Trpm1

Functionⁱ

Calcium channel which may play a role in metastasis suppression. May act as a spontaneously active, calcium-permeable plasma membrane channel (By similarity).By similarity

GO - Molecular functionⁱ

calcium channel activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium ion transport into cytosol Source: UniProtKB
cellular response to light stimulus Source: InterPro
G-protein coupled glutamate receptor signaling pathway Source: UniProtKB
protein tetramerization Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Ligand-gated ion channel, Receptor
Biological process	Ion transport, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Transient receptor potential cation channel subfamily M member 1 Alternative name(s): Melastatin-1
Gene namesⁱ	Name:Trpm1Imported
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	1597140 Trpm1

RGDⁱ

1597140 Trpm1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 790	ExtracellularSequence analysisAdd BLAST	790
Transmembraneⁱ	791 – 811	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	812 – 875	CytoplasmicSequence analysisAdd BLAST	64
Transmembraneⁱ	876 – 896	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	897	ExtracellularSequence analysis	1
Transmembraneⁱ	898 – 918	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	919 – 942	CytoplasmicSequence analysisAdd BLAST	24
Transmembraneⁱ	943 – 963	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	964 – 973	ExtracellularSequence analysis	10
Transmembraneⁱ	974 – 994	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	995 – 1006	CytoplasmicSequence analysisAdd BLAST	12
Transmembraneⁱ	1007 – 1027	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	1028 – 1105	ExtracellularSequence analysisAdd BLAST	78
Transmembraneⁱ	1106 – 1126	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	1127 – 1156	CytoplasmicSequence analysisAdd BLAST	30
Transmembraneⁱ	1157 – 1177	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	1178 – 1628	ExtracellularSequence analysisAdd BLAST	451

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000328932	1 – 1628	Transient receptor potential cation channel subfamily M member 1Add BLAST		1628

Proteomic databases

PaxDbⁱ	Q2WEA5
PRIDEⁱ	Q2WEA5

PTM databases

CarbonylDBⁱ	Q2WEA5
iPTMnetⁱ	Q2WEA5
PhosphoSitePlusⁱ	Q2WEA5

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000062990

STRINGⁱ

10116.ENSRNOP00000062990

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	1230 – 1259	Sequence analysisAdd BLAST		30

Sequence similaritiesⁱ

Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM1 sub-subfamily. [View classification]Curated

Keywords - Domainⁱ

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3614 Eukaryota ENOG410XR5B LUCA
HOGENOMⁱ	HOG000230920
HOVERGENⁱ	HBG055663
InParanoidⁱ	Q2WEA5
KEGG Orthology (KO) More...KOⁱ	K04976
PhylomeDBⁱ	Q2WEA5

Family and domain databases

Gene3Dⁱ	1.20.5.1010, 1 hit
InterProⁱ	View protein in InterPro IPR005821 Ion_trans_dom IPR029588 TRPM1 IPR032415 TRPM_tetra IPR037162 TRPM_tetra_sf
PANTHERⁱ	PTHR13800:SF13 PTHR13800:SF13, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00520 Ion_trans, 1 hit PF16519 TRPM_tetra, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.ⁱShow all

