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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Prochlorococcus marinus (strain MIT 9312)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei64SubstrateUniRule annotation1
Binding sitei138SubstrateUniRule annotation1
Binding sitei198SubstrateUniRule annotation1
Binding sitei228SubstrateUniRule annotation1
Binding sitei232SubstrateUniRule annotation1
Binding sitei233NADUniRule annotation1
Binding sitei285NADUniRule annotation1
Binding sitei320NADUniRule annotation1
Binding sitei386NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi199 – 201NADUniRule annotation3
Nucleotide bindingi262 – 267NADUniRule annotation6
Nucleotide bindingi341 – 343NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

BioCyciPMAR74546:G1G51-1790-MONOMER
UniPathwayiUPA00314; UER00076

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:PMT9312_1718
OrganismiProchlorococcus marinus (strain MIT 9312)
Taxonomic identifieri74546 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesProchloraceaeProchlorococcus
Proteomesi
  • UP000002715 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000247461 – 472AdenosylhomocysteinaseAdd BLAST472

Proteomic databases

PRIDEiQ318B6

Interactioni

Protein-protein interaction databases

STRINGi74546.PMT9312_1718

Structurei

3D structure databases

ProteinModelPortaliQ318B6
SMRiQ318B6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E Bacteria
COG0499 LUCA
HOGENOMiHOG000227986
KOiK01251
OMAiTGNRDII
OrthoDBiPOG091H00W2

Family and domain databases

CDDicd00401 SAHH, 1 hit
HAMAPiMF_00563 AdoHcyase, 1 hit
InterProiView protein in InterPro
IPR034373 Adenosylhomocysteinase
IPR000043 Adenosylhomocysteinase-like
IPR015878 Ado_hCys_hydrolase_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020082 S-Ado-L-homoCys_hydrolase_CS
PANTHERiPTHR23420 PTHR23420, 1 hit
PfamiView protein in Pfam
PF05221 AdoHcyase, 1 hit
PF00670 AdoHcyase_NAD, 1 hit
PIRSFiPIRSF001109 Ad_hcy_hydrolase, 1 hit
SMARTiView protein in SMART
SM00996 AdoHcyase, 1 hit
SM00997 AdoHcyase_NAD, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00936 ahcY, 1 hit
PROSITEiView protein in PROSITE
PS00738 ADOHCYASE_1, 1 hit
PS00739 ADOHCYASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q318B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVIANSVKSS TTNYVVADIS LSDFGRKEIK IAETEMPGLM ALRDKYQSEK
60 70 80 90 100
PLKGAKIAGS LHMTIQTAVL IETLVDLGAE VKWASCNIFS TQDHAAAAIA
110 120 130 140 150
DQGISVYAKK GETLDEYWQY THCILDWGAD SPNMILDDGG DATGLLILGS
160 170 180 190 200
KAEKDLSVLD NPGNEEEIAL FNSIKYKLET DSDFYSRIKS NIIGVTEETT
210 220 230 240 250
TGVARLYQLQ KQNALPFPAI NVNDSVTKSK FDNLYGCRES LVDSIKRATD
260 270 280 290 300
VMIAGKVALV MGFGDVGKGS AQSLRGLGAI VKVAEVDPIC ALQAAMEGFS
310 320 330 340 350
VVTLDDVVED IDIFVTATGN YQVITNKNLV KMKDEAIVCN IGHFDNEIDV
360 370 380 390 400
ASLKDYPWEN IKPQVDHITL PSGNKIILLA EGRLVNLGCA TGHPSFVMSN
410 420 430 440 450
SFTNQVLAQI ELFNKSEKYA KEVYVLPKHL DEMVARLHLD KIGAKLTKLT
460 470
EEQADYINVS VEGPYKPELY RY
Length:472
Mass (Da):51,708
Last modified:December 6, 2005 - v1
Checksum:i479D396EDE5DFFA6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000111 Genomic DNA Translation: ABB50779.1
RefSeqiWP_011377260.1, NC_007577.1

Genome annotation databases

EnsemblBacteriaiABB50779; ABB50779; PMT9312_1718
KEGGipmi:PMT9312_1718

Similar proteinsi

Entry informationi

Entry nameiSAHH_PROM9
AccessioniPrimary (citable) accession number: Q318B6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 6, 2005
Last modified: February 28, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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