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Protein

Protein FAM214A

Gene

FAM214A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM214A
Gene namesi
Name:FAM214A
Synonyms:KIAA1370
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000047346.12
HGNCiHGNC:25609 FAM214A
neXtProtiNX_Q32MH5

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000047346
PharmGKBiPA142671609

Polymorphism and mutation databases

BioMutaiFAM214A
DMDMi166218826

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003156131 – 1076Protein FAM214AAdd BLAST1076

Proteomic databases

EPDiQ32MH5
PaxDbiQ32MH5
PeptideAtlasiQ32MH5
PRIDEiQ32MH5
ProteomicsDBi61600
61601 [Q32MH5-2]
61602 [Q32MH5-3]

PTM databases

iPTMnetiQ32MH5
PhosphoSitePlusiQ32MH5

Expressioni

Gene expression databases

BgeeiENSG00000047346 Expressed in 202 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_KIAA1370
ExpressionAtlasiQ32MH5 baseline and differential
GenevisibleiQ32MH5 HS

Organism-specific databases

HPAiHPA039369
HPA040180

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi121108, 8 interactors
IntActiQ32MH5, 8 interactors

Structurei

3D structure databases

ProteinModelPortaliQ32MH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM214 family.Curated

Phylogenomic databases

eggNOGiKOG2306 Eukaryota
ENOG41115V6 LUCA
GeneTreeiENSGT00530000063568
HOGENOMiHOG000113164
HOVERGENiHBG108035
InParanoidiQ32MH5
OMAiVPSKVFR
OrthoDBiEOG091G09N8
PhylomeDBiQ32MH5
TreeFamiTF325496

Family and domain databases

InterProiView protein in InterPro
IPR025261 DUF4210
IPR033473 FAM214/SPAC3H8.04_C
PfamiView protein in Pfam
PF13889 Chromosome_seg, 1 hit
PF13915 DUF4210, 1 hit
SMARTiView protein in SMART
SM01177 DUF4210, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q32MH5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKPDRDTLDE YFEYDAEEFL VSLALLITEG RTPECSVKGR TESFHCPPAQ
60 70 80 90 100
SCYPVTTKHE CSDKLAQCRQ ARRTRSEVTL LWKNNLPIMV EMMLLPDCCY
110 120 130 140 150
SDDGPTTEGI DLNDPAIKQD ALLLERWILE PVPRQNGDRF IEEKTLLLAV
160 170 180 190 200
RSFVFFSQLS AWLSVSHGAI PRNILYRISA ADVDLQWNFS QTPIEHVFPV
210 220 230 240 250
PNVSHNVALK VSVQSLPRQS NYPVLTCSIH TNIGLYEKRI QQHKLKTHQH
260 270 280 290 300
HNPNEAEQCG TNSSQRLCSK QTWTMAPESV LHAKSGPSPE YTAAVKNIKL
310 320 330 340 350
YPGTGSKSDH GTSQANILGF SGIGDIKSQE TSVRTLKSFS MVDSSISNRQ
360 370 380 390 400
SFWQSAGETN PLIGSLIQER QEIIARIAQH LIHCDPSTSH VSGRPFNTQE
410 420 430 440 450
SSSLHSKLFR VSQENENVGK GKEAFSMTFG SPEFSSPEDT NEGKIRLKPE
460 470 480 490 500
TPRSETCISN DFYSHMPVGE TNPLIGSLLQ ERQDVIARIA QHLEHIDPTA
510 520 530 540 550
SHIPRQSFNM HDSSSVASKV FRSSYEDKNL LKKNKDESSV SISHTKCSLL
560 570 580 590 600
GDISDGKNLV PNKCFTSFKN NSKEKCSLKH QTRNQCQNNP SEIIQSTYQE
610 620 630 640 650
TQNKSSSLST SSILSQHKEN NLDLTSRFKE QEMSNGIDKQ YSNCTTIDKQ
660 670 680 690 700
ICTNKYKEKI INENYNPKFF GNLQSDDSKK NDSKIKVTVL EMSEYLNKYE
710 720 730 740 750
SMSSNKDSKR PKTCEQNTQL NSIENYLNKD NEGFKCKKSD QLKNEQDKQE
760 770 780 790 800
DPTNEKSQNY SQRRSIKDCL STCEQPKNTE VLRTTLKHSN VWRKHNFHSL
810 820 830 840 850
DGTSTRAFHP QTGLPLLSSP VPQRKTQSGC FDLDSSLLHL KSFSSRSPRP
860 870 880 890 900
CLNIEDDPDI HEKPFLSSSA PPITSLSLLG NFEESVLNYR FDPLGIVDGF
910 920 930 940 950
TAEVGASGAF CPTHLTLPVE VSFYSVSDDN APSPYMGVIT LESLGKRGYR
960 970 980 990 1000
VPPSGTIQVT LFNPNKTVVK MFVVIYDLRD MPANHQTFLR QRTFSVPVKQ
1010 1020 1030 1040 1050
EVKRSVNKEN IRHTEERLLR YLIHLRFQSS KSGKIYLHRD VRLLFSRKSM
1060 1070
EVDSGAAYEL KSYTESPTNP QFSPRC
Length:1,076
Mass (Da):121,670
Last modified:January 15, 2008 - v2
Checksum:i304B1C93DB92B18E
GO
Isoform 2 (identifier: Q32MH5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     960-963: TLFN → VCVL
     964-1076: Missing.

