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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei59Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
Name:ungUniRule annotation
Ordered Locus Names:SAB0531
OrganismiStaphylococcus aureus (strain bovine RF122 / ET3-1)
Taxonomic identifieri273036 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000099461 – 218Uracil-DNA glycosylaseAdd BLAST218

Structurei

3D structure databases

ProteinModelPortaliQ2YS83
SMRiQ2YS83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229528
KOiK03648
OMAiQANGLCF

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q2YS83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEWSQIFHDI TTKHDFKAMH DFLEKEYSTA IVYPDRENIY QAFDLTPFEN
60 70 80 90 100
IKVVILGQDP YHGPNQAHGL AFSVQPNAKF PPSLRNMYKE LADDIGCVRQ
110 120 130 140 150
TPHLQDWARE GVLLLNTVLT VRQGEANSHR DIGWETFTDE IIKAVSDYKE
160 170 180 190 200
HVVFILWGKP AQQKIKLIDT SKHCIIKSVH PSPLSAYRGF FGSKPYSKAN
210
TYLESVGKSP INWCESEA
Length:218
Mass (Da):24,967
Last modified:December 20, 2005 - v1
Checksum:i5731B93297F0D154
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ938182 Genomic DNA Translation: CAI80219.1
RefSeqiWP_000455258.1, NC_007622.1

Genome annotation databases

EnsemblBacteriaiCAI80219; CAI80219; SAB0531
KEGGisab:SAB0531

Similar proteinsi

Entry informationi

Entry nameiUNG_STAAB
AccessioniPrimary (citable) accession number: Q2YS83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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