UniProtKB - Q2YDR3 (IMPA3_DANRE)
Protein
Inositol monophosphatase 3
Gene
bpnt2
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Catalytic activityi
- EC:3.1.3.25
Cofactori
Mg2+By similarity
: myo-inositol biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate.Proteins known to be involved in the 2 steps of the subpathway in this organism are:
- no protein annotated in this organism
- Inositol-1-monophosphatase (impa1), Inositol-1-monophosphatase (impa1), Inositol monophosphatase 3 (bpnt2), Inositol-1-monophosphatase (impa2)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes myo-inositol from D-glucose 6-phosphate, the pathway myo-inositol biosynthesis and in Polyol metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 117 | Magnesium 1By similarity | 1 | |
Binding sitei | 117 | SubstrateBy similarity | 1 | |
Metal bindingi | 157 | Magnesium 1By similarity | 1 | |
Metal bindingi | 157 | Magnesium 2By similarity | 1 | |
Metal bindingi | 159 | Magnesium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 160 | Magnesium 2By similarity | 1 | |
Metal bindingi | 283 | Magnesium 2By similarity | 1 | |
Binding sitei | 283 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- 3'-nucleotidase activity Source: GO_Central
- inositol monophosphate 1-phosphatase activity Source: UniProtKB-EC
- inositol monophosphate 3-phosphatase activity Source: UniProtKB-EC
- inositol monophosphate 4-phosphatase activity Source: UniProtKB-EC
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- inositol biosynthetic process Source: UniProtKB-UniPathway
- inositol phosphate dephosphorylation Source: InterPro
- phosphatidylinositol phosphorylation Source: InterPro
Keywordsi
Molecular function | Hydrolase |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
Reactomei | R-DRE-156584, Cytosolic sulfonation of small molecules |
UniPathwayi | UPA00823;UER00788 |
Names & Taxonomyi
Protein namesi | Recommended name: Inositol monophosphatase 3 (EC:3.1.3.25)Short name: IMP 3 Short name: IMPase 3 Alternative name(s): 3'(2'), 5'-bisphosphate nucleotidase 2 Inositol monophosphatase domain-containing protein 1 Inositol-1(or 4)-monophosphatase 3 Myo-inositol monophosphatase A3 |
Gene namesi | Name:bpnt2 Synonyms:impa3, impad1 ORF Names:zgc:123256 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-051127-23, bpnt2 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- endomembrane system Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 11 – 31 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000289043 | 1 – 341 | Inositol monophosphatase 3Add BLAST | 341 |
Proteomic databases
PaxDbi | Q2YDR3 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000058114, Expressed in embryo and 24 other tissues |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 159 – 162 | Substrate bindingBy similarity | 4 |
Sequence similaritiesi
Belongs to the inositol monophosphatase superfamily.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3853, Eukaryota |
GeneTreei | ENSGT00940000164879 |
HOGENOMi | CLU_034742_0_0_1 |
InParanoidi | Q2YDR3 |
OMAi | GQTAWAW |
OrthoDBi | 1096950at2759 |
PhylomeDBi | Q2YDR3 |
TreeFami | TF314300 |
Family and domain databases
InterProi | View protein in InterPro IPR000760, Inositol_monophosphatase-like IPR020550, Inositol_monophosphatase_CS |
Pfami | View protein in Pfam PF00459, Inositol_P, 1 hit |
PROSITEi | View protein in PROSITE PS00630, IMP_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q2YDR3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAPMGIRLSP LGIAVFCLLG VGVIYHLYAG VLSSRLAFFR QKRTVDLREL
60 70 80 90 100
LALSIDAAVQ GGREVKRIRE DNTLEEKSKG KTKEGASEKY TLGDLNSHRK
110 120 130 140 150
MYYLIKNTFP NIQVNSEEHA NAEGEATVWT RMIPEDILAK VSGGKEIPAE
160 170 180 190 200
KITVWIDPLD ATQEYTENLL KYVTTMVCVA VDGEPVIGVI HKPFTGYTVW
210 220 230 240 250
GFVGEGSNVA PRDSYNTNSP KVIVSRSHAG KVKSFVQTAF GNNTEIIPAG
260 270 280 290 300
GAGYKALALL NPTDDKQETA DIYIHVTYIK KWDICAGDAI LKSLGGQMTT
310 320 330 340
LKGEQIDYSG LEGNKGGLLA SMKVDHKALV KRLPLWEDNK Q
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC110106 mRNA Translation: AAI10107.1 |
RefSeqi | NP_001032657.1, NM_001037568.1 |
Genome annotation databases
Ensembli | ENSDART00000080925; ENSDARP00000075369; ENSDARG00000058114 |
GeneIDi | 641570 |
KEGGi | dre:641570 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC110106 mRNA Translation: AAI10107.1 |
RefSeqi | NP_001032657.1, NM_001037568.1 |
3D structure databases
SMRi | Q2YDR3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000075369 |
Proteomic databases
PaxDbi | Q2YDR3 |
Genome annotation databases
Ensembli | ENSDART00000080925; ENSDARP00000075369; ENSDARG00000058114 |
GeneIDi | 641570 |
KEGGi | dre:641570 |
Organism-specific databases
CTDi | 54928 |
ZFINi | ZDB-GENE-051127-23, bpnt2 |
Phylogenomic databases
eggNOGi | KOG3853, Eukaryota |
GeneTreei | ENSGT00940000164879 |
HOGENOMi | CLU_034742_0_0_1 |
InParanoidi | Q2YDR3 |
OMAi | GQTAWAW |
OrthoDBi | 1096950at2759 |
PhylomeDBi | Q2YDR3 |
TreeFami | TF314300 |
Enzyme and pathway databases
UniPathwayi | UPA00823;UER00788 |
Reactomei | R-DRE-156584, Cytosolic sulfonation of small molecules |
Miscellaneous databases
PROi | PR:Q2YDR3 |
Gene expression databases
Bgeei | ENSDARG00000058114, Expressed in embryo and 24 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000760, Inositol_monophosphatase-like IPR020550, Inositol_monophosphatase_CS |
Pfami | View protein in Pfam PF00459, Inositol_P, 1 hit |
PROSITEi | View protein in PROSITE PS00630, IMP_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IMPA3_DANRE | |
Accessioni | Q2YDR3Primary (citable) accession number: Q2YDR3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | December 20, 2005 | |
Last modified: | December 2, 2020 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families