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UniProtKB - Q2Y0W8 (S4A8_HUMAN)

Entry version 136 (25 May 2022)
Sequence version 1 (20 Dec 2005)
Previous versions | rss
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Protein

Electroneutral sodium bicarbonate exchanger 1

Gene

SLC4A8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3- exchange with a Na+:HCO3- stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3- from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3- into the cells. Also mediates lithium-dependent HCO3- cotransport. May be regulated by osmolarity.

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAnion exchange, Antiport, Ion transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q2Y0W8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-425381, Bicarbonate transporters

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q2Y0W8

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q2Y0W8

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.31.2.4, the anion exchanger (ae) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Electroneutral sodium bicarbonate exchanger 1
Alternative name(s):
Electroneutral Na(+)-driven Cl-HCO3 exchanger
Solute carrier family 4 member 8
k-NBC3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC4A8Imported
Synonyms:KIAA0739, NBCImported, NBC31 Publication, NDCBE11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11034, SLC4A8

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605024, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q2Y0W8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000050438

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 478ExtracellularSequence analysisAdd BLAST478
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei479 – 499HelicalSequence analysisAdd BLAST21
Topological domaini500 – 523CytoplasmicSequence analysisAdd BLAST24
Transmembranei524 – 544HelicalSequence analysisAdd BLAST21
Topological domaini545 – 565ExtracellularSequence analysisAdd BLAST21
Transmembranei566 – 586HelicalSequence analysisAdd BLAST21
Topological domaini587 – 595CytoplasmicSequence analysis9
Transmembranei596 – 616HelicalSequence analysisAdd BLAST21
Topological domaini617 – 687ExtracellularSequence analysisAdd BLAST71
Transmembranei688 – 708HelicalSequence analysisAdd BLAST21
Topological domaini709 – 731CytoplasmicSequence analysisAdd BLAST23
Transmembranei732 – 752HelicalSequence analysisAdd BLAST21
Topological domaini753 – 778ExtracellularSequence analysisAdd BLAST26
Transmembranei779 – 799HelicalSequence analysisAdd BLAST21
Topological domaini800 – 824CytoplasmicSequence analysisAdd BLAST25
Transmembranei825 – 845HelicalSequence analysisAdd BLAST21
Topological domaini846 – 881ExtracellularSequence analysisAdd BLAST36
Transmembranei882 – 902HelicalSequence analysisAdd BLAST21
Topological domaini903 – 904CytoplasmicSequence analysis2
Transmembranei905 – 925HelicalSequence analysisAdd BLAST21
Topological domaini926 – 962ExtracellularSequence analysisAdd BLAST37
Transmembranei963 – 983HelicalSequence analysisAdd BLAST21
Topological domaini984 – 1093CytoplasmicSequence analysisAdd BLAST110

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9498

Open Targets

More...OpenTargetsi		ENSG00000050438

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35900

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q2Y0W8, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB01390, Sodium bicarbonate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC4A8

Domain mapping of disease mutations (DMDM)

More...DMDMi		121942008

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003289221 – 1093Electroneutral sodium bicarbonate exchanger 1Add BLAST1093

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi636 ↔ 638By similarity
Disulfide bondi672 ↔ 684By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q2Y0W8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q2Y0W8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q2Y0W8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q2Y0W8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q2Y0W8

PeptideAtlas

More...PeptideAtlasi		Q2Y0W8

PRoteomics IDEntifications database

More...PRIDEi		Q2Y0W8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		16963
24921
61540 [Q2Y0W8-1]
61541 [Q2Y0W8-2]
61542 [Q2Y0W8-3]
61543 [Q2Y0W8-4]
61544 [Q2Y0W8-5]
61545 [Q2Y0W8-6]
61546 [Q2Y0W8-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q2Y0W8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q2Y0W8

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q2Y0W8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the pyramidal cells of the hippocampus (at protein level). Highly expressed in all major regions of the brain, spinal column and in testis, and moderate levels in trachea, thyroid and medulla region of kidney. Low expression levels observed in pancreas and kidney cortex.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000050438, Expressed in corpus callosum and 201 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q2Y0W8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000050438, Group enriched (brain, pituitary gland, retina, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114877, 34 interactors

