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Entry version 113 (12 Aug 2020)
Sequence version 2 (03 Nov 2009)
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Protein

Fer-1-like protein 6

Gene

FER1L6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi842Calcium 1PROSITE-ProRule annotation1
Metal bindingi848Calcium 1PROSITE-ProRule annotation1
Metal bindingi904Calcium 1PROSITE-ProRule annotation1
Metal bindingi906Calcium 1PROSITE-ProRule annotation1
Metal bindingi1372Calcium 2PROSITE-ProRule annotation1
Metal bindingi1372Calcium 3PROSITE-ProRule annotation1
Metal bindingi1378Calcium 2PROSITE-ProRule annotation1
Metal bindingi1427Calcium 2PROSITE-ProRule annotation1
Metal bindingi1427Calcium 3PROSITE-ProRule annotation1
Metal bindingi1429Calcium 2PROSITE-ProRule annotation1
Metal bindingi1429Calcium 3PROSITE-ProRule annotation1
Metal bindingi1435Calcium 3PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q2WGJ9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fer-1-like protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FER1L6
Synonyms:C8orfK23
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000214814.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28065, FER1L6

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q2WGJ9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 1824CytoplasmicSequence analysisAdd BLAST1824
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1825 – 1845HelicalSequence analysisAdd BLAST21
Topological domaini1846 – 1857ExtracellularSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
654463

Open Targets

More...
OpenTargetsi
ENSG00000214814

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162388227

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q2WGJ9, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FER1L6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
262527544

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003236741 – 1857Fer-1-like protein 6Add BLAST1857

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q2WGJ9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q2WGJ9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q2WGJ9

PeptideAtlas

More...
PeptideAtlasi
Q2WGJ9

PRoteomics IDEntifications database

More...
PRIDEi
Q2WGJ9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
61537

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2040, 2 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q2WGJ9, 2 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q2WGJ9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q2WGJ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000214814, Expressed in stomach and 48 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000214814, Tissue enriched (stomach)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q2WGJ9, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000428280

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q2WGJ9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q2WGJ9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini65 – 181C2 1PROSITE-ProRule annotationAdd BLAST117
Domaini225 – 356C2 2PROSITE-ProRule annotationAdd BLAST132
Domaini810 – 937C2 3PROSITE-ProRule annotationAdd BLAST128
Domaini969 – 1099C2 4PROSITE-ProRule annotationAdd BLAST131
Domaini1338 – 1457C2 5PROSITE-ProRule annotationAdd BLAST120
Domaini1578 – 1729C2 6PROSITE-ProRule annotationAdd BLAST152

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ferlin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1326, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159069

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001183_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q2WGJ9

KEGG Orthology (KO)

More...
KOi
K22127

Identification of Orthologs from Complete Genome Data

More...
OMAi
VEEPQHT

Database of Orthologous Groups

More...
OrthoDBi
20162at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q2WGJ9

TreeFam database of animal gene trees

More...
TreeFami
TF316871

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04011, C2B_Ferlin, 1 hit
cd04018, C2C_Ferlin, 1 hit
cd04017, C2D_Ferlin, 1 hit
cd04037, C2E_Ferlin, 1 hit
cd08374, C2F_Ferlin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR037720, C2B_Ferlin
IPR037722, C2C_Ferlin
IPR037723, C2D_Ferlin
IPR037724, C2E_Ferlin
IPR037725, C2F_Ferlin
IPR030000, FER1L6
IPR012968, FerIin_dom
IPR037721, Ferlin
IPR012561, Ferlin_B-domain
IPR032362, Ferlin_C

