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UniProtKB - Q32M00 (CRBL2_MOUSE)
Protein
cAMP-responsive element-binding protein-like 2
Gene
Crebl2
Organism
Mus musculus (Mouse)
Status
Functioni
Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle.
1 PublicationGO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity Source: InterPro
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- positive regulation of fat cell differentiation Source: UniProtKB
- positive regulation of glucose import Source: UniProtKB
- positive regulation of lipid biosynthetic process Source: UniProtKB
- positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- protein stabilization Source: UniProtKB
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Differentiation, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: cAMP-responsive element-binding protein-like 2 |
Gene namesi | Name:Crebl2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1889385, Crebl2 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Nucleus
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000318193 | 1 – 123 | cAMP-responsive element-binding protein-like 2Add BLAST | 123 |
Post-translational modificationi
Phosphorylated by AMPK.By similarity
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q32M00 |
PRIDEi | Q32M00 |
Expressioni
Tissue specificityi
Widely expressed with higher expression in adipose tissue, skeletal muscle, and liver (at protein level).1 Publication
Inductioni
Up-regulated during preadipocyte differentiation (at protein level).1 Publication
Interactioni
Subunit structurei
Interacts with CREB1; regulates CREB1 phosphorylation, stability and transcriptional activity.
1 PublicationBinary interactionsi
Q32M00
With | #Exp. | IntAct |
---|---|---|
Creb1 [Q01147] | 4 | EBI-5314489,EBI-2291098 |
Protein-protein interaction databases
IntActi | Q32M00, 1 interactor |
STRINGi | 10090.ENSMUSP00000035304 |
Miscellaneous databases
RNActi | Q32M00, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 86 | bZIPAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 29 – 60 | Basic motifBy similarityAdd BLAST | 32 | |
Regioni | 62 – 69 | Leucine-zipperBy similarity | 8 | |
Regioni | 92 – 123 | DisorderedSequence analysisAdd BLAST | 32 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 95 – 123 | Polar residuesSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4515, Eukaryota |
InParanoidi | Q32M00 |
OrthoDBi | 1551209at2759 |
PhylomeDBi | Q32M00 |
TreeFami | TF323305 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR046347, bZIP_sf IPR039250, CREBL2/REPTOR-BP |
PANTHERi | PTHR21051, PTHR21051, 1 hit |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q32M00-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDDSKVVGGK VKKPGKRGRK PAKIDLKAKL ERSRQSAREC RARKKLRYQY
60 70 80 90 100
LEELVSSRER AICALREELE MYKQWCMAMD QGKIPSEIRA LLTGEEQSKP
110 120
QQNSSRHPKA GKTDANTNSL VGN
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4J0D8 | A0A0R4J0D8_MOUSE | cAMP-responsive element-binding pro... | Crebl2 | 123 | Annotation score: | ||
D3Z200 | D3Z200_MOUSE | cAMP-responsive element-binding pro... | Crebl2 | 84 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 103 | N → S in BAC32383 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 116 | N → D in BAC32383 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK045467 mRNA Translation: BAC32383.1 BC109358 mRNA Translation: AAI09359.1 BC109359 mRNA Translation: AAI09360.1 |
CCDSi | CCDS20640.1 |
RefSeqi | NP_808355.1, NM_177687.3 XP_011239631.1, XM_011241329.2 |
Genome annotation databases
GeneIDi | 232430 |
KEGGi | mmu:232430 |
UCSCi | uc009ekt.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK045467 mRNA Translation: BAC32383.1 BC109358 mRNA Translation: AAI09359.1 BC109359 mRNA Translation: AAI09360.1 |
CCDSi | CCDS20640.1 |
RefSeqi | NP_808355.1, NM_177687.3 XP_011239631.1, XM_011241329.2 |
3D structure databases
AlphaFoldDBi | Q32M00 |
SMRi | Q32M00 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q32M00, 1 interactor |
STRINGi | 10090.ENSMUSP00000035304 |
Proteomic databases
PaxDbi | Q32M00 |
PRIDEi | Q32M00 |
Protocols and materials databases
DNASUi | 232430 |
Genome annotation databases
GeneIDi | 232430 |
KEGGi | mmu:232430 |
UCSCi | uc009ekt.1, mouse |
Organism-specific databases
CTDi | 1389 |
MGIi | MGI:1889385, Crebl2 |
Phylogenomic databases
eggNOGi | KOG4515, Eukaryota |
InParanoidi | Q32M00 |
OrthoDBi | 1551209at2759 |
PhylomeDBi | Q32M00 |
TreeFami | TF323305 |
Miscellaneous databases
BioGRID-ORCSi | 232430, 2 hits in 72 CRISPR screens |
ChiTaRSi | Crebl2, mouse |
PROi | PR:Q32M00 |
RNActi | Q32M00, protein |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR046347, bZIP_sf IPR039250, CREBL2/REPTOR-BP |
PANTHERi | PTHR21051, PTHR21051, 1 hit |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
SUPFAMi | SSF57959, SSF57959, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CRBL2_MOUSE | |
Accessioni | Q32M00Primary (citable) accession number: Q32M00 Secondary accession number(s): Q8BR67 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | December 6, 2005 | |
Last modified: | May 25, 2022 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families