Show »
Length:963
Mass (Da):108,211
Checksum:iB5F260D26383BDD2
GO
Isoform 3 (identifier: Q32MH5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MKPDR → MVFSGNKGLHRE

Note: No experimental confirmation available.
Show »
Length:1,083
Mass (Da):122,398
Checksum:iA7519EA191A38F42
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y3Q9H0Y3Q9_HUMAN
Protein FAM214A
FAM214A
938Annotation score:
H3BVB3H3BVB3_HUMAN
Protein FAM214A
FAM214A
222Annotation score:
H3BQ29H3BQ29_HUMAN
Protein FAM214A
FAM214A
126Annotation score:
H3BU00H3BU00_HUMAN
Protein FAM214A
FAM214A
118Annotation score:
H3BNT9H3BNT9_HUMAN
Protein FAM214A
FAM214A
45Annotation score:
H3BSJ2H3BSJ2_HUMAN
Protein FAM214A
FAM214A
89Annotation score:
H3BTD0H3BTD0_HUMAN
Protein FAM214A
FAM214A
95Annotation score:
H3BUJ2H3BUJ2_HUMAN
Protein FAM214A
FAM214A
142Annotation score:
A0A087WV94A0A087WV94_HUMAN
Protein FAM214A
FAM214A
30Annotation score:

Sequence cautioni

The sequence BAA91936 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA92608 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAG57156 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41T → I in AAI09128 (PubMed:15489334).Curated1
Sequence conflicti207V → A in BAF85606 (PubMed:14702039).Curated1
Sequence conflicti610T → A in BAF85606 (PubMed:14702039).Curated1
Sequence conflicti610T → A in BAG57301 (PubMed:14702039).Curated1
Sequence conflicti610T → A in AAI09129 (PubMed:15489334).Curated1
Sequence conflicti641Y → C in BAG57301 (PubMed:14702039).Curated1
Sequence conflicti750E → G in BAF85606 (PubMed:14702039).Curated1
Sequence conflicti956T → A in BAA91936 (PubMed:14702039).Curated1
Sequence conflicti1028Q → R in AAH83498 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038258135Q → R. Corresponds to variant dbSNP:rs8036680Ensembl.1
Natural variantiVAR_038259560V → I4 PublicationsCorresponds to variant dbSNP:rs12915981Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0424351 – 5MKPDR → MVFSGNKGLHRE in isoform 3. 1 Publication5
Alternative sequenceiVSP_030580960 – 963TLFN → VCVL in isoform 2. 2 Publications4
Alternative sequenceiVSP_030581964 – 1076Missing in isoform 2. 2 PublicationsAdd BLAST113

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037791 mRNA Translation: BAA92608.1 Different initiation.
AK001842 mRNA Translation: BAA91936.1 Different initiation.
AK292917 mRNA Translation: BAF85606.1
AK293730 mRNA Translation: BAG57156.1 Different initiation.
AK293920 mRNA Translation: BAG57301.1
AC009754 Genomic DNA No translation available.
AC025917 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77460.1
BC040548 mRNA Translation: AAH40548.1
BC058839 mRNA Translation: AAH58839.1
BC083498 mRNA Translation: AAH83498.1
BC109127 mRNA Translation: AAI09128.1
BC109128 mRNA Translation: AAI09129.1
CCDSiCCDS45263.1 [Q32MH5-1]
CCDS66773.1 [Q32MH5-3]
RefSeqiNP_001273424.1, NM_001286495.1 [Q32MH5-3]
NP_062546.2, NM_019600.3 [Q32MH5-1]
XP_005254604.1, XM_005254547.2 [Q32MH5-1]
XP_005254605.1, XM_005254548.2 [Q32MH5-1]
XP_011520091.1, XM_011521789.2 [Q32MH5-1]
UniGeneiHs.152385

