Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q30154 (DRB5_HUMAN)

Entry version 180 (10 Feb 2021)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Add a publicationFeedback
Protein

HLA class II histocompatibility antigen, DR beta 5 chain

Gene

HLA-DRB5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

Caution

HLA-DRB3, HLA-DRB4 and HLA-DRB5 may represent a unique gene.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q30154

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-202424, Downstream TCR signaling
R-HSA-202427, Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430, Translocation of ZAP-70 to Immunological synapse
R-HSA-202433, Generation of second messenger molecules
R-HSA-2132295, MHC class II antigen presentation
R-HSA-389948, PD-1 signaling
R-HSA-877300, Interferon gamma signaling

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q30154

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HLA class II histocompatibility antigen, DR beta 5 chain
Alternative name(s):
DR beta-5
DR2-beta-2
Dw2
MHC class II antigen DRB5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HLA-DRB5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:4953, HLA-DRB5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604776, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q30154

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000198502.5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 227ExtracellularSequence analysisAdd BLAST198
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 266CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC II

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		3127

NIAGADS Genomics Database

More...NIAGADSi		ENSG00000198502

Open Targets

More...OpenTargetsi		ENSG00000198502

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35076

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q30154, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3988561

Drug and drug target database

More...DrugBanki		DB05121, 1D09C3
DB11294, Coccidioides immitis spherule

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HLA-DRB5

Domain mapping of disease mutations (DMDM)

More...DMDMi		74754558

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 291 PublicationAdd BLAST29
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500014310630 – 266HLA class II histocompatibility antigen, DR beta 5 chainAdd BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi44 ↔ 108
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi48N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi146 ↔ 202

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by MARCH1 and MARCH8 at Lys-254 leading to down-regulation of MHC class II.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q30154

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q30154

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q30154

PeptideAtlas

More...PeptideAtlasi		Q30154

PRoteomics IDEntifications database

More...PRIDEi		Q30154

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		61556

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1378, 2 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q30154, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q30154

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q30154

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198502, Expressed in lung and 114 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q30154, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q30154, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198502, Tissue enhanced (lung, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.

4 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109372, 16 interactors

Protein interaction database and analysis system

More...IntActi		Q30154, 11 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000364114

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q30154, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1266
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q30154

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q30154

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini126 – 214Ig-like C1-typeSequence analysisAdd BLAST89

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni30 – 124Beta-1Sequence analysisAdd BLAST95
Regioni125 – 227Beta-2Sequence analysisAdd BLAST103

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MHC class II family.Sequence analysis

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RYBQ, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154993

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_047501_13_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q30154

Identification of Orthologs from Complete Genome Data

More...OMAi		YFYNREE

Database of Orthologous Groups

More...OrthoDBi		1249505at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q30154

