Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Long-chain-fatty-acid--CoA ligase ACSBG2

Gene

Acsbg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis (By similarity).By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei496ATPBy similarity1
Binding sitei511ATPBy similarity1
Binding sitei624ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi227 – 235ATPBy similarity9
Nucleotide bindingi418 – 423ATPBy similarity6

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • fatty acid beta-oxidation Source: MGI
  • fatty acid metabolic process Source: MGI
  • multicellular organism development Source: UniProtKB-KW
  • spermatogenesis Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, Ligase
Biological processDifferentiation, Fatty acid metabolism, Lipid metabolism, Spermatogenesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-75876 Synthesis of very long-chain fatty acyl-CoAs

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain-fatty-acid--CoA ligase ACSBG2 (EC:6.2.1.3)
Alternative name(s):
Acyl-CoA synthetase bubblegum family member 2
Bubblegum-related protein
Gene namesi
Name:Acsbg2
Synonyms:Bgr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:3587728 Acsbg2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003158131 – 667Long-chain-fatty-acid--CoA ligase ACSBG2Add BLAST667

Proteomic databases

PaxDbiQ2XU92
PRIDEiQ2XU92

PTM databases

iPTMnetiQ2XU92
PhosphoSitePlusiQ2XU92

Expressioni

Tissue specificityi

Testis- and brainstem-specific. Expressed in pubertal and adult testis. Enriched in germ cells and Sertoli cells while present at a lower level in Leydig cells. Present in testicular Sertoli cells and large motoneurons in the medulla oblongata and cervical spinal cord (at protein level).2 Publications

Gene expression databases

BgeeiENSMUSG00000024207
CleanExiMM_ACSBG2
GenevisibleiQ2XU92 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042352

Structurei

3D structure databases

ProteinModelPortaliQ2XU92
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1256 Eukaryota
COG1022 LUCA
GeneTreeiENSGT00690000101725
HOGENOMiHOG000230004
HOVERGENiHBG054660
InParanoidiQ2XU92
KOiK15013
OMAiEIGPTYY
OrthoDBiEOG091G03FO
PhylomeDBiQ2XU92
TreeFamiTF354286

Family and domain databases

InterProiView protein in InterPro
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q2XU92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQEKKAEDL ERGTDATSAV PRLWSTHCDG EVLLRLSKHG PGHETPMTIP
60 70 80 90 100
ELFQESAERF SAYPALASKN GKKWDTLTFS QYYEMCRKAA KSLIKLGLQR
110 120 130 140 150
FQCVGILGFN SVEWVVTALG TILAGGLCVG IYATNSAEAC QYVIQQANVS
160 170 180 190 200
ILIVENDQQL QKILLIPPDK METVKAIVQY KLPLMESMAN LYSWNDFMEL
210 220 230 240 250
GNDIPNIQLD RVILSQKANQ CAVILYTSGT TGTPKGVLLS HDNITWTAGA
260 270 280 290 300
MSQEMEINRV SGKQNTIVSY LPLSHIAAQL TDIWIPIKIG ALTFFAQPDA
310 320 330 340 350
LRGTLVYTLQ EVKPTLFMGV PRIWEKMQDT IKENVARSSR LRKKAFAWAK
360 370 380 390 400
MLGLKVNTKR MLGKRDIPMN YRMAKALVFA KVRTSLGLDN CHAFFSSASP
410 420 430 440 450
LSQDVSEFFL SLDIPIGEIY GMSECSGPHT VSNKSVYRVL SCGKVLSGCK
460 470 480 490 500
NMLYNQNKEG VGEVCMWGRH VFMGYLNKEE ATLEALDENG WLHSGDIGRL
510 520 530 540 550
DSHDFLYITG RIKEILITAG GENVSPIPIE TLVKEKIPII SHAMLVGDKA
560 570 580 590 600
KFLCMLLTLK CETDRKSGEP LNKLSVEAKS FCQMLGSQAT TVSDILKSRD
610 620 630 640 650
QVVYTAIQYG IDIVNQQAMS DSHRIRKWII LEKDFSIQGG ELGPTSKLKR
660
SVITQKYKAQ IDSMYLS
Length:667
Mass (Da):74,319
Last modified:December 20, 2005 - v1
Checksum:i70E1D0EC8AC4726F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ250679 mRNA Translation: ABB54488.1
CCDSiCCDS28916.1
RefSeqiNP_001034203.1, NM_001039114.1
UniGeneiMm.179421

Genome annotation databases

EnsembliENSMUST00000043062; ENSMUSP00000042352; ENSMUSG00000024207
GeneIDi328845
KEGGimmu:328845
UCSCiuc008ddi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiACBG2_MOUSE
AccessioniPrimary (citable) accession number: Q2XU92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: April 25, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health