UniProtKB - Q2WEA5 (TRPM1_RAT)
Protein
Transient receptor potential cation channel subfamily M member 1
Gene
Trpm1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Forms nonselective divalent cation-conducting channels which mediate the influx of Na2+, Ca2+, Mg2+, Mn2+, Ba2+, and Ni2+ into the cytoplasm, leading to membrane depolarization (By similarity). Impermeable to zinc ions (By similarity). In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions (By similarity). Essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. Calcium channel which may play a role in metastasis suppression. May act as a spontaneously active, calcium-permeable plasma membrane channel (By similarity).By similarity
Activity regulationi
Inhibited by zinc ions.By similarity
GO - Molecular functioni
- calcium channel activity Source: UniProtKB
- cation channel activity Source: RGD
GO - Biological processi
- calcium ion transport into cytosol Source: UniProtKB
- cation transmembrane transport Source: GO_Central
- cellular response to light stimulus Source: RGD
- divalent metal ion transport Source: GO_Central
- G protein-coupled glutamate receptor signaling pathway Source: UniProtKB
- protein tetramerization Source: InterPro
- retinal rod cell development Source: RGD
- signal transduction Source: RGD
- visual perception Source: RGD
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Transport |
Enzyme and pathway databases
Reactomei | R-RNO-3295583, TRP channels |
Names & Taxonomyi
Protein namesi | Recommended name: Transient receptor potential cation channel subfamily M member 1Alternative name(s): Melastatin-1 |
Gene namesi | Name:Trpm1Imported |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1597140, Trpm1 |
Subcellular locationi
Plasma membrane
- Cell membrane Sequence analysis; Multi-pass membrane protein Sequence analysisBy similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Other locations
- axon By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- new growing cell tip Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 875 | CytoplasmicCuratedAdd BLAST | 875 | |
Transmembranei | 876 – 896 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 897 – 942 | ExtracellularCuratedAdd BLAST | 46 | |
Transmembranei | 943 – 963 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 964 – 973 | CytoplasmicCurated | 10 | |
Transmembranei | 974 – 994 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 995 – 1006 | ExtracellularCuratedAdd BLAST | 12 | |
Transmembranei | 1007 – 1027 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1028 – 1105 | CytoplasmicCuratedAdd BLAST | 78 | |
Transmembranei | 1106 – 1126 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1127 – 1156 | ExtracellularCuratedAdd BLAST | 30 | |
Transmembranei | 1157 – 1177 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 1178 – 1628 | CytoplasmicCuratedAdd BLAST | 451 |
Keywords - Cellular componenti
Cell membrane, Cell projection, Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000328932 | 1 – 1628 | Transient receptor potential cation channel subfamily M member 1Add BLAST | 1628 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 1127 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q2WEA5 |
PRIDEi | Q2WEA5 |
PTM databases
CarbonylDBi | Q2WEA5 |
iPTMneti | Q2WEA5 |
PhosphoSitePlusi | Q2WEA5 |
Interactioni
Subunit structurei
Interacts with TRPM3; the interaction results in the formation of a heteromultimeric cation channel complex.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000062990 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1233 – 1253 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM1 sub-subfamily. [View classification]Curated
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3614, Eukaryota |
InParanoidi | Q2WEA5 |
OrthoDBi | 738147at2759 |
PhylomeDBi | Q2WEA5 |
Family and domain databases
Gene3Di | 1.20.5.1010, 1 hit |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR029588, TRPM1 IPR041491, TRPM_SLOG IPR032415, TRPM_tetra IPR037162, TRPM_tetra_sf |
PANTHERi | PTHR13800:SF13, PTHR13800:SF13, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit PF18139, LSDAT_euk, 1 hit PF16519, TRPM_tetra, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 11 Publication (identifier: Q2WEA5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGSMRKMSSS FKRGSIKSST SGSQKGQKAW IEKTFCKREC IFVIPSTKDP
60 70 80 90 100
NRCCCGQLTN QHIPPLPSVT PSSTAEDTKQ GDAQSGKWSV SKHTQSYPTD
110 120 130 140 150
