H2-DMa

Functionⁱ

GO - Molecular functionⁱ

MHC class II protein complex binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

immune response Source: InterPro
peptide antigen assembly with MHC class II protein complex Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Immunity

Biological process

Immunity

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2132295 MHC class II antigen presentation

Reactomeⁱ

R-MMU-2132295 MHC class II antigen presentation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Class II histocompatibility antigen, M alpha chainImported Submitted name: H2-M alphaImported Submitted name: Histocompatibility 2, class II, locus DMaImported Submitted name: MAq1 proteinImported Submitted name: MAq2 proteinImported Submitted name: MAq4 proteinImported Submitted name: MAq5 proteinImported Submitted name: MAq6 proteinImported Submitted name: MHC class II H2-M alpha chainImported Submitted name: MHC class II antigenImported
Gene namesⁱ	Name:H2-DMaImported Synonyms:H2-M alphaImported, H2-MaImported, MAq1Imported, MAq2Imported, MAq3Imported, MAq4Imported, MAq5Imported, MAq6Imported, MMMAq6Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 17

Organism-specific databases

MGIⁱ	MGI:95921 H2-DMa

Subcellular locationⁱ

GO - Cellular component

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	234 – 253	HelicalSequence analysisAdd BLAST		20

Keywords - Cellular componentⁱ

Membrane, MHC IISAAS annotation

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 26	Sequence analysisAdd BLAST		26
ChainⁱPRO_5015097372	27 – 261	Sequence analysisAdd BLAST		235

Keywords - PTMⁱ

Disulfide bondSAAS annotation

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000037649 Expressed in 151 organ(s), highest expression level in lymph node

Bgeeⁱ

ENSMUSG00000037649 Expressed in 151 organ(s), highest expression level in lymph node

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	121 – 215	Ig-likeInterPro annotationAdd BLAST		95

Sequence similaritiesⁱ

Belongs to the MHC class II family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGⁱ	ENOG410IR26 Eukaryota ENOG410YJDD LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140882
HOVERGENⁱ	HBG001688
OMAⁱ	NHTFRHT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LMN
TreeFamⁱ	TF333797

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.10.320.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR011162 MHC_I/II-like_Ag-recog IPR014745 MHC_II_a/b_N IPR001003 MHC_II_a_N
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07654 C1-set, 1 hit PF00993 MHC_II_alpha, 1 hit
SMARTⁱ	View protein in SMART SM00407 IGc1, 1 hit SM00920 MHC_II_alpha, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00290 IG_MHC, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q31621-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEHEQKSGAV LLRLLRLLWL LPHSWAVLEA STPVFWDDPQ NHTFRHTLFC 
        60         70         80         90        100
QDGIPNIGLS ETYDEDELFS FDFSQNTRVP RLPDFAEWAQ GQGDASAIAF 
       110        120        130        140        150
DKSFCEMLMR EVSPKLEGQI PVSRGLPVAE VFTLKPLEFG KPNTLVCFIS 
       160        170        180        190        200
NLFPPTLTVN WQLHSAPVEG ASPTSISAVD GLTFQAFSYL NFTPEPFDLY 
       210        220        230        240        250
SCTVTHEIDR YTAIAYWVPQ NALPSDLLEN ALCGVAFGLG VLGTIMGIVF 
       260 
FLCSQRPCSG D

Length:261

Mass (Da):29,056

Last modified:November 1, 1996 - v1

Checksum:ⁱF4EB12EE2FE72A57

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	P28078	DMA_MOUSE		Class II histocompatibility antigen... Class II histocompatibility antigen, M alpha chain	H2-DMa H2-Ma, Ma	261	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CR974422 Genomic DNA No translation available. U35324 mRNA Translation: AAA91134.1 U35327 mRNA Translation: AAA91137.1 AF100956 Genomic DNA Translation: AAC69910.1 BC049992 mRNA Translation: AAH49992.1 AK146950 mRNA Translation: BAE27559.1 AK160460 mRNA Translation: BAE35801.1 X90785 mRNA Translation: CAA62304.1 X90786 mRNA Translation: CAA62305.1 X90790 mRNA Translation: CAA62309.1 X90793 mRNA Translation: CAA62312.1 X90794 mRNA Translation: CAA62313.1 X90795 mRNA Translation: CAA62314.1 X90963 mRNA Translation: CAA62451.1
NCBI Reference Sequences More...RefSeqⁱ	NP_034516.3, NM_010386.4 XP_006523747.1, XM_006523684.3 XP_017172749.1, XM_017317260.1
UniGeneⁱ	Mm.16373

