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Protein

Holo-[acyl-carrier-protein] synthase

Gene

acpS

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.UniRule annotation

Catalytic activityi

CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein].UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi8MagnesiumUniRule annotation1
Metal bindingi57MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Holo-[acyl-carrier-protein] synthaseUniRule annotation (EC:2.7.8.7UniRule annotation)
Short name:
Holo-ACP synthaseUniRule annotation
Alternative name(s):
4'-phosphopantetheinyl transferase AcpSUniRule annotation
Gene namesi
Name:acpSUniRule annotation
Ordered Locus Names:BAB1_0679
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000002719 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002282751 – 134Holo-[acyl-carrier-protein] synthaseAdd BLAST134

Structurei

3D structure databases

ProteinModelPortaliQ2YN04
SMRiQ2YN04
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P-Pant transferase superfamily. AcpS family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000014316
KOiK00997
OMAiDERHYAV

Family and domain databases

Gene3Di3.90.470.20, 1 hit
HAMAPiMF_00101 AcpS, 1 hit
InterProiView protein in InterPro
IPR008278 4-PPantetheinyl_Trfase_dom
IPR037143 4-PPantetheinyl_Trfase_dom_sf
IPR002582 ACPS
IPR004568 Ppantetheine-prot_Trfase_dom
PANTHERiPTHR45198 PTHR45198, 1 hit
PfamiView protein in Pfam
PF01648 ACPS, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004282 PPantethiene-prot_Trfase, 1 hit
SUPFAMiSSF56214 SSF56214, 1 hit
TIGRFAMsiTIGR00516 acpS, 1 hit
TIGR00556 pantethn_trn, 1 hit

Sequencei

Sequence statusi: Complete.

Q2YN04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVGIGSDLI DIRRVEKTLE RHGSRFRDRV FTEIEQRKSE GRKQRAASYA
60 70 80 90 100
KRFAAKEACA KALGTGIAEG VFWRDMGVVN TPSGKPTMHL TGGAAKQLQK
110 120 130
LLPAGTNAAI HLTITDDFPL AQAFVIIEAL PVLE
Length:134
Mass (Da):14,645
Last modified:February 7, 2006 - v1
Checksum:i95A7F7D426A07BDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA Translation: CAJ10635.1
RefSeqiWP_002963803.1, NZ_KN046823.1

Genome annotation databases

EnsemblBacteriaiCAJ10635; CAJ10635; BAB1_0679
GeneIDi29594128
KEGGibmf:BAB1_0679
PATRICifig|359391.11.peg.2993

Similar proteinsi

Entry informationi

Entry nameiACPS_BRUA2
AccessioniPrimary (citable) accession number: Q2YN04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: February 7, 2006
Last modified: November 22, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health