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Protein

Paired immunoglobulin-like type 2 receptor alpha

Gene

Pilra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. Receptor for CD99 and PIANP.1 Publication

GO - Molecular functioni

  • MHC class I protein binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
Paired immunoglobulin-like type 2 receptor alpha
Alternative name(s):
Cell surface receptor FDF03
Inhibitory receptor PILR-alpha
Gene namesi
Name:Pilra
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2450529 Pilra

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 198ExtracellularSequence analysisAdd BLAST167
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 302CytoplasmicSequence analysisAdd BLAST83

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000022682332 – 302Paired immunoglobulin-like type 2 receptor alphaAdd BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated on tyrosine residues.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ2YFS3
PaxDbiQ2YFS3
PRIDEiQ2YFS3

PTM databases

PhosphoSitePlusiQ2YFS3

Expressioni

Gene expression databases

BgeeiENSMUSG00000046245 Expressed in 126 organ(s), highest expression level in blood
CleanExiMM_PILRA
ExpressionAtlasiQ2YFS3 baseline and differential
GenevisibleiQ2YFS3 MM

Interactioni

Subunit structurei

Interacts with CD99.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ2YFS3, 1 interactor
STRINGi10090.ENSMUSP00000050313

Structurei

3D structure databases

ProteinModelPortaliQ2YFS3
SMRiQ2YFS3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi265 – 270ITIM motif 16
Motifi294 – 299ITIM motif 26

Domaini

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW80 Eukaryota
ENOG41114MH LUCA
GeneTreeiENSGT00390000008831
HOGENOMiHOG000035130
HOVERGENiHBG082142
InParanoidiQ2YFS3
KOiK15411
OMAiYENIGND
OrthoDBiEOG091G0NZB
PhylomeDBiQ2YFS3
TreeFamiTF338478

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
SUPFAMiSSF48726 SSF48726, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q2YFS3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALLISLPGG TPAMAQILLL LSSACLHAGN SERSNRKNGF GVNQPESCSG
60 70 80 90 100
VQGGSIDIPF SFYFPWKLAK DPQMSIAWRW KDFHGEFIYN SSLPFIHEHF
110 120 130 140 150
KGRLILNWTQ GQTSGVLRIL NLKESDQTRY FGRVFLQTTE GIQFWQSIPG
160 170 180 190 200
TQLNVTNATC TPTTLPSTTA ATSAHTQNDI TEVKSANIGG LDLQTTVGLA
210 220 230 240 250
TAAAVFLVGV LGLIVFLWWK RRRQGQKTKA EIPAREPLET SEKHESVGHE
260 270 280 290 300
GQCMDPKENP KDNNIVYASI SLSSPTSPGT APNLPVHGNP QEETVYSIVK

AK
Length:302
Mass (Da):33,064
Last modified:December 20, 2005 - v1
Checksum:iF5F38725B91A3FEC
GO
Isoform 2 (identifier: Q2YFS3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: MALLISLPGGTPAMAQILLLLSSACLHA → MFCVVLSMFPVTVPCSGFRVSPSFP

Show »
Length:299
Mass (Da):32,992
Checksum:iC1158DC3E1B3F74F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JE49A0A0G2JE49_MOUSE
Paired immunoglobulin-like type 2 r...
Pilra
94Annotation score:
A0A0G2JDJ3A0A0G2JDJ3_MOUSE
Paired immunoglobulin-like type 2 r...
Pilra
69Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0175051 – 28MALLI…ACLHA → MFCVVLSMFPVTVPCSGFRV SPSFP in isoform 2. 1 PublicationAdd BLAST28

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ400844 mRNA Translation: CAC01617.1
AY823670 Genomic DNA Translation: AAX39494.1
AK041413 mRNA Translation: BAC30935.1
CCDSiCCDS19780.1 [Q2YFS3-1]
RefSeqiNP_705730.1, NM_153510.3 [Q2YFS3-1]
UniGeneiMm.379385

Genome annotation databases

EnsembliENSMUST00000058897; ENSMUSP00000050313; ENSMUSG00000046245 [Q2YFS3-1]
ENSMUST00000110980; ENSMUSP00000106608; ENSMUSG00000046245 [Q2YFS3-2]
GeneIDi231805
KEGGimmu:231805
UCSCiuc009aea.2 mouse [Q2YFS3-1]
uc009aeb.2 mouse [Q2YFS3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ400844 mRNA Translation: CAC01617.1
AY823670 Genomic DNA Translation: AAX39494.1
AK041413 mRNA Translation: BAC30935.1
CCDSiCCDS19780.1 [Q2YFS3-1]
RefSeqiNP_705730.1, NM_153510.3 [Q2YFS3-1]
UniGeneiMm.379385

3D structure databases

ProteinModelPortaliQ2YFS3
SMRiQ2YFS3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ2YFS3, 1 interactor
STRINGi10090.ENSMUSP00000050313

PTM databases

PhosphoSitePlusiQ2YFS3

Proteomic databases

MaxQBiQ2YFS3
PaxDbiQ2YFS3
PRIDEiQ2YFS3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058897; ENSMUSP00000050313; ENSMUSG00000046245 [Q2YFS3-1]
ENSMUST00000110980; ENSMUSP00000106608; ENSMUSG00000046245 [Q2YFS3-2]
GeneIDi231805
KEGGimmu:231805
UCSCiuc009aea.2 mouse [Q2YFS3-1]
uc009aeb.2 mouse [Q2YFS3-2]

Organism-specific databases

CTDi29992
MGIiMGI:2450529 Pilra

Phylogenomic databases

eggNOGiENOG410IW80 Eukaryota
ENOG41114MH LUCA
GeneTreeiENSGT00390000008831
HOGENOMiHOG000035130
HOVERGENiHBG082142
InParanoidiQ2YFS3
KOiK15411
OMAiYENIGND
OrthoDBiEOG091G0NZB
PhylomeDBiQ2YFS3
TreeFamiTF338478

Enzyme and pathway databases

ReactomeiR-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

PROiPR:Q2YFS3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046245 Expressed in 126 organ(s), highest expression level in blood
CleanExiMM_PILRA
ExpressionAtlasiQ2YFS3 baseline and differential
GenevisibleiQ2YFS3 MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
SUPFAMiSSF48726 SSF48726, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPILRA_MOUSE
AccessioniPrimary (citable) accession number: Q2YFS3
Secondary accession number(s): Q8BYA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: December 20, 2005
Last modified: November 7, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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