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Protein

Galactose-6-phosphate isomerase subunit LacA

Gene

lacA

Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-galactose 6-phosphate = D-tagatose 6-phosphate.UniRule annotation

Pathwayi: D-galactose 6-phosphate degradation

This protein is involved in step 1 of the subpathway that synthesizes D-tagatose 6-phosphate from D-galactose 6-phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Galactose-6-phosphate isomerase subunit LacA (lacA), Galactose-6-phosphate isomerase subunit LacB (lacB)
This subpathway is part of the pathway D-galactose 6-phosphate degradation, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-tagatose 6-phosphate from D-galactose 6-phosphate, the pathway D-galactose 6-phosphate degradation and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processLactose metabolism

Enzyme and pathway databases

UniPathwayi
UPA00702;UER00714

Names & Taxonomyi

Protein namesi
Recommended name:
Galactose-6-phosphate isomerase subunit LacAUniRule annotation (EC:5.3.1.26UniRule annotation)
Gene namesi
Name:lacAUniRule annotation
Ordered Locus Names:SAB2076c
OrganismiStaphylococcus aureus (strain bovine RF122 / ET3-1)
Taxonomic identifieri273036 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000689231 – 142Galactose-6-phosphate isomerase subunit LacAAdd BLAST142

Interactioni

Subunit structurei

Heteromultimeric protein consisting of LacA and LacB.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ2YYJ3
SMRiQ2YYJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LacAB/RpiB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000226301
KOiK01819
OMAiLKVTHEV

Family and domain databases

Gene3Di3.40.1400.10, 1 hit
HAMAPiMF_01555 LacA, 1 hit
InterProiView protein in InterPro
IPR004783 LacA
IPR003500 RpiB_LacA_LacB
IPR036569 RpiB_LacA_LacB_sf
PANTHERiPTHR30345 PTHR30345, 1 hit
PfamiView protein in Pfam
PF02502 LacAB_rpiB, 1 hit
PIRSFiPIRSF005384 RpiB_LacA_B, 1 hit
SUPFAMiSSF89623 SSF89623, 1 hit
TIGRFAMsiTIGR01118 lacA, 1 hit
TIGR00689 rpiB_lacA_lacB, 1 hit

Sequencei

Sequence statusi: Complete.

Q2YYJ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIIIGSDEA GKRLKEVIKS YLLDNKYDVV DVTEGQEVDF VDATLAVAKD
60 70 80 90 100
VQSQEGNLGI VIDAFGAGSF MVATKIKGMI AAEVSDERSG YMTRGHNNSR
110 120 130 140
MITMGSEIVG DTLAKNVVKG FVEGKYDGGR HQIRVDMLNK MC
Length:142
Mass (Da):15,395
Last modified:December 20, 2005 - v1
Checksum:iA52C4A7DBF30BE19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ938182 Genomic DNA Translation: CAI81765.1
RefSeqiWP_000974608.1, NC_007622.1

Genome annotation databases

EnsemblBacteriaiCAI81765; CAI81765; SAB2076c
KEGGisab:SAB2076c

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ938182 Genomic DNA Translation: CAI81765.1
RefSeqiWP_000974608.1, NC_007622.1

3D structure databases

ProteinModelPortaliQ2YYJ3
SMRiQ2YYJ3
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI81765; CAI81765; SAB2076c
KEGGisab:SAB2076c

Phylogenomic databases

HOGENOMiHOG000226301
KOiK01819
OMAiLKVTHEV

Enzyme and pathway databases

UniPathwayi
UPA00702;UER00714

Family and domain databases

Gene3Di3.40.1400.10, 1 hit
HAMAPiMF_01555 LacA, 1 hit
InterProiView protein in InterPro
IPR004783 LacA
IPR003500 RpiB_LacA_LacB
IPR036569 RpiB_LacA_LacB_sf
PANTHERiPTHR30345 PTHR30345, 1 hit
PfamiView protein in Pfam
PF02502 LacAB_rpiB, 1 hit
PIRSFiPIRSF005384 RpiB_LacA_B, 1 hit
SUPFAMiSSF89623 SSF89623, 1 hit
TIGRFAMsiTIGR01118 lacA, 1 hit
TIGR00689 rpiB_lacA_lacB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLACA_STAAB
AccessioniPrimary (citable) accession number: Q2YYJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 20, 2005
Last modified: October 10, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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