UniProtKB - Q31621 (Q31621_MOUSE)
Protein
Submitted name:
Class II histocompatibility antigen, M alpha chain
Gene
H2-DMa
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
Keywordsi
Biological process | Adaptive immunity, Immunity |
Names & Taxonomyi
Protein namesi | Submitted name: Class II histocompatibility antigen, M alpha chainImportedSubmitted name: H2-M alphaImportedSubmitted name: Histocompatibility 2, class II, locus DMaImportedSubmitted name: MAq1 proteinImportedSubmitted name: MAq2 proteinImportedSubmitted name: MAq4 proteinImportedSubmitted name: MAq5 proteinImportedSubmitted name: MAq6 proteinImportedSubmitted name: MHC class II H2-M alpha chainImportedSubmitted name: MHC class II antigenImported |
Gene namesi | Name:H2-DMaImported Synonyms:H2-M alphaImported, H2-MaImported, MAq1Imported, MAq2Imported, MAq3Imported, MAq4Imported, MAq5Imported, MAq6Imported, MMMAq6Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95921, H2-DMa |
Subcellular locationi
Other locations
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Plasma Membrane
- MHC class II protein complex Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 234 – 253 | HelicalSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
Membrane, MHC IIARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_5015097372 | 27 – 261 | Sequence analysisAdd BLAST | 235 |
Keywords - PTMi
GlycoproteinARBA annotationProteomic databases
PRIDEi | Q31621 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000037649, Expressed in lymph node and 180 other tissues |
ExpressionAtlasi | Q31621, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 121 – 215 | Ig-likeInterPro annotationAdd BLAST | 95 |
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000161157 |
HOGENOMi | CLU_069380_1_0_1 |
OMAi | AIAFWVP |
OrthoDBi | 1057709at2759 |
TreeFami | TF333797 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR001003, MHC_II_a_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00993, MHC_II_alpha, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00920, MHC_II_alpha, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q31621-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEHEQKSGAV LLRLLRLLWL LPHSWAVLEA STPVFWDDPQ NHTFRHTLFC
60 70 80 90 100
QDGIPNIGLS ETYDEDELFS FDFSQNTRVP RLPDFAEWAQ GQGDASAIAF
110 120 130 140 150
DKSFCEMLMR EVSPKLEGQI PVSRGLPVAE VFTLKPLEFG KPNTLVCFIS
160 170 180 190 200
NLFPPTLTVN WQLHSAPVEG ASPTSISAVD GLTFQAFSYL NFTPEPFDLY
210 220 230 240 250
SCTVTHEIDR YTAIAYWVPQ NALPSDLLEN ALCGVAFGLG VLGTIMGIVF
260
FLCSQRPCSG D
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP28078 | DMA_MOUSE | Class II histocompatibility antigen... | H2-DMa H2-Ma, Ma | 261 | Annotation score: | ||
A0A494BAR2 | A0A494BAR2_MOUSE | Class II histocompatibility antigen... | H2-DMa | 41 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR974422 Genomic DNA No translation available. CR974462 Genomic DNA No translation available. U35324 mRNA Translation: AAA91134.1 U35327 mRNA Translation: AAA91137.1 AF100956 Genomic DNA Translation: AAC69910.1 BC049992 mRNA Translation: AAH49992.1 AK146950 mRNA Translation: BAE27559.1 AK160460 mRNA Translation: BAE35801.1 X90785 mRNA Translation: CAA62304.1 X90786 mRNA Translation: CAA62305.1 X90790 mRNA Translation: CAA62309.1 X90793 mRNA Translation: CAA62312.1 X90794 mRNA Translation: CAA62313.1 X90795 mRNA Translation: CAA62314.1 X90963 mRNA Translation: CAA62451.1 |
RefSeqi | NP_034516.3, NM_010386.4 XP_006523747.1, XM_006523684.3 XP_017172749.1, XM_017317260.1 |
Genome annotation databases
Ensembli | ENSMUST00000042121; ENSMUSP00000037088; ENSMUSG00000037649 ENSMUST00000236322; ENSMUSP00000157660; ENSMUSG00000037649 |
GeneIDi | 14998 |
UCSCi | uc008cbl.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR974422 Genomic DNA No translation available. CR974462 Genomic DNA No translation available. U35324 mRNA Translation: AAA91134.1 U35327 mRNA Translation: AAA91137.1 AF100956 Genomic DNA Translation: AAC69910.1 BC049992 mRNA Translation: AAH49992.1 AK146950 mRNA Translation: BAE27559.1 AK160460 mRNA Translation: BAE35801.1 X90785 mRNA Translation: CAA62304.1 X90786 mRNA Translation: CAA62305.1 X90790 mRNA Translation: CAA62309.1 X90793 mRNA Translation: CAA62312.1 X90794 mRNA Translation: CAA62313.1 X90795 mRNA Translation: CAA62314.1 X90963 mRNA Translation: CAA62451.1 |
RefSeqi | NP_034516.3, NM_010386.4 XP_006523747.1, XM_006523684.3 XP_017172749.1, XM_017317260.1 |
3D structure databases
SMRi | Q31621 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q31621 |
Protocols and materials databases
Antibodypediai | 2402, 373 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000042121; ENSMUSP00000037088; ENSMUSG00000037649 ENSMUST00000236322; ENSMUSP00000157660; ENSMUSG00000037649 |
GeneIDi | 14998 |
UCSCi | uc008cbl.2, mouse |
Organism-specific databases
CTDi | 14998 |
MGIi | MGI:95921, H2-DMa |
Phylogenomic databases
GeneTreei | ENSGT00940000161157 |
HOGENOMi | CLU_069380_1_0_1 |
OMAi | AIAFWVP |
OrthoDBi | 1057709at2759 |
TreeFami | TF333797 |
Miscellaneous databases
BioGRID-ORCSi | 14998, 1 hit in 15 CRISPR screens |
ChiTaRSi | H2-DMa, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037649, Expressed in lymph node and 180 other tissues |
ExpressionAtlasi | Q31621, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR001003, MHC_II_a_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00993, MHC_II_alpha, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00920, MHC_II_alpha, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q31621_MOUSE | |
Accessioni | Q31621Primary (citable) accession number: Q31621 Secondary accession number(s): Q9QWV0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 1, 1996 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 205 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |