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UniProtKB - Q32LU1 (MIRO2_DANRE)
Protein
Mitochondrial Rho GTPase 2
Gene
rhot2
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 11 – 18 | GTP 1Sequence analysis | 8 | |
Nucleotide bindingi | 57 – 61 | GTP 1Sequence analysis | 5 | |
Nucleotide bindingi | 118 – 121 | GTP 1Sequence analysis | 4 | |
Calcium bindingi | 197 – 208 | 1PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 317 – 328 | 2PROSITE-ProRule annotationAdd BLAST | 12 | |
Nucleotide bindingi | 425 – 432 | GTP 2Sequence analysis | 8 | |
Nucleotide bindingi | 462 – 466 | GTP 2Sequence analysis | 5 | |
Nucleotide bindingi | 527 – 530 | GTP 2Sequence analysis | 4 |
GO - Molecular functioni
- calcium ion binding Source: InterPro
- GTPase activity Source: GO_Central
- GTP binding Source: GO_Central
GO - Biological processi
- cellular homeostasis Source: UniProtKB
- mitochondrial outer membrane permeabilization Source: UniProtKB
- mitochondrion organization Source: GO_Central
- mitochondrion transport along microtubule Source: UniProtKB
- regulation of mitochondrion organization Source: GO_Central
- small GTPase mediated signal transduction Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Ligand | Calcium, GTP-binding, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-DRE-9013419, RHOT2 GTPase cycle |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial Rho GTPase 2 (EC:3.6.5.-)Short name: MIRO-2 Alternative name(s): Ras homolog gene family member T2 |
Gene namesi | Name:rhot2 ORF Names:zgc:123249 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-051120-96, rhot2 |
Subcellular locationi
Mitochondrion
- Mitochondrion outer membrane By similarity; Single-pass type IV membrane protein By similarity
Mitochondrion
- integral component of mitochondrial outer membrane Source: UniProtKB
- mitochondrion Source: ZFIN
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 590 | CytoplasmicSequence analysisAdd BLAST | 590 | |
Transmembranei | 591 – 613 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 23 | |
Topological domaini | 614 – 617 | Mitochondrial intermembraneSequence analysis | 4 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion outer membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000239323 | 1 – 617 | Mitochondrial Rho GTPase 2Add BLAST | 617 |
Post-translational modificationi
Ubiquitinated by PRKN in a PINK1-dependent manner, leading to its degradation.By similarity
Keywords - PTMi
Ubl conjugationProteomic databases
PaxDbi | Q32LU1 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000056328, Expressed in mature ovarian follicle and 29 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 168 | Miro 1PROSITE-ProRule annotationAdd BLAST | 167 | |
Domaini | 184 – 219 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 304 – 339 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 416 – 578 | Miro 2PROSITE-ProRule annotationAdd BLAST | 163 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1707, Eukaryota |
GeneTreei | ENSGT00940000158109 |
HOGENOMi | CLU_014255_3_1_1 |
InParanoidi | Q32LU1 |
OMAi | HYMDSQI |
OrthoDBi | 538388at2759 |
PhylomeDBi | Q32LU1 |
TreeFami | TF300814 |
Family and domain databases
Gene3Di | 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR013566, EF_hand_assoc_1 IPR013567, EF_hand_assoc_2 IPR002048, EF_hand_dom IPR021181, Miro IPR020860, MIRO_dom IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR003578, Small_GTPase_Rho |
PANTHERi | PTHR24072, PTHR24072, 1 hit |
Pfami | View protein in Pfam PF08355, EF_assoc_1, 1 hit PF08356, EF_assoc_2, 1 hit PF00071, Ras, 1 hit |
PIRSFi | PIRSF037488, Mt_Rho_GTPase, 1 hit |
SMARTi | View protein in SMART SM00174, RHO, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF52540, SSF52540, 2 hits |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits PS51423, MIRO, 2 hits |
i Sequence
Sequence statusi: Complete.
