UniProtKB - Q30154 (DRB5_HUMAN)
HLA class II histocompatibility antigen, DR beta 5 chain
HLA-DRB5
Functioni
Caution
GO - Molecular functioni
- peptide antigen binding Source: UniProtKB
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
- interferon-gamma-mediated signaling pathway Source: Reactome
- T cell receptor signaling pathway Source: Reactome
Keywordsi
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
PathwayCommonsi | Q30154 |
Reactomei | R-HSA-202424, Downstream TCR signaling R-HSA-202427, Phosphorylation of CD3 and TCR zeta chains R-HSA-202430, Translocation of ZAP-70 to Immunological synapse R-HSA-202433, Generation of second messenger molecules R-HSA-2132295, MHC class II antigen presentation R-HSA-389948, PD-1 signaling R-HSA-877300, Interferon gamma signaling |
SIGNORi | Q30154 |
Names & Taxonomyi
Protein namesi | Recommended name: HLA class II histocompatibility antigen, DR beta 5 chainAlternative name(s): DR beta-5 DR2-beta-2 Dw2 MHC class II antigen DRB5 |
Gene namesi | Name:HLA-DRB5Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4953, HLA-DRB5 |
MIMi | 604776, gene |
neXtProti | NX_Q30154 |
VEuPathDBi | HostDB:ENSG00000198502.5 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Curated1 Publication
Endosome
- Endosome membrane 1 Publication; Single-pass type I membrane protein Curated1 Publication
- Late endosome membrane 1 Publication; Single-pass type I membrane protein Curated1 Publication
Golgi apparatus
- trans-Golgi network membrane 1 Publication; Single-pass type I membrane protein Curated1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Single-pass type I membrane protein Curated1 Publication
Lysosome
- Lysosome membrane 1 Publication; Single-pass type I membrane protein Curated1 Publication
Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
Endoplasmic reticulum
- integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
Endosome
- late endosome membrane Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi membrane Source: Reactome
- trans-Golgi network membrane Source: Reactome
Lysosome
- lysosomal membrane Source: UniProtKB
Plasma Membrane
- MHC class II protein complex Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
- clathrin-coated endocytic vesicle membrane Source: Reactome
- endocytic vesicle membrane Source: Reactome
- ER to Golgi transport vesicle membrane Source: Reactome
- transport vesicle membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 30 – 227 | ExtracellularSequence analysisAdd BLAST | 198 | |
Transmembranei | 228 – 248 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 249 – 266 | CytoplasmicSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, MHC IIPathology & Biotechi
Organism-specific databases
DisGeNETi | 3127 |
NIAGADSi | ENSG00000198502 |
OpenTargetsi | ENSG00000198502 |
PharmGKBi | PA35076 |
Miscellaneous databases
Pharosi | Q30154, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3988561 |
DrugBanki | DB05121, 1D09C3 DB11294, Coccidioides immitis spherule |
Genetic variation databases
BioMutai | HLA-DRB5 |
DMDMi | 74754558 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | 1 PublicationAdd BLAST | 29 | |
ChainiPRO_5000143106 | 30 – 266 | HLA class II histocompatibility antigen, DR beta 5 chainAdd BLAST | 237 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 44 ↔ 108 | |||
Glycosylationi | 48 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 146 ↔ 202 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, Ubl conjugationProteomic databases
jPOSTi | Q30154 |
MassIVEi | Q30154 |
PaxDbi | Q30154 |
PeptideAtlasi | Q30154 |
PRIDEi | Q30154 |
ProteomicsDBi | 61556 |
PTM databases
GlyConnecti | 1378, 2 N-Linked glycans (1 site) |
GlyGeni | Q30154, 1 site |
iPTMneti | Q30154 |
SwissPalmi | Q30154 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198502, Expressed in lung and 114 other tissues |
ExpressionAtlasi | Q30154, baseline and differential |
Genevisiblei | Q30154, HS |
Organism-specific databases
HPAi | ENSG00000198502, Tissue enhanced (lung, lymphoid tissue) |
Interactioni
Subunit structurei
Heterodimer of an alpha and a beta subunit; also referred as MHC class II molecule. In the endoplasmic reticulum (ER) it forms a heterononamer; 3 MHC class II molecules bind to a CD74 homotrimer (also known as invariant chain or HLA class II histocompatibility antigen gamma chain). In the endosomal/lysosomal system; CD74 undergoes sequential degradation by various proteases; leaving a small fragment termed CLIP on each MHC class II molecule. MHC class II molecule interacts with HLA_DM, and HLA_DO in B-cells, in order to release CLIP and facilitate the binding of antigenic peptides.