Protein interaction database and analysis system

More...IntActi		Q2Y0W8, 30 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000405812

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q2Y0W8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11093
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q2Y0W8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q2Y0W8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 25DisorderedSequence analysisAdd BLAST25
Regioni55 – 95DisorderedSequence analysisAdd BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1010 – 1036Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi57 – 77Basic residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]Sequence analysis

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1172, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157422

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002289_5_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q2Y0W8

Identification of Orthologs from Complete Genome Data

More...OMAi		VCHIEAE

Database of Orthologous Groups

More...OrthoDBi		265068at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q2Y0W8

TreeFam database of animal gene trees

More...TreeFami		TF313630

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013769, Band3_cytoplasmic_dom
IPR011531, HCO3_transpt-like_TM_dom
IPR003020, HCO3_transpt_euk
IPR003024, Na/HCO3_transpt
IPR016152, PTrfase/Anion_transptr

The PANTHER Classification System

More...PANTHERi		PTHR11453, PTHR11453, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07565, Band_3_cyto, 1 hit
PF00955, HCO3_cotransp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01231, HCO3TRNSPORT
PR01232, NAHCO3TRSPRT

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55804, SSF55804, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00834, ae, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 11 Publication (identifier: Q2Y0W8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPAAGSNEPD GVLSYQRPDE EAVVDQGGTS TILNIHYEKE ELEGHRTLYV 
        60         70         80         90        100
GVRMPLGRQS HRHHRTHGQK HRRRGRGKGA SQGEEGLEAL AHDTPSQRVQ 
       110        120        130        140        150
FILGTEEDEE HVPHELFTEL DEICMKEGED AEWKETARWL KFEEDVEDGG 
       160        170        180        190        200
ERWSKPYVAT LSLHSLFELR SCLINGTVLL DMHANSIEEI SDLILDQQEL 
       210        220        230        240        250
SSDLNDSMRV KVREALLKKH HHQNEKKRNN LIPIVRSFAE VGKKQSDPHL 
       260        270        280        290        300
MDKHGQTVSP QSVPTTNLEV KNGVNCEHSP VDLSKVDLHF MKKIPTGAEA 
       310        320        330        340        350
SNVLVGEVDI LDRPIVAFVR LSPAVLLSGL TEVPIPTRFL FILLGPVGKG 
       360        370        380        390        400
QQYHEIGRSM ATIMTDEIFH DVAYKAKERD DLLAGIDEFL DQVTVLPPGE 
       410        420        430        440        450
WDPSIRIEPP KNVPSQEKRK MPGVPNGNVC HIEQEPHGGH SGPELQRTGR 
       460        470        480        490        500
LFGGLVLDIK RKAPWYWSDY RDALSLQCLA SFLFLYCACM SPVITFGGLL 
       510        520        530        540        550
GEATEGRISA IESLFGASMT GIAYSLFAGQ ALTILGSTGP VLVFEKILFK 
       560        570        580        590        600
FCKDYALSYL SLRACIGLWT AFLCIVLVAT DASSLVCYIT RFTEEAFASL 
       610        620        630        640        650
ICIIFIYEAI EKLIHLAETY PIHMHSQLDH LSLYYCRCTL PENPNNHTLQ 
       660        670        680        690        700
YWKDHNIVTA EVHWANLTVS ECQEMHGEFM GSACGHHGPY TPDVLFWSCI 
       710        720        730        740        750
LFFTTFILSS TLKTFKTSRY FPTRVRSMVS DFAVFLTIFT MVIIDFLIGV 
       760        770        780        790        800
PSPKLQVPSV FKPTRDDRGW IINPIGPNPW WTVIAAIIPA LLCTILIFMD 
       810        820        830        840        850
QQITAVIINR KEHKLKKGCG YHLDLLMVAI MLGVCSIMGL PWFVAATVLS 
       860        870        880        890        900
ITHVNSLKLE SECSAPGEQP KFLGIREQRV TGLMIFVLMG CSVFMTAILK 
       910        920        930        940        950
FIPMPVLYGV FLYMGVSSLQ GIQFFDRLKL FGMPAKHQPD FIYLRHVPLR 
       960        970        980        990       1000
KVHLFTLIQL TCLVLLWVIK ASPAAIVFPM MVLALVFVRK VMDLCFSKRE 
      1010       1020       1030       1040       1050
LSWLDDLMPE SKKKKLDDAK KKAKEEEEAE KMLEIGGDKF PLESRKLLSS 
      1060       1070       1080       1090 
PGKNISCRCD PSEINISDEM PKTTVWKALS MNSGNAKEKS LFN
Length:1,093
Mass (Da):122,938
Last modified:December 20, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDDF9D0BC3CBD1A06
GO
Isoform 21 Publication (identifier: Q2Y0W8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MPAAGSNEPDGVLSYQ → MFNKNNSNKLRSTPRYRRGDPGYLNFTELGPLKPEQKDQWSQH
     1028-1093: EAEKMLEIGG...GNAKEKSLFN → VIVLAPTVYLGASNYRT