Q32LU1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKRDVRILLL GEPKVGKTSL IMSLVGEEFP EQVPLRAEEI TIPADVTPEK
60 70 80 90 100
VPTHIVDYSE NEQTDEVLRE EIVKANVVCV VYDVTQEETI DKIRTKWIPL
110 120 130 140 150
VNGGAEKGSK IPIILVGNKS DLRSGSSMET ILPIMNQFSE IETCVECSAK
160 170 180 190 200
NLKNISELFY YAQKAVLHPT APLYDPEDKQ LKAQCVRALS RIFSISDQDN
210 220 230 240 250
DHILSDAELN CFQKLCFGNP LAPQALEDVK TVVWKNTSDG VQDNGLTLNG
260 270 280 290 300
FLFLNTLFIQ RGRHETTWTI LRKFGYDDTL ELTDDYLYPV LRVSVGCTTE
310 320 330 340 350
LNHLGHQFLL KLFEKYDEDK DSALSPAELK NLFSVLPYMP WSSTVYSNIP
360 370 380 390 400
LTDDCYISQH GYLCQWMLLA YLDVHRCLEH LGYLGYPILM EQECQTSAIT
410 420 430 440 450
VTREKALDLD NRQTQRTVFL CKVIGPRGTG KTDFLRAFLQ RSTERSDRDP
460 470 480 490 500
GAPSIYAINT VSIANQDKYL ILEEVDVETE FLKAADAACD VACLMYDVSD
510 520 530 540 550
PDSFNYCASI YKQHYMDSGI PCVVLGSKAD LVEVKQHHGM SPSEFCYKHR
560 570 580 590 600
LPSPLHFSAL LTHTHTHIYS KLTWAAMYPH LNGSDMSSTS FWLRVTLGAT
610
IAAMLGFALY RAFSRHK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC109430 mRNA Translation: AAI09431.1 |
RefSeqi | NP_001032768.1, NM_001037679.1 |
Genome annotation databases
Ensembli | ENSDART00000061203; ENSDARP00000061202; ENSDARG00000056328 |
GeneIDi | 557574 |
KEGGi | dre:557574 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC109430 mRNA Translation: AAI09431.1 |
RefSeqi | NP_001032768.1, NM_001037679.1 |
3D structure databases
SMRi | Q32LU1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000061202 |
Proteomic databases
PaxDbi | Q32LU1 |
Genome annotation databases
Ensembli | ENSDART00000061203; ENSDARP00000061202; ENSDARG00000056328 |
GeneIDi | 557574 |
KEGGi | dre:557574 |
Organism-specific databases
CTDi | 89941 |
ZFINi | ZDB-GENE-051120-96, rhot2 |
Phylogenomic databases
eggNOGi | KOG1707, Eukaryota |
GeneTreei | ENSGT00940000158109 |
HOGENOMi | CLU_014255_3_1_1 |
InParanoidi | Q32LU1 |
OMAi | HYMDSQI |
OrthoDBi | 538388at2759 |
PhylomeDBi | Q32LU1 |
TreeFami | TF300814 |
Enzyme and pathway databases
Reactomei | R-DRE-9013419, RHOT2 GTPase cycle |
Miscellaneous databases
PROi | PR:Q32LU1 |
Gene expression databases
Bgeei | ENSDARG00000056328, Expressed in mature ovarian follicle and 29 other tissues |
Family and domain databases
Gene3Di | 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR013566, EF_hand_assoc_1 IPR013567, EF_hand_assoc_2 IPR002048, EF_hand_dom IPR021181, Miro IPR020860, MIRO_dom IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR003578, Small_GTPase_Rho |
PANTHERi | PTHR24072, PTHR24072, 1 hit |
Pfami | View protein in Pfam PF08355, EF_assoc_1, 1 hit PF08356, EF_assoc_2, 1 hit PF00071, Ras, 1 hit |
PIRSFi | PIRSF037488, Mt_Rho_GTPase, 1 hit |
SMARTi | View protein in SMART SM00174, RHO, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit SSF52540, SSF52540, 2 hits |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 2 hits PS51423, MIRO, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | MIRO2_DANRE | |
Accessioni | Q32LU1Primary (citable) accession number: Q32LU1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 13, 2006 |
Last sequence update: | December 6, 2005 | |
Last modified: | February 23, 2022 | |
This is version 111 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families