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Protein

WD repeat-containing protein 61

Gene

WDR61

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-BTA-112382 Formation of RNA Pol II elongation complex
R-BTA-429958 mRNA decay by 3' to 5' exoribonuclease
R-BTA-674695 RNA Polymerase II Pre-transcription Events
R-BTA-75955 RNA Polymerase II Transcription Elongation
R-BTA-8866654 E3 ubiquitin ligases ubiquitinate target proteins

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 61
Cleaved into the following chain:
Gene namesi
Name:WDR61
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 21

Organism-specific databases

VGNCiVGNC:50151 WDR61

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004257471 – 305WD repeat-containing protein 61Add BLAST305
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00002458502 – 305WD repeat-containing protein 61, N-terminally processedAdd BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylthreonine; in WD repeat-containing protein 61, N-terminally processedBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ32LN7
PRIDEiQ32LN7

Expressioni

Gene expression databases

BgeeiENSBTAG00000015944 Expressed in 10 organ(s), highest expression level in testis

Interactioni

Subunit structurei

Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61 (By similarity). The PAF1 complex interacts with PHF5A. Within the PAF1 complex interacts directly with PHF5A (By similarity). Component of the SKI complex which consists of WDR61, SKIV2L and TTC37 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021203

Structurei

3D structure databases

ProteinModelPortaliQ32LN7
SMRiQ32LN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati14 – 57WD 1Add BLAST44
Repeati62 – 101WD 2Add BLAST40
Repeati104 – 143WD 3Add BLAST40
Repeati146 – 187WD 4Add BLAST42
Repeati188 – 227WD 5Add BLAST40
Repeati230 – 269WD 6Add BLAST40
Repeati272 – 305WD 7Add BLAST34

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG4155 Eukaryota
ENOG410XP1Z LUCA
GeneTreeiENSGT00810000125363
HOGENOMiHOG000036765
HOVERGENiHBG059813
InParanoidiQ32LN7
KOiK12602
OMAiERKCLHT
OrthoDBiEOG091G0F6P
TreeFamiTF324549

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 6 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q32LN7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNQYSILFK QEQAHDDAIW SVAWGSNKKE NSETVVTGSL DDLVKVWKWR
60 70 80 90 100
DEKLDLQWSL EGHQLGVVSV DISHTLPIAA SSSLDAHIRL WDLENGKQIK
110 120 130 140 150
SIDAGPVDAW TLAFSPDSQY LATGTHVGKV NIFGVESGKK EYSLDTRGKF
160 170 180 190 200
ILSIAYSPDG KYLASGAIDG IINIFDIATG KLLHTLEGHA MPIRSLTFSP
210 220 230 240 250
DSQLLVTASD DGYIKIYDVQ HANLAGTLSG HASWVLNVAF CPDDTHFVSS
260 270 280 290 300
SSDKSVKVWD VGTRTCVHTF FDHQDQVWGV KYNGNGSKIV SVGDDQEIHI

YDCPI
Length:305
Mass (Da):33,569
Last modified:December 6, 2005 - v1
Checksum:iEE16426E2DC0DB9E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109495 mRNA Translation: AAI09496.1
RefSeqiNP_001033186.1, NM_001038097.2
XP_005221988.1, XM_005221931.3
UniGeneiBt.20040

Genome annotation databases

EnsembliENSBTAT00000021203; ENSBTAP00000021203; ENSBTAG00000015944
GeneIDi513208
KEGGibta:513208

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109495 mRNA Translation: AAI09496.1
RefSeqiNP_001033186.1, NM_001038097.2
XP_005221988.1, XM_005221931.3
UniGeneiBt.20040

3D structure databases

ProteinModelPortaliQ32LN7
SMRiQ32LN7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021203

Proteomic databases

PaxDbiQ32LN7
PRIDEiQ32LN7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000021203; ENSBTAP00000021203; ENSBTAG00000015944
GeneIDi513208
KEGGibta:513208

Organism-specific databases

CTDi80349
VGNCiVGNC:50151 WDR61

Phylogenomic databases

eggNOGiKOG4155 Eukaryota
ENOG410XP1Z LUCA
GeneTreeiENSGT00810000125363
HOGENOMiHOG000036765
HOVERGENiHBG059813
InParanoidiQ32LN7
KOiK12602
OMAiERKCLHT
OrthoDBiEOG091G0F6P
TreeFamiTF324549

Enzyme and pathway databases

ReactomeiR-BTA-112382 Formation of RNA Pol II elongation complex
R-BTA-429958 mRNA decay by 3' to 5' exoribonuclease
R-BTA-674695 RNA Polymerase II Pre-transcription Events
R-BTA-75955 RNA Polymerase II Transcription Elongation
R-BTA-8866654 E3 ubiquitin ligases ubiquitinate target proteins

Gene expression databases

BgeeiENSBTAG00000015944 Expressed in 10 organ(s), highest expression level in testis

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 6 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWDR61_BOVIN
AccessioniPrimary (citable) accession number: Q32LN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: December 6, 2005
Last modified: September 12, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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