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UniProtKB - Q2WEA5 (TRPM1_RAT)

Entry version 93 (10 Feb 2021)
Sequence version 1 (10 Jan 2006)
Previous versions | rss
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Protein

Transient receptor potential cation channel subfamily M member 1

Gene

Trpm1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Forms nonselective divalent cation-conducting channels which mediate the influx of Na2+, Ca2+, Mg2+, Mn2+, Ba2+, and Ni2+ into the cytoplasm, leading to membrane depolarization (By similarity). Impermