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Protein

Kelch-like protein 38

Gene

KLHL38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kelch-like protein 38
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KLHL38
Synonyms:C8orfK36
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000175946.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:34435 KLHL38

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q2WGJ6

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
340359

Open Targets

More...
OpenTargetsi
ENSG00000175946

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162393613

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KLHL38

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439315

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003258091 – 581Kelch-like protein 38Add BLAST581

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q2WGJ6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q2WGJ6

PeptideAtlas

More...
PeptideAtlasi
Q2WGJ6

PRoteomics IDEntifications database

More...
PRIDEi
Q2WGJ6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
61535

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q2WGJ6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q2WGJ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000175946 Expressed in 65 organ(s), highest expression level in muscle of leg

CleanEx database of gene expression profiles

More...
CleanExi
HS_KLHL38

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024770
HPA027115

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
131043, 23 interactors

Protein interaction database and analysis system

More...
IntActi
Q2WGJ6, 97 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000321475

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q2WGJ6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q2WGJ6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 101BTBPROSITE-ProRule annotationAdd BLAST68
Domaini136 – 237BACKAdd BLAST102
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati285 – 332Kelch 1Add BLAST48
Repeati334 – 383Kelch 2Add BLAST50
Repeati384 – 431Kelch 3Add BLAST48
Repeati433 – 479Kelch 4Add BLAST47
Repeati480 – 521Kelch 5Add BLAST42
Repeati523 – 573Kelch 6Add BLAST51

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4441 Eukaryota
ENOG410XNX8 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157647

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082537

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG095739

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q2WGJ6

KEGG Orthology (KO)

More...
KOi
K13959

Identification of Orthologs from Complete Genome Data

More...
OMAi
VPCHRNV

Database of Orthologous Groups

More...
OrthoDBi
EOG091G03OC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q2WGJ6

TreeFam database of animal gene trees

More...
TreeFami
TF329218

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR030568 KLHL38
IPR011333 SKP1/BTB/POZ_sf

The PANTHER Classification System

More...
PANTHERi
PTHR24412:SF8 PTHR24412:SF8, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037037 Kelch-like_protein_gigaxonin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097 BTB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q2WGJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEESLDGLL FKDHDFSSDL LRQLNSLRQS RILTDVSICA GAREIPCHRN
60 70 80 90 100
VLASSSPYFR AMFCSSFREK SEAKVQLKGI DPPTLDQIVS YVYTGEAHIA
110 120 130 140 150
TDNVLPVMEA ASMLQFPKLF EACSSYLQSQ LAPSNCLGMI RLSEILSCET
160 170 180 190 200
LKKKAREVAL TSFPEVAASA DLKELCALEL RDYLGDDGLC GEEEKVFEAL
210 220 230 240 250
MVWIKHDLQA RKRYMQELFK QVRLQYIHPA FFHHFIANDA LLQSSPACQI
260 270 280 290 300
ILETAKRQMF SLCGTTVPDC KLLLHVPPRN SYQDFLILLG GRKDSQQTTR
310 320 330 340 350
DVLLYSKQTG QWQSLAKLPT RLYKASAITL HRSIYVLGGM AVSSGRSLVS
360 370 380 390 400
HNVYIFSLKL NQWRLGEPML VARYSHRSTA HKNFIFSIGG IGEGQELMGS
410 420 430 440 450
MERYDSICNV WESMASMPVG VLHPAVAVKD QRLYLFGGED IMQNPVRLIQ
460 470 480 490 500
VYHISRNSWF KMETRMIKNV CAPAVVLGER IVIVGGYTRR ILAYDPQSNK
510 520 530 540 550
FVKCADMKDR RMHHGATVMG NKLYVTGGRR LTTDCNIEDS ASFDCYDPET
560 570 580
DTWTSQGQLP HKLFDHACLT LQCIPRTSGL P
Length:581
Mass (Da):65,541
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6655BD039F4C757
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti98H → R in EAW92045 (Ref. 3) Curated1
Sequence conflicti98H → R in AAI27887 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059437310G → S. Corresponds to variant dbSNP:rs16898693Ensembl.1
Natural variantiVAR_060485334I → V2 PublicationsCorresponds to variant dbSNP:rs11784192Ensembl.1
Natural variantiVAR_060486346R → K2 PublicationsCorresponds to variant dbSNP:rs11780509Ensembl.1
Natural variantiVAR_059438352N → Y. Corresponds to variant dbSNP:rs11784175Ensembl.1
Natural variantiVAR_059439394G → R. Corresponds to variant dbSNP:rs16898691Ensembl.1
Natural variantiVAR_059440504C → Y. Corresponds to variant dbSNP:rs11779866Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB196636 mRNA Translation: BAE53438.1
AC135166 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW92045.1
BC127886 mRNA Translation: AAI27887.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43766.1

