UniProtKB - Q309B1 (TR16L_HUMAN)
Protein
Tripartite motif-containing protein 16-like protein
Gene
TRIM16L
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Tripartite motif-containing protein 16-like proteinAlternative name(s): Tripartite motif-containing protein 70 |
Gene namesi | Name:TRIM16L Synonyms:TRIM70 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:32670, TRIM16L |
neXtProti | NX_Q309B1 |
VEuPathDBi | HostDB:ENSG00000108448.20 |
Subcellular locationi
Other locations
- Cytoplasm By similarity
Cytosol
- cytosol Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 147166 |
OpenTargetsi | ENSG00000108448 |
PharmGKBi | PA144596249 |
Miscellaneous databases
Pharosi | Q309B1, Tdark |
Genetic variation databases
BioMutai | TRIM16L |
DMDMi | 296453011 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000279515 | 1 – 348 | Tripartite motif-containing protein 16-like proteinAdd BLAST | 348 |
Proteomic databases
EPDi | Q309B1 |
jPOSTi | Q309B1 |
MassIVEi | Q309B1 |
MaxQBi | Q309B1 |
PaxDbi | Q309B1 |
PeptideAtlasi | Q309B1 |
PRIDEi | Q309B1 |
ProteomicsDBi | 5371 61570 [Q309B1-1] |
PTM databases
iPTMneti | Q309B1 |
PhosphoSitePlusi | Q309B1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000108448, Expressed in heart left ventricle and 115 other tissues |
Genevisiblei | Q309B1, HS |
Organism-specific databases
HPAi | ENSG00000108448, Tissue enhanced (skeletal) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 127041, 12 interactors |
IntActi | Q309B1, 11 interactors |
STRINGi | 9606.ENSP00000461386 |
Miscellaneous databases
RNActi | Q309B1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 139 – 337 | B30.2/SPRYPROSITE-ProRule annotationAdd BLAST | 199 |
Sequence similaritiesi
Belongs to the TRIM/RBCC family.Curated
Phylogenomic databases
eggNOGi | KOG0274, Eukaryota |
GeneTreei | ENSGT00940000161116 |
HOGENOMi | CLU_013137_0_2_1 |
InParanoidi | Q309B1 |
OMAi | FEYWRQA |
OrthoDBi | 273204at2759 |
PhylomeDBi | Q309B1 |
TreeFami | TF332213 |
Family and domain databases
Gene3Di | 2.60.120.920, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR006574, PRY IPR003877, SPRY_dom |
Pfami | View protein in Pfam PF13765, PRY, 1 hit PF00622, SPRY, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00589, PRY, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q309B1-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQFGELLAAV RKAQANVMLF LEEKEQAALS QANGIKAHLE YRSAEMEKSK
60 70 80 90 100
QELETMAAIS NTVQFLEEYC KFKNTEDITF PSVYIGLKDK LSGIRKVITE
110 120 130 140 150
STVHLIQLLE NYKKKLQEFS KEEEYDIRTQ VSAIVQRKYW TSKPEPSTRE
160 170 180 190 200
QFLQYVHDIT FDPDTAHKYL RLQEENRKVT NTTPWEHPYP DLPSRFLHWR
210 220 230 240 250
QVLSQQSLYL HRYYFEVEIF GAGTYVGLTC KGIDQKGEER SSCISGNNFS
260 270 280 290 300
WSLQWNGKEF TAWYSDMETP LKAGPFWRLG VYIDFPGGIL SFYGVEYDSM
310 320 330 340
TLVHKFACKF SEPVYAAFWL SKKENAIRIV DLGEEPEKPA PSLVGTAP
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 42 | R → K in BAG60964 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 42 | R → K in AAI27828 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 42 | R → K in AAI28592 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_044369 | 68 – 140 | EYCKF…QRKYW → MCMTSRSTRTQHTSISGCRR RTARSPTPRPGSIPTRTSPA GSCTGGRCCPSRVCTCTGTI LRWRSSGQAPMLA in isoform 2. 1 PublicationAdd BLAST | 73 | |
Alternative sequenceiVSP_044370 | 141 – 348 | Missing in isoform 2. 1 PublicationAdd BLAST | 208 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ232882 mRNA Translation: ABB18375.1 AK298836 mRNA Translation: BAG60964.1 AK301639 mRNA Translation: BAG63120.1 AK301647 mRNA Translation: BAH13530.1 AK316368 mRNA Translation: BAH14739.1 AC026271 Genomic DNA No translation available. AC107982 Genomic DNA No translation available. BC127827 mRNA Translation: AAI27828.1 BC128591 mRNA Translation: AAI28592.1 BC146907 mRNA Translation: AAI46908.1 BC146902 mRNA Translation: AAI46903.1 |
CCDSi | CCDS32588.1 [Q309B1-1] |