Isoform 11 Publication (identifier: Q2WEA5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSMRKMSSS FKRGSIKSST SGSQKGQKAW IEKTFCKREC IFVIPSTKDP 
        60         70         80         90        100
NRCCCGQLTN QHIPPLPSVT PSSTAEDTKQ GDAQSGKWSV SKHTQSYPTD 
       110        120        130        140        150
SYGILEFQGG GYSNKAMYIR VSYDTKPDSL LHLMVKDWQL ELPKLLISVH 
       160        170        180        190        200
GGLQSFEMQP KLKQVFGKGL IKAAMTTGAW IFTGGVSTGV VSHVGDALKD 
       210        220        230        240        250
HSSKSRGRLC AIGIAPWGMV ENKEDLVGKD VTRVYQTMSN PLSKLSVLNN 
       260        270        280        290        300
SHTHFILADN GTLGKYGAEV KLRRQLEKHI SLQKINTRLG QGVPVVGLVV 
       310        320        330        340        350
EGGPNVVSIV LEYLREDPPV PVVVCDGSGR ASDILSFAHK YCDEGGVINE 
       360        370        380        390        400
SLRDQLLVTI QKTFNYSKSQ SHQLFAIIME CMKKKELVTV FRMGSEGQQD 
       410        420        430        440        450
VEMAILTALL KGTNVSAPDQ LSLALAWNRV DIARSQIFVF GPHWPPLGSL 
       460        470        480        490        500
APPVDTKVAE KEKKPPTATT KGRGKGKGKK KGKVKEEVEE ETDPRKIELL 
       510        520        530        540        550
NWVNALEQAM LDALVLDRVD FVKLLIENGV NMQHFLTIPR LEELYNTRLG 
       560        570        580        590        600
PPNTLHLLVR DVKKSNLPPD YHISLIDIGL VLEYLMGGAY RCNYTRKSFR 
       610        620        630        640        650
TLYNNLFGPK RPKALKLLGM EDDEPPAKGK KKKKKKKEEE IDIDVDDPAV 
       660        670        680        690        700
SRFQYPFHEL MVWAVLMKRQ KMAVFLWQRG EECMAKALVA CKLYKAMAHE 
       710        720        730        740        750
SSESELVDDI SQDLDNNSKD FGQLAVELLD QSYKHDEQVA MKLLTYELKN 
       760        770        780        790        800
WSNSTCLKLA VAAKHRDFIA HTCSQMLLTD MWMGRLRMRK NPGLKVIMGI 
       810        820        830        840        850
LIPPTILFLE FRSYDDFSYQ TSKENEDGKE KEEENVDANA DAGSRKGDEE 
       860        870        880        890        900
NEHKKQRSIP IGTKICEFYN APIVKFWFYT ISYLGYLLLF NYVILVRMDG 
       910        920        930        940        950
WPSPQEWIVI SYIVSLALEK IREILMSEPG KLSQKIKVWL QEYWNITDLV 
       960        970        980        990       1000
AISMFMVGAI LRLQNQPYMG YGRVIYCVDI ILWYIRVLDI FGVNKYLGPY 
      1010       1020       1030       1040       1050
VMMIGKMMID MLYFVVIMLV VLMSFGVARQ AILHPEEKPS WKLARNIFYM 
      1060       1070       1080       1090       1100
PYWMIYGEVF ADQIDRKTRI HIYAMEINPP CGENLYDEEG KRLPPCIPGA 
      1110       1120       1130       1140       1150
WLTPALMACY LLVANILLVN LLIAVFNNTF FEVKSISNQV WKFQRYQLIM 
      1160       1170       1180       1190       1200
TFHDRPVLPP PMIILSHIYI IVMRLSGRCR KKREGDQEER DRGLKLFLSD 
      1210       1220       1230       1240       1250
EELKKLHEFE EQCVQEHFRE KEDEQQSSSD ERIRVTSERV ENMSMRLEEI 
      1260       1270       1280       1290       1300
NERENFMKAS LQTVDLRLSQ LEELSGRMVG ALENLAGIDR SDLIQARSRA 
      1310       1320       1330       1340       1350
SSECEATYLL RQSSINSADG YSMYRYHFNG EELLFEEPAL STSPGTVFRK 
      1360       1370       1380       1390       1400
KTCSFRVKEE DVKPHLDQPS SLHHTPGPSP PATPGRSRLA LDGPLSTELR 
      1410       1420       1430       1440       1450
PGLDPGISAG ELDPRADFKS AEVAPSLNTA NVASTQLTVE STVSHPLRES 
      1460       1470       1480       1490       1500
KLARYYPGDL NTYKTMKSRS FVYSEGRKLV RGLSNWGAEY SSIMDQTWNS 
      1510       1520       1530       1540       1550
AEWRCQVQRI TRSRSTDIPY IVSEAASQDE FEDEHRESLL APQISRSALT 
      1560       1570       1580       1590       1600
VSDRPEKENL LSVKPHQTLG FPCLRSRSLH GHPRSAKPSP SKLDRAGHAS 
      1610       1620 
STSNLAVMSD APEGQNTQQE KGNPETEC

