Histocompatibility 2, M region locus 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• CD8 receptor binding Source: MGI
• identical protein binding Source: MGI
• peptide antigen binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "H2-M3-restricted CD8+ T cells are not required for MHC class Ib-restricted immunity against Listeria monocytogenes."
    D'Orazio S.E., Shaw C.A., Starnbach M.N.
    J. Exp. Med. 203:383-391(2006) [PubMed] [Europe PMC] [Abstract]
  • "Impaired response to Listeria in H2-M3-deficient mice reveals a nonredundant role of MHC class Ib-specific T cells in host defense."
    Xu H., Chun T., Choi H.J., Wang B., Wang C.R.
    J. Exp. Med. 203:449-459(2006) [PubMed] [Europe PMC] [Abstract]
  • "HMT, encoded by H-2M3, is a neoclassical major histocompatibility class I antigen."
    Wang C.R., Lindahl K.F.
    Proc. Natl. Acad. Sci. U.S.A. 90:2784-2788(1993) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: MGI
• signaling receptor binding Source: MGI

GO - Biological processⁱ

• alpha-beta T cell activation involved in immune response Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Impaired response to Listeria in H2-M3-deficient mice reveals a nonredundant role of MHC class Ib-specific T cells in host defense."
    Xu H., Chun T., Choi H.J., Wang B., Wang C.R.
    J. Exp. Med. 203:449-459(2006) [PubMed] [Europe PMC] [Abstract]
• antigen processing and presentation of endogenous peptide antigen via MHC class Ib Source: MGIInferred from direct assayⁱ
  • "HMT, encoded by H-2M3, is a neoclassical major histocompatibility class I antigen."
    Wang C.R., Lindahl K.F.
    Proc. Natl. Acad. Sci. U.S.A. 90:2784-2788(1993) [PubMed] [Europe PMC] [Abstract]
• antigen processing and presentation of exogenous peptide antigen via MHC class Ib Source: MGIInferred from direct assayⁱ
  • "H2-M3-restricted CD8+ T cells are not required for MHC class Ib-restricted immunity against Listeria monocytogenes."
    D'Orazio S.E., Shaw C.A., Starnbach M.N.
    J. Exp. Med. 203:383-391(2006) [PubMed] [Europe PMC] [Abstract]
• antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent Source: MGIInferred from direct assayⁱ
  • "H2-M3 major histocompatibility complex class Ib-restricted CD8 T cells induced by Salmonella enterica serovar Typhimurium infection recognize proteins released by Salmonella serovar Typhimurium."
    Ugrinovic S., Brooks C.G., Robson J., Blacklaws B.A., Hormaeche C.E., Robinson J.H.
    Infect. Immun. 73:8002-8008(2005) [PubMed] [Europe PMC] [Abstract]
• defense response to bacterium Source: MGIInferred from direct assayⁱ
  • "H2-M3-restricted CD8+ T cells are not required for MHC class Ib-restricted immunity against Listeria monocytogenes."
    D'Orazio S.E., Shaw C.A., Starnbach M.N.
    J. Exp. Med. 203:383-391(2006) [PubMed] [Europe PMC] [Abstract]
  • "Impaired response to Listeria in H2-M3-deficient mice reveals a nonredundant role of MHC class Ib-specific T cells in host defense."
    Xu H., Chun T., Choi H.J., Wang B., Wang C.R.
    J. Exp. Med. 203:449-459(2006) [PubMed] [Europe PMC] [Abstract]
• immune response-inhibiting cell surface receptor signaling pathway Source: MGI
• negative regulation of angiogenesis Source: MGI
• negative regulation of dendritic cell differentiation Source: MGI
• negative regulation of G0 to G1 transition Source: MGI
• negative regulation of natural killer cell mediated cytotoxicity Source: MGI
• negative regulation of protein kinase B signaling Source: MGI
• negative regulation of T cell mediated cytotoxicity Source: MGI
• negative regulation of T cell proliferation Source: MGI
• peripheral B cell tolerance induction Source: MGI
• positive regulation of cellular senescence Source: MGI
• positive regulation of endothelial cell apoptotic process Source: MGI
• positive regulation of interferon-gamma production Source: MGIInferred from mutant phenotypeⁱ
  • "Impaired response to Listeria in H2-M3-deficient mice reveals a nonredundant role of MHC class Ib-specific T cells in host defense."