RefSeqi | NP_001032407.1, NM_001037330.1 [Q309B1-1] XP_005256538.1, XM_005256481.4 XP_005256540.1, XM_005256483.4 XP_011521992.1, XM_011523690.2 [Q309B1-1] XP_016879734.1, XM_017024245.1 [Q309B1-1] XP_016879735.1, XM_017024246.1 [Q309B1-1] XP_016879736.1, XM_017024247.1 [Q309B1-1] XP_016879737.1, XM_017024248.1 [Q309B1-1] XP_016879738.1, XM_017024249.1 [Q309B1-1] XP_016879739.1, XM_017024250.1 [Q309B1-1] XP_016879740.1, XM_017024251.1 XP_016879741.1, XM_017024252.1 [Q309B1-1] |
Genome annotation databases
Ensembli | ENST00000395671; ENSP00000379030; ENSG00000108448 [Q309B1-1] |
GeneIDi | 147166 |
KEGGi | hsa:147166 |
UCSCi | uc002gug.2, human [Q309B1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ232882 mRNA Translation: ABB18375.1 AK298836 mRNA Translation: BAG60964.1 AK301639 mRNA Translation: BAG63120.1 AK301647 mRNA Translation: BAH13530.1 AK316368 mRNA Translation: BAH14739.1 AC026271 Genomic DNA No translation available. AC107982 Genomic DNA No translation available. BC127827 mRNA Translation: AAI27828.1 BC128591 mRNA Translation: AAI28592.1 BC146907 mRNA Translation: AAI46908.1 BC146902 mRNA Translation: AAI46903.1 |
CCDSi | CCDS32588.1 [Q309B1-1] |
RefSeqi | NP_001032407.1, NM_001037330.1 [Q309B1-1] XP_005256538.1, XM_005256481.4 XP_005256540.1, XM_005256483.4 XP_011521992.1, XM_011523690.2 [Q309B1-1] XP_016879734.1, XM_017024245.1 [Q309B1-1] XP_016879735.1, XM_017024246.1 [Q309B1-1] XP_016879736.1, XM_017024247.1 [Q309B1-1] XP_016879737.1, XM_017024248.1 [Q309B1-1] XP_016879738.1, XM_017024249.1 [Q309B1-1] XP_016879739.1, XM_017024250.1 [Q309B1-1] XP_016879740.1, XM_017024251.1 XP_016879741.1, XM_017024252.1 [Q309B1-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127041, 12 interactors |
IntActi | Q309B1, 11 interactors |
STRINGi | 9606.ENSP00000461386 |
PTM databases
iPTMneti | Q309B1 |
PhosphoSitePlusi | Q309B1 |
Genetic variation databases
BioMutai | TRIM16L |
DMDMi | 296453011 |
Proteomic databases
EPDi | Q309B1 |
jPOSTi | Q309B1 |
MassIVEi | Q309B1 |
MaxQBi | Q309B1 |
PaxDbi | Q309B1 |
PeptideAtlasi | Q309B1 |
PRIDEi | Q309B1 |
ProteomicsDBi | 5371 61570 [Q309B1-1] |
Protocols and materials databases
Antibodypediai | 2838, 19 antibodies |
Genome annotation databases
Ensembli | ENST00000395671; ENSP00000379030; ENSG00000108448 [Q309B1-1] |
GeneIDi | 147166 |
KEGGi | hsa:147166 |
UCSCi | uc002gug.2, human [Q309B1-1] |
Organism-specific databases
CTDi | 147166 |
DisGeNETi | 147166 |
GeneCardsi | TRIM16L |
HGNCi | HGNC:32670, TRIM16L |
HPAi | ENSG00000108448, Tissue enhanced (skeletal) |
neXtProti | NX_Q309B1 |
OpenTargetsi | ENSG00000108448 |
PharmGKBi | PA144596249 |
VEuPathDBi | HostDB:ENSG00000108448.20 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0274, Eukaryota |
GeneTreei | ENSGT00940000161116 |
HOGENOMi | CLU_013137_0_2_1 |
InParanoidi | Q309B1 |
OMAi | FEYWRQA |
OrthoDBi | 273204at2759 |
PhylomeDBi | Q309B1 |
TreeFami | TF332213 |
Enzyme and pathway databases
PathwayCommonsi | Q309B1 |
Miscellaneous databases
BioGRID-ORCSi | 147166, 3 hits in 848 CRISPR screens |
ChiTaRSi | TRIM16L, human |
GenomeRNAii | 147166 |
Pharosi | Q309B1, Tdark |
PROi | PR:Q309B1 |
RNActi | Q309B1, protein |
Gene expression databases
Bgeei | ENSG00000108448, Expressed in heart left ventricle and 115 other tissues |
Genevisiblei | Q309B1, HS |
Family and domain databases
Gene3Di | 2.60.120.920, 1 hit |
InterProi | View protein in InterPro IPR001870, B30.2/SPRY IPR043136, B30.2/SPRY_sf IPR003879, Butyrophylin_SPRY IPR013320, ConA-like_dom_sf IPR006574, PRY IPR003877, SPRY_dom |
Pfami | View protein in Pfam PF13765, PRY, 1 hit PF00622, SPRY, 1 hit |
PRINTSi | PR01407, BUTYPHLNCDUF |
SMARTi | View protein in SMART SM00589, PRY, 1 hit SM00449, SPRY, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS50188, B302_SPRY, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TR16L_HUMAN | |
Accessioni | Q309B1Primary (citable) accession number: Q309B1 Secondary accession number(s): A0PK10 B4DWQ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 6, 2007 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 10, 2021 | |
This is version 121 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families