Show »
Length:1,071
Mass (Da):120,987
Checksum:i6CF28C557074A1EE
GO
Isoform 31 Publication (identifier: Q2Y0W8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1028-1093: EAEKMLEIGG...GNAKEKSLFN → VIVLAPTVYLGASNYRT

Note: May be due to an intron retention.Curated
Show »
Length:1,044
Mass (Da):117,473
Checksum:i083CF203D4D7FB55
GO
Isoform 41 Publication (identifier: Q2Y0W8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.
     1028-1093: EAEKMLEIGG...GNAKEKSLFN → VIVLAPTVYLGASNYRT

Note: May be due to an intron retention.Curated
Show »
Length:991
Mass (Da):111,661
Checksum:i41DFC25D0B88F845
GO
Isoform 51 Publication (identifier: Q2Y0W8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Show »
Length:1,040
Mass (Da):117,126
Checksum:iA9CB5DD413DCDED7
GO
Isoform 61 Publication (identifier: Q2Y0W8-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     671-691: ECQEMHGEFMGSACGHHGPYT → VSLGAARCPSIVTTGLGGTSK
     692-1093: Missing.

Show »
Length:691
Mass (Da):77,094
Checksum:iEACAA9A36A17394B
GO
Isoform 7 (identifier: Q2Y0W8-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.
     725-800: VRSMVSDFAV...LLCTILIFMD → MESCSVAWLE...RPPKMLGLQA
     801-1093: Missing.

Show »
Length:747
Mass (Da):83,968
Checksum:iB02294FA3EB6A40E
GO
Isoform 8 (identifier: Q2Y0W8-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.
     671-691: ECQEMHGEFMGSACGHHGPYT → VSLGAARCPSIVTTGLGGTSK
     692-1093: Missing.

Show »
Length:638
Mass (Da):71,283
Checksum:iB8605D6EB82E7098
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA34459 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAD38576 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti482F → L in BAG58292 (PubMed:14702039).Curated1
Sequence conflicti1008M → T in AAC82380 (PubMed:11133997).Curated1
Isoform 7 (identifier: Q2Y0W8-7)
Sequence conflicti707Q → R in CAD38576 (PubMed:17974005).Curated1
Sequence conflicti716R → G in CAD38576 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048351312D → A. Corresponds to variant dbSNP:rs35966334Ensembl.1
Natural variantiVAR_048352898I → V. Corresponds to variant dbSNP:rs12318785Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0527591 – 53Missing in isoform 4, isoform 5, isoform 7 and isoform 8. 3 PublicationsAdd BLAST53
Alternative sequenceiVSP_0527601 – 16MPAAG…VLSYQ → MFNKNNSNKLRSTPRYRRGD PGYLNFTELGPLKPEQKDQW SQH in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_052761671 – 691ECQEM…HGPYT → VSLGAARCPSIVTTGLGGTS K in isoform 6 and isoform 8. 2 PublicationsAdd BLAST21
Alternative sequenceiVSP_052762692 – 1093Missing in isoform 6 and isoform 8. 2 PublicationsAdd BLAST402
Alternative sequenceiVSP_052763725 – 800VRSMV…LIFMD → MESCSVAWLECGGVILAHCN LRLLPSSWDYRHAPPQPANF CIFSRDGVSPCWPGWSQSLD LVICLPRPPKMLGLQA in isoform 7. 1 PublicationAdd BLAST76
Alternative sequenceiVSP_052764801 – 1093Missing in isoform 7. 1 PublicationAdd BLAST293
Alternative sequenceiVSP_0527651028 – 1093EAEKM…KSLFN → VIVLAPTVYLGASNYRT in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST66