TreeFam database of animal gene trees

More...TreeFami		TF336626

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit
3.10.320.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003597, Ig_C1-set
IPR011162, MHC_I/II-like_Ag-recog
IPR014745, MHC_II_a/b_N
IPR000353, MHC_II_b_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07654, C1-set, 1 hit
PF00969, MHC_II_beta, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00407, IGc1, 1 hit
SM00921, MHC_II_beta, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 1 hit
SSF54452, SSF54452, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS00290, IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q30154-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVCLKLPGGS YMAKLTVTLM VLSSPLALAG DTRPRFLQQD KYECHFFNGT 
        60         70         80         90        100
ERVRFLHRDI YNQEEDLRFD SDVGEYRAVT ELGRPDAEYW NSQKDFLEDR 
       110        120        130        140        150
RAAVDTYCRH NYGVGESFTV QRRVEPKVTV YPARTQTLQH HNLLVCSVNG 
       160        170        180        190        200
FYPGSIEVRW FRNSQEEKAG VVSTGLIQNG DWTFQTLVML ETVPRSGEVY 
       210        220        230        240        250
TCQVEHPSVT SPLTVEWRAQ SESAQSKMLS GVGGFVLGLL FLGAGLFIYF 
       260 
KNQKGHSGLH PTGLVS
Length:266
Mass (Da):30,056
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D4335BAEEA6AF22
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti139Q → E AA sequence (PubMed:6576979).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The following alleles of DRB5 are known: DRB5*01:01, DRB5*01:02, DRB5*01:03, DRB5*01:04, DRB5*01:05, DRB5*01:06, DRB5*01:07, DRB5*01:09, DRB5*01:11, DRB5*01:12 DRB5*01:13, DRB5*01:14, DRB5*02:02, DRB5*02:03, DRB5*02:04, DRB5*02:05. The sequence shown is that of DRB5*01:01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06095114K → M. Corresponds to variant dbSNP:rs1064587Ensembl.1
Natural variantiVAR_06095214K → Q. Corresponds to variant dbSNP:rs701884Ensembl.1
Natural variantiVAR_06095314K → V in allele DRB5*02:02; requires 2 nucleotide substitutions. 1
Natural variantiVAR_05035520M → T. Corresponds to variant dbSNP:rs17211043Ensembl.1
Natural variantiVAR_03987128L → S3 Publications1
Natural variantiVAR_05035633R → Q. Corresponds to variant dbSNP:rs1141741Ensembl.1
Natural variantiVAR_06095435R → C in allele DRB5*02:02, allele DRB5*02:04 and allele DRB5*02:05. Corresponds to variant dbSNP:rs1136744Ensembl.1
Natural variantiVAR_05035741K → T. Corresponds to variant dbSNP:rs200581589Ensembl.1
Natural variantiVAR_06095557H → Q. Corresponds to variant dbSNP:rs202185589Ensembl.1
Natural variantiVAR_06095659D → G in allele DRB5*01:02, allele DRB5*01:03, allele DRB5*02:02, allele DRB5*02:03, allele DRB5*02:04 and allele DRB5*02:05. Corresponds to variant dbSNP:rs41546317Ensembl.1
Natural variantiVAR_05035862N → H. Corresponds to variant dbSNP:rs1059576Ensembl.1
Natural variantiVAR_06095866D → N in allele DRB5*01:02, allele DRB5*01:03, allele DRB5*02:02, allele DRB5*02:03, allele DRB5*02:04 and allele DRB5*02:05. Corresponds to variant dbSNP:rs707956Ensembl.1
Natural variantiVAR_06095966D → Y in allele DRB5*01:14. Corresponds to variant dbSNP:rs707956Ensembl.1
Natural variantiVAR_06096067L → V in allele DRB5*01:02, allele DRB5*01:03, allele DRB5*01:05, allele DRB5*01:14, allele DRB5*02:02, allele DRB5*02:03, allele DRB5*02:04 and allele DRB5*02:05. Corresponds to variant dbSNP:rs1059580Ensembl.1
Natural variantiVAR_06096187A → E in allele DRB5*01:13. 1
Natural variantiVAR_06096289Y → S in allele DRB5*01:12. Corresponds to variant dbSNP:rs41541218Ensembl.1
Natural variantiVAR_06096496F → I in allele DRB5*01:06, allele DRB5*01:07, allele DRB5*01:11, allele DRB5*02:02 and allele DRB5*02:03. Corresponds to variant dbSNP:rs696318Ensembl.1
Natural variantiVAR_06096396F → L in allele DRB5*02:05. Corresponds to variant dbSNP:rs696318Ensembl.1
Natural variantiVAR_06096599D → E. Corresponds to variant dbSNP:rs41559913Ensembl.1
Natural variantiVAR_06096699D → G. Corresponds to variant dbSNP:rs41545413Ensembl.1
Natural variantiVAR_06096799D → H. Corresponds to variant dbSNP:rs41547217Ensembl.1
Natural variantiVAR_06096899D → N in allele DRB5*01:09. Corresponds to variant dbSNP:rs41547217Ensembl.1
Natural variantiVAR_06096999D → Q in allele DRB5*01:06, allele DRB5*01:11, allele DRB5*02:02, allele DRB5*02:03, allele DRB5*02:04 and allele DRB5*02:05; requires 2 nucleotide substitutions. 1
Natural variantiVAR_06097099D → R in allele DRB5*01:12; requires 2 nucleotide substitutions. 1
Natural variantiVAR_060971100R → A in allele DRB5*01:06, allele DRB5*01:11, allele DRB5*02:02, allele DRB5*02:03 and allele DRB5*02:04; requires 2 nucleotide substitutions. 1
Natural variantiVAR_060972100R → G. Corresponds to variant dbSNP:rs41551116Ensembl.1
Natural variantiVAR_060973100R → T in allele DRB5*01:03. Corresponds to variant dbSNP:rs41544215Ensembl.1
Natural variantiVAR_060974103A → E in allele DRB5*01:12. Corresponds to variant dbSNP:rs1059598Ensembl.1
Natural variantiVAR_060975103A → L in allele DRB5*01:04; requires 2 nucleotide substitutions. 1
Natural variantiVAR_050359106T → N. Corresponds to variant dbSNP:rs115817940Ensembl.1
Natural variantiVAR_060976107Y → V in allele DRB5*01:12; requires 2 nucleotide substitutions. 1
Natural variantiVAR_060977114V → A in allele DRB5*01:06, allele DRB5*02:02, allele DRB5*02:04 and allele DRB5*02:05. Corresponds to variant dbSNP:rs1136778Ensembl.1
Natural variantiVAR_060978115G → V in allele DRB5*01:06, allele DRB5*02:02, allele DRB5*02:04 and allele DRB5*02:05. Corresponds to variant dbSNP:rs41556512Ensembl.1
Natural variantiVAR_039872154G → A2 PublicationsCorresponds to variant dbSNP:rs113395425Ensembl.1
Natural variantiVAR_060979164S → G in allele DRB5*02:02. Corresponds to variant dbSNP:rs1059633Ensembl.1
Natural variantiVAR_060980186T → I in allele DRB5*02:02. Corresponds to variant dbSNP:rs41559420Ensembl.1
Natural variantiVAR_060981232V → I in allele DRB5*02:02. Corresponds to variant dbSNP:rs41553512Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M20429 mRNA Translation: AAA59822.1
M35159 Genomic DNA Translation: AAA59791.1
AL713966 Genomic DNA Translation: CAI18079.1
AK314834 mRNA Translation: BAG37353.1
BC009234 mRNA Translation: AAH09234.1
U31770 mRNA Translation: AAB63983.1
U59685 Genomic DNA Translation: AAB52229.1
M16954 mRNA Translation: AAA36276.1
M16955 mRNA Translation: AAA36277.1
M17377 mRNA Translation: AAA59818.1
X87210 Genomic DNA No translation available.
FN430425 Genomic DNA Translation: CAZ86696.1
Z83201 Genomic DNA Translation: CAB05668.1
AF122887 Genomic DNA Translation: AAD31766.1
AJ271159 Genomic DNA Translation: CAB71144.1
AY141137 Genomic DNA Translation: AAN28924.1
AJ427352 Genomic DNA Translation: CAD20460.1
AY457037 Genomic DNA Translation: AAR20446.2
Y09342 Genomic DNA Translation: CAA70524.1
Y13727 Genomic DNA Translation: CAA74055.1
M91001 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4751.1