Genome annotation databases

EnsembliENST00000261844; ENSP00000261844; ENSG00000047346 [Q32MH5-1]
ENST00000534964; ENSP00000444447; ENSG00000047346 [Q32MH5-2]
ENST00000546305; ENSP00000443598; ENSG00000047346 [Q32MH5-3]
ENST00000619572; ENSP00000484641; ENSG00000047346 [Q32MH5-1]
GeneIDi56204
KEGGihsa:56204
UCSCiuc002acg.6 human [Q32MH5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037791 mRNA Translation: BAA92608.1 Different initiation.
AK001842 mRNA Translation: BAA91936.1 Different initiation.
AK292917 mRNA Translation: BAF85606.1
AK293730 mRNA Translation: BAG57156.1 Different initiation.
AK293920 mRNA Translation: BAG57301.1
AC009754 Genomic DNA No translation available.
AC025917 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77460.1
BC040548 mRNA Translation: AAH40548.1
BC058839 mRNA Translation: AAH58839.1
BC083498 mRNA Translation: AAH83498.1
BC109127 mRNA Translation: AAI09128.1
BC109128 mRNA Translation: AAI09129.1
CCDSiCCDS45263.1 [Q32MH5-1]
CCDS66773.1 [Q32MH5-3]
RefSeqiNP_001273424.1, NM_001286495.1 [Q32MH5-3]
NP_062546.2, NM_019600.3 [Q32MH5-1]
XP_005254604.1, XM_005254547.2 [Q32MH5-1]
XP_005254605.1, XM_005254548.2 [Q32MH5-1]
XP_011520091.1, XM_011521789.2 [Q32MH5-1]
UniGeneiHs.152385

3D structure databases

ProteinModelPortaliQ32MH5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121108, 8 interactors
IntActiQ32MH5, 8 interactors

PTM databases

iPTMnetiQ32MH5
PhosphoSitePlusiQ32MH5

Polymorphism and mutation databases

BioMutaiFAM214A
DMDMi166218826

Proteomic databases

EPDiQ32MH5
PaxDbiQ32MH5
PeptideAtlasiQ32MH5
PRIDEiQ32MH5
ProteomicsDBi61600
61601 [Q32MH5-2]
61602 [Q32MH5-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261844; ENSP00000261844; ENSG00000047346 [Q32MH5-1]
ENST00000534964; ENSP00000444447; ENSG00000047346 [Q32MH5-2]
ENST00000546305; ENSP00000443598; ENSG00000047346 [Q32MH5-3]
ENST00000619572; ENSP00000484641; ENSG00000047346 [Q32MH5-1]
GeneIDi56204
KEGGihsa:56204
UCSCiuc002acg.6 human [Q32MH5-1]

Organism-specific databases

CTDi56204
EuPathDBiHostDB:ENSG00000047346.12
GeneCardsiFAM214A
HGNCiHGNC:25609 FAM214A
HPAiHPA039369
HPA040180
neXtProtiNX_Q32MH5
OpenTargetsiENSG00000047346
PharmGKBiPA142671609
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2306 Eukaryota
ENOG41115V6 LUCA
GeneTreeiENSGT00530000063568
HOGENOMiHOG000113164
HOVERGENiHBG108035
InParanoidiQ32MH5
OMAiVPSKVFR
OrthoDBiEOG091G09N8
PhylomeDBiQ32MH5
TreeFamiTF325496

Miscellaneous databases

ChiTaRSiFAM214A human
GenomeRNAii56204
PROiPR:Q32MH5

Gene expression databases

BgeeiENSG00000047346 Expressed in 202 organ(s), highest expression level in small intestine Peyer's patch
CleanExiHS_KIAA1370
ExpressionAtlasiQ32MH5 baseline and differential
GenevisibleiQ32MH5 HS

Family and domain databases

InterProiView protein in InterPro
IPR025261 DUF4210
IPR033473 FAM214/SPAC3H8.04_C
PfamiView protein in Pfam
PF13889 Chromosome_seg, 1 hit
PF13915 DUF4210, 1 hit
SMARTiView protein in SMART
SM01177 DUF4210, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF214A_HUMAN
AccessioniPrimary (citable) accession number: Q32MH5
Secondary accession number(s): A8KA52
, B4DEP5, B4DF40, F5H8G0, Q32MH6, Q4G0R7, Q5XJ16, Q6PDA3, Q9NV24, Q9P2H7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 7, 2018
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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