UniProtKB - Q31093 (Q31093_MOUSE)
Protein
Submitted name:
Histocompatibility 2, M region locus 3
Gene
H2-M3
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- CD8 receptor binding Source: MGI
- identical protein binding Source: MGI
- peptide antigen binding Source: MGI
- protein homodimerization activity Source: MGI
- signaling receptor binding Source: MGI
GO - Biological processi
- alpha-beta T cell activation involved in immune response Source: MGI
- antigen processing and presentation of endogenous peptide antigen via MHC class Ib Source: MGI
- antigen processing and presentation of exogenous peptide antigen via MHC class Ib Source: MGI
- antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent Source: MGI
- defense response to bacterium Source: MGI
- immune response-inhibiting cell surface receptor signaling pathway Source: MGI
- negative regulation of angiogenesis Source: MGI
- negative regulation of dendritic cell differentiation Source: MGI
- negative regulation of G0 to G1 transition Source: MGI
- negative regulation of natural killer cell mediated cytotoxicity Source: MGI
- negative regulation of protein kinase B signaling Source: MGI
- negative regulation of T cell mediated cytotoxicity Source: MGI
- negative regulation of T cell proliferation Source: MGI
- peripheral B cell tolerance induction Source: MGI
- positive regulation of cellular senescence Source: MGI
- positive regulation of endothelial cell apoptotic process Source: MGI
- positive regulation of interferon-gamma production Source: MGI
- positive regulation of interleukin-12 production Source: MGI
- positive regulation of macrophage cytokine production Source: MGI
- positive regulation of natural killer cell cytokine production Source: MGI
- positive regulation of natural killer cell mediated cytotoxicity Source: MGI
- positive regulation of nitric oxide biosynthetic process Source: MGI
- positive regulation of regulatory T cell differentiation Source: MGI
- positive regulation of T cell mediated cytotoxicity Source: MGI
- positive regulation of T cell tolerance induction Source: MGI
- positive regulation of tolerance induction Source: MGI
- protection from natural killer cell mediated cytotoxicity Source: MGI
- protein homotrimerization Source: MGI
- response to molecule of bacterial origin Source: MGI
Enzyme and pathway databases
Reactomei | R-MMU-1236974 ER-Phagosome pathway R-MMU-1236977 Endosomal/Vacuolar pathway R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-2172127 DAP12 interactions R-MMU-2424491 DAP12 signaling R-MMU-6798695 Neutrophil degranulation R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
Names & Taxonomyi
Protein namesi | Submitted name: Histocompatibility 2, M region locus 3ImportedSubmitted name: MHC class I antigen H-2M3Imported |
Gene namesi | ORF Names:mCG_23393Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95915 H2-M3 |
Subcellular locationi
Endosome
- early endosome Source: MGI
Extracellular region or secreted
- extracellular space Source: GO_Central
Golgi apparatus
- cis-Golgi network membrane Source: MGI
Plasma Membrane
- external side of plasma membrane Source: MGI
- MHC class Ib protein complex Source: MGI
- plasma membrane Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 306 – 328 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_5015097374 | 26 – 336 | Sequence analysisAdd BLAST | 311 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 110 | N-linked (GlcNAc...) asparagineCombined sources | 1 | |
Disulfide bondi | 125 ↔ 188 | Combined sources | ||
Disulfide bondi | 227 ↔ 283 | Combined sources |
Keywords - PTMi
Disulfide bondSAAS annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000016206 Expressed in 177 organ(s), highest expression level in spleen |
Interactioni
GO - Molecular functioni
- CD8 receptor binding Source: MGI
- identical protein binding Source: MGI
- protein homodimerization activity Source: MGI
- signaling receptor binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000035687 |
Structurei
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 209 – 297 | Ig-likeInterPro annotationAdd BLAST | 89 |
Sequence similaritiesi
Belongs to the MHC class I family.UniRule annotation
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | ENOG410KII2 Eukaryota ENOG4111K8F LUCA |
GeneTreei | ENSGT00970000193340 |
HOGENOMi | HOG000296917 |
KOi | K06751 |
OMAi | VEGECLE |
OrthoDBi | 912212at2759 |
TreeFami | TF336617 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR011161 MHC_I-like_Ag-recog IPR037055 MHC_I-like_Ag-recog_sf IPR011162 MHC_I/II-like_Ag-recog IPR001039 MHC_I_a_a1/a2 |
Pfami | View protein in Pfam PF07654 C1-set, 1 hit PF00129 MHC_I, 1 hit |
PRINTSi | PR01638 MHCCLASSI |
SMARTi | View protein in SMART SM00407 IGc1, 1 hit |
SUPFAMi | SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00290 IG_MHC, 1 hit |
i Sequence
Sequence statusi: Complete.