Genome annotation databases

Ensemblⁱ	ENSMUST00000042121; ENSMUSP00000037088; ENSMUSG00000037649
GeneIDⁱ	14998
UCSC genome browser More...UCSCⁱ	uc008cbl.2 mouse

Protein	Similar proteins		Species	Score	Length	Source
Q31621	Putative HLA class II histocompatibility antigen, DMalpha chain protein (Fragment)		Daphnia magna		173	UniRef100_Q31621
UPI00001120BA		MOUSE		191

Protein	Similar proteins		Species	Score	Length	Source
Q31621	Class II histocompatibility antigen, M alpha chain	)	MOUSE		261	UniRef90_P28078
Putative HLA class II histocompatibility antigen, DMalpha chain protein (Fragment)		Daphnia magna		173
UPI000A31001E		MUSPA		261
UPI000A3161A9		MUSCR		261
MAp protein		MOUSE		261
+8

Protein	Similar proteins		Species	Score	Length	Source
Q31621	Class II histocompatibility antigen, M alpha chain	)	MOUSE		261	UniRef50_P28078
HLA class II histocompatibility antigen, DM alpha chain	)	HUMAN		261
Putative HLA class II histocompatibility antigen, DMalpha chain protein (Fragment)		Daphnia magna		173
Uncharacterized protein		NOMLE		292
Uncharacterized protein		PANPA		268
+241

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CR974422 Genomic DNA No translation available. U35324 mRNA Translation: AAA91134.1 U35327 mRNA Translation: AAA91137.1 AF100956 Genomic DNA Translation: AAC69910.1 BC049992 mRNA Translation: AAH49992.1 AK146950 mRNA Translation: BAE27559.1 AK160460 mRNA Translation: BAE35801.1 X90785 mRNA Translation: CAA62304.1 X90786 mRNA Translation: CAA62305.1 X90790 mRNA Translation: CAA62309.1 X90793 mRNA Translation: CAA62312.1 X90794 mRNA Translation: CAA62313.1 X90795 mRNA Translation: CAA62314.1 X90963 mRNA Translation: CAA62451.1
RefSeqⁱ	NP_034516.3, NM_010386.4 XP_006523747.1, XM_006523684.3 XP_017172749.1, XM_017317260.1
UniGeneⁱ	Mm.16373

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000042121; ENSMUSP00000037088; ENSMUSG00000037649
GeneIDⁱ	14998
UCSCⁱ	uc008cbl.2 mouse

Organism-specific databases

CTDⁱ	14998
MGIⁱ	MGI:95921 H2-DMa

Phylogenomic databases

eggNOGⁱ	ENOG410IR26 Eukaryota ENOG410YJDD LUCA
GeneTreeⁱ	ENSGT00900000140882
HOVERGENⁱ	HBG001688
OMAⁱ	NHTFRHT
OrthoDBⁱ	EOG091G0LMN
TreeFamⁱ	TF333797

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2132295 MHC class II antigen presentation

Reactomeⁱ

R-MMU-2132295 MHC class II antigen presentation

Miscellaneous databases

ChiTaRSⁱ	H2-DMa mouse
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000037649 Expressed in 151 organ(s), highest expression level in lymph node

Bgeeⁱ

ENSMUSG00000037649 Expressed in 151 organ(s), highest expression level in lymph node

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit 3.10.320.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR011162 MHC_I/II-like_Ag-recog IPR014745 MHC_II_a/b_N IPR001003 MHC_II_a_N
Pfamⁱ	View protein in Pfam PF07654 C1-set, 1 hit PF00993 MHC_II_alpha, 1 hit
SMARTⁱ	View protein in SMART SM00407 IGc1, 1 hit SM00920 MHC_II_alpha, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00290 IG_MHC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q31621_MOUSE
Accessionⁱ	Q31621Primary (citable) accession number: Q31621 Secondary accession number(s): Q9QWV0
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	November 1, 1996
	Last sequence update:	November 1, 1996
	Last modified:	November 7, 2018
	This is version 188 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q31621 (Q31621_MOUSE)

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Class II histocompatibility antigen, M alpha chain

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