NCBI Reference Sequences

More...
RefSeqi
NP_001075144.2, NM_001081675.2
XP_005250958.1, XM_005250901.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.450252

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000325995; ENSP00000321475; ENSG00000175946

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
340359

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:340359

UCSC genome browser

More...
UCSCi
uc003yqs.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB196636 mRNA Translation: BAE53438.1
AC135166 Genomic DNA No translation available.
CH471060 Genomic DNA Translation: EAW92045.1
BC127886 mRNA Translation: AAI27887.1
CCDSiCCDS43766.1
RefSeqiNP_001075144.2, NM_001081675.2
XP_005250958.1, XM_005250901.4
UniGeneiHs.450252

3D structure databases

ProteinModelPortaliQ2WGJ6
SMRiQ2WGJ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131043, 23 interactors
IntActiQ2WGJ6, 97 interactors
STRINGi9606.ENSP00000321475

PTM databases

iPTMnetiQ2WGJ6
PhosphoSitePlusiQ2WGJ6

Polymorphism and mutation databases

BioMutaiKLHL38
DMDMi296439315

Proteomic databases

EPDiQ2WGJ6
PaxDbiQ2WGJ6
PeptideAtlasiQ2WGJ6
PRIDEiQ2WGJ6
ProteomicsDBi61535

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000325995; ENSP00000321475; ENSG00000175946
GeneIDi340359
KEGGihsa:340359
UCSCiuc003yqs.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
340359
DisGeNETi340359
EuPathDBiHostDB:ENSG00000175946.8

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KLHL38
HGNCiHGNC:34435 KLHL38
HPAiHPA024770
HPA027115
neXtProtiNX_Q2WGJ6
OpenTargetsiENSG00000175946
PharmGKBiPA162393613

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4441 Eukaryota
ENOG410XNX8 LUCA
GeneTreeiENSGT00940000157647
HOGENOMiHOG000082537
HOVERGENiHBG095739
InParanoidiQ2WGJ6
KOiK13959
OMAiVPCHRNV
OrthoDBiEOG091G03OC
PhylomeDBiQ2WGJ6
TreeFamiTF329218

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
340359

Protein Ontology

More...
PROi
PR:Q2WGJ6

Gene expression databases

BgeeiENSG00000175946 Expressed in 65 organ(s), highest expression level in muscle of leg
CleanExiHS_KLHL38

Family and domain databases

Gene3Di2.120.10.80, 2 hits
InterProiView protein in InterPro
IPR011705 BACK
IPR017096 BTB-kelch_protein
IPR000210 BTB/POZ_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR030568 KLHL38
IPR011333 SKP1/BTB/POZ_sf
PANTHERiPTHR24412:SF8 PTHR24412:SF8, 1 hit
PfamiView protein in Pfam
PF07707 BACK, 1 hit
PF00651 BTB, 1 hit
PF01344 Kelch_1, 2 hits
PIRSFiPIRSF037037 Kelch-like_protein_gigaxonin, 1 hit
SMARTiView protein in SMART
SM00875 BACK, 1 hit
SM00225 BTB, 1 hit
SM00612 Kelch, 5 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKLH38_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2WGJ6
Secondary accession number(s): A0PK12
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 18, 2010
Last modified: December 5, 2018
This is version 112 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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