Length:1,628

Mass (Da):184,318

Last modified:January 10, 2006 - v1

Checksum:ⁱ2CFB057DF62CB102

GO

Isoform 21 Publication (identifier: Q2WEA5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1066-1072: RKTRIHI → L

« Hide

        10         20         30         40         50
MGSMRKMSSS FKRGSIKSST SGSQKGQKAW IEKTFCKREC IFVIPSTKDP 
        60         70         80         90        100
NRCCCGQLTN QHIPPLPSVT PSSTAEDTKQ GDAQSGKWSV SKHTQSYPTD 
       110        120        130        140        150
SYGILEFQGG GYSNKAMYIR VSYDTKPDSL LHLMVKDWQL ELPKLLISVH 
       160        170        180        190        200
GGLQSFEMQP KLKQVFGKGL IKAAMTTGAW IFTGGVSTGV VSHVGDALKD 
       210        220        230        240        250
HSSKSRGRLC AIGIAPWGMV ENKEDLVGKD VTRVYQTMSN PLSKLSVLNN 
       260        270        280        290        300
SHTHFILADN GTLGKYGAEV KLRRQLEKHI SLQKINTRLG QGVPVVGLVV 
       310        320        330        340        350
EGGPNVVSIV LEYLREDPPV PVVVCDGSGR ASDILSFAHK YCDEGGVINE 
       360        370        380        390        400
SLRDQLLVTI QKTFNYSKSQ SHQLFAIIME CMKKKELVTV FRMGSEGQQD 
       410        420        430        440        450
VEMAILTALL KGTNVSAPDQ LSLALAWNRV DIARSQIFVF GPHWPPLGSL 
       460        470        480        490        500
APPVDTKVAE KEKKPPTATT KGRGKGKGKK KGKVKEEVEE ETDPRKIELL 
       510        520        530        540        550
NWVNALEQAM LDALVLDRVD FVKLLIENGV NMQHFLTIPR LEELYNTRLG 
       560        570        580        590        600
PPNTLHLLVR DVKKSNLPPD YHISLIDIGL VLEYLMGGAY RCNYTRKSFR 
       610        620        630        640        650
TLYNNLFGPK RPKALKLLGM EDDEPPAKGK KKKKKKKEEE IDIDVDDPAV 
       660        670        680        690        700
SRFQYPFHEL MVWAVLMKRQ KMAVFLWQRG EECMAKALVA CKLYKAMAHE 
       710        720        730        740        750
SSESELVDDI SQDLDNNSKD FGQLAVELLD QSYKHDEQVA MKLLTYELKN 
       760        770        780        790        800
WSNSTCLKLA VAAKHRDFIA HTCSQMLLTD MWMGRLRMRK NPGLKVIMGI 
       810        820        830        840        850
LIPPTILFLE FRSYDDFSYQ TSKENEDGKE KEEENVDANA DAGSRKGDEE 
       860        870        880        890        900
NEHKKQRSIP IGTKICEFYN APIVKFWFYT ISYLGYLLLF NYVILVRMDG 
       910        920        930        940        950
WPSPQEWIVI SYIVSLALEK IREILMSEPG KLSQKIKVWL QEYWNITDLV 
       960        970        980        990       1000
AISMFMVGAI LRLQNQPYMG YGRVIYCVDI ILWYIRVLDI FGVNKYLGPY 
      1010       1020       1030       1040       1050
VMMIGKMMID MLYFVVIMLV VLMSFGVARQ AILHPEEKPS WKLARNIFYM 
      1060       1070       1080       1090       1100
PYWMIYGEVF ADQIDLYAME INPPCGENLY DEEGKRLPPC IPGAWLTPAL 
      1110       1120       1130       1140       1150
MACYLLVANI LLVNLLIAVF NNTFFEVKSI SNQVWKFQRY QLIMTFHDRP 
      1160       1170       1180       1190       1200
VLPPPMIILS HIYIIVMRLS GRCRKKREGD QEERDRGLKL FLSDEELKKL 
      1210       1220       1230       1240       1250
HEFEEQCVQE HFREKEDEQQ SSSDERIRVT SERVENMSMR LEEINERENF 
      1260       1270       1280       1290       1300
MKASLQTVDL RLSQLEELSG RMVGALENLA GIDRSDLIQA RSRASSECEA 
      1310       1320       1330       1340       1350
TYLLRQSSIN SADGYSMYRY HFNGEELLFE EPALSTSPGT VFRKKTCSFR 
      1360       1370       1380       1390       1400
VKEEDVKPHL DQPSSLHHTP GPSPPATPGR SRLALDGPLS TELRPGLDPG 
      1410       1420       1430       1440       1450
ISAGELDPRA DFKSAEVAPS LNTANVASTQ LTVESTVSHP LRESKLARYY 
      1460       1470       1480       1490       1500
PGDLNTYKTM KSRSFVYSEG RKLVRGLSNW GAEYSSIMDQ TWNSAEWRCQ 
      1510       1520       1530       1540       1550
VQRITRSRST DIPYIVSEAA SQDEFEDEHR ESLLAPQISR SALTVSDRPE 
      1560       1570       1580       1590       1600
KENLLSVKPH QTLGFPCLRS RSLHGHPRSA KPSPSKLDRA GHASSTSNLA 
      1610       1620 
VMSDAPEGQN TQQEKGNPET EC

