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Entry version 103 (13 Feb 2019)
Sequence version 2 (18 May 2010)
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Protein

UV-stimulated scaffold protein A

Gene

UVSSA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA polymerase II complex binding Source: UniProtKB

GO - Biological processi

  • protein ubiquitination Source: UniProtKB
  • response to UV Source: UniProtKB
  • transcription-coupled nucleotide-excision repair Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
UV-stimulated scaffold protein A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UVSSA
Synonyms:KIAA1530
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000163945.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29304 UVSSA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614632 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q2YD98

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

UV-sensitive syndrome 3 (UVSS3)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by cutaneous photosensitivity and slight dyspigmentation, without an increased risk of skin tumors.
See also OMIM:614640
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06779832C → R in UVSS3; mild phenotype; impairs transcription-coupled nucleotide excision repair ability. 1 PublicationCorresponds to variant dbSNP:rs387907164EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi120W → A: Impairs transcription-coupled nucleotide excision repair ability. 1 Publication1
Mutagenesisi157 – 159RKR → EEE: Impairs transcription-coupled nucleotide excision repair ability. 1 Publication3

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
57654

MalaCards human disease database

More...
MalaCardsi
UVSSA
MIMi614640 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000163945

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
178338 UV-sensitive syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162393105

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UVSSA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434546

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003172821 – 709UV-stimulated scaffold protein AAdd BLAST709

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei281PhosphoserineCombined sources1
Modified residuei287PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Monoubiquitinated: ubiquitination does not increase in response to UV.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q2YD98

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q2YD98

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q2YD98

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q2YD98

PeptideAtlas

More...
PeptideAtlasi
Q2YD98

PRoteomics IDEntifications database

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PRIDEi
Q2YD98

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61547
61548 [Q2YD98-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q2YD98

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q2YD98

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163945 Expressed in 199 organ(s), highest expression level in oviduct epithelium

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q2YD98 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q2YD98 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050824
HPA053496

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the elongating form of RNA polymerase II (RNA pol IIo). Interacts with ERCC6, ERCC8 and USP7.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121689, 12 interactors

Protein interaction database and analysis system

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IntActi
Q2YD98, 5 interactors

Molecular INTeraction database

More...
MINTi
Q2YD98

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000374501

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1709
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XV8NMR-A390-434[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q2YD98

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q2YD98

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 145VHS-likeAdd BLAST144

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili165 – 199Sequence analysisAdd BLAST35

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UVSSA family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2374 Eukaryota
ENOG410XP15 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000377

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000060117

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG076421

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q2YD98

Identification of Orthologs from Complete Genome Data

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OMAi
YEPHIPD

Database of Orthologous Groups

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OrthoDBi
996127at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q2YD98

TreeFam database of animal gene trees

More...
TreeFami
TF321660

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR018610 UVSSA

The PANTHER Classification System

More...
PANTHERi
PTHR28670 PTHR28670, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09740 DUF2043, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q2YD98-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDQKLSKLVE ELTTSGEPRL NPEKMKELKK ICKSSEEQLS RAYRLLIAQL
60 70 80 90 100
TQEHAEIRLS AFQIVEELFV RSHQFRMLVV SNFQEFLELT LGTDPAQPLP
110 120 130 140 150
PPREAAQRLR QATTRAVEGW NEKFGEAYKK LALGYHFLRH NKKVDFQDTN
160 170 180 190 200
ARSLAERKRE EEKQKHLDKI YQERASQAER EMQEMSGEIE SCLTEVESCF
210 220 230 240 250
RLLVPFDFDP NPETESLGMA SGMSDALRSS CAGQVGPCRS GTPDPRDGEQ
260 270 280 290 300
PCCSRDLPAS AGHPRAGGGA QPSQTATGDP SDEDEDSDLE EFVRSHGLGS
310 320 330 340 350
HKYTLDVELC SEGLKVQENE DNLALIHAAR DTLKLIRNKF LPAVCSWIQR
360 370 380 390 400
FTRVGTHGGC LKRAIDLKAE LELVLRKYKE LDIEPEGGER RRTEALGDAE
410 420 430 440 450
EDEDDEDFVE VPEKEGYEPH IPDHLRPEYG LEAAPEKDTV VRCLRTRTRM
460 470 480 490 500
DEEVSDPTSA AAQLRQLRDH LPPPSSASPS RALPEPQEAQ KLAAERARAP
510 520 530 540 550
VVPYGVDLHY WGQELPTAGK IVKSDSQHRF WKPSEVEEEV VNADISEMLR
560 570 580 590 600
SRHITFAGKF EPVQHWCRAP RPDGRLCERQ DRLKCPFHGK IVPRDDEGRP
610 620 630 640 650
LDPEDRAREQ RRQLQKQERP EWQDPELMRD VEAATGQDLG SSRYSGKGRG
660 670 680 690 700
KKRRYPSLTN LKAQADTARA RIGRKVFAKA AVRRVVAAMN RMDQKKHEKF

SNQFNYALN
Length:709
Mass (Da):80,591
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i34698BE37A43BF2F
GO
Isoform 2 (identifier: Q2YD98-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-449: Missing.

