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Protein

CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

Gene

PGS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.By similarity

Catalytic activityi

CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.

Activity regulationi

Activated by calcium and magnesium and inhibited by other bivalent cations.By similarity

Pathwayi: phosphatidylglycerol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial (PGS1), CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (PGS1), CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (PGS1), CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (hCG_1642326), CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (PGS1), CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (PGS1)
  2. Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (PTPMT1)
This subpathway is part of the pathway phosphatidylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylglycerol from CDP-diacylglycerol, the pathway phosphatidylglycerol biosynthesis and in Phospholipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei220PROSITE-ProRule annotation1
Active sitei222PROSITE-ProRule annotation1
Active sitei227PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi124 – 131ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS01560-MONOMER
ReactomeiR-HSA-1483148 Synthesis of PG
UniPathwayi
UPA00084;UER00503

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial (EC:2.7.8.5)
Alternative name(s):
Phosphatidylglycerophosphate synthase 1
Short name:
PGP synthase 1
Gene namesi
Name:PGS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000087157.18
HGNCiHGNC:30029 PGS1
MIMi614942 gene
neXtProtiNX_Q32NB8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000087157
PharmGKBiPA142671180

Polymorphism and mutation databases

BioMutaiPGS1
DMDMi121942206

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28MitochondrionSequence analysisAdd BLAST28
ChainiPRO_000033710529 – 556CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrialAdd BLAST528

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ32NB8
MaxQBiQ32NB8
PaxDbiQ32NB8
PeptideAtlasiQ32NB8
PRIDEiQ32NB8
ProteomicsDBi61615
61616 [Q32NB8-2]
61617 [Q32NB8-3]
61618 [Q32NB8-4]
TopDownProteomicsiQ32NB8-1 [Q32NB8-1]
Q32NB8-2 [Q32NB8-2]
Q32NB8-3 [Q32NB8-3]

PTM databases

CarbonylDBiQ32NB8
iPTMnetiQ32NB8
PhosphoSitePlusiQ32NB8

Expressioni

Gene expression databases

BgeeiENSG00000087157 Expressed in 206 organ(s), highest expression level in blood
CleanExiHS_PGS1
ExpressionAtlasiQ32NB8 baseline and differential
GenevisibleiQ32NB8 HS

Organism-specific databases

HPAiHPA022526

Interactioni

Protein-protein interaction databases

BioGridi114871, 1 interactor
IntActiQ32NB8, 3 interactors
STRINGi9606.ENSP00000262764

Structurei

3D structure databases

ProteinModelPortaliQ32NB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini215 – 241PLD phosphodiesterase 1PROSITE-ProRule annotationAdd BLAST27
Domaini460 – 493PLD phosphodiesterase 2PROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG3964 Eukaryota
COG1502 LUCA
GeneTreeiENSGT00390000002373
HOVERGENiHBG057228
InParanoidiQ32NB8
KOiK00995
OMAiHLKGFVI
OrthoDBiEOG091G0DQT
PhylomeDBiQ32NB8
TreeFamiTF314768

Family and domain databases

InterProiView protein in InterPro
IPR016270 PGS1
IPR001736 PLipase_D/transphosphatidylase
PANTHERiPTHR12586 PTHR12586, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q32NB8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAVAAAAAAG PVFWRRLLGL LPGRPGLAAL LGRLSDRLGR NRDRQRRRSP
60 70 80 90 100
WLLLAPLLSP AVPQVTSPPC CLCPEGVHRF QWIRNLVPEF GVSSSHVRVL
110 120 130 140 150
SSPAEFFELM KGQIRVAKRR VVMASLYLGT GPLEQELVDC LESTLEKSLQ
160 170 180 190 200
AKFPSNLKVS ILLDFTRGSR GRKNSRTMLL PLLRRFPEQV RVSLFHTPHL
210 220 230 240 250
RGLLRLLIPE RFNETIGLQH IKVYLFDNSV ILSGANLSDS YFTNRQDRYV
260 270 280 290 300
FLQDCAEIAD FFTELVDAVG DVSLQLQGDD TVQVVDGMVH PYKGDRAEYC
310 320 330 340 350
KAANKRVMDV INSARTRQQM LHAQTFHSNS LLTQEDAAAA GDRRPAPDTW
360 370 380 390 400
IYPLIQMKPF EIQIDEIVTE TLLTEAERGA KVYLTTGYFN LTQAYMDLVL
410 420 430 440 450
GTRAEYQILL ASPEVNGFFG AKGVAGAIPA AYVHIERQFF SEVCSLGQQE
460 470 480 490 500
RVQLQEYWRR GWTFHAKGLW LYLAGSSLPC LTLIGSPNFG YRSVHRDLEA
510 520 530 540 550
QIAIVTENQA LQQQLHQEQE QLYLRSGVVS SATFEQPSRQ VKLWVKMVTP

