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Protein

Paired immunoglobulin-like type 2 receptor beta

Gene

Pilrb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface. Seems to associate with DAP12 and is a receptor for CD99. May be involved in target cell recognition by natural killer cells and in activation of dendritic cells.1 Publication

GO - Molecular functioni

  • MHC class I protein binding Source: UniProtKB

GO - Biological processi

  • myeloid dendritic cell activation Source: MGI
  • negative regulation of osteoclast differentiation Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
Paired immunoglobulin-like type 2 receptor beta
Alternative name(s):
Activating receptor PILR-beta
Cell surface receptor FDFACT
Gene namesi
Name:Pilrb
Synonyms:Fdfact, Pilrb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2450532 Pilrb1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 195ExtracellularSequence analysisAdd BLAST167
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 224CytoplasmicSequence analysis8

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000022682429 – 224Paired immunoglobulin-like type 2 receptor betaAdd BLAST196

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi107N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi154N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ2YFS2
PaxDbiQ2YFS2
PRIDEiQ2YFS2

Expressioni

Tissue specificityi

Widely expressed with highest levels in spleen, liver and lung. Predominantly expressed by natural killer cells, macrophages, and granulocytes and dendritic cells (BM-DC).1 Publication

Gene expression databases

BgeeiENSMUSG00000066684 Expressed in 15 organ(s), highest expression level in bone marrow
CleanExiMM_PILRB1
ExpressionAtlasiQ2YFS2 baseline and differential
GenevisibleiQ2YFS2 MM

Interactioni

Subunit structurei

Interacts with CD99. Probably associates with DAP12.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ2YFS2, 1 interactor
STRINGi10090.ENSMUSP00000106606

Structurei

3D structure databases

ProteinModelPortaliQ2YFS2
SMRiQ2YFS2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IW80 Eukaryota
ENOG41114MH LUCA
GeneTreeiENSGT00390000008831
HOGENOMiHOG000035130
HOVERGENiHBG082142
InParanoidiQ2YFS2
OMAiFWRWKHF
PhylomeDBiQ2YFS2
TreeFamiTF338478

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
SUPFAMiSSF48726 SSF48726, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q2YFS2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLISLPGG TPAMAQVLLL LSSGCLHAGN SERYNRKNGF GVNQPERCSG
60 70 80 90 100
VQGGSIDIPF SFYFPWKLAK DPQMSIAWKW KDFHGEVIYN SSLPFIHEHF
110 120 130 140 150
KGRLILNWTQ GQTSGVLRIL NLKESDQAQY FSRVNLQSTE GMKLWQSIPG
160 170 180 190 200
TQLNVTQALN TTMRSPFIVT SEFTTAGLEH TSDQRNPSLM NLGAMVTMLL
210 220
AKVLVIVLVY GWMIFLRWKQ RPAH
Length:224
Mass (Da):25,200
Last modified:December 20, 2005 - v1
Checksum:i0BB15D5E0A6D08CE
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7ZWH4B7ZWH4_MOUSE
Paired immunoglobin-like type 2 rec...
Pilrb1
225Annotation score:
A0A0G2JE34A0A0G2JE34_MOUSE
Paired immunoglobin-like type 2 rec...
Pilrb1
29Annotation score:
A0A0G2JH07A0A0G2JH07_MOUSE
Paired immunoglobin-like type 2 rec...
Pilrb1
69Annotation score:
A0A0G2JDM1A0A0G2JDM1_MOUSE
Paired immunoglobin-like type 2 rec...
Pilrb1
96Annotation score:

Sequence cautioni

The sequence CAC19332 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB122024 mRNA Translation: BAD12395.2
AJ400847 mRNA Translation: CAC19332.1 Different initiation.
AY823670 Genomic DNA Translation: AAX39495.1
CCDSiCCDS51675.1
RefSeqiNP_573472.2, NM_133209.2
UniGeneiMm.347593

Genome annotation databases

EnsembliENSMUST00000110978; ENSMUSP00000106606; ENSMUSG00000066684
GeneIDi170741
KEGGimmu:170741
UCSCiuc009aec.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB122024 mRNA Translation: BAD12395.2
AJ400847 mRNA Translation: CAC19332.1 Different initiation.
AY823670 Genomic DNA Translation: AAX39495.1
CCDSiCCDS51675.1
RefSeqiNP_573472.2, NM_133209.2
UniGeneiMm.347593

3D structure databases

ProteinModelPortaliQ2YFS2
SMRiQ2YFS2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ2YFS2, 1 interactor
STRINGi10090.ENSMUSP00000106606

Proteomic databases

MaxQBiQ2YFS2
PaxDbiQ2YFS2
PRIDEiQ2YFS2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110978; ENSMUSP00000106606; ENSMUSG00000066684
GeneIDi170741
KEGGimmu:170741
UCSCiuc009aec.2 mouse

Organism-specific databases

CTDi170741
MGIiMGI:2450532 Pilrb1

Phylogenomic databases

eggNOGiENOG410IW80 Eukaryota
ENOG41114MH LUCA
GeneTreeiENSGT00390000008831
HOGENOMiHOG000035130
HOVERGENiHBG082142
InParanoidiQ2YFS2
OMAiFWRWKHF
PhylomeDBiQ2YFS2
TreeFamiTF338478

Enzyme and pathway databases

ReactomeiR-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Miscellaneous databases

PROiPR:Q2YFS2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000066684 Expressed in 15 organ(s), highest expression level in bone marrow
CleanExiMM_PILRB1
ExpressionAtlasiQ2YFS2 baseline and differential
GenevisibleiQ2YFS2 MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
SUPFAMiSSF48726 SSF48726, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPILRB_MOUSE
AccessioniPrimary (citable) accession number: Q2YFS2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: December 20, 2005
Last modified: November 7, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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