Show »
Length:260
Mass (Da):29,763
Checksum:i5A72163E1A43CE42
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y924H0Y924_HUMAN
UV-stimulated scaffold protein A
UVSSA
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA96054 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06779832C → R in UVSS3; mild phenotype; impairs transcription-coupled nucleotide excision repair ability. 1 PublicationCorresponds to variant dbSNP:rs387907164EnsemblClinVar.1
Natural variantiVAR_038499391R → H. Corresponds to variant dbSNP:rs2276904Ensembl.1
Natural variantiVAR_038500620P → L3 PublicationsCorresponds to variant dbSNP:rs28522910Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0309321 – 449Missing in isoform 2. 2 PublicationsAdd BLAST449

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB040963 mRNA Translation: BAA96054.1 Different initiation.
AK292661 mRNA Translation: BAF85350.1
AC078852 Genomic DNA No translation available.
AC118281 Genomic DNA No translation available.
BC021930 mRNA Translation: AAH21930.1
BC110331 mRNA Translation: AAI10332.1
BC140901 mRNA Translation: AAI40902.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33938.1 [Q2YD98-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001304863.1, NM_001317934.1 [Q2YD98-1]
NP_001304864.1, NM_001317935.1 [Q2YD98-1]
NP_065945.2, NM_020894.3 [Q2YD98-1]
XP_016863979.1, XM_017008490.1 [Q2YD98-1]
XP_016863980.1, XM_017008491.1 [Q2YD98-1]
XP_016863981.1, XM_017008492.1 [Q2YD98-1]
XP_016863982.1, XM_017008493.1 [Q2YD98-1]
XP_016863983.1, XM_017008494.1 [Q2YD98-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.380475
Hs.744620

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000389851; ENSP00000374501; ENSG00000163945 [Q2YD98-1]
ENST00000507531; ENSP00000421741; ENSG00000163945 [Q2YD98-1]
ENST00000511216; ENSP00000425130; ENSG00000163945 [Q2YD98-1]
ENST00000511563; ENSP00000423340; ENSG00000163945 [Q2YD98-2]
ENST00000512728; ENSP00000427701; ENSG00000163945 [Q2YD98-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
57654

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:57654

UCSC genome browser

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UCSCi
uc003gde.5 human [Q2YD98-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040963 mRNA Translation: BAA96054.1 Different initiation.
AK292661 mRNA Translation: BAF85350.1
AC078852 Genomic DNA No translation available.
AC118281 Genomic DNA No translation available.
BC021930 mRNA Translation: AAH21930.1
BC110331 mRNA Translation: AAI10332.1
BC140901 mRNA Translation: AAI40902.1
CCDSiCCDS33938.1 [Q2YD98-1]
RefSeqiNP_001304863.1, NM_001317934.1 [Q2YD98-1]
NP_001304864.1, NM_001317935.1 [Q2YD98-1]
NP_065945.2, NM_020894.3 [Q2YD98-1]
XP_016863979.1, XM_017008490.1 [Q2YD98-1]
XP_016863980.1, XM_017008491.1 [Q2YD98-1]
XP_016863981.1, XM_017008492.1 [Q2YD98-1]
XP_016863982.1, XM_017008493.1 [Q2YD98-1]
XP_016863983.1, XM_017008494.1 [Q2YD98-1]
UniGeneiHs.380475
Hs.744620

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5XV8NMR-A390-434[»]
ProteinModelPortaliQ2YD98
SMRiQ2YD98
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121689, 12 interactors
IntActiQ2YD98, 5 interactors
MINTiQ2YD98
STRINGi9606.ENSP00000374501

PTM databases

iPTMnetiQ2YD98
PhosphoSitePlusiQ2YD98

Polymorphism and mutation databases

BioMutaiUVSSA
DMDMi296434546

Proteomic databases

EPDiQ2YD98
jPOSTiQ2YD98
MaxQBiQ2YD98
PaxDbiQ2YD98
PeptideAtlasiQ2YD98
PRIDEiQ2YD98
ProteomicsDBi61547
61548 [Q2YD98-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000389851; ENSP00000374501; ENSG00000163945 [Q2YD98-1]
ENST00000507531; ENSP00000421741; ENSG00000163945 [Q2YD98-1]
ENST00000511216; ENSP00000425130; ENSG00000163945 [Q2YD98-1]
ENST00000511563; ENSP00000423340; ENSG00000163945 [Q2YD98-2]
ENST00000512728; ENSP00000427701; ENSG00000163945 [Q2YD98-2]
GeneIDi57654
KEGGihsa:57654
UCSCiuc003gde.5 human [Q2YD98-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57654
DisGeNETi57654
EuPathDBiHostDB:ENSG00000163945.15

GeneCards: human genes, protein and diseases

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GeneCardsi
UVSSA
HGNCiHGNC:29304 UVSSA
HPAiHPA050824
HPA053496
MalaCardsiUVSSA
MIMi614632 gene
614640 phenotype
neXtProtiNX_Q2YD98
OpenTargetsiENSG00000163945
Orphaneti178338 UV-sensitive syndrome
PharmGKBiPA162393105

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2374 Eukaryota
ENOG410XP15 LUCA
GeneTreeiENSGT00390000000377
HOGENOMiHOG000060117
HOVERGENiHBG076421
InParanoidiQ2YD98
OMAiYEPHIPD
OrthoDBi996127at2759
PhylomeDBiQ2YD98
TreeFamiTF321660

Enzyme and pathway databases

ReactomeiR-HSA-6781823 Formation of TC-NER Pre-Incision Complex
R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-6782135 Dual incision in TC-NER
R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
UVSSA human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KIAA1530

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
57654

Protein Ontology

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PROi
PR:Q2YD98

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000163945 Expressed in 199 organ(s), highest expression level in oviduct epithelium
ExpressionAtlasiQ2YD98 baseline and differential
GenevisibleiQ2YD98 HS

Family and domain databases

InterProiView protein in InterPro
IPR018610 UVSSA
PANTHERiPTHR28670 PTHR28670, 1 hit
PfamiView protein in Pfam
PF09740 DUF2043, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUVSSA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2YD98
Secondary accession number(s): A8K9E6
, B2RU11, Q8WTX4, Q9P1Z8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 18, 2010
Last modified: February 13, 2019
This is version 103 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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