LIKNFF
Length:556
Mass (Da):62,730
Last modified:December 6, 2005 - v1
Checksum:iC6263E6F7D9B2462
GO
Isoform 2 (identifier: Q32NB8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     112-137: Missing.
     469-480: LWLYLAGSSLPC → QFTGTWRPRLRS
     481-556: Missing.

Show »
Length:454
Mass (Da):51,306
Checksum:i383490EF68CB6A63
GO
Isoform 3 (identifier: Q32NB8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     328-330: SNS → RTL
     331-556: Missing.

Note: No experimental confirmation available.
Show »
Length:330
Mass (Da):37,212
Checksum:iE4E48DD7BB208BEE
GO
Isoform 4 (identifier: Q32NB8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-50: RSP → RGR
     51-556: Missing.

Note: No experimental confirmation available.
Show »
Length:50
Mass (Da):5,463
Checksum:i937C583532218D16
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ELT9K7ELT9_HUMAN
CDP-diacylglycerol--glycerol-3-phos...
PGS1
329Annotation score:
K7EPX0K7EPX0_HUMAN
CDP-diacylglycerol--glycerol-3-phos...
PGS1
132Annotation score:
K7EL44K7EL44_HUMAN
CDP-diacylglycerol--glycerol-3-phos...
PGS1
384Annotation score:
K7EJP6K7EJP6_HUMAN
CDP-diacylglycerol--glycerol-3-phos...
PGS1
264Annotation score:
K7EQF5K7EQF5_HUMAN
CDP-diacylglycerol--glycerol-3-phos...
PGS1
84Annotation score:
U3KQD9U3KQD9_HUMAN
CDP-diacylglycerol--glycerol-3-phos...
PGS1
150Annotation score:
K7EQ89K7EQ89_HUMAN
CDP-diacylglycerol--glycerol-3-phos...
PGS1
114Annotation score:

Sequence cautioni

The sequence AAH08903 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH15570 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH35662 differs from that shown. Reason: Frameshift at position 420.Curated
The sequence AAH35662 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB14921 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03389748 – 50RSP → RGR in isoform 4. 1 Publication3
Alternative sequenceiVSP_03389851 – 556Missing in isoform 4. 1 PublicationAdd BLAST506
Alternative sequenceiVSP_033899112 – 137Missing in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_033900328 – 330SNS → RTL in isoform 3. 1 Publication3
Alternative sequenceiVSP_033901331 – 556Missing in isoform 3. 1 PublicationAdd BLAST226
Alternative sequenceiVSP_033902469 – 480LWLYL…SSLPC → QFTGTWRPRLRS in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_033903481 – 556Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024529 mRNA Translation: BAB14921.1 Sequence problems.
AK316147 mRNA Translation: BAH14518.1
CH471099 Genomic DNA Translation: EAW89524.1
BC008903 mRNA Translation: AAH08903.2 Different initiation.
BC015570 mRNA Translation: AAH15570.2 Different initiation.
BC025951 mRNA Translation: AAH25951.2
BC035662 mRNA Translation: AAH35662.1 Sequence problems.
BC108732 mRNA Translation: AAI08733.1
AL359590 mRNA Translation: CAB94876.1
CR749720 mRNA Translation: CAH18487.1
CCDSiCCDS42391.1 [Q32NB8-1]
PIRiT50620
RefSeqiNP_077733.3, NM_024419.4 [Q32NB8-1]
XP_016880850.1, XM_017025361.1 [Q32NB8-1]
XP_016880851.1, XM_017025362.1 [Q32NB8-1]
UniGeneiHs.654671

