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Protein

Beta-defensin 114

Gene

DEFB114

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality.1 Publication

GO - Molecular functioni

  • lipopolysaccharide binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 114
Alternative name(s):
Beta-defensin 14
Short name:
DEFB-14
Defensin, beta 114
Gene namesi
Name:DEFB114
Synonyms:DEFB14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000177684.3
HGNCiHGNC:18095 DEFB114
MIMi615243 gene
neXtProtiNX_Q30KQ6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi245928
OpenTargetsiENSG00000177684
PharmGKBiPA38491

Polymorphism and mutation databases

BioMutaiDEFB114
DMDMi85540943

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000004534227 – 69Beta-defensin 114Add BLAST43

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 57By similarity
Disulfide bondi36 ↔ 50By similarity
Disulfide bondi40 ↔ 58By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ30KQ6
PRIDEiQ30KQ6
ProteomicsDBi61578

Expressioni

Tissue specificityi

Expressed in epididymis, predominantly in the caput (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000177684 Expressed in 12 organ(s), highest expression level in testis
CleanExiHS_DEFB114

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000312702

Structurei

3D structure databases

ProteinModelPortaliQ30KQ6
SMRiQ30KQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2YN Eukaryota
ENOG41118KN LUCA
GeneTreeiENSGT00390000016155
HOGENOMiHOG000112153
HOVERGENiHBG081409
InParanoidiQ30KQ6
OMAiHFLCYVT
OrthoDBiEOG091G144T
PhylomeDBiQ30KQ6
TreeFamiTF341328

Family and domain databases

InterProiView protein in InterPro
IPR025933 Beta_defensin
PfamiView protein in Pfam
PF13841 Defensin_beta_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KQ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRIFYYLHFL CYVTFILPAT CTLVNADRCT KRYGRCKRDC LESEKQIDIC
60
SLPRKICCTE KLYEEDDMF
Length:69
Mass (Da):8,318
Last modified:December 6, 2005 - v1
Checksum:i3ACF561F6636F772
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54R → G in AAM93912 (PubMed:11854508).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012018 mRNA Translation: AAY59754.1
AY122470 mRNA Translation: AAM93912.1
CCDSiCCDS34474.1
RefSeqiNP_001032588.1, NM_001037499.1
UniGeneiHs.381372

Genome annotation databases

EnsembliENST00000322066; ENSP00000312702; ENSG00000177684
GeneIDi245928
KEGGihsa:245928
UCSCiuc011dwp.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012018 mRNA Translation: AAY59754.1
AY122470 mRNA Translation: AAM93912.1
CCDSiCCDS34474.1
RefSeqiNP_001032588.1, NM_001037499.1
UniGeneiHs.381372

3D structure databases

ProteinModelPortaliQ30KQ6
SMRiQ30KQ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000312702

Polymorphism and mutation databases

BioMutaiDEFB114
DMDMi85540943

Proteomic databases

PaxDbiQ30KQ6
PRIDEiQ30KQ6
ProteomicsDBi61578

Protocols and materials databases

DNASUi245928
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322066; ENSP00000312702; ENSG00000177684
GeneIDi245928
KEGGihsa:245928
UCSCiuc011dwp.3 human

Organism-specific databases

CTDi245928
DisGeNETi245928
EuPathDBiHostDB:ENSG00000177684.3
GeneCardsiDEFB114
HGNCiHGNC:18095 DEFB114
MIMi615243 gene
neXtProtiNX_Q30KQ6
OpenTargetsiENSG00000177684
PharmGKBiPA38491
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2YN Eukaryota
ENOG41118KN LUCA
GeneTreeiENSGT00390000016155
HOGENOMiHOG000112153
HOVERGENiHBG081409
InParanoidiQ30KQ6
OMAiHFLCYVT
OrthoDBiEOG091G144T
PhylomeDBiQ30KQ6
TreeFamiTF341328

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Miscellaneous databases

GenomeRNAii245928
PROiPR:Q30KQ6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177684 Expressed in 12 organ(s), highest expression level in testis
CleanExiHS_DEFB114

Family and domain databases

InterProiView protein in InterPro
IPR025933 Beta_defensin
PfamiView protein in Pfam
PF13841 Defensin_beta_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDB114_HUMAN
AccessioniPrimary (citable) accession number: Q30KQ6
Secondary accession number(s): Q8NES9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 6, 2005
Last modified: September 12, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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