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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Hydrogenovibrio crunogenus (strain XCL-2) (Thiomicrospira crunogena)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei239ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTCRU317025:G1G4Z-1280-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Ordered Locus Names:Tcr_1216
OrganismiHydrogenovibrio crunogenus (strain XCL-2) (Thiomicrospira crunogena)
Taxonomic identifieri317025 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeHydrogenovibrio
Proteomesi
  • UP000002713 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002374171 – 470Glutamate--tRNA ligaseAdd BLAST470

Proteomic databases

PRIDEiQ31GB2

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi317025.Tcr_1216

Structurei

3D structure databases

ProteinModelPortaliQ31GB2
SMRiQ31GB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi8 – 18"HIGH" regionUniRule annotationAdd BLAST11
Motifi236 – 240"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
1.10.8.70, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020752 aa-tRNA-synth_I_codon-bd_sub1
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q31GB2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKTRFAPSP TGYLHIGGVR TALFSWLYAK QKKGEFTLRI EDTDLERSTQ
60 70 80 90 100
ESVQAILDGM AWLGLDYDKG PIYQTERFDR YKAVIQDLMD RGLAYYCYAS
110 120 130 140 150
PEELDEMREA QKARGDKPRY DGRYRDFDGT PPEGVKPVIR FKNPEDGEVV
160 170 180 190 200
IDDLVKGRIV VANKELDDLV IARSDGTPTY NLTVVVDDWD MEMTHVIRGD
210 220 230 240 250
DHINNTPRQI NLYKALGAEP PKFAHIPMVL GEDGSRLSKR HGAVSVLQYK
260 270 280 290 300
EDGFLPEALL NYLVRLGWSY KDQEIFTIQE MIDLFQLESV NASPSTFNLE
310 320 330 340 350
KLLWINQQHI QMTDIDNLVK NLKPFMDQKG IDTEKGPELS HVANLLRERA
360 370 380 390 400
KTLIEMADSA AYFYQDFTEF EAGAAKKHLR PVAEEPLRLV QKKFAELTEW
410 420 430 440 450
KADKIHEAVH QAAEDLEIGM GKVGMPLRVA ITGGGQSPSI DATAELIGQQ
460 470
KCVARIDLAL QAIEARKANS
Length:470
Mass (Da):53,165
Last modified:December 6, 2005 - v1
Checksum:iEF5066C4A530B54B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000109 Genomic DNA Translation: ABB41811.1
RefSeqiWP_011370639.1, NC_007520.2

Genome annotation databases

EnsemblBacteriaiABB41811; ABB41811; Tcr_1216
KEGGitcx:Tcr_1216

Similar proteinsi

Entry informationi

Entry nameiSYE_HYDCU
AccessioniPrimary (citable) accession number: Q31GB2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: December 6, 2005
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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