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Protein

Probable diguanylate cyclase DgcQ

Gene

dgcQ

Organism
Shigella dysenteriae serotype 1 (strain Sd197)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of cyclic-di-GMP (c-di-GMP) via the condensation of 2 GTP molecules (By similarity). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria. Involved in the regulation of cellulose production (By similarity).By similarity

Catalytic activityi

2 GTP = 2 diphosphate + cyclic di-3',5'-guanylate.By similarity

Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per monomer.By similarity

Pathwayi: bacterial cellulose biosynthesis

This protein is involved in the pathway bacterial cellulose biosynthesis, which is part of Glycan metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway bacterial cellulose biosynthesis and in Glycan metabolism.

Pathwayi: 3',5'-cyclic di-GMP biosynthesis

This protein is involved in the pathway 3',5'-cyclic di-GMP biosynthesis, which is part of Purine metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway 3',5'-cyclic di-GMP biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi436MagnesiumBy similarity1
Sitei441Transition state stabilizerSequence analysis1
Binding sitei444SubstrateBy similarity1
Binding sitei449Substrate; via carbonyl oxygenBy similarity1
Binding sitei453SubstrateBy similarity1
Active sitei479Proton acceptorSequence analysis1
Metal bindingi479MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCellulose biosynthesis
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00599
UPA00694

Names & Taxonomyi

Protein namesi
Recommended name:
Probable diguanylate cyclase DgcQBy similarity (EC:2.7.7.65By similarity)
Short name:
DGCBy similarity
Alternative name(s):
Cellulose synthesis regulatory proteinBy similarity
Gene namesi
Name:dgcQBy similarity
Synonyms:yedQ
Ordered Locus Names:SDY_1050
OrganismiShigella dysenteriae serotype 1 (strain Sd197)
Taxonomic identifieri300267 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002716 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Transmembranei360 – 380HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002480361 – 564Probable diguanylate cyclase DgcQAdd BLAST564

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ32HJ0
SMRiQ32HJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini428 – 563GGDEFPROSITE-ProRule annotationAdd BLAST136

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000121343
KOiK21085
OrthoDBiPOG091H049G

Family and domain databases

CDDicd01949 GGDEF, 1 hit
InterProiView protein in InterPro
IPR033416 CHASE7
IPR000160 GGDEF_dom
IPR029787 Nucleotide_cyclase
PfamiView protein in Pfam
PF17151 CHASE7, 1 hit
PF00990 GGDEF, 1 hit
SMARTiView protein in SMART
SM00267 GGDEF, 1 hit
SUPFAMiSSF55073 SSF55073, 1 hit
TIGRFAMsiTIGR00254 GGDEF, 1 hit
PROSITEiView protein in PROSITE
PS50887 GGDEF, 1 hit

Sequencei

Sequence statusi: Complete.

Q32HJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQHETKMENQ SWLKKLARRL GPGHIVNLCF IVVLLFSTLL TWREVVVLED
60 70 80 90 100
AYISSQRNHL ENVANALDKH LQYNVDKLIF LRNGMREALI APLDFTSLRD
110 120 130 140 150
AVTEFEQHRD EHAWQIELNR RRTLPVNGVS DALVSEGNLL SRENESLDNE
160 170 180 190 200
ITAALEVGYL LRLAHNSSSM VEQAMYVSRA GFYVSTQPTL FTRNVPTRYY
210 220 230 240 250
GYVTQPWFIG HSQRENRHRA VRWFTSQPEH ASNTEPQVTV SVPVDSNNYW
260 270 280 290 300
YGVLGMSIPV RTMQQFLRNA IDKNLDGEYQ LYDSKLRFLT SSNPDHPTGN
310 320 330 340 350
IFDPRELAFL AQAMEHDTRG GIRMDSRYVS WERLDHFDGV LVRVHTLSEG
360 370 380 390 400
VRGDFGSISI ALTLLWALFT TMLLISWYVI RRMVSNMYVL QSSLQWQAWH
410 420 430 440 450
DTLTRLYNRG ALFEKARPLA KLCQTHQHPF SVIQVDLDHF KAINDRFGHQ
460 470 480 490 500
AGDRVLSHAA GLISSSLRAQ DVAGRVGGEE FCVILPGASL TEAAEVAERI
510 520 530 540 550
RLKLNEKEML IAKSTTIRIS ASLGVSSSEE TGDYDFEQLQ SLADRRLYLA
560
KQAGRNRVFA SDNT
Length:564
Mass (Da):64,375
Last modified:September 5, 2006 - v2
Checksum:iB549BD1E17168EB6
GO

Sequence cautioni

The sequence ABB61215 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000034 Genomic DNA Translation: ABB61215.1 Different initiation.
RefSeqiYP_402706.1, NC_007606.1

Genome annotation databases

EnsemblBacteriaiABB61215; ABB61215; SDY_1050
GeneIDi3796731
KEGGisdy:SDY_1050
PATRICifig|300267.13.peg.1227

Similar proteinsi

Entry informationi

Entry nameiDGCQ_SHIDS
AccessioniPrimary (citable) accession number: Q32HJ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: April 25, 2018
This is version 68 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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