4 PublicationsProtein-protein interaction databases
BioGRIDi | 109372, 16 interactors |
IntActi | Q30154, 11 interactors |
STRINGi | 9606.ENSP00000364114 |
Miscellaneous databases
RNActi | Q30154, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q30154 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q30154 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 126 – 214 | Ig-like C1-typeSequence analysisAdd BLAST | 89 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 30 – 124 | Beta-1Sequence analysisAdd BLAST | 95 | |
Regioni | 125 – 227 | Beta-2Sequence analysisAdd BLAST | 103 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RYBQ, Eukaryota |
GeneTreei | ENSGT00940000154993 |
HOGENOMi | CLU_047501_13_1_1 |
InParanoidi | Q30154 |
OMAi | YFYNREE |
OrthoDBi | 1249505at2759 |
PhylomeDBi | Q30154 |
TreeFami | TF336626 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MVCLKLPGGS YMAKLTVTLM VLSSPLALAG DTRPRFLQQD KYECHFFNGT
60 70 80 90 100
ERVRFLHRDI YNQEEDLRFD SDVGEYRAVT ELGRPDAEYW NSQKDFLEDR
110 120 130 140 150
RAAVDTYCRH NYGVGESFTV QRRVEPKVTV YPARTQTLQH HNLLVCSVNG
160 170 180 190 200
FYPGSIEVRW FRNSQEEKAG VVSTGLIQNG DWTFQTLVML ETVPRSGEVY
210 220 230 240 250
TCQVEHPSVT SPLTVEWRAQ SESAQSKMLS GVGGFVLGLL FLGAGLFIYF
260
KNQKGHSGLH PTGLVS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 139 | Q → E AA sequence (PubMed:6576979).Curated | 1 |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_060951 | 14 | K → M. Corresponds to variant dbSNP:rs1064587Ensembl. | 1 | |
Natural variantiVAR_060952 | 14 | K → Q. Corresponds to variant dbSNP:rs701884Ensembl. | 1 | |
Natural variantiVAR_060953 | 14 | K → V in allele DRB5*02:02; requires 2 nucleotide substitutions. | 1 | |
Natural variantiVAR_050355 | 20 | M → T. Corresponds to variant dbSNP:rs17211043Ensembl. | 1 | |
Natural variantiVAR_039871 | 28 | L → S3 Publications | 1 | |
Natural variantiVAR_050356 | 33 | R → Q. Corresponds to variant dbSNP:rs1141741Ensembl. | 1 | |
Natural variantiVAR_060954 | 35 | R → C in allele DRB5*02:02, allele DRB5*02:04 and allele DRB5*02:05. Corresponds to variant dbSNP:rs1136744Ensembl. | 1 | |
Natural variantiVAR_050357 | 41 | K → T. Corresponds to variant dbSNP:rs200581589Ensembl. | 1 | |
Natural variantiVAR_060955 | 57 | H → Q. Corresponds to variant dbSNP:rs202185589Ensembl. | 1 | |
Natural variantiVAR_060956 | 59 | D → G in allele DRB5*01:02, allele DRB5*01:03, allele DRB5*02:02, allele DRB5*02:03, allele DRB5*02:04 and allele DRB5*02:05. Corresponds to variant dbSNP:rs41546317Ensembl. | 1 | |
Natural variantiVAR_050358 | 62 | N → H. Corresponds to variant dbSNP:rs1059576Ensembl. | 1 | |
Natural variantiVAR_060958 | 66 | D → N in allele DRB5*01:02, allele DRB5*01:03, allele DRB5*02:02, allele DRB5*02:03, allele DRB5*02:04 and allele DRB5*02:05. Corresponds to variant dbSNP:rs707956Ensembl. | 1 | |