The PANTHER Classification System

More...
PANTHERi
PTHR12546, PTHR12546, 1 hit
PTHR12546:SF37, PTHR12546:SF37, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 6 hits
PF08150, FerB, 1 hit
PF08151, FerI, 1 hit
PF16165, Ferlin_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 5 hits
SM01201, FerB, 1 hit
SM01202, FerI, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q2WGJ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFGLKVKKKR NKAEKGLILA NKAAKDSQGD TEALQEEPSH QEGPRGDLVH
60 70 80 90 100
DDASIFPVPS ASPKRRSKLL TKIHDGEVRS QNYQIAITIT EARQLVGENI
110 120 130 140 150
DPVVTIEIGD EKKQSTVKEG TNSPFYNEYF VFDFIGPQVH LFDKIIKISV
160 170 180 190 200
FHHKLIGSVL IGSFKVDLGT VYNQPGHQFC NKWALLTDPG DIRTGTKGYL
210 220 230 240 250
KCDISVMGKG DVLKTSPKTS DTEEPIEKNL LIPNGFPLER PWARFYVRLY
260 270 280 290 300
KAEGLPKMNS SIMANVTKAF VGDSKDLVDP FVEVSFAGQM GRTTVQKNCA
310 320 330 340 350
DPVWHEQVIF KEMFPPLCRR VKIQVWDEGS MNDVALATHF IDLKKISNEQ
360 370 380 390 400
DGDKGFLPTF GPAWINLYGS PRNHSLMDDY QEMNEGFGEG VSFRGRILVE
410 420 430 440 450
IAVEILSGRA QESKFSKALK ELKLPSKDKD SKSSKGKDKA DKTEDGKSQQ
460 470 480 490 500
ASNKTNSTEV EVESFDVPPE IVPEKNEEFL LFGAFFEATM IDRKIGDKPI
510 520 530 540 550
SFEVSIGNFG NLIDGGSHHG SKKSAESAEE DLLPLLHEGQ GDVAHDVPIP
560 570 580 590 600
MASTTHPEKP LVTEGNRNYN YLPFEAKKPC VYFISSWGDQ TFRLHWSNML
610 620 630 640 650
EKMADFLEES IEEVRELIKI SQEAPEEKMK TVLSDFISRS SAFISEAEKK
660 670 680 690 700
PKMLNQTTLD KKRLTLCWQE LEAMCKEAKG IIQQQKKKLS VDEMIHEAQN
710 720 730 740 750
FVEKIRFLVD EPQHTIPDVF IWMLSNNRRV AYARIASKDL LYSPVAGQMG
760 770 780 790 800
KHCGKIKTHF LKPPGKRPAG WSVQAKVDVY LWLGSIKHAS AILDNLPVGY
810 820 830 840 850
EAEMSSKGAG TNHPPSNLLY QEQHVFQLRA HMYQARGLIA ADSNGLSDPF
860 870 880 890 900
AKVTFLSHCQ TTKIISQTLS PTWNQMLLFN DLVLHGDVKE LAESPPLVVV
910 920 930 940 950
ELYDSDAVGK PEYLGATVAA PVVKLADQDY EPPRLCYHPI FCGNLSGGDL
960 970 980 990 1000
LAVFELLQVP PSGLQGLPPV EPPDITQIYP VPANIRPVLS KYRVEVLFWG
1010 1020 1030 1040 1050
VREMKKVQLL SVDRPQALIE CGGQGVKSCV IQSYKNNPNF SIQADAFEVE
1060 1070 1080 1090 1100
LPENELLHPP LSICVVDWRA FGRSTLVGTY TINYLKQFLC KLREPLAPIT
1110 1120 1130 1140 1150
QVDGTQPGHD ISDSLTATES SGAHSSSQDP PADHIYVDVE PPPTVVPDSA
1160 1170 1180 1190 1200
QAQPAILVDV PDSSPMLEPE HTPVAQEPPK DGKPKDPRKP SRRSTKRRKR
1210 1220 1230 1240 1250
TIADESAENV IDWWSKYYAS LKKAQKAKER NPKGKKGNTE AKPDEVVVDI
1260 1270 1280 1290 1300
EDGPKKKKDK MLKKKPKDDG IPNLAILQIY DGDLESEFNN FEDWVKTFEL
1310 1320 1330 1340 1350
FRGKSTEDDH GLDGDRVIGK FKGSFCIYKS PQDSSSEDSG QLRIQQGIPP
1360 1370 1380 1390 1400
NHPVTVLIRV YIVAAFNLSP ADPDGKSDPY IVIKLGKTEI KDRDKYIPKQ
1410 1420 1430 1440 1450
LNPVFGRSFE IQATFPKESL LSILIYDHDM IGTDDLIGET KIDLENRFYS
1460 1470 1480 1490 1500
KHRAICGLQS QYEIEGYNAW RDTSKPTEIL TKLCKDNKLD GPYFHPGKIQ
1510 1520 1530 1540 1550
IGNQVFSGKT IFTEEDTDET VESYEHLALK VLHSWEDIPE VGCRLVPEHI
1560 1570 1580 1590 1600
ETRPLYHKDK PGMEQGRLQM WVDMFPKDMP QPGPPVDISP RRPKGYELRV
1610 1620 1630 1640 1650
TIWNTEDVIL EDENIFTGQK SSDIYVKGWL KGLEDDKQET DVHYNSLTGE
1660 1670 1680 1690 1700
GNFNWRFLFP FQYLPAEKQM VITKRENIFS LEKMECKTPA VLVLQVWDFE
1710 1720 1730 1740 1750
RLSSDDFLGT LEMNLNSFPR AAKSAKACDL AKFENASEET KISIFQQKRV
1760 1770 1780 1790 1800
RGWWPFSKSK ELTGKVEAEF HLVTAEEAEK NPVGKARKEP EPLAKPNRPD
1810 1820 1830 1840 1850
TSFSWFMSPF KCLYYLIWKN YKKYIIIAFI LIILIIFLVL FIYTLPGAIS

