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Protein

Fascin-2

Gene

Fscn2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis. Important for maintaining functional hair-cell bundless in the inner ear. May stiffen the longer stereocilia of hair-cell bundles in the inner ear enabling better force transmission to tip links.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: UniProtKB
  • actin filament bundle assembly Source: GO_Central
  • cell migration Source: GO_Central
  • establishment or maintenance of cell polarity Source: GO_Central
  • eye photoreceptor cell development Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fascin-2
Alternative name(s):
Retinal fascin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Fscn2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443337 Fscn2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Fscn2 lead to hair-cell degeneration in the inner ear and are a key contributor to the early-onset, age-related hearing loss (prebycusis) phenotype when in combination with waltzer cadherin 23 mutant.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004042021 – 492Fascin-2Add BLAST492

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q32M02

PRoteomics IDEntifications database

More...
PRIDEi
Q32M02

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q32M02

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the inner ear.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Developmentally regulated, appearing in inner-hair cell stereocilia during final stages of elongation.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000025380 Expressed in 25 organ(s), highest expression level in retina

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q32M02 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000026445

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q32M02

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q32M02

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fascin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF4E Eukaryota
ENOG410XPHV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159807

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000267034

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000968

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q32M02

KEGG Orthology (KO)

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KOi
K17455

Identification of Orthologs from Complete Genome Data

More...
OMAi
CMKKNGQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0C6S

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q32M02

TreeFam database of animal gene trees

More...
TreeFami
TF323992

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00257 Fascin, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008999 Actin-crosslinking
IPR010431 Fascin
IPR022768 Fascin-domain
IPR024703 Fascin_metazoans
IPR030144 FSCN2

The PANTHER Classification System

More...
PANTHERi
PTHR10551 PTHR10551, 1 hit
PTHR10551:SF22 PTHR10551:SF22, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06268 Fascin, 4 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF005682 Fascin, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50405 SSF50405, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q32M02-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTNGLHQVL KIQFGLVNDA DRYLTAESFG FKVNASAASL KRKQIWVLEP
60 70 80 90 100
DPGQGTAVLF RSSHLGRYLS AEEDGRVACE MDQPGRDCRF LVLPQPDGRW
110 120 130 140 150
VLQSEPHGRF FGGIEDRLSC FATAISPAEL WTVHLAIHPQ AHLLSVSRRR
160 170 180 190 200
YVHLCLQEDE MAADGDMPWG VDALVTLIFQ SRRYCLKSYD SRYLRSDGRL
210 220 230 240 250
VWEPEAHACY TLEFKAGKLA FKDCDGRYLA PVGPAGTLKA GRNTRPSKDE
260 270 280 290 300
LFDLEQSHPQ VVLVAANRRY ISVRQGINVS ANQDEELGHE TFLMQIDQET
310 320 330 340 350
KKCTFYSSTG GYWTLVTHGG IQATATQVSA NTMFEIEWHG RRVALKASNG
360 370 380 390 400
RFVCMKKNGQ LAAISDFVGE DELFTLKLIN RPLLVLRGLD GFVCHRRGSN
410 420 430 440 450
QLDTNRSTYD VFHLSFRDGA YQIRGRGGGF WYTGSHGSVC SDGDLAEDFL
460 470 480 490
FEFRERGRLA IRALSGKYLR GGASGLLRAD ADLPVGEALW EY
Length:492
Mass (Da):55,073
Last modified:December 6, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B848783E8E778D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti395H → P in BAC34026 (PubMed:16141072).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti109R → H in prebycusis phenotype; when associated with waltzer cadherin 23 mutant. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK050002 mRNA Translation: BAC34026.1
AL669855 Genomic DNA Translation: CAM27038.1
CH466558 Genomic DNA Translation: EDL34739.1
BC109356 mRNA Translation: AAI09357.1
BC109357 mRNA Translation: AAI09358.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS25731.1

NCBI Reference Sequences

More...
RefSeqi
NP_766390.2, NM_172802.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.481403

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000026445; ENSMUSP00000026445; ENSMUSG00000025380

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
238021

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:238021

UCSC genome browser

More...
UCSCi
uc007msk.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050002 mRNA Translation: BAC34026.1
AL669855 Genomic DNA Translation: CAM27038.1
CH466558 Genomic DNA Translation: EDL34739.1
BC109356 mRNA Translation: AAI09357.1
BC109357 mRNA Translation: AAI09358.1
CCDSiCCDS25731.1
RefSeqiNP_766390.2, NM_172802.4
UniGeneiMm.481403

3D structure databases

ProteinModelPortaliQ32M02
SMRiQ32M02
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026445

PTM databases

PhosphoSitePlusiQ32M02

Proteomic databases

PaxDbiQ32M02
PRIDEiQ32M02

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026445; ENSMUSP00000026445; ENSMUSG00000025380
GeneIDi238021
KEGGimmu:238021
UCSCiuc007msk.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25794
MGIiMGI:2443337 Fscn2

Phylogenomic databases

eggNOGiENOG410IF4E Eukaryota
ENOG410XPHV LUCA
GeneTreeiENSGT00940000159807
HOGENOMiHOG000267034
HOVERGENiHBG000968
InParanoidiQ32M02
KOiK17455
OMAiCMKKNGQ
OrthoDBiEOG091G0C6S
PhylomeDBiQ32M02
TreeFamiTF323992

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q32M02

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000025380 Expressed in 25 organ(s), highest expression level in retina
GenevisibleiQ32M02 MM

Family and domain databases

CDDicd00257 Fascin, 4 hits
InterProiView protein in InterPro
IPR008999 Actin-crosslinking
IPR010431 Fascin
IPR022768 Fascin-domain
IPR024703 Fascin_metazoans
IPR030144 FSCN2
PANTHERiPTHR10551 PTHR10551, 1 hit
PTHR10551:SF22 PTHR10551:SF22, 1 hit
PfamiView protein in Pfam
PF06268 Fascin, 4 hits
PIRSFiPIRSF005682 Fascin, 1 hit
SUPFAMiSSF50405 SSF50405, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFSCN2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q32M02
Secondary accession number(s): Q8BWU0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: December 6, 2005
Last modified: December 5, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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