UniProtKB - Q32LE3 (CETN1_BOVIN)
Protein
Centrin-1
Gene
CETN1
Organism
Bos taurus (Bovine)
Status
Functioni
Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation (By similarity).By similarity
Miscellaneous
Binds two moles of calcium per mole of protein.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 41 – 52 | 1CuratedAdd BLAST | 12 | |
Calcium bindingi | 150 – 161 | 2CuratedAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: GO_Central
- G-protein beta/gamma-subunit complex binding Source: Ensembl
- heterotrimeric G-protein binding Source: Ensembl
- microtubule binding Source: Ensembl
GO - Biological processi
- cell division Source: UniProtKB-KW
- cellular response to heat Source: Ensembl
- centriole replication Source: GO_Central
- mitotic cell cycle Source: GO_Central
- nucleotide-excision repair Source: GO_Central
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
Reactomei | R-BTA-9646399, Aggrephagy |
Names & Taxonomyi
Protein namesi | Recommended name: Centrin-1 |
Gene namesi | Name:CETN1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:27233, CETN1 |
Subcellular locationi
Cytoskeleton
Note: Centrosome of interphase and mitotic cells.By similarity
Cytoskeleton
- centriole Source: GO_Central
- centrosome Source: GO_Central
- spindle pole Source: Ensembl
Other locations
- cytoplasm Source: UniProtKB-KW
- photoreceptor connecting cilium Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000244557 | 1 – 172 | Centrin-1Add BLAST | 172 |
Proteomic databases
PaxDbi | Q32LE3 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000012320, Expressed in testis and 8 other tissues |
Interactioni
Subunit structurei
Monomer (By similarity).
Interacts with PIFO (By similarity).
By similarityGO - Molecular functioni
- microtubule binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000052557 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 63 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 64 – 99 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 101 – 136 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 137 – 172 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the centrin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0028, Eukaryota |
GeneTreei | ENSGT00940000157209 |
HOGENOMi | CLU_061288_18_2_1 |
InParanoidi | Q32LE3 |
OMAi | GIQKIFA |
OrthoDBi | 1382571at2759 |
TreeFami | TF101141 |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR000629, RNA-helicase_DEAD-box_CS |
Pfami | View protein in Pfam PF13499, EF-hand_7, 2 hits |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 4 hits |
i Sequence
Sequence statusi: Complete.
Q32LE3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASSYRKPTV ASTSQKRKVG PKPELTEEQK QEVREAFDLF DADGSGTIDV
60 70 80 90 100
KELKVAMRAL GFEPRKEEMK RMIADVDKEG TGKISFNDFL AVMTQKMAEK
110 120 130 140 150
DTKEEILKAF RLFDDDETGK ISFKNLKRVA KELGENLTDE ELQEMIDEAD
160 170
RDGDGEVNED EFLRIMKKTN LY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC109624 mRNA Translation: AAI09625.1 |
RefSeqi | NP_001072974.1, NM_001079506.2 |
Genome annotation databases
Ensembli | ENSBTAT00000016356; ENSBTAP00000052557; ENSBTAG00000012320 |
GeneIDi | 512850 |
KEGGi | bta:512850 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC109624 mRNA Translation: AAI09625.1 |
RefSeqi | NP_001072974.1, NM_001079506.2 |
3D structure databases
SMRi | Q32LE3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000052557 |
Proteomic databases
PaxDbi | Q32LE3 |
Genome annotation databases
Ensembli | ENSBTAT00000016356; ENSBTAP00000052557; ENSBTAG00000012320 |
GeneIDi | 512850 |
KEGGi | bta:512850 |
Organism-specific databases
CTDi | 1068 |
VGNCi | VGNC:27233, CETN1 |
Phylogenomic databases
eggNOGi | KOG0028, Eukaryota |
GeneTreei | ENSGT00940000157209 |
HOGENOMi | CLU_061288_18_2_1 |
InParanoidi | Q32LE3 |
OMAi | GIQKIFA |
OrthoDBi | 1382571at2759 |
TreeFami | TF101141 |
Enzyme and pathway databases
Reactomei | R-BTA-9646399, Aggrephagy |
Gene expression databases
Bgeei | ENSBTAG00000012320, Expressed in testis and 8 other tissues |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR000629, RNA-helicase_DEAD-box_CS |
Pfami | View protein in Pfam PF13499, EF-hand_7, 2 hits |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CETN1_BOVIN | |
Accessioni | Q32LE3Primary (citable) accession number: Q32LE3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | December 6, 2005 | |
Last modified: | December 2, 2020 | |
This is version 113 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families