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Protein

Ankyrin repeat and SOCS box protein 17

Gene

ASB17

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat and SOCS box protein 17
Short name:
ASB-17
Gene namesi
Name:ASB17
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002830601 – 295Ankyrin repeat and SOCS box protein 17Add BLAST295

Proteomic databases

PaxDbiQ32KY8
PRIDEiQ32KY8

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007708

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati146 – 176ANKAdd BLAST31
Domaini232 – 295SOCS boxPROSITE-ProRule annotationAdd BLAST64

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes.By similarity

Sequence similaritiesi

Belongs to the ankyrin SOCS box (ASB) family.Curated

Keywords - Domaini

ANK repeat

Phylogenomic databases

eggNOGiENOG410IHXS Eukaryota
ENOG4111HC1 LUCA
HOGENOMiHOG000034087
HOVERGENiHBG050587
InParanoidiQ32KY8
KOiK10339

Family and domain databases

InterProiView protein in InterPro
IPR039147 ASB17
IPR001496 SOCS_box
PANTHERiPTHR20966 PTHR20966, 1 hit
PfamiView protein in Pfam
PF07525 SOCS_box, 1 hit
SMARTiView protein in SMART
SM00969 SOCS_box, 1 hit
PROSITEiView protein in PROSITE
PS50225 SOCS, 1 hit

Sequencei

Sequence statusi: Complete.

Q32KY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKSSKLCCK TSCPRSNIFC SLVDKVFKRP SLQSLHQWGY HCYEPRVYRT
60 70 80 90 100
LAKILRYVDL EGFDILLSDY IAFVEKSGCH LEVNFNLEFT EICVNTILYW
110 120 130 140 150
VFARKGNPDF VELLLKKTKD YVQDRSFNLA LIWRTFTPVY CPSPLSGITP
160 170 180 190 200
LLYVAQTRQS NILKILLQYG ILERENNPIN IVLTILLYPS RVRIMVDHEL
210 220 230 240 250
VDIEEDAKTC LVLCSRVLST ISIREIEMQL SLGRRPIISN WLDYIPSTRY
260 270 280 290
KDPCELLHLC RITIRAQLLT NNMLPNGIFS LLIPVCLQNY LNLES
Length:295
Mass (Da):34,253
Last modified:December 6, 2005 - v1
Checksum:iA06CEE8E3F4CAFE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC109851 mRNA Translation: AAI09852.1
RefSeqiNP_001069898.1, NM_001076430.2
UniGeneiBt.50682

Genome annotation databases

GeneIDi616654
KEGGibta:616654

Similar proteinsi

Entry informationi

Entry nameiASB17_BOVIN
AccessioniPrimary (citable) accession number: Q32KY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 6, 2005
Last modified: July 18, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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