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Protein

Fascin-2

Gene

Fscn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis. Important for maintaining functional hair-cell bundless in the inner ear. May stiffen the longer stereocilia of hair-cell bundles in the inner ear enabling better force transmission to tip links.1 Publication

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: UniProtKB
  • actin filament bundle assembly Source: GO_Central
  • cell migration Source: GO_Central
  • establishment or maintenance of cell polarity Source: GO_Central
  • eye photoreceptor cell development Source: MGI

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fascin-2
Alternative name(s):
Retinal fascin
Gene namesi
Name:Fscn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2443337 Fscn2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Involvement in diseasei

Defects in Fscn2 lead to hair-cell degeneration in the inner ear and are a key contributor to the early-onset, age-related hearing loss (prebycusis) phenotype when in combination with waltzer cadherin 23 mutant.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004042021 – 492Fascin-2Add BLAST492

Proteomic databases

PaxDbiQ32M02
PRIDEiQ32M02

PTM databases

PhosphoSitePlusiQ32M02

Expressioni

Tissue specificityi

Expressed in the inner ear.

Developmental stagei

Developmentally regulated, appearing in inner-hair cell stereocilia during final stages of elongation.

Gene expression databases

BgeeiENSMUSG00000025380 Expressed in 25 organ(s), highest expression level in retina
GenevisibleiQ32M02 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026445

Structurei

3D structure databases

ProteinModelPortaliQ32M02
SMRiQ32M02
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the fascin family.Curated

Phylogenomic databases

eggNOGiENOG410IF4E Eukaryota
ENOG410XPHV LUCA
GeneTreeiENSGT00530000063373
HOGENOMiHOG000267034
HOVERGENiHBG000968
InParanoidiQ32M02
KOiK17455
OMAiCMKKNGQ
OrthoDBiEOG091G0C6S
PhylomeDBiQ32M02
TreeFamiTF323992

Family and domain databases

CDDicd00257 Fascin, 4 hits
InterProiView protein in InterPro
IPR008999 Actin-crosslinking
IPR010431 Fascin
IPR022768 Fascin-domain
IPR024703 Fascin_metazoans
IPR030144 FSCN2
PANTHERiPTHR10551 PTHR10551, 1 hit
PTHR10551:SF22 PTHR10551:SF22, 1 hit
PfamiView protein in Pfam
PF06268 Fascin, 4 hits
PIRSFiPIRSF005682 Fascin, 1 hit
SUPFAMiSSF50405 SSF50405, 4 hits

Sequencei

Sequence statusi: Complete.

Q32M02-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTNGLHQVL KIQFGLVNDA DRYLTAESFG FKVNASAASL KRKQIWVLEP
60 70 80 90 100
DPGQGTAVLF RSSHLGRYLS AEEDGRVACE MDQPGRDCRF LVLPQPDGRW
110 120 130 140 150
VLQSEPHGRF FGGIEDRLSC FATAISPAEL WTVHLAIHPQ AHLLSVSRRR
160 170 180 190 200
YVHLCLQEDE MAADGDMPWG VDALVTLIFQ SRRYCLKSYD SRYLRSDGRL
210 220 230 240 250
VWEPEAHACY TLEFKAGKLA FKDCDGRYLA PVGPAGTLKA GRNTRPSKDE
260 270 280 290 300
LFDLEQSHPQ VVLVAANRRY ISVRQGINVS ANQDEELGHE TFLMQIDQET
310 320 330 340 350
KKCTFYSSTG GYWTLVTHGG IQATATQVSA NTMFEIEWHG RRVALKASNG
360 370 380 390 400
RFVCMKKNGQ LAAISDFVGE DELFTLKLIN RPLLVLRGLD GFVCHRRGSN
410 420 430 440 450
QLDTNRSTYD VFHLSFRDGA YQIRGRGGGF WYTGSHGSVC SDGDLAEDFL
460 470 480 490
FEFRERGRLA IRALSGKYLR GGASGLLRAD ADLPVGEALW EY
Length:492
Mass (Da):55,073
Last modified:December 6, 2005 - v1
Checksum:i8B848783E8E778D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti395H → P in BAC34026 (PubMed:16141072).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti109R → H in prebycusis phenotype; when associated with waltzer cadherin 23 mutant. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050002 mRNA Translation: BAC34026.1
AL669855 Genomic DNA Translation: CAM27038.1
CH466558 Genomic DNA Translation: EDL34739.1
BC109356 mRNA Translation: AAI09357.1
BC109357 mRNA Translation: AAI09358.1
CCDSiCCDS25731.1
RefSeqiNP_766390.2, NM_172802.4
UniGeneiMm.481403

Genome annotation databases

EnsembliENSMUST00000026445; ENSMUSP00000026445; ENSMUSG00000025380
GeneIDi238021
KEGGimmu:238021
UCSCiuc007msk.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050002 mRNA Translation: BAC34026.1
AL669855 Genomic DNA Translation: CAM27038.1
CH466558 Genomic DNA Translation: EDL34739.1
BC109356 mRNA Translation: AAI09357.1
BC109357 mRNA Translation: AAI09358.1
CCDSiCCDS25731.1
RefSeqiNP_766390.2, NM_172802.4
UniGeneiMm.481403

3D structure databases

ProteinModelPortaliQ32M02
SMRiQ32M02
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026445

PTM databases

PhosphoSitePlusiQ32M02

Proteomic databases

PaxDbiQ32M02
PRIDEiQ32M02

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026445; ENSMUSP00000026445; ENSMUSG00000025380
GeneIDi238021
KEGGimmu:238021
UCSCiuc007msk.2 mouse

Organism-specific databases

CTDi25794
MGIiMGI:2443337 Fscn2

Phylogenomic databases

eggNOGiENOG410IF4E Eukaryota
ENOG410XPHV LUCA
GeneTreeiENSGT00530000063373
HOGENOMiHOG000267034
HOVERGENiHBG000968
InParanoidiQ32M02
KOiK17455
OMAiCMKKNGQ
OrthoDBiEOG091G0C6S
PhylomeDBiQ32M02
TreeFamiTF323992

Miscellaneous databases

PROiPR:Q32M02
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025380 Expressed in 25 organ(s), highest expression level in retina
GenevisibleiQ32M02 MM

Family and domain databases

CDDicd00257 Fascin, 4 hits
InterProiView protein in InterPro
IPR008999 Actin-crosslinking
IPR010431 Fascin
IPR022768 Fascin-domain
IPR024703 Fascin_metazoans
IPR030144 FSCN2
PANTHERiPTHR10551 PTHR10551, 1 hit
PTHR10551:SF22 PTHR10551:SF22, 1 hit
PfamiView protein in Pfam
PF06268 Fascin, 4 hits
PIRSFiPIRSF005682 Fascin, 1 hit
SUPFAMiSSF50405 SSF50405, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFSCN2_MOUSE
AccessioniPrimary (citable) accession number: Q32M02
Secondary accession number(s): Q8BWU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: December 6, 2005
Last modified: November 7, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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