Show »

Length:1,622

Mass (Da):183,526

Checksum:ⁱDD4594078C460875

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	F1M9X0	F1M9X0_RAT		Transient receptor potential cation... Transient receptor potential cation channel subfamily M member 1	Trpm1	1,628	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_052740	1066 – 1072	RKTRIHI → L in isoform 2. 1 Publication		7

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ867482 mRNA Translation: CAI30141.1 AJ867483 mRNA Translation: CAI30142.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001032822.1, NM_001037733.1 [Q2WEA5-2] NP_001032823.1, NM_001037734.1 [Q2WEA5-1]
UniGeneⁱ	Rn.211311

Genome annotation databases

GeneIDⁱ	361586
KEGGⁱ	rno:361586
UCSC genome browser More...UCSCⁱ	RGD:1597140 rat [Q2WEA5-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q2WEA5	Transient receptor potential cation channel subfamily M member 1		MOUSE		1622	UniRef90_Q2TV84
Transient receptor potential cation channel subfamily M member 1		RAT		1628
transient receptor potential cation channel subfamily M member 1		MESAU		1624
UPI000A30BA00		MUSPA		1628
UPI00042AC45B		PERMB		1627
+10

Protein	Similar proteins		Species	Score	Length	Source
Q2WEA5	Transient receptor potential cation channel subfamily M member 1		MOUSE		1622	UniRef50_Q2TV84
Transient receptor potential cation channel subfamily M member 1		RAT		1628
transient receptor potential cation channel subfamily M member 1		MESAU		1624
Transient receptor potential cation channel subfamily M member 1		MELGA		1623
Transient receptor potential cation channel subfamily M member 1		ANAPL		1600
+28

Entry informationⁱ

Entry nameⁱ	TRPM1_RAT
Accessionⁱ	Q2WEA5Primary (citable) accession number: Q2WEA5 Secondary accession number(s): Q2WEA4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
	Last sequence update:	January 10, 2006
	Last modified:	May 23, 2018
	This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB - Q2WEA5 (TRPM1_RAT)

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Transient receptor potential cation channel subfamily M member 1

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

Interactionⁱ

Protein-protein interaction databases

Family & Domainsⁱ

Coiled coil

Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequences (2+)ⁱ

Computationally mapped potential isoform sequencesⁱ

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Similar proteinsⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q2WEA5 (TRPM1_RAT)

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Transient receptor potential cation channel subfamily M member 1

Trpm1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