Natural variantiVAR_060959 | 66 | D → Y in allele DRB5*01:14. Corresponds to variant dbSNP:rs707956Ensembl. | 1 | |
Natural variantiVAR_060960 | 67 | L → V in allele DRB5*01:02, allele DRB5*01:03, allele DRB5*01:05, allele DRB5*01:14, allele DRB5*02:02, allele DRB5*02:03, allele DRB5*02:04 and allele DRB5*02:05. Corresponds to variant dbSNP:rs1059580Ensembl. | 1 | |
Natural variantiVAR_060961 | 87 | A → E in allele DRB5*01:13. | 1 | |
Natural variantiVAR_060962 | 89 | Y → S in allele DRB5*01:12. Corresponds to variant dbSNP:rs41541218Ensembl. | 1 | |
Natural variantiVAR_060964 | 96 | F → I in allele DRB5*01:06, allele DRB5*01:07, allele DRB5*01:11, allele DRB5*02:02 and allele DRB5*02:03. Corresponds to variant dbSNP:rs696318Ensembl. | 1 | |
Natural variantiVAR_060963 | 96 | F → L in allele DRB5*02:05. Corresponds to variant dbSNP:rs696318Ensembl. | 1 | |
Natural variantiVAR_060965 | 99 | D → E. Corresponds to variant dbSNP:rs41559913Ensembl. | 1 | |
Natural variantiVAR_060966 | 99 | D → G. Corresponds to variant dbSNP:rs41545413Ensembl. | 1 | |
Natural variantiVAR_060967 | 99 | D → H. Corresponds to variant dbSNP:rs41547217Ensembl. | 1 | |
Natural variantiVAR_060968 | 99 | D → N in allele DRB5*01:09. Corresponds to variant dbSNP:rs41547217Ensembl. | 1 | |
Natural variantiVAR_060969 | 99 | D → Q in allele DRB5*01:06, allele DRB5*01:11, allele DRB5*02:02, allele DRB5*02:03, allele DRB5*02:04 and allele DRB5*02:05; requires 2 nucleotide substitutions. | 1 | |
Natural variantiVAR_060970 | 99 | D → R in allele DRB5*01:12; requires 2 nucleotide substitutions. | 1 | |
Natural variantiVAR_060971 | 100 | R → A in allele DRB5*01:06, allele DRB5*01:11, allele DRB5*02:02, allele DRB5*02:03 and allele DRB5*02:04; requires 2 nucleotide substitutions. | 1 | |
Natural variantiVAR_060972 | 100 | R → G. Corresponds to variant dbSNP:rs41551116Ensembl. | 1 | |
Natural variantiVAR_060973 | 100 | R → T in allele DRB5*01:03. Corresponds to variant dbSNP:rs41544215Ensembl. | 1 | |
Natural variantiVAR_060974 | 103 | A → E in allele DRB5*01:12. Corresponds to variant dbSNP:rs1059598Ensembl. | 1 | |
Natural variantiVAR_060975 | 103 | A → L in allele DRB5*01:04; requires 2 nucleotide substitutions. | 1 | |
Natural variantiVAR_050359 | 106 | T → N. Corresponds to variant dbSNP:rs115817940Ensembl. | 1 | |
Natural variantiVAR_060976 | 107 | Y → V in allele DRB5*01:12; requires 2 nucleotide substitutions. | 1 | |
Natural variantiVAR_060977 | 114 | V → A in allele DRB5*01:06, allele DRB5*02:02, allele DRB5*02:04 and allele DRB5*02:05. Corresponds to variant dbSNP:rs1136778Ensembl. | 1 | |
Natural variantiVAR_060978 | 115 | G → V in allele DRB5*01:06, allele DRB5*02:02, allele DRB5*02:04 and allele DRB5*02:05. Corresponds to variant dbSNP:rs41556512Ensembl. | 1 | |
Natural variantiVAR_039872 | 154 | G → A2 PublicationsCorresponds to variant dbSNP:rs113395425Ensembl. | 1 | |
Natural variantiVAR_060979 | 164 | S → G in allele DRB5*02:02. Corresponds to variant dbSNP:rs1059633Ensembl. | 1 | |
Natural variantiVAR_060980 | 186 | T → I in allele DRB5*02:02. Corresponds to variant dbSNP:rs41559420Ensembl. | 1 | |
Natural variantiVAR_060981 | 232 | V → I in allele DRB5*02:02. Corresponds to variant dbSNP:rs41553512Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M20429 mRNA Translation: AAA59822.1 M35159 Genomic DNA Translation: AAA59791.1 AL713966 Genomic DNA Translation: CAI18079.1 AK314834 mRNA Translation: BAG37353.1 BC009234 mRNA Translation: AAH09234.1 U31770 mRNA Translation: AAB63983.1 U59685 Genomic DNA Translation: AAB52229.1 M16954 mRNA Translation: AAA36276.1 M16955 mRNA Translation: AAA36277.1 M17377 mRNA Translation: AAA59818.1 X87210 Genomic DNA No translation available. FN430425 Genomic DNA Translation: CAZ86696.1 Z83201 Genomic DNA Translation: CAB05668.1 AF122887 Genomic DNA Translation: AAD31766.1 AJ271159 Genomic DNA Translation: CAB71144.1 AY141137 Genomic DNA Translation: AAN28924.1 AJ427352 Genomic DNA Translation: CAD20460.1 AY457037 Genomic DNA Translation: AAR20446.2 Y09342 Genomic DNA Translation: CAA70524.1 Y13727 Genomic DNA Translation: CAA74055.1 M91001 Genomic DNA No translation available. |
CCDSi | CCDS4751.1 |
PIRi | B27060 B28043 B28756 C32526 D25239 I68733 PT0169 PT0170 PT0171 |
RefSeqi | NP_002116.2, NM_002125.3 |
Genome annotation databases
Ensembli | ENST00000374975; ENSP00000364114; ENSG00000198502 |
GeneIDi | 3127 |
KEGGi | hsa:3127 |
UCSCi | uc003obj.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M20429 mRNA Translation: AAA59822.1 M35159 Genomic DNA Translation: AAA59791.1 AL713966 Genomic DNA Translation: CAI18079.1 AK314834 mRNA Translation: BAG37353.1 BC009234 mRNA Translation: AAH09234.1 U31770 mRNA Translation: AAB63983.1 U59685 Genomic DNA Translation: AAB52229.1 M16954 mRNA Translation: AAA36276.1 M16955 mRNA Translation: AAA36277.1 M17377 mRNA Translation: AAA59818.1 X87210 Genomic DNA No translation available. FN430425 Genomic DNA Translation: CAZ86696.1 Z83201 Genomic DNA Translation: CAB05668.1 AF122887 Genomic DNA Translation: AAD31766.1 AJ271159 Genomic DNA Translation: CAB71144.1 AY141137 Genomic DNA Translation: AAN28924.1 AJ427352 Genomic DNA Translation: CAD20460.1 AY457037 Genomic DNA Translation: AAR20446.2 Y09342 Genomic DNA Translation: CAA70524.1 Y13727 Genomic DNA Translation: CAA74055.1 M91001 Genomic DNA No translation available. |
CCDSi | CCDS4751.1 |
PIRi | B27060 B28043 B28756 C32526 D25239 I68733 PT0169 PT0170 PT0171 |
RefSeqi | NP_002116.2, NM_002125.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1FV1 | X-ray | 1.90 | B/E | 30-219 | [»] | |
1H15 | X-ray | 3.10 | B/E | 30-219 | [»] | |
1HQR | X-ray | 3.20 | B | 30-219 | [»] | |
1ZGL | X-ray | 2.80 | B/E/H/K | 30-221 | [»] | |
SMRi | Q30154 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109372, 16 interactors |
IntActi | Q30154, 11 interactors |
STRINGi | 9606.ENSP00000364114 |
Chemistry databases
ChEMBLi | CHEMBL3988561 |
DrugBanki | DB05121, 1D09C3 DB11294, Coccidioides immitis spherule |
PTM databases
GlyConnecti | 1378, 2 N-Linked glycans (1 site) |
GlyGeni | Q30154, 1 site |
iPTMneti | Q30154 |
SwissPalmi | Q30154 |
Genetic variation databases
BioMutai | HLA-DRB5 |
DMDMi | 74754558 |
Proteomic databases
jPOSTi | Q30154 |
MassIVEi | Q30154 |
PaxDbi | Q30154 |
PeptideAtlasi | Q30154 |
PRIDEi | Q30154 |
ProteomicsDBi | 61556 |
Protocols and materials databases
Antibodypediai | 13708, 129 antibodies |
DNASUi | 3127 |
Genome annotation databases
Ensembli | ENST00000374975; ENSP00000364114; ENSG00000198502 |
GeneIDi | 3127 |
KEGGi | hsa:3127 |
UCSCi | uc003obj.4, human |
Organism-specific databases
CTDi | 3127 |
DisGeNETi | 3127 |
GeneCardsi | HLA-DRB5 |
HGNCi | HGNC:4953, HLA-DRB5 |
HPAi | ENSG00000198502, Tissue enhanced (lung, lymphoid tissue) |
MIMi | 604776, gene |
neXtProti | NX_Q30154 |
NIAGADSi | ENSG00000198502 |
OpenTargetsi | ENSG00000198502 |
PharmGKBi | PA35076 |
VEuPathDBi | HostDB:ENSG00000198502.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RYBQ, Eukaryota |
GeneTreei | ENSGT00940000154993 |
HOGENOMi | CLU_047501_13_1_1 |
InParanoidi | Q30154 |
OMAi | YFYNREE |
OrthoDBi | 1249505at2759 |
PhylomeDBi | Q30154 |
TreeFami | TF336626 |
Enzyme and pathway databases
PathwayCommonsi | Q30154 |
Reactomei | R-HSA-202424, Downstream TCR signaling R-HSA-202427, Phosphorylation of CD3 and TCR zeta chains R-HSA-202430, Translocation of ZAP-70 to Immunological synapse R-HSA-202433, Generation of second messenger molecules R-HSA-2132295, MHC class II antigen presentation R-HSA-389948, PD-1 signaling R-HSA-877300, Interferon gamma signaling |
SIGNORi | Q30154 |
Miscellaneous databases
BioGRID-ORCSi | 3127, 4 hits in 848 CRISPR screens |
ChiTaRSi | HLA-DRB5, human |
EvolutionaryTracei | Q30154 |
GeneWikii | HLA-DRB5 |
GenomeRNAii | 3127 |
Pharosi | Q30154, Tbio |
PROi | PR:Q30154 |
RNActi | Q30154, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198502, Expressed in lung and 114 other tissues |
ExpressionAtlasi | Q30154, baseline and differential |
Genevisiblei | Q30154, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DRB5_HUMAN | |
Accessioni | Q30154Primary (citable) accession number: Q30154 Secondary accession number(s): B2RBV6 Q9XRX6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 180 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants