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Protein

Beta-defensin 136

Gene

DEFB136

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has antibacterial activity.Curated

Caution

Was termed (Ref. 2) DEFB137.Curated

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 136
Alternative name(s):
Defensin, beta 136
Gene namesi
Name:DEFB136
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000205884.2
HGNCiHGNC:34433 DEFB136
neXtProtiNX_Q30KP8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000205884
PharmGKBiPA165585543

Polymorphism and mutation databases

BioMutaiDEFB136
DMDMi84028899

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000004536422 – 78Beta-defensin 136Add BLAST57

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 60By similarity
Disulfide bondi40 ↔ 54By similarity
Disulfide bondi44 ↔ 61By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ30KP8
PeptideAtlasiQ30KP8
PRIDEiQ30KP8
ProteomicsDBi61571

Expressioni

Gene expression databases

BgeeiENSG00000205884 Expressed in 50 organ(s), highest expression level in body of pancreas

Organism-specific databases

HPAiHPA068255

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371644

Structurei

3D structure databases

ProteinModelPortaliQ30KP8
SMRiQ30KP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JGWX Eukaryota
ENOG411149T LUCA
GeneTreeiENSGT00390000001862
HOGENOMiHOG000112165
HOVERGENiHBG069057
InParanoidiQ30KP8
OMAiCFFGCKP
OrthoDBiEOG091G1831
PhylomeDBiQ30KP8
TreeFamiTF343350

Family and domain databases

InterProiView protein in InterPro
IPR035307 DEFB136/42
PANTHERiPTHR39413 PTHR39413, 1 hit
PfamiView protein in Pfam
PF17333 DEFB136, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD745294 PD745294, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KP8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLCLSALLF FLVILLPSGK GMFGNDGVKV RTCTSQKAVC FFGCPPGYRW
60 70
IAFCHNILSC CKNMTRFQPP QAKDPWVH
Length:78
Mass (Da):8,755
Last modified:December 6, 2005 - v1
Checksum:i26F291E8E0EF3A40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012026 mRNA Translation: AAY59762.1
AY621333 mRNA Translation: AAT51872.1
CCDSiCCDS43709.1
RefSeqiNP_001028190.2, NM_001033018.2
XP_016885978.1, XM_017030489.1
UniGeneiHs.558285

Genome annotation databases

EnsembliENST00000382209; ENSP00000371644; ENSG00000205884
ENST00000646795; ENSP00000494776; ENSG00000285087
GeneIDi613210
KEGGihsa:613210
UCSCiuc011kxm.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012026 mRNA Translation: AAY59762.1
AY621333 mRNA Translation: AAT51872.1
CCDSiCCDS43709.1
RefSeqiNP_001028190.2, NM_001033018.2
XP_016885978.1, XM_017030489.1
UniGeneiHs.558285

3D structure databases

ProteinModelPortaliQ30KP8
SMRiQ30KP8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000371644

Polymorphism and mutation databases

BioMutaiDEFB136
DMDMi84028899

Proteomic databases

PaxDbiQ30KP8
PeptideAtlasiQ30KP8
PRIDEiQ30KP8
ProteomicsDBi61571

Protocols and materials databases

DNASUi613210
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382209; ENSP00000371644; ENSG00000205884
ENST00000646795; ENSP00000494776; ENSG00000285087
GeneIDi613210
KEGGihsa:613210
UCSCiuc011kxm.2 human

Organism-specific databases

CTDi613210
EuPathDBiHostDB:ENSG00000205884.2
GeneCardsiDEFB136
HGNCiHGNC:34433 DEFB136
HPAiHPA068255
neXtProtiNX_Q30KP8
OpenTargetsiENSG00000205884
PharmGKBiPA165585543
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JGWX Eukaryota
ENOG411149T LUCA
GeneTreeiENSGT00390000001862
HOGENOMiHOG000112165
HOVERGENiHBG069057
InParanoidiQ30KP8
OMAiCFFGCKP
OrthoDBiEOG091G1831
PhylomeDBiQ30KP8
TreeFamiTF343350

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Miscellaneous databases

GenomeRNAii613210
PROiPR:Q30KP8

Gene expression databases

BgeeiENSG00000205884 Expressed in 50 organ(s), highest expression level in body of pancreas

Family and domain databases

InterProiView protein in InterPro
IPR035307 DEFB136/42
PANTHERiPTHR39413 PTHR39413, 1 hit
PfamiView protein in Pfam
PF17333 DEFB136, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD745294 PD745294, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDB136_HUMAN
AccessioniPrimary (citable) accession number: Q30KP8
Secondary accession number(s): Q4QY36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: November 7, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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