Protein sequence database of the Protein Information Resource

More...PIRi		B27060
B28043
B28756
C32526
D25239
I68733
PT0169
PT0170
PT0171

NCBI Reference Sequences

More...RefSeqi		NP_002116.2, NM_002125.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000374975; ENSP00000364114; ENSG00000198502

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3127

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3127

UCSC genome browser

More...UCSCi		uc003obj.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20429 mRNA Translation: AAA59822.1
M35159 Genomic DNA Translation: AAA59791.1
AL713966 Genomic DNA Translation: CAI18079.1
AK314834 mRNA Translation: BAG37353.1
BC009234 mRNA Translation: AAH09234.1
U31770 mRNA Translation: AAB63983.1
U59685 Genomic DNA Translation: AAB52229.1
M16954 mRNA Translation: AAA36276.1
M16955 mRNA Translation: AAA36277.1
M17377 mRNA Translation: AAA59818.1
X87210 Genomic DNA No translation available.
FN430425 Genomic DNA Translation: CAZ86696.1
Z83201 Genomic DNA Translation: CAB05668.1
AF122887 Genomic DNA Translation: AAD31766.1
AJ271159 Genomic DNA Translation: CAB71144.1
AY141137 Genomic DNA Translation: AAN28924.1
AJ427352 Genomic DNA Translation: CAD20460.1
AY457037 Genomic DNA Translation: AAR20446.2
Y09342 Genomic DNA Translation: CAA70524.1
Y13727 Genomic DNA Translation: CAA74055.1
M91001 Genomic DNA No translation available.
CCDSiCCDS4751.1
PIRiB27060
B28043
B28756
C32526
D25239
I68733
PT0169
PT0170
PT0171
RefSeqiNP_002116.2, NM_002125.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FV1X-ray1.90B/E30-219[»]
1H15X-ray3.10B/E30-219[»]
1HQRX-ray3.20B30-219[»]
1ZGLX-ray2.80B/E/H/K30-221[»]
SMRiQ30154
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109372, 16 interactors
IntActiQ30154, 11 interactors
STRINGi9606.ENSP00000364114

