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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Nitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayi
UPA00219

Protein family/group databases

CAZyiGT28 Glycosyltransferase Family 28

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
Gene namesi
Name:murGUniRule annotation
Ordered Locus Names:Nmul_A2494
OrganismiNitrosospira multiformis (strain ATCC 25196 / NCIMB 11849 / C 71)
Taxonomic identifieri323848 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNitrosomonadalesNitrosomonadaceaeNitrosospira
Proteomesi
  • UP000002718 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003151281 – 357UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseAdd BLAST357

Interactioni

Protein-protein interaction databases

STRINGi323848.Nmul_A2494

Structurei

3D structure databases

ProteinModelPortaliQ2Y638
SMRiQ2Y638
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DVQ Bacteria
COG0707 LUCA
HOGENOMiHOG000218321
KOiK02563
OMAiHQTKNAM
OrthoDBiPOG091H02FX

Family and domain databases

CDDicd03785 GT1_MurG, 1 hit
HAMAPiMF_00033 MurG, 1 hit
InterProiView protein in InterPro
IPR006009 GlcNAc_MurG
IPR007235 Glyco_trans_28_C
IPR004276 GlycoTrans_28_N
PfamiView protein in Pfam
PF04101 Glyco_tran_28_C, 1 hit
PF03033 Glyco_transf_28, 1 hit
TIGRFAMsiTIGR01133 murG, 1 hit

Sequencei

Sequence statusi: Complete.

Q2Y638-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHTILIMAG GTGGHVFPGL AVAEYLKAAG WRIVWLGTEG GMETTLARQQ
60 70 80 90 100
GHALETIRFS GLRGKNVRTW LLLPARLLLA FWQSARVIRK VRPDVVLGMG
110 120 130 140 150
GYPAFPGGMM ASLLARPLLI HEQNSIPGLA NRILSRLADR VLLGFPDAIK
160 170 180 190 200
SEKKAVFCGN PVRDEITRLA PPAQRYAGRS GSIKLLVVGG SLGAQALNTI
210 220 230 240 250
VPRALKRIPE GMRPQVTHQA GARHLEALKQ NYSEAGVEGE LVTFIDNMAS
260 270 280 290 300
RYGESDLVIC RAGALTVSEL AAAGVASILV PFPYAVDDHQ STNAKFLSGK
310 320 330 340 350
GAAILLPQSQ LTPEGLAELL VGMSRGQLME MACRARELAQ PDATRCVAET

CMQMVAV
Length:357
Mass (Da):38,219
Last modified:December 20, 2005 - v1
Checksum:iEE8584A89543811F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000103 Genomic DNA Translation: ABB75783.1

Genome annotation databases

EnsemblBacteriaiABB75783; ABB75783; Nmul_A2494
KEGGinmu:Nmul_A2494

Similar proteinsi

Entry informationi

Entry nameiMURG_NITMU
AccessioniPrimary (citable) accession number: Q2Y638
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: June 7, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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