SYGILEFQGG GYSNKAMYIR VSYDTKPDSL LHLMVKDWQL ELPKLLISVH
160 170 180 190 200
GGLQSFEMQP KLKQVFGKGL IKAAMTTGAW IFTGGVSTGV VSHVGDALKD
210 220 230 240 250
HSSKSRGRLC AIGIAPWGMV ENKEDLVGKD VTRVYQTMSN PLSKLSVLNN
260 270 280 290 300
SHTHFILADN GTLGKYGAEV KLRRQLEKHI SLQKINTRLG QGVPVVGLVV
310 320 330 340 350
EGGPNVVSIV LEYLREDPPV PVVVCDGSGR ASDILSFAHK YCDEGGVINE
360 370 380 390 400
SLRDQLLVTI QKTFNYSKSQ SHQLFAIIME CMKKKELVTV FRMGSEGQQD
410 420 430 440 450
VEMAILTALL KGTNVSAPDQ LSLALAWNRV DIARSQIFVF GPHWPPLGSL
460 470 480 490 500
APPVDTKVAE KEKKPPTATT KGRGKGKGKK KGKVKEEVEE ETDPRKIELL
510 520 530 540 550
NWVNALEQAM LDALVLDRVD FVKLLIENGV NMQHFLTIPR LEELYNTRLG
560 570 580 590 600
PPNTLHLLVR DVKKSNLPPD YHISLIDIGL VLEYLMGGAY RCNYTRKSFR
610 620 630 640 650
TLYNNLFGPK RPKALKLLGM EDDEPPAKGK KKKKKKKEEE IDIDVDDPAV
660 670 680 690 700
SRFQYPFHEL MVWAVLMKRQ KMAVFLWQRG EECMAKALVA CKLYKAMAHE
710 720 730 740 750
SSESELVDDI SQDLDNNSKD FGQLAVELLD QSYKHDEQVA MKLLTYELKN
760 770 780 790 800
WSNSTCLKLA VAAKHRDFIA HTCSQMLLTD MWMGRLRMRK NPGLKVIMGI
810 820 830 840 850
LIPPTILFLE FRSYDDFSYQ TSKENEDGKE KEEENVDANA DAGSRKGDEE
860 870 880 890 900
NEHKKQRSIP IGTKICEFYN APIVKFWFYT ISYLGYLLLF NYVILVRMDG
910 920 930 940 950
WPSPQEWIVI SYIVSLALEK IREILMSEPG KLSQKIKVWL QEYWNITDLV
960 970 980 990 1000
AISMFMVGAI LRLQNQPYMG YGRVIYCVDI ILWYIRVLDI FGVNKYLGPY
1010 1020 1030 1040 1050
VMMIGKMMID MLYFVVIMLV VLMSFGVARQ AILHPEEKPS WKLARNIFYM
1060 1070 1080 1090 1100
PYWMIYGEVF ADQIDRKTRI HIYAMEINPP CGENLYDEEG KRLPPCIPGA
1110 1120 1130 1140 1150
WLTPALMACY LLVANILLVN LLIAVFNNTF FEVKSISNQV WKFQRYQLIM
1160 1170 1180 1190 1200
TFHDRPVLPP PMIILSHIYI IVMRLSGRCR KKREGDQEER DRGLKLFLSD
1210 1220 1230 1240 1250
EELKKLHEFE EQCVQEHFRE KEDEQQSSSD ERIRVTSERV ENMSMRLEEI
1260 1270 1280 1290 1300
NERENFMKAS LQTVDLRLSQ LEELSGRMVG ALENLAGIDR SDLIQARSRA
1310 1320 1330 1340 1350
SSECEATYLL RQSSINSADG YSMYRYHFNG EELLFEEPAL STSPGTVFRK
1360 1370 1380 1390 1400
KTCSFRVKEE DVKPHLDQPS SLHHTPGPSP PATPGRSRLA LDGPLSTELR
1410 1420 1430 1440 1450
PGLDPGISAG ELDPRADFKS AEVAPSLNTA NVASTQLTVE STVSHPLRES
1460 1470 1480 1490 1500
KLARYYPGDL NTYKTMKSRS FVYSEGRKLV RGLSNWGAEY SSIMDQTWNS
1510 1520 1530 1540 1550
AEWRCQVQRI TRSRSTDIPY IVSEAASQDE FEDEHRESLL APQISRSALT
1560 1570 1580 1590 1600
VSDRPEKENL LSVKPHQTLG FPCLRSRSLH GHPRSAKPSP SKLDRAGHAS
1610 1620
STSNLAVMSD APEGQNTQQE KGNPETEC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF1M9X0 | F1M9X0_RAT | Transient receptor potential cation... | Trpm1 | 1,628 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_052740 | 1066 – 1072 | RKTRIHI → L in isoform 2. 1 Publication | 7 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ867482 mRNA Translation: CAI30141.1 AJ867483 mRNA Translation: CAI30142.1 |
RefSeqi | NP_001032822.1, NM_001037733.1 [Q2WEA5-2] NP_001032823.1, NM_001037734.1 [Q2WEA5-1] |
Genome annotation databases
GeneIDi | 361586 |
KEGGi | rno:361586 |
UCSCi | RGD:1597140, rat [Q2WEA5-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ867482 mRNA Translation: CAI30141.1 AJ867483 mRNA Translation: CAI30142.1 |
RefSeqi | NP_001032822.1, NM_001037733.1 [Q2WEA5-2] NP_001032823.1, NM_001037734.1 [Q2WEA5-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000062990 |
PTM databases
CarbonylDBi | Q2WEA5 |
iPTMneti | Q2WEA5 |
PhosphoSitePlusi | Q2WEA5 |
Proteomic databases
PaxDbi | Q2WEA5 |
PRIDEi | Q2WEA5 |
Genome annotation databases
GeneIDi | 361586 |
KEGGi | rno:361586 |
UCSCi | RGD:1597140, rat [Q2WEA5-1] |
Organism-specific databases
CTDi | 4308 |
RGDi | 1597140, Trpm1 |
Phylogenomic databases
eggNOGi | KOG3614, Eukaryota |
InParanoidi | Q2WEA5 |
OrthoDBi | 738147at2759 |
PhylomeDBi | Q2WEA5 |
Enzyme and pathway databases
Reactomei | R-RNO-3295583, TRP channels |
Miscellaneous databases
PROi | PR:Q2WEA5 |
Family and domain databases
Gene3Di | 1.20.5.1010, 1 hit |
InterProi | View protein in InterPro IPR005821, Ion_trans_dom IPR029588, TRPM1 IPR041491, TRPM_SLOG IPR032415, TRPM_tetra IPR037162, TRPM_tetra_sf |
PANTHERi | PTHR13800:SF13, PTHR13800:SF13, 1 hit |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit PF18139, LSDAT_euk, 1 hit PF16519, TRPM_tetra, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRPM1_RAT | |
Accessioni | Q2WEA5Primary (citable) accession number: Q2WEA5 Secondary accession number(s): Q2WEA4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 8, 2008 |
Last sequence update: | January 10, 2006 | |
Last modified: | February 10, 2021 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families