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF069512 mRNA Translation: AAC82380.1
DQ063579 mRNA Translation: AAY79176.1
DQ975204 mRNA Translation: ABJ09587.1
DQ996537 mRNA Translation: ABJ91576.1
DQ996398 mRNA Translation: ABJ91577.1
AB018282 mRNA Translation: BAA34459.1 Different initiation.
AK295315 mRNA Translation: BAG58292.1
AL831915 mRNA Translation: CAD38576.2 Different initiation.
AC025097 Genomic DNA No translation available.
AC046135 Genomic DNA No translation available.
AC107031 Genomic DNA No translation available.
CH471111 Genomic DNA Translation: EAW58192.1
BC025994 mRNA Translation: AAH25994.1
AF107099 mRNA Translation: AAD52981.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44890.1 [Q2Y0W8-1]
CCDS58232.1 [Q2Y0W8-7]
CCDS58233.1 [Q2Y0W8-8]
CCDS73470.1 [Q2Y0W8-5]

NCBI Reference Sequences

More...RefSeqi		NP_001035049.1, NM_001039960.2 [Q2Y0W8-1]
NP_001245330.1, NM_001258401.2 [Q2Y0W8-5]
NP_001245331.1, NM_001258402.1 [Q2Y0W8-6]
NP_001245332.1, NM_001258403.1 [Q2Y0W8-7]
NP_001254544.1, NM_001267615.1 [Q2Y0W8-8]
XP_016875730.1, XM_017020241.1 [Q2Y0W8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000358657.7; ENSP00000351483.4; ENSG00000050438.17 [Q2Y0W8-5]
ENST00000453097.7; ENSP00000405812.2; ENSG00000050438.17
ENST00000514353.7; ENSP00000442561.2; ENSG00000050438.17 [Q2Y0W8-7]
ENST00000535225.6; ENSP00000441520.1; ENSG00000050438.17 [Q2Y0W8-8]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9498

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9498

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000453097.7; ENSP00000405812.2; NM_001039960.3; NP_001035049.1

UCSC genome browser

More...UCSCi		uc001rys.3, human [Q2Y0W8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF069512 mRNA Translation: AAC82380.1
DQ063579 mRNA Translation: AAY79176.1
DQ975204 mRNA Translation: ABJ09587.1
DQ996537 mRNA Translation: ABJ91576.1
DQ996398 mRNA Translation: ABJ91577.1
AB018282 mRNA Translation: BAA34459.1 Different initiation.
AK295315 mRNA Translation: BAG58292.1
AL831915 mRNA Translation: CAD38576.2 Different initiation.
AC025097 Genomic DNA No translation available.
AC046135 Genomic DNA No translation available.
AC107031 Genomic DNA No translation available.
CH471111 Genomic DNA Translation: EAW58192.1
BC025994 mRNA Translation: AAH25994.1
AF107099 mRNA Translation: AAD52981.1
CCDSiCCDS44890.1 [Q2Y0W8-1]
CCDS58232.1 [Q2Y0W8-7]
CCDS58233.1 [Q2Y0W8-8]
CCDS73470.1 [Q2Y0W8-5]
RefSeqiNP_001035049.1, NM_001039960.2 [Q2Y0W8-1]
NP_001245330.1, NM_001258401.2 [Q2Y0W8-5]
NP_001245331.1, NM_001258402.1 [Q2Y0W8-6]
NP_001245332.1, NM_001258403.1 [Q2Y0W8-7]
NP_001254544.1, NM_001267615.1 [Q2Y0W8-8]
XP_016875730.1, XM_017020241.1 [Q2Y0W8-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5JHOX-ray2.80A/B54-397[»]
AlphaFoldDBiQ2Y0W8
SMRiQ2Y0W8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114877, 34 interactors
IntActiQ2Y0W8, 30 interactors
STRINGi9606.ENSP00000405812

