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Protein

LL-diaminopimelate aminotransferase

Gene

dapL

Organism
Desulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.UniRule annotation

Catalytic activityi

LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. LL-diaminopimelate aminotransferase (dapL)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei16SubstrateUniRule annotation1
Binding sitei41Substrate; via amide nitrogenUniRule annotation1
Binding sitei70Pyridoxal phosphateUniRule annotation1
Binding sitei105SubstrateUniRule annotation1
Binding sitei129Pyridoxal phosphateUniRule annotation1
Binding sitei129SubstrateUniRule annotation1
Binding sitei179Pyridoxal phosphateUniRule annotation1
Binding sitei179SubstrateUniRule annotation1
Binding sitei210Pyridoxal phosphateUniRule annotation1
Binding sitei250Pyridoxal phosphateUniRule annotation1
Binding sitei368SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciDALA207559:G1G52-1845-MONOMER
UniPathwayi
UPA00034;UER00466

Names & Taxonomyi

Protein namesi
Recommended name:
LL-diaminopimelate aminotransferaseUniRule annotation (EC:2.6.1.83UniRule annotation)
Short name:
DAP-ATUniRule annotation
Short name:
DAP-aminotransferaseUniRule annotation
Short name:
LL-DAP-aminotransferaseUniRule annotation
Gene namesi
Name:dapLUniRule annotation
Ordered Locus Names:Dde_1970
OrganismiDesulfovibrio alaskensis (strain G20) (Desulfovibrio desulfuricans (strain G20))
Taxonomic identifieri207559 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000002710 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003422351 – 388LL-diaminopimelate aminotransferaseAdd BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei242N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi207559.Dde_1970

Structurei

3D structure databases

ProteinModelPortaliQ30ZX9
SMRiQ30ZX9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni104 – 105Pyridoxal phosphate bindingUniRule annotation2
Regioni239 – 241Pyridoxal phosphate bindingUniRule annotation3

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CHM Bacteria
COG0436 LUCA
HOGENOMiHOG000223051
KOiK10206
OMAiTGTRCAF
OrthoDBiPOG091H09WQ

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01642 DapL_aminotrans_1, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR019881 DAP-NH2Trfase_DapL_Desulfo
IPR019942 DapL/ALD1
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03540 DapC_direct, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q30ZX9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTQFTLADRL ATLPPYLFAQ IDKVKAEVAA RGVDIISLGI GDPDMPTPDF
60 70 80 90 100
VIEALKKAAE KPANHQYPSY TGMLAFRQEV ANWYKRRYAV ELDPKTEVLT
110 120 130 140 150
LIGSKEGIAH FPTAFVNPGD LVLVCPPCYP VYAIASRFMG GVVQELPLLE
160 170 180 190 200
ENDFLPDLDA VDEATWEKAR CIFVNYPNNP TAAMAPRSFF EKLIGIARKH
210 220 230 240 250
NVIVVHDAAY TEMYYNENNR PLSIMEIPGA MDVAIEFNSL SKPYNMTGWR
260 270 280 290 300
IAMAVGNASL VAGLGKVKEN MDSGAFQAVQ EAAIVALRDG DAFLAEIRDI
310 320 330 340 350
YRKRRDTVIA ALNKIGITCR VPEASLYVWA RVPEGYTSSD FVTRVLQETG
360 370 380
VVMTPGNGFG AAGEGYFRIS LTVNDERLEE AVSRIASL
Length:388
Mass (Da):42,773
Last modified:December 6, 2005 - v1
Checksum:i68CA2F7BA4A6942C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000112 Genomic DNA Translation: ABB38767.1
RefSeqiWP_011367877.1, NC_007519.1

Genome annotation databases

EnsemblBacteriaiABB38767; ABB38767; Dde_1970
KEGGidde:Dde_1970

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000112 Genomic DNA Translation: ABB38767.1
RefSeqiWP_011367877.1, NC_007519.1

3D structure databases

ProteinModelPortaliQ30ZX9
SMRiQ30ZX9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi207559.Dde_1970

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB38767; ABB38767; Dde_1970
KEGGidde:Dde_1970

Phylogenomic databases

eggNOGiENOG4105CHM Bacteria
COG0436 LUCA
HOGENOMiHOG000223051
KOiK10206
OMAiTGTRCAF
OrthoDBiPOG091H09WQ

Enzyme and pathway databases

UniPathwayi
UPA00034;UER00466

BioCyciDALA207559:G1G52-1845-MONOMER

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01642 DapL_aminotrans_1, 1 hit
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR019881 DAP-NH2Trfase_DapL_Desulfo
IPR019942 DapL/ALD1
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03540 DapC_direct, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDAPAT_DESAG
AccessioniPrimary (citable) accession number: Q30ZX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: December 6, 2005
Last modified: October 10, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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