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Protein

cAMP-responsive element-binding protein-like 2

Gene

Crebl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • positive regulation of fat cell differentiation Source: UniProtKB
  • positive regulation of glucose import Source: UniProtKB
  • positive regulation of lipid biosynthetic process Source: UniProtKB
  • positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • protein stabilization Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-responsive element-binding protein-like 2
Gene namesi
Name:Crebl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1889385 Crebl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003181931 – 123cAMP-responsive element-binding protein-like 2Add BLAST123

Post-translational modificationi

Phosphorylated by AMPK.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ32M00
PRIDEiQ32M00

Expressioni

Tissue specificityi

Widely expressed with higher expression in adipose tissue, skeletal muscle, and liver (at protein level).1 Publication

Inductioni

Up-regulated during preadipocyte differentiation (at protein level).1 Publication

Gene expression databases

CleanExiMM_CREBL2

Interactioni

Subunit structurei

Interacts with CREB1; regulates CREB1 phosphorylation, stability and transcriptional activity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Creb1Q011474EBI-5314489,EBI-2291098

Protein-protein interaction databases

IntActiQ32M00, 1 interactor
STRINGi10090.ENSMUSP00000035304

Structurei

3D structure databases

ProteinModelPortaliQ32M00
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 86bZIPAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni29 – 60Basic motifBy similarityAdd BLAST32
Regioni62 – 69Leucine-zipperBy similarity8

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Phylogenomic databases

eggNOGiENOG410J0Q3 Eukaryota
ENOG4111T4Y LUCA
HOGENOMiHOG000111966
HOVERGENiHBG107761
InParanoidiQ32M00
PhylomeDBiQ32M00
TreeFamiTF323305

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR039250 CREBL2
PANTHERiPTHR21051 PTHR21051, 1 hit
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q32M00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDSKVVGGK VKKPGKRGRK PAKIDLKAKL ERSRQSAREC RARKKLRYQY
60 70 80 90 100
LEELVSSRER AICALREELE MYKQWCMAMD QGKIPSEIRA LLTGEEQSKP
110 120
QQNSSRHPKA GKTDANTNSL VGN
Length:123
Mass (Da):14,002
Last modified:December 6, 2005 - v1
Checksum:iA1B85B8AA582D62E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti103N → S in BAC32383 (PubMed:16141072).Curated1
Sequence conflicti116N → D in BAC32383 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045467 mRNA Translation: BAC32383.1
BC109358 mRNA Translation: AAI09359.1
BC109359 mRNA Translation: AAI09360.1
CCDSiCCDS20640.1
RefSeqiNP_808355.1, NM_177687.3
UniGeneiMm.267010

Genome annotation databases

GeneIDi232430
KEGGimmu:232430
UCSCiuc009ekt.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCRBL2_MOUSE
AccessioniPrimary (citable) accession number: Q32M00
Secondary accession number(s): Q8BR67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 6, 2005
Last modified: July 18, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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