    Xu H., Chun T., Choi H.J., Wang B., Wang C.R.
    J. Exp. Med. 203:449-459(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-12 production Source: MGI
• positive regulation of macrophage cytokine production Source: MGI
• positive regulation of natural killer cell cytokine production Source: MGI
• positive regulation of natural killer cell mediated cytotoxicity Source: MGIInferred from mutant phenotypeⁱ
  • "Impaired response to Listeria in H2-M3-deficient mice reveals a nonredundant role of MHC class Ib-specific T cells in host defense."
    Xu H., Chun T., Choi H.J., Wang B., Wang C.R.
    J. Exp. Med. 203:449-459(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of nitric oxide biosynthetic process Source: MGIInferred from mutant phenotypeⁱ
  • "Impaired response to Listeria in H2-M3-deficient mice reveals a nonredundant role of MHC class Ib-specific T cells in host defense."
    Xu H., Chun T., Choi H.J., Wang B., Wang C.R.
    J. Exp. Med. 203:449-459(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of regulatory T cell differentiation Source: MGI
• positive regulation of T cell mediated cytotoxicity Source: MGIInferred from direct assayⁱ
  • "H2-M3 major histocompatibility complex class Ib-restricted CD8 T cells induced by Salmonella enterica serovar Typhimurium infection recognize proteins released by Salmonella serovar Typhimurium."
    Ugrinovic S., Brooks C.G., Robson J., Blacklaws B.A., Hormaeche C.E., Robinson J.H.
    Infect. Immun. 73:8002-8008(2005) [PubMed] [Europe PMC] [Abstract]
  • "H2-M3-restricted CD8+ T cells are not required for MHC class Ib-restricted immunity against Listeria monocytogenes."
    D'Orazio S.E., Shaw C.A., Starnbach M.N.
    J. Exp. Med. 203:383-391(2006) [PubMed] [Europe PMC] [Abstract]
  • "Impaired response to Listeria in H2-M3-deficient mice reveals a nonredundant role of MHC class Ib-specific T cells in host defense."
    Xu H., Chun T., Choi H.J., Wang B., Wang C.R.
    J. Exp. Med. 203:449-459(2006) [PubMed] [Europe PMC] [Abstract]
  • "HMT, encoded by H-2M3, is a neoclassical major histocompatibility class I antigen."
    Wang C.R., Lindahl K.F.
    Proc. Natl. Acad. Sci. U.S.A. 90:2784-2788(1993) [PubMed] [Europe PMC] [Abstract]
• positive regulation of T cell tolerance induction Source: MGI
• positive regulation of tolerance induction Source: MGI
• protection from natural killer cell mediated cytotoxicity Source: MGI
• protein homotrimerization Source: MGI
• response to molecule of bacterial origin Source: MGIInferred from direct assayⁱ
  • "H2-M3 major histocompatibility complex class Ib-restricted CD8 T cells induced by Salmonella enterica serovar Typhimurium infection recognize proteins released by Salmonella serovar Typhimurium."
    Ugrinovic S., Brooks C.G., Robson J., Blacklaws B.A., Hormaeche C.E., Robinson J.H.
    Infect. Immun. 73:8002-8008(2005) [PubMed] [Europe PMC] [Abstract]

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• CD8 receptor binding Source: MGI
• identical protein binding Source: MGI
• protein homodimerization activity Source: MGI
• signaling receptor binding Source: MGI

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MGSSSNRALL HMVVVSLAVT QTGSGSHSLR YFHTAVSRPG RGEPQYISVG 
        60         70         80         90        100
YVDDVQFQRC DSIEEIPRME PRAPWMEKER PEYWKELKLK VKNIAQSARA 
       110        120        130        140        150
NLRTLLRYYN QSEGGSHILQ WMVSCEVGPD MRLLGAHYQA AYDGSDYITL 
       160        170        180        190        200
NEDLSSWTAV DMVSQITKSR LESAGTAEYF RAYVEGECLE LLHRFLRNGK 
       210        220        230        240        250
EILQRADPPK AHVAHHPRPK GDVTLRCWAL GFYPADITLT WQKDEEDLTQ 
       260        270        280        290        300
DMELVETRPS GDGTFQKWAA VVVPSGEEQR YTCYVHHEGL TEPLALKWGR 
       310        320        330 
SSQSSVVIMV IVASLVLLGG VITIVVVCKR RGAGER                

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