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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi), Glucose-6-phosphate isomerase (pgi)
  3. Pyrophosphate--fructose 6-phosphate 1-phosphotransferase (pfp)
  4. Fructose-1,6-bisphosphate aldolase (Nmul_A0384), Fructose-bisphosphate aldolase (Nmul_A1561)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei354Proton donorUniRule annotation1
Active sitei385UniRule annotation1
Active sitei505UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:Nmul_A0469
OrganismiNitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)
Taxonomic identifieri323848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosospira
Proteomesi
  • UP000002718 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002309221 – 542Glucose-6-phosphate isomeraseAdd BLAST542

Proteomic databases

PRIDEiQ2YBU4

Interactioni

Protein-protein interaction databases

STRINGi323848.Nmul_A0469

Structurei

3D structure databases

ProteinModelPortaliQ2YBU4
SMRiQ2YBU4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QP8 Bacteria
COG0166 LUCA
HOGENOMiHOG000261371
KOiK01810
OrthoDBiPOG091H04C3

Family and domain databases

CDDicd05015 SIS_PGI_1, 1 hit
cd05016 SIS_PGI_2, 1 hit
Gene3Di1.10.1390.10, 1 hit
HAMAPiMF_00473 G6P_isomerase, 1 hit
InterProiView protein in InterPro
IPR001672 G6P_Isomerase
IPR023096 G6P_Isomerase_C
IPR018189 Phosphoglucose_isomerase_CS
IPR035476 SIS_PGI_1
IPR035482 SIS_PGI_2
PANTHERiPTHR11469 PTHR11469, 1 hit
PfamiView protein in Pfam
PF00342 PGI, 1 hit
PRINTSiPR00662 G6PISOMERASE
PROSITEiView protein in PROSITE
PS00765 P_GLUCOSE_ISOMERASE_1, 1 hit
PS00174 P_GLUCOSE_ISOMERASE_2, 1 hit
PS51463 P_GLUCOSE_ISOMERASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q2YBU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITPLTQRPA WKALEAHYQT IKGMHLRQLF ADDPKRGERF TAEAVGLYLD
60 70 80 90 100
YSKNRITDET LHLLVQLAEE CGLRERIEAM FRGDAINVTE QRAVLHIALR
110 120 130 140 150
APRNEKILVD GNDVVPGVHA VLDRMADFSD KIRSGDWQGH TGKRIRNIIN
160 170 180 190 200
IGIGGSDLGP VMAYEALRHY SLHNLSFRFI SNVDGTDFVE ATRGLDPEET
210 220 230 240 250
LFIICSKTFT TTETLANAHT ARRWMLRQIK DLEGVRKHFV AVSTNAEEVA
260 270 280 290 300
RFGIDTANMF EFWDWVGGRY SMDSAIGLST MIAVGPENFR EMLAGFHAMD
310 320 330 340 350
QHFYSAPFDR NLPVLMGLLS LWYNNFFGAQ TLAVLPYEQY LKRFPAYLQQ
360 370 380 390 400
LTMESNGKHI TLNGSQVDYQ TSPIVWGEPG TNGQHSFYQL IHQGTRLIPC
410 420 430 440 450
DFIGFCQTLN PLGDHHDLLM ANLFAQTEAL AFGKTEDEVK AEGVPDWLCP
460 470 480 490 500
HRSFEGNRPT NTILAERLTP HTLGALVALY EQSVFTQGTI WQIDSFDQWG
510 520 530 540
VELGKVLAHR IGQELEDENG KSLKHDSSTN ALIQRYNRLK QK
Length:542
Mass (Da):61,372
Last modified:April 4, 2006 - v2
Checksum:iAE18529F71512298
GO

Sequence cautioni

The sequence ABB73777 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000103 Genomic DNA Translation: ABB73777.1 Different initiation.

Genome annotation databases

EnsemblBacteriaiABB73777; ABB73777; Nmul_A0469
KEGGinmu:Nmul_A0469

Similar proteinsi

Entry informationi

Entry nameiG6PI_NITMU
AccessioniPrimary (citable) accession number: Q2YBU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: April 4, 2006
Last modified: November 22, 2017
This is version 76 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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