Chemistry databases

DrugBankiDB01390, Sodium bicarbonate

Protein family/group databases

TCDBi2.A.31.2.4, the anion exchanger (ae) family

PTM databases

iPTMnetiQ2Y0W8
PhosphoSitePlusiQ2Y0W8
SwissPalmiQ2Y0W8

Genetic variation databases

BioMutaiSLC4A8
DMDMi121942008

Proteomic databases

EPDiQ2Y0W8
jPOSTiQ2Y0W8
MassIVEiQ2Y0W8
MaxQBiQ2Y0W8
PaxDbiQ2Y0W8
PeptideAtlasiQ2Y0W8
PRIDEiQ2Y0W8
ProteomicsDBi16963
24921
61540 [Q2Y0W8-1]
61541 [Q2Y0W8-2]
61542 [Q2Y0W8-3]
61543 [Q2Y0W8-4]
61544 [Q2Y0W8-5]
61545 [Q2Y0W8-6]
61546 [Q2Y0W8-7]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26410, 176 antibodies from 25 providers

The DNASU plasmid repository

More...DNASUi		9498

Genome annotation databases

EnsembliENST00000358657.7; ENSP00000351483.4; ENSG00000050438.17 [Q2Y0W8-5]
ENST00000453097.7; ENSP00000405812.2; ENSG00000050438.17
ENST00000514353.7; ENSP00000442561.2; ENSG00000050438.17 [Q2Y0W8-7]
ENST00000535225.6; ENSP00000441520.1; ENSG00000050438.17 [Q2Y0W8-8]
GeneIDi9498
KEGGihsa:9498
MANE-SelectiENST00000453097.7; ENSP00000405812.2; NM_001039960.3; NP_001035049.1
UCSCiuc001rys.3, human [Q2Y0W8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9498
DisGeNETi9498

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC4A8
HGNCiHGNC:11034, SLC4A8
HPAiENSG00000050438, Group enriched (brain, pituitary gland, retina, testis)
MIMi605024, gene
neXtProtiNX_Q2Y0W8
OpenTargetsiENSG00000050438
PharmGKBiPA35900
VEuPathDBiHostDB:ENSG00000050438

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1172, Eukaryota
GeneTreeiENSGT00940000157422
HOGENOMiCLU_002289_5_3_1
InParanoidiQ2Y0W8
OMAiVCHIEAE
OrthoDBi265068at2759
PhylomeDBiQ2Y0W8
TreeFamiTF313630

Enzyme and pathway databases

PathwayCommonsiQ2Y0W8
ReactomeiR-HSA-425381, Bicarbonate transporters
SignaLinkiQ2Y0W8
SIGNORiQ2Y0W8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9498, 17 hits in 1072 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC4A8, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SLC4A8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9498
PharosiQ2Y0W8, Tbio

Protein Ontology

More...PROi		PR:Q2Y0W8
RNActiQ2Y0W8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000050438, Expressed in corpus callosum and 201 other tissues
GenevisibleiQ2Y0W8, HS

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR013769, Band3_cytoplasmic_dom
IPR011531, HCO3_transpt-like_TM_dom
IPR003020, HCO3_transpt_euk
IPR003024, Na/HCO3_transpt
IPR016152, PTrfase/Anion_transptr
PANTHERiPTHR11453, PTHR11453, 1 hit
PfamiView protein in Pfam
PF07565, Band_3_cyto, 1 hit
PF00955, HCO3_cotransp, 1 hit
PRINTSiPR01231, HCO3TRNSPORT
PR01232, NAHCO3TRSPRT
SUPFAMiSSF55804, SSF55804, 1 hit
TIGRFAMsiTIGR00834, ae, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS4A8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2Y0W8
Secondary accession number(s): A0MMZ1
, B4DHY0, E7EML0, F5GZ31, F5H7F5, O94843, O95233, Q004B4, Q8N3U2, Q8TC60, Q9UKX8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: December 20, 2005
Last modified: May 25, 2022
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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