2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q32P41-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLWILWRPF GFSGRFLKLE SHSITESKSL IPVAWTSLTQ MLLEAPGIFL
60 70 80 90 100
LGQRKRFSTM PETETHERET ELFSPPSDVR GMTKLDRTAF KKTVNIPVLK
110 120 130 140 150
VRKEIVSKLM RSLKRAALQR PGIRRVIEDP EDKESRLIML DPYKIFTHDS
160 170 180 190 200
FEKAELSVLE QLNVSPQISK YNLELTYEHF KSEEILRAVL PEGQDVTSGF
210 220 230 240 250
SRIGHIAHLN LRDHQLSFKH LIGQVMIDKN PGITSAVNKI NNIDNMYRNF
260 270 280 290 300
QMEVLSGEQN MMTKVRENNY TYEFDFSKVY WNPRLSTEHS RITELLKPGD
310 320 330 340 350
VLFDVFAGVG PFAIPVAKKN CTVFANDLNP ESHKWLLYNC KLNKVDQKVK
360 370 380 390 400
VFNLDGKDFL QGPVKEELMQ LLGLSKERKP SVHVVMNLPA KAIEFLSAFK
410 420 430 440 450
WLLDGQPCSS EFLPIVHCYS FSKDANPAED VRQRAGAVLG ISLEACSSVH
460 470 480 490 500
LVRNVAPNKE MLCITFQIPA SVLYKNQTRN PENHEDPPLK RQRTAEAFSD

EKTQIVSNT
Length:509
Mass (Da):58,246
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4BCF6A00EBACD4FB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V494G3V494_HUMAN
tRNA (guanine(37)-N1)-methyltransfe...
TRMT5
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5X1G3V5X1_HUMAN
tRNA (guanine(37)-N1)-methyltransfe...
TRMT5
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti394E → K in BAA92631 (PubMed:10718198).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028898217S → P4 PublicationsCorresponds to variant dbSNP:rs7142228Ensembl.1
Natural variantiVAR_028899255L → P. Corresponds to variant dbSNP:rs2882686Ensembl.1
Natural variantiVAR_075655291R → H in COXPD26; decreased mitochondrial tRNA methylation. 1 PublicationCorresponds to variant dbSNP:rs746738473EnsemblClinVar.1
Natural variantiVAR_028900294E → A. Corresponds to variant dbSNP:rs2296928EnsemblClinVar.1
Natural variantiVAR_075656386M → V in COXPD26; decreased mitochondrial tRNA methylation. 1 PublicationCorresponds to variant dbSNP:rs1057517685EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK293158 mRNA Translation: BAG56703.1
AL160236 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW80792.1
BC108284 mRNA Translation: AAI08285.1
BC136606 mRNA Translation: AAI36607.1
BC136607 mRNA Translation: AAI36608.1
AB037814 mRNA Translation: BAA92631.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32092.1

NCBI Reference Sequences

More...
RefSeqi
NP_065861.3, NM_020810.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261249; ENSP00000261249; ENSG00000126814

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57570

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57570

UCSC genome browser

More...
UCSCi
uc001xff.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293158 mRNA Translation: BAG56703.1
AL160236 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW80792.1
BC108284 mRNA Translation: AAI08285.1
BC136606 mRNA Translation: AAI36607.1
BC136607 mRNA Translation: AAI36608.1
AB037814 mRNA Translation: BAA92631.1
CCDSiCCDS32092.1
RefSeqiNP_065861.3, NM_020810.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi121623, 23 interactors
IntActiQ32P41, 4 interactors
STRINGi9606.ENSP00000261249

PTM databases

iPTMnetiQ32P41
PhosphoSitePlusiQ32P41

Genetic variation databases

BioMutaiTRMT5
DMDMi145559536

Proteomic databases

EPDiQ32P41
jPOSTiQ32P41
MassIVEiQ32P41
MaxQBiQ32P41
PaxDbiQ32P41
PeptideAtlasiQ32P41
PRIDEiQ32P41
ProteomicsDBi61623

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
85, 69 antibodies

The DNASU plasmid repository

More...
DNASUi
57570

Genome annotation databases

EnsembliENST00000261249; ENSP00000261249; ENSG00000126814
GeneIDi57570
KEGGihsa:57570
UCSCiuc001xff.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57570
DisGeNETi57570

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TRMT5
HGNCiHGNC:23141, TRMT5
HPAiENSG00000126814, Low tissue specificity
MalaCardsiTRMT5
MIMi611023, gene
616539, phenotype
neXtProtiNX_Q32P41
Orphaneti477684, Combined oxidative phosphorylation defect type 26
PharmGKBiPA134952106
VEuPathDBiHostDB:ENSG00000126814

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2078, Eukaryota
HOGENOMiCLU_022610_2_3_1
InParanoidiQ32P41
PhylomeDBiQ32P41
TreeFamiTF315073

Enzyme and pathway databases

BRENDAi2.1.1.228, 2681
PathwayCommonsiQ32P41
ReactomeiR-HSA-6782861, Synthesis of wybutosine at G37 of tRNA(Phe)
SABIO-RKiQ32P41

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
57570, 567 hits in 1036 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TRMT5, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57570
PharosiQ32P41, Tbio

Protein Ontology

More...
PROi
PR:Q32P41
RNActiQ32P41, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000126814, Expressed in sperm and 196 other tissues
ExpressionAtlasiQ32P41, baseline and differential
GenevisibleiQ32P41, HS

Family and domain databases

HAMAPiMF_03152, TRM5, 1 hit
InterProiView protein in InterPro
IPR030382, MeTrfase_TRM5/TYW2
IPR029063, SAM-dependent_MTases
IPR025792, tRNA_Gua_MeTrfase_euk
PfamiView protein in Pfam
PF02475, Met_10, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51684, SAM_MT_TRM5_TYW2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRM5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q32P41
Secondary accession number(s): B2RN19, Q9P2F4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 17, 2007
Last modified: September 29, 2021
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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