Q31093-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSSSNRALL HMVVVSLAVT QTGSGSHSLR YFHTAVSRPG RGEPQYISVG
60 70 80 90 100
YVDDVQFQRC DSIEEIPRME PRAPWMEKER PEYWKELKLK VKNIAQSARA
110 120 130 140 150
NLRTLLRYYN QSEGGSHILQ WMVSCEVGPD MRLLGAHYQA AYDGSDYITL
160 170 180 190 200
NEDLSSWTAV DMVSQITKSR LESAGTAEYF RAYVEGECLE LLHRFLRNGK
210 220 230 240 250
EILQRADPPK AHVAHHPRPK GDVTLRCWAL GFYPADITLT WQKDEEDLTQ
260 270 280 290 300
DMELVETRPS GDGTFQKWAA VVVPSGEEQR YTCYVHHEGL TEPLALKWGR
310 320 330
SSQSSVVIMV IVASLVLLGG VITIVVVCKR RGAGER
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CT033782 Genomic DNA No translation available. U18797 mRNA Translation: AAA60335.1 CH466559 Genomic DNA Translation: EDL23336.1 |
RefSeqi | NP_038847.1, NM_013819.2 |
Genome annotation databases
Ensembli | ENSMUST00000038580; ENSMUSP00000035687; ENSMUSG00000016206 |
GeneIDi | 14991 |
KEGGi | mmu:14991 |
UCSCi | uc008cmo.1 mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CT033782 Genomic DNA No translation available. U18797 mRNA Translation: AAA60335.1 CH466559 Genomic DNA Translation: EDL23336.1 |
RefSeqi | NP_038847.1, NM_013819.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1MHC | X-ray | 2.10 | A/D | 25-298 | [»] | |
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000035687 |
Genome annotation databases
Ensembli | ENSMUST00000038580; ENSMUSP00000035687; ENSMUSG00000016206 |
GeneIDi | 14991 |
KEGGi | mmu:14991 |
UCSCi | uc008cmo.1 mouse |
Organism-specific databases
CTDi | 14991 |
MGIi | MGI:95915 H2-M3 |
Phylogenomic databases
eggNOGi | ENOG410KII2 Eukaryota ENOG4111K8F LUCA |
GeneTreei | ENSGT00970000193340 |
HOGENOMi | HOG000296917 |
KOi | K06751 |
OMAi | VEGECLE |
OrthoDBi | 912212at2759 |
TreeFami | TF336617 |
Enzyme and pathway databases
Reactomei | R-MMU-1236974 ER-Phagosome pathway R-MMU-1236977 Endosomal/Vacuolar pathway R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-2172127 DAP12 interactions R-MMU-2424491 DAP12 signaling R-MMU-6798695 Neutrophil degranulation R-MMU-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
Miscellaneous databases
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000016206 Expressed in 177 organ(s), highest expression level in spleen |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set IPR011161 MHC_I-like_Ag-recog IPR037055 MHC_I-like_Ag-recog_sf IPR011162 MHC_I/II-like_Ag-recog IPR001039 MHC_I_a_a1/a2 |
Pfami | View protein in Pfam PF07654 C1-set, 1 hit PF00129 MHC_I, 1 hit |
PRINTSi | PR01638 MHCCLASSI |
SMARTi | View protein in SMART SM00407 IGc1, 1 hit |
SUPFAMi | SSF48726 SSF48726, 1 hit SSF54452 SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835 IG_LIKE, 1 hit PS00290 IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q31093_MOUSE | |
Accessioni | Q31093Primary (citable) accession number: Q31093 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 1, 1996 |
Last sequence update: | November 1, 1996 | |
Last modified: | November 13, 2019 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |