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Protein
Submitted name:

Class II histocompatibility antigen, M alpha chain

Gene

H2-DMa

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation

Names & Taxonomyi

Protein namesi
Submitted name:
Class II histocompatibility antigen, M alpha chainImported
Submitted name:
H2-M alphaImported
Submitted name:
Histocompatibility 2, class II, locus DMaImported
Submitted name:
MAq1 proteinImported
Submitted name:
MAq2 proteinImported
Submitted name:
MAq4 proteinImported
Submitted name:
MAq5 proteinImported
Submitted name:
MAq6 proteinImported
Submitted name:
MHC class II H2-M alpha chainImported
Submitted name:
MHC class II antigenImported
Gene namesi
Name:H2-DMaImported
Synonyms:H2-M alphaImported, H2-MaImported, MAq1Imported, MAq2Imported, MAq3Imported, MAq4Imported, MAq5Imported, MAq6Imported, MMMAq6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:95921 H2-DMa

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei234 – 253HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_501509737227 – 261Sequence analysisAdd BLAST235

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000037649 Expressed in 151 organ(s), highest expression level in lymph node

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini121 – 215Ig-likeInterPro annotationAdd BLAST95

Sequence similaritiesi

Belongs to the MHC class II family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IR26 Eukaryota
ENOG410YJDD LUCA
GeneTreeiENSGT00900000140882
HOVERGENiHBG001688
OMAiNHTFRHT
OrthoDBiEOG091G0LMN
TreeFamiTF333797

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q31621-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHEQKSGAV LLRLLRLLWL LPHSWAVLEA STPVFWDDPQ NHTFRHTLFC
60 70 80 90 100
QDGIPNIGLS ETYDEDELFS FDFSQNTRVP RLPDFAEWAQ GQGDASAIAF
110 120 130 140 150
DKSFCEMLMR EVSPKLEGQI PVSRGLPVAE VFTLKPLEFG KPNTLVCFIS
160 170 180 190 200
NLFPPTLTVN WQLHSAPVEG ASPTSISAVD GLTFQAFSYL NFTPEPFDLY
210 220 230 240 250
SCTVTHEIDR YTAIAYWVPQ NALPSDLLEN ALCGVAFGLG VLGTIMGIVF
260
FLCSQRPCSG D
Length:261
Mass (Da):29,056
Last modified:November 1, 1996 - v1
Checksum:iF4EB12EE2FE72A57
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P28078DMA_MOUSE
Class II histocompatibility antigen...
H2-DMa H2-Ma, Ma
261Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR974422 Genomic DNA No translation available.
U35324 mRNA Translation: AAA91134.1
U35327 mRNA Translation: AAA91137.1
AF100956 Genomic DNA Translation: AAC69910.1
BC049992 mRNA Translation: AAH49992.1
AK146950 mRNA Translation: BAE27559.1
AK160460 mRNA Translation: BAE35801.1
X90785 mRNA Translation: CAA62304.1
X90786 mRNA Translation: CAA62305.1
X90790 mRNA Translation: CAA62309.1
X90793 mRNA Translation: CAA62312.1
X90794 mRNA Translation: CAA62313.1
X90795 mRNA Translation: CAA62314.1
X90963 mRNA Translation: CAA62451.1
RefSeqiNP_034516.3, NM_010386.4
XP_006523747.1, XM_006523684.3
XP_017172749.1, XM_017317260.1
UniGeneiMm.16373

Genome annotation databases

EnsembliENSMUST00000042121; ENSMUSP00000037088; ENSMUSG00000037649
GeneIDi14998
UCSCiuc008cbl.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR974422 Genomic DNA No translation available.
U35324 mRNA Translation: AAA91134.1
U35327 mRNA Translation: AAA91137.1
AF100956 Genomic DNA Translation: AAC69910.1
BC049992 mRNA Translation: AAH49992.1
AK146950 mRNA Translation: BAE27559.1
AK160460 mRNA Translation: BAE35801.1
X90785 mRNA Translation: CAA62304.1
X90786 mRNA Translation: CAA62305.1
X90790 mRNA Translation: CAA62309.1
X90793 mRNA Translation: CAA62312.1
X90794 mRNA Translation: CAA62313.1
X90795 mRNA Translation: CAA62314.1
X90963 mRNA Translation: CAA62451.1
RefSeqiNP_034516.3, NM_010386.4
XP_006523747.1, XM_006523684.3
XP_017172749.1, XM_017317260.1
UniGeneiMm.16373

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042121; ENSMUSP00000037088; ENSMUSG00000037649
GeneIDi14998
UCSCiuc008cbl.2 mouse

Organism-specific databases

CTDi14998
MGIiMGI:95921 H2-DMa

Phylogenomic databases

eggNOGiENOG410IR26 Eukaryota
ENOG410YJDD LUCA
GeneTreeiENSGT00900000140882
HOVERGENiHBG001688
OMAiNHTFRHT
OrthoDBiEOG091G0LMN
TreeFamiTF333797

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation

Miscellaneous databases

ChiTaRSiH2-DMa mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037649 Expressed in 151 organ(s), highest expression level in lymph node

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ31621_MOUSE
AccessioniPrimary (citable) accession number: Q31621
Secondary accession number(s): Q9QWV0
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 188 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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