Chemistry databases

ChEMBLiCHEMBL3988561
DrugBankiDB05121, 1D09C3
DB11294, Coccidioides immitis spherule

PTM databases

GlyConnecti1378, 2 N-Linked glycans (1 site)
GlyGeniQ30154, 1 site
iPTMnetiQ30154
SwissPalmiQ30154

Genetic variation databases

BioMutaiHLA-DRB5
DMDMi74754558

Proteomic databases

jPOSTiQ30154
MassIVEiQ30154
PaxDbiQ30154
PeptideAtlasiQ30154
PRIDEiQ30154
ProteomicsDBi61556

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		13708, 129 antibodies

The DNASU plasmid repository

More...DNASUi		3127

Genome annotation databases

EnsembliENST00000374975; ENSP00000364114; ENSG00000198502
GeneIDi3127
KEGGihsa:3127
UCSCiuc003obj.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3127
DisGeNETi3127

GeneCards: human genes, protein and diseases

More...GeneCardsi		HLA-DRB5
HGNCiHGNC:4953, HLA-DRB5
HPAiENSG00000198502, Tissue enhanced (lung, lymphoid tissue)
MIMi604776, gene
neXtProtiNX_Q30154
NIAGADSiENSG00000198502
OpenTargetsiENSG00000198502
PharmGKBiPA35076
VEuPathDBiHostDB:ENSG00000198502.5

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RYBQ, Eukaryota
GeneTreeiENSGT00940000154993
HOGENOMiCLU_047501_13_1_1
InParanoidiQ30154
OMAiYFYNREE
OrthoDBi1249505at2759
PhylomeDBiQ30154
TreeFamiTF336626

Enzyme and pathway databases

PathwayCommonsiQ30154
ReactomeiR-HSA-202424, Downstream TCR signaling
R-HSA-202427, Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430, Translocation of ZAP-70 to Immunological synapse
R-HSA-202433, Generation of second messenger molecules
R-HSA-2132295, MHC class II antigen presentation
R-HSA-389948, PD-1 signaling
R-HSA-877300, Interferon gamma signaling
SIGNORiQ30154

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3127, 4 hits in 848 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HLA-DRB5, human
EvolutionaryTraceiQ30154

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HLA-DRB5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3127
PharosiQ30154, Tbio

Protein Ontology

More...PROi		PR:Q30154
RNActiQ30154, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000198502, Expressed in lung and 114 other tissues
ExpressionAtlasiQ30154, baseline and differential
GenevisibleiQ30154, HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003597, Ig_C1-set
IPR011162, MHC_I/II-like_Ag-recog
IPR014745, MHC_II_a/b_N
IPR000353, MHC_II_b_N
PfamiView protein in Pfam
PF07654, C1-set, 1 hit
PF00969, MHC_II_beta, 1 hit
SMARTiView protein in SMART
SM00407, IGc1, 1 hit
SM00921, MHC_II_beta, 1 hit
SUPFAMiSSF48726, SSF48726, 1 hit
SSF54452, SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS00290, IG_MHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDRB5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q30154
Secondary accession number(s): B2RBV6
, C7C4X3, O00157, O00283, O46700, Q29703, Q29787, Q29788, Q30126, Q30150, Q30199, Q6SJR2, Q7M2H9, Q8HWS7, Q8WLR5, Q9MY54, Q9XRX6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 1, 1996
Last modified: February 10, 2021
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human variants curated from literature reports
    Index of human variants curated from literature reports
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  6. Human entries with genetic variants
    List of human entries with genetic variants
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again