Genome annotation databases

EnsembliENST00000262764; ENSP00000262764; ENSG00000087157 [Q32NB8-1]
ENST00000589425; ENSP00000465278; ENSG00000087157 [Q32NB8-4]
ENST00000589426; ENSP00000468431; ENSG00000087157 [Q32NB8-2]
GeneIDi9489
KEGGihsa:9489
UCSCiuc002jvm.4 human [Q32NB8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024529 mRNA Translation: BAB14921.1 Sequence problems.
AK316147 mRNA Translation: BAH14518.1
CH471099 Genomic DNA Translation: EAW89524.1
BC008903 mRNA Translation: AAH08903.2 Different initiation.
BC015570 mRNA Translation: AAH15570.2 Different initiation.
BC025951 mRNA Translation: AAH25951.2
BC035662 mRNA Translation: AAH35662.1 Sequence problems.
BC108732 mRNA Translation: AAI08733.1
AL359590 mRNA Translation: CAB94876.1
CR749720 mRNA Translation: CAH18487.1
CCDSiCCDS42391.1 [Q32NB8-1]
PIRiT50620
RefSeqiNP_077733.3, NM_024419.4 [Q32NB8-1]
XP_016880850.1, XM_017025361.1 [Q32NB8-1]
XP_016880851.1, XM_017025362.1 [Q32NB8-1]
UniGeneiHs.654671

3D structure databases

ProteinModelPortaliQ32NB8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114871, 1 interactor
IntActiQ32NB8, 3 interactors
STRINGi9606.ENSP00000262764

PTM databases

CarbonylDBiQ32NB8
iPTMnetiQ32NB8
PhosphoSitePlusiQ32NB8

Polymorphism and mutation databases

BioMutaiPGS1
DMDMi121942206

Proteomic databases

EPDiQ32NB8
MaxQBiQ32NB8
PaxDbiQ32NB8
PeptideAtlasiQ32NB8
PRIDEiQ32NB8
ProteomicsDBi61615
61616 [Q32NB8-2]
61617 [Q32NB8-3]
61618 [Q32NB8-4]
TopDownProteomicsiQ32NB8-1 [Q32NB8-1]
Q32NB8-2 [Q32NB8-2]
Q32NB8-3 [Q32NB8-3]

Protocols and materials databases

DNASUi9489
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262764; ENSP00000262764; ENSG00000087157 [Q32NB8-1]
ENST00000589425; ENSP00000465278; ENSG00000087157 [Q32NB8-4]
ENST00000589426; ENSP00000468431; ENSG00000087157 [Q32NB8-2]
GeneIDi9489
KEGGihsa:9489
UCSCiuc002jvm.4 human [Q32NB8-1]

Organism-specific databases

CTDi9489
EuPathDBiHostDB:ENSG00000087157.18
GeneCardsiPGS1
HGNCiHGNC:30029 PGS1
HPAiHPA022526
MIMi614942 gene
neXtProtiNX_Q32NB8
OpenTargetsiENSG00000087157
PharmGKBiPA142671180
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3964 Eukaryota
COG1502 LUCA
GeneTreeiENSGT00390000002373
HOVERGENiHBG057228
InParanoidiQ32NB8
KOiK00995
OMAiHLKGFVI
OrthoDBiEOG091G0DQT
PhylomeDBiQ32NB8
TreeFamiTF314768

Enzyme and pathway databases

UniPathwayi
UPA00084;UER00503

BioCyciMetaCyc:HS01560-MONOMER
ReactomeiR-HSA-1483148 Synthesis of PG

Miscellaneous databases

ChiTaRSiPGS1 human
GenomeRNAii9489
PROiPR:Q32NB8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000087157 Expressed in 206 organ(s), highest expression level in blood
CleanExiHS_PGS1
ExpressionAtlasiQ32NB8 baseline and differential
GenevisibleiQ32NB8 HS

Family and domain databases

InterProiView protein in InterPro
IPR016270 PGS1
IPR001736 PLipase_D/transphosphatidylase
PANTHERiPTHR12586 PTHR12586, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPGPS1_HUMAN
AccessioniPrimary (citable) accession number: Q32NB8
Secondary accession number(s): B7ZA32
, Q8IYK9, Q8TA85, Q96A75, Q9H7G9, Q9NPW7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: December 6, 2005
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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