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UniProtKB - Q32NG5 (GTR12_XENLA)
Protein
Solute carrier family 2, facilitated glucose transporter member 12
Gene
slc2a12
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Insulin-regulated facilitative glucose transporter.
By similarityCatalytic activityi
GO - Molecular functioni
- transmembrane transporter activity Source: InterPro
GO - Biological processi
- carbohydrate transport Source: UniProtKB-KW
Keywordsi
Biological process | Sugar transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 2, facilitated glucose transporter member 12CuratedAlternative name(s): Glucose transporter type 12By similarity Short name: GLUT-12By similarity |
Gene namesi | Name:slc2a12By similarity Synonyms:glut12By similarity |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Proteomesi |
|
Organism-specific databases
Xenbasei | XB-GENE-1012139, slc2a12.L |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Other locations
- Endomembrane system By similarity; Multi-pass membrane protein Sequence analysis
- perinuclear region By similarity
Note: Localizes primarily perinuclear region in the absence of insulin.By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- endomembrane system Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
- perinuclear region of cytoplasm Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 28 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 29 – 49 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 50 – 74 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 75 – 95 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 96 – 103 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 104 – 124 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 125 – 131 | ExtracellularSequence analysis | 7 | |
Transmembranei | 132 – 152 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 153 – 158 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 159 – 179 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 180 – 191 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 192 – 212 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 213 – 272 | CytoplasmicSequence analysisAdd BLAST | 60 | |
Transmembranei | 273 – 293 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 294 – 311 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 312 – 332 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 333 – 339 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 340 – 360 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 361 – 459 | ExtracellularSequence analysisAdd BLAST | 99 | |
Transmembranei | 460 – 480 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 481 – 492 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 493 – 513 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 514 – 522 | ExtracellularSequence analysis | 9 | |
Transmembranei | 523 – 543 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 544 – 588 | CytoplasmicSequence analysisAdd BLAST | 45 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000292018 | 1 – 588 | Solute carrier family 2, facilitated glucose transporter member 12Add BLAST | 588 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 377 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 395 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 419 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinFamily & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
OrthoDBi | 430696at2759 |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 2 hits |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q32NG5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLAHSTAQDL ILQQRSSDDH PQTNPRQTGC GAFIILSSVI AAISGLLVGY
60 70 80 90 100
ELGIISGALL QLQSLLELTC QQQEIVVSAL LIGALVASLV GGCLIDLYGR
110 120 130 140 150
RTTIIFTSIL LVFANLLPVV VVSYGSLIAG RIFIGVSISL SAIATCVYIA
160 170 180 190 200
ELSPQDKRGM LVSLNELMIV AGILLAYICN YLFASVNNGW KYMFGLITPL
210 220 230 240 250
AALQAVAMFF LPRSPRFLIM KGYDDAAGKV LQKLRATTDI NEELTAIKSS
260 270 280 290 300
IKAEYQYKFL DLFCSRDNMR ARLLIGLTLS FFVQITGQPN ILFYASTVLK
310 320 330 340 350
SVGFQSTEAA SLASTGIGVV KVVSTIPAIF LVDKIGSKTF LCIGSAVMAV
360 370 380 390 400
SLVSVGLVSL QLDVNYNNIC KVHTVQNHSL QDSFVYGPVA LAKHNESLFE
410 420 430 440 450
ETGTWLESTK ASYHSTSQNG TKLLHVSAPE DSSFGFTVKE PKVKSQSDEI
460 470 480 490 500
PEYMKWLCLS SLLAFVAAFS IGLGPMAWLV QSEIFPAGIK GRAFAITSSM
510 520 530 540 550
NWGMNLLISL TFLTLTEMIG LPWMLFGYAL MSIASLVFVI MFVPNTKGRP
560 570 580
LEEISKELAN RSYMCNAVCH RRRSKKKLTP VALIQSPA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC108638 mRNA Translation: AAI08639.1 |
RefSeqi | NP_001089895.1, NM_001096426.1 |
Genome annotation databases
GeneIDi | 734962 |
KEGGi | xla:734962 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC108638 mRNA Translation: AAI08639.1 |
RefSeqi | NP_001089895.1, NM_001096426.1 |
3D structure databases
AlphaFoldDBi | Q32NG5 |
SMRi | Q32NG5 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 734962 |
KEGGi | xla:734962 |
Organism-specific databases
CTDi | 734962 |
Xenbasei | XB-GENE-1012139, slc2a12.L |
Phylogenomic databases
OrthoDBi | 430696at2759 |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 2 hits |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GTR12_XENLA | |
Accessioni | Q32NG5Primary (citable) accession number: Q32NG5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 26, 2007 |
Last sequence update: | December 6, 2005 | |
Last modified: | May 25, 2022 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families