RRIVVGS
Length:1,857
Mass (Da):209,308
Last modified:November 3, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9A86F3E7E924B16B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti519H → Y in BAE53435 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0395581110D → E. Corresponds to variant dbSNP:rs7012186Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB196633 mRNA Translation: BAE53435.1
AC090753 Genomic DNA No translation available.
AC100871 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43767.1

NCBI Reference Sequences

More...
RefSeqi
NP_001034201.2, NM_001039112.2
XP_011515534.1, XM_011517232.2
XP_011515535.1, XM_011517233.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000522917; ENSP00000428280; ENSG00000214814

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
654463

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:654463

UCSC genome browser

More...
UCSCi
uc003yqw.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB196633 mRNA Translation: BAE53435.1
AC090753 Genomic DNA No translation available.
AC100871 Genomic DNA No translation available.
CCDSiCCDS43767.1
RefSeqiNP_001034201.2, NM_001039112.2
XP_011515534.1, XM_011517232.2
XP_011515535.1, XM_011517233.2

3D structure databases

SMRiQ2WGJ9
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ2WGJ9, 1 interactor
STRINGi9606.ENSP00000428280

PTM databases

GlyConnecti2040, 2 N-Linked glycans (1 site)
GlyGeniQ2WGJ9, 2 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (1 site)
iPTMnetiQ2WGJ9
PhosphoSitePlusiQ2WGJ9

Polymorphism and mutation databases

BioMutaiFER1L6
DMDMi262527544

Proteomic databases

jPOSTiQ2WGJ9
MassIVEiQ2WGJ9
PaxDbiQ2WGJ9
PeptideAtlasiQ2WGJ9
PRIDEiQ2WGJ9
ProteomicsDBi61537

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
65278, 11 antibodies

Genome annotation databases

EnsembliENST00000522917; ENSP00000428280; ENSG00000214814
GeneIDi654463
KEGGihsa:654463
UCSCiuc003yqw.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
654463
DisGeNETi654463
EuPathDBiHostDB:ENSG00000214814.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FER1L6
HGNCiHGNC:28065, FER1L6
HPAiENSG00000214814, Tissue enriched (stomach)
neXtProtiNX_Q2WGJ9
OpenTargetsiENSG00000214814
PharmGKBiPA162388227

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1326, Eukaryota
GeneTreeiENSGT00940000159069
HOGENOMiCLU_001183_3_1_1
InParanoidiQ2WGJ9
KOiK22127
OMAiVEEPQHT
OrthoDBi20162at2759
PhylomeDBiQ2WGJ9
TreeFamiTF316871

Enzyme and pathway databases

PathwayCommonsiQ2WGJ9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
654463, 4 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FER1L6, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
654463
PharosiQ2WGJ9, Tdark

Protein Ontology

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PROi
PR:Q2WGJ9
RNActiQ2WGJ9, protein

Gene expression databases

BgeeiENSG00000214814, Expressed in stomach and 48 other tissues

Family and domain databases

CDDicd04011, C2B_Ferlin, 1 hit
cd04018, C2C_Ferlin, 1 hit
cd04017, C2D_Ferlin, 1 hit
cd04037, C2E_Ferlin, 1 hit
cd08374, C2F_Ferlin, 1 hit
Gene3Di2.60.40.150, 5 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR037720, C2B_Ferlin
IPR037722, C2C_Ferlin
IPR037723, C2D_Ferlin
IPR037724, C2E_Ferlin
IPR037725, C2F_Ferlin
IPR030000, FER1L6
IPR012968, FerIin_dom
IPR037721, Ferlin
IPR012561, Ferlin_B-domain
IPR032362, Ferlin_C
PANTHERiPTHR12546, PTHR12546, 1 hit
PTHR12546:SF37, PTHR12546:SF37, 1 hit
PfamiView protein in Pfam
PF00168, C2, 6 hits
PF08150, FerB, 1 hit
PF08151, FerI, 1 hit
PF16165, Ferlin_C, 1 hit
SMARTiView protein in SMART
SM00239, C2, 5 hits
SM01201, FerB, 1 hit
SM01202, FerI, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFR1L6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2WGJ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 3, 2009
Last modified: August 12, 2020
This is version 113 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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