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Protein

Phosphothreonine lyase OspF

Gene

ospF

Organism
Shigella boydii serotype 4 (strain Sb227)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the removal of the phosphate group from the phosphothreonine in the mitogen-activated protein kinases p38, phosphothreonine in the mitogen-activated protein kinases such as MAPK2/ERK2, MAPK3/ERK1, MAPK8 and MAPK14 in an irreversible reaction, thus preventing the downstream phosphorylation of histone H3. This epigenetic modification results in inhibition of the transcription of a specific subset of proinflammatory genes, and ultimately to a reduced immune response against the invading pathogen. The diminished immune response enhances the bacterium's ability to disseminate and multiply within the host (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei104Proton donorBy similarity1
Active sitei134Proton acceptorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processVirulence

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphothreonine lyase OspF (EC:4.2.3.-)
Alternative name(s):
Effector protein OspF
Gene namesi
Name:ospF
Synonyms:mkaD
Ordered Locus Names:SBO_P017
Encoded oniPlasmid pSB4_2270 Publication
OrganismiShigella boydii serotype 4 (strain Sb227)
Taxonomic identifieri300268 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000007067 Componenti: Plasmid pSB4_227

Subcellular locationi

  • Secreted
  • Note: Secreted via the type III secretion system (TTSS). Localizes in the nucleus of the infected cell (By similarity).By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002993511 – 239Phosphothreonine lyase OspFAdd BLAST239

Structurei

3D structure databases

ProteinModelPortaliQ31SR9
SMRiQ31SR9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphothreonine lyase family.Curated

Phylogenomic databases

HOGENOMiHOG000028458
KOiK13450
OMAiFTLYVKP

Family and domain databases

Gene3Di3.30.2430.10, 1 hit
InterProiView protein in InterPro
IPR003519 OspF/SpvC
IPR038498 OspF/SpvC_sf
PfamiView protein in Pfam
PF03536 VRP3, 1 hit
PRINTSiPR01342 SALVRPPROT

Sequencei

Sequence statusi: Complete.

Q31SR9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPIKKPCLKL NLDSLNVVRS EIPQMLSANE RLKNNFNILY NQIRQYPAYY
60 70 80 90 100
FKVASNVPTY SDICQFFSVM YQGFQIVNHS GDVFIHACRE NPQSKGDFVG
110 120 130 140 150
DKFHISIARE QVPLAFQILS GLLFSEDSPI DKWKITDMNR VSQQSRVGIG
160 170 180 190 200
AQFTLYVKSD QECSQYSALL LHKIRQFIMC LESNLLRSKI APGEYPASDV
210 220 230
RPEDWKYVSY RNELRSDRDG SERQEQMLRE EPFYRLMIE
Length:239
Mass (Da):27,888
Last modified:December 6, 2005 - v1
Checksum:i7A53F087DFF6AA8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000037 Genomic DNA Translation: ABB68889.1

Genome annotation databases

EnsemblBacteriaiABB68889; ABB68889; SBO_P017
KEGGisbo:SBO_P017

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000037 Genomic DNA Translation: ABB68889.1

3D structure databases

ProteinModelPortaliQ31SR9
SMRiQ31SR9
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB68889; ABB68889; SBO_P017
KEGGisbo:SBO_P017

Phylogenomic databases

HOGENOMiHOG000028458
KOiK13450
OMAiFTLYVKP

Family and domain databases

Gene3Di3.30.2430.10, 1 hit
InterProiView protein in InterPro
IPR003519 OspF/SpvC
IPR038498 OspF/SpvC_sf
PfamiView protein in Pfam
PF03536 VRP3, 1 hit
PRINTSiPR01342 SALVRPPROT
ProtoNetiSearch...

Entry informationi

Entry nameiOSPF_SHIBS
AccessioniPrimary (citable) accession number: Q31SR9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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