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Protein

BTB/POZ domain-containing protein 16

Gene

BTBD16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein 16
Gene namesi
Name:BTBD16
Synonyms:C10orf87
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000138152.8
HGNCiHGNC:26340 BTBD16
neXtProtiNX_Q32M84

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi118663
OpenTargetsiENSG00000138152
PharmGKBiPA134900594

Polymorphism and mutation databases

BioMutaiBTBD16
DMDMi110832778

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002471211 – 506BTB/POZ domain-containing protein 16Add BLAST506

Proteomic databases

MaxQBiQ32M84
PaxDbiQ32M84
PeptideAtlasiQ32M84
PRIDEiQ32M84
ProteomicsDBi61594
61595 [Q32M84-2]

PTM databases

iPTMnetiQ32M84
PhosphoSitePlusiQ32M84

Expressioni

Gene expression databases

BgeeiENSG00000138152
CleanExiHS_BTBD16
GenevisibleiQ32M84 HS

Organism-specific databases

HPAiHPA040529
HPA057638

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ROPN1Q9HAT04EBI-11961432,EBI-1378139

Protein-protein interaction databases

BioGridi125616, 1 interactor
IntActiQ32M84, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ32M84
SMRiQ32M84
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini150 – 206BTBAdd BLAST57

Phylogenomic databases

eggNOGiENOG410INKX Eukaryota
ENOG410XQHV LUCA
GeneTreeiENSGT00390000003212
HOGENOMiHOG000095274
HOVERGENiHBG080936
InParanoidiQ32M84
KOiK10487
OMAiAGCKYKE
OrthoDBiEOG091G07PI
PhylomeDBiQ32M84
TreeFamiTF316048

Family and domain databases

InterProiView protein in InterPro
IPR011333 SKP1/BTB/POZ_sf
SUPFAMiSSF54695 SSF54695, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q32M84-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIMSNTHKAR LERRVTGSTN RWRLPKQPFS GDLLSLSQMC KALSIDFEEA
60 70 80 90 100
LRNPDRLCIS QIQKFFFENF KNKDIQSGEA DVILECLGFK WELHQPQLFQ
110 120 130 140 150
SETLAKLYLK ALAQGTTHPL RELEELLRAQ SPKKTKEKSP AKRIIISLKI
160 170 180 190 200
NDPLVTKVAF ATALKNLYMS EVEINLEDLL GVLASAHILQ FSGLFQRCVD
210 220 230 240 250
VMIARLKPST IKKFYEAGCK YKEEQLTTGC EKWLEMNLVP LGGTQIHLHK
260 270 280 290 300
IPQDLLHKVL KSPRLFTFSE FHLLKTMLLW VFLQLNYKIQ AIPTYETVMT
310 320 330 340 350
FFKSFPENCC FLDRDIGRSL RPLFLCLRLH GITKGKDLEV LRHLNFFPES
360 370 380 390 400
WLDQVTVNHY HALENGGDMV HLKDLNTQAV RFGLLFNQEN TTYSKTIALY
410 420 430 440 450
GFFFKIKGLK HDTTSYSFYM QRIKHTDLES PSAVYEHNHV SLRAARLVKY
460 470 480 490 500
EIRAEALVDG KWQEFRTNQI KQKFGLTTSS CKSHTLKIQT VGIPIYVSFA

FIFPAS
Length:506
Mass (Da):58,481
Last modified:July 25, 2006 - v2
Checksum:iA5E006B7F7014AD4
GO
Isoform 2 (identifier: Q32M84-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     6-6: T → TQ

Note: No experimental confirmation available.
Show »
Length:507
Mass (Da):58,609
Checksum:iDF5273A65B3A7E79
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97Q → R in BAB71658 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027070318R → Q. Corresponds to variant dbSNP:rs2421013Ensembl.1
Natural variantiVAR_027071331G → D. Corresponds to variant dbSNP:rs986178Ensembl.1
Natural variantiVAR_027072439H → P. Corresponds to variant dbSNP:rs1048347Ensembl.1
Natural variantiVAR_027073472Q → R. Corresponds to variant dbSNP:rs10510108Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0199296T → TQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK058088 mRNA Translation: BAB71658.1
AL135793 Genomic DNA No translation available.
BX842243 Genomic DNA No translation available.
BC109262 mRNA Translation: AAI09263.1
BC109261 mRNA Translation: AAI09262.1
CCDSiCCDS31301.1 [Q32M84-1]
RefSeqiNP_001305118.1, NM_001318189.1 [Q32M84-2]
NP_653188.2, NM_144587.3 [Q32M84-1]
XP_016871125.1, XM_017015636.1 [Q32M84-2]
UniGeneiHs.422466

Genome annotation databases

EnsembliENST00000260723; ENSP00000260723; ENSG00000138152 [Q32M84-1]
GeneIDi118663
KEGGihsa:118663
UCSCiuc001lgc.2 human [Q32M84-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiBTBDG_HUMAN
AccessioniPrimary (citable) accession number: Q32M84
Secondary accession number(s): A6NM63, Q4VXL1, Q96LN0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: June 20, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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