UniProtKB - Q32KR8 (ADPRH_BOVIN)
Protein
[Protein ADP-ribosylarginine] hydrolase
Gene
ADPRH
Organism
Bos taurus (Bovine)
Status
Functioni
Specifically acts as a arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.By similarity
Catalytic activityi
- EC:3.2.2.19By similarity
Cofactori
Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 59 | Magnesium 1By similarity | 1 | |
Metal bindingi | 60 | Magnesium 1By similarity | 1 | |
Metal bindingi | 61 | Magnesium 1By similarity | 1 | |
Binding sitei | 90 | SubstrateBy similarity | 1 | |
Binding sitei | 129 | Substrate; via carbonyl oxygenBy similarity | 1 | |
Binding sitei | 135 | Substrate; via amide nitrogenBy similarity | 1 | |
Metal bindingi | 307 | Magnesium 2By similarity | 1 | |
Metal bindingi | 309 | Magnesium 1By similarity | 1 | |
Metal bindingi | 309 | Magnesium 2By similarity | 1 | |
Metal bindingi | 310 | Magnesium 2By similarity | 1 |
GO - Molecular functioni
- ADP-ribosylarginine hydrolase activity Source: UniProtKB
- magnesium ion binding Source: UniProtKB
- potassium ion binding Source: UniProtKB
GO - Biological processi
- cellular protein modification process Source: UniProtKB
- protein de-ADP-ribosylation Source: UniProtKB
Keywordsi
Molecular function | Hydrolase |
Ligand | Magnesium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: [Protein ADP-ribosylarginine] hydrolase (EC:3.2.2.19By similarity)Short name: ADP-ribosylarginine hydrolase Alternative name(s): ADP-ribose-L-arginine cleaving enzyme |
Gene namesi | Name:ADPRH Synonyms:ARH1 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:25690, ADPRH |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000247292 | 1 – 353 | [Protein ADP-ribosylarginine] hydrolaseAdd BLAST | 353 |
Proteomic databases
PaxDbi | Q32KR8 |
PRIDEi | Q32KR8 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000009391, Expressed in liver and 19 other tissues |
ExpressionAtlasi | Q32KR8, baseline and differential |
Interactioni
Subunit structurei
Monomer.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000049744 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 106 – 108 | SubstrateBy similarity | 3 | |
Regioni | 168 – 170 | SubstrateBy similarity | 3 | |
Regioni | 268 – 270 | SubstrateBy similarity | 3 | |
Regioni | 274 – 275 | SubstrateBy similarity | 2 |
Sequence similaritiesi
Belongs to the ADP-ribosylglycohydrolase family.Curated
Phylogenomic databases
eggNOGi | ENOG502QPMI, Eukaryota |
GeneTreei | ENSGT00940000159279 |
HOGENOMi | CLU_047061_0_0_1 |
InParanoidi | Q32KR8 |
OMAi | NRKWEFL |
OrthoDBi | 1112828at2759 |
TreeFami | TF329417 |
Family and domain databases
Gene3Di | 1.10.4080.10, 1 hit |
InterProi | View protein in InterPro IPR012108, ADP-ribosylarg_hydro IPR005502, Ribosyl_crysJ1 IPR036705, Ribosyl_crysJ1_sf |
Pfami | View protein in Pfam PF03747, ADP_ribosyl_GH, 1 hit |
PIRSFi | PIRSF016939, ADP_ribslarg_hdr, 1 hit |
SUPFAMi | SSF101478, SSF101478, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q32KR8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCGALMERYV AAMVLSAAGD ALGYFNGKWE FLQNGEKIHR QLAQLGGLDA
60 70 80 90 100
IDVERWRVSD DTVMHLATAE ALLEAGKVSD LTHLYSLLAK HYQDCMGDMD
110 120 130 140 150
GRAPGGASVQ NAMLLEPDKA DGWRIPFNSH EGGCGAAMRA MCIGLRFPHS
160 170 180 190 200
SQLDSLIQVS IESGRMTHHH PTGYLGALVS ALFTAYAVNG KPPQQWGRGL
210 220 230 240 250
MEVLPEAKKY IVQSGFFVEQ NLQHWSYFQD QWEKYLKLRG IWDGKSAPTF
260 270 280 290 300
PKPFDVKERD QFYSSVSYSG WGGSSGHDAP MIAYDAILAA GDSWKELAHR
310 320 330 340 350
AFFHGGDSDS TAAIAGCWWG VMYGFKGVSP SNYEKLEYRN RLEETARALY
SLR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A452DIA9 | A0A452DIA9_BOVIN | Phospholipase A1 member A | ADPRH PLA1A | 491 | Annotation score: | ||
A0A452DJG8 | A0A452DJG8_BOVIN | Phospholipase A1 member A | ADPRH PLA1A | 368 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC109957 mRNA Translation: AAI09958.1 |
RefSeqi | NP_001033643.1, NM_001038554.1 |
Genome annotation databases
Ensembli | ENSBTAT00000072794; ENSBTAP00000062367; ENSBTAG00000009391 |
GeneIDi | 525738 |
KEGGi | bta:525738 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC109957 mRNA Translation: AAI09958.1 |
RefSeqi | NP_001033643.1, NM_001038554.1 |
3D structure databases
SMRi | Q32KR8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000049744 |
Proteomic databases
PaxDbi | Q32KR8 |
PRIDEi | Q32KR8 |
Genome annotation databases
Ensembli | ENSBTAT00000072794; ENSBTAP00000062367; ENSBTAG00000009391 |
GeneIDi | 525738 |
KEGGi | bta:525738 |
Organism-specific databases
CTDi | 141 |
VGNCi | VGNC:25690, ADPRH |
Phylogenomic databases
eggNOGi | ENOG502QPMI, Eukaryota |
GeneTreei | ENSGT00940000159279 |
HOGENOMi | CLU_047061_0_0_1 |
InParanoidi | Q32KR8 |
OMAi | NRKWEFL |
OrthoDBi | 1112828at2759 |
TreeFami | TF329417 |
Gene expression databases
Bgeei | ENSBTAG00000009391, Expressed in liver and 19 other tissues |
ExpressionAtlasi | Q32KR8, baseline and differential |
Family and domain databases
Gene3Di | 1.10.4080.10, 1 hit |
InterProi | View protein in InterPro IPR012108, ADP-ribosylarg_hydro IPR005502, Ribosyl_crysJ1 IPR036705, Ribosyl_crysJ1_sf |
Pfami | View protein in Pfam PF03747, ADP_ribosyl_GH, 1 hit |
PIRSFi | PIRSF016939, ADP_ribslarg_hdr, 1 hit |
SUPFAMi | SSF101478, SSF101478, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADPRH_BOVIN | |
Accessioni | Q32KR8Primary (citable) accession number: Q32KR8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 25, 2006 |
Last sequence update: | December 6, 2005 | |
Last modified: | December 2, 2020 | |
This is version 90 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families