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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Hydrogenovibrio crunogenus (strain XCL-2) (Thiomicrospira crunogena)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei150May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

UniPathwayi
UPA00848;UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:Tcr_1875
OrganismiHydrogenovibrio crunogenus (strain XCL-2) (Thiomicrospira crunogena)
Taxonomic identifieri317025 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaThiotrichalesPiscirickettsiaceaeHydrogenovibrio
Proteomesi
  • UP000002713 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002895301 – 311GTP cyclohydrolase FolE2Add BLAST311

Proteomic databases

PRIDEiQ31EF8

Interactioni

Protein-protein interaction databases

STRINGi317025.Tcr_1875

Structurei

3D structure databases

SMRiQ31EF8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DZA Bacteria
COG1469 LUCA
HOGENOMiHOG000247517
KOiK09007
OrthoDBiPOG091H0MIO

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

Q31EF8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPDIACQPHQ DPQGKLNWVG MSGIELPIKI EQDSQTLTLS SQVQAYVSLD
60 70 80 90 100
DPLSKGIHMS RLYLILDEMG SNAPLNPASI QTLLTAFIES HQGLSQNAFV
110 120 130 140 150
EFRFDYYERR RSLKSDNSGW KHYPCTLRGE MRNGQFECEI SISVPYSSTC
160 170 180 190 200
PCSAALSRQL IQEAFEQQFN GQDLDYNQVL EWLGTPEGIC ATPHSQRSYA
210 220 230 240 250
QVKLKVNAEH PLNLSNVINQ IEDAVKTPVQ STVKREDEQE FARLNATNLM
260 270 280 290 300
FCEDAARRLQ AKLESCPEYK DYWVRVNHLE SLHPHDAVAI VTKNVPGGYS
310
DEPNFMERFQ N
Length:311
Mass (Da):35,302
Last modified:May 5, 2009 - v2
Checksum:iA943996682D67EA6
GO

Sequence cautioni

The sequence ABB42465 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000109 Genomic DNA Translation: ABB42465.1 Different initiation.

Genome annotation databases

EnsemblBacteriaiABB42465; ABB42465; Tcr_1875
KEGGitcx:Tcr_1875

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000109 Genomic DNA Translation: ABB42465.1 Different initiation.

3D structure databases

SMRiQ31EF8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi317025.Tcr_1875

Proteomic databases

PRIDEiQ31EF8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB42465; ABB42465; Tcr_1875
KEGGitcx:Tcr_1875

Phylogenomic databases

eggNOGiENOG4105DZA Bacteria
COG1469 LUCA
HOGENOMiHOG000247517
KOiK09007
OrthoDBiPOG091H0MIO

Enzyme and pathway databases

UniPathwayi
UPA00848;UER00151

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGCH4_HYDCU
AccessioniPrimary (citable) accession number: Q31EF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 5, 2009
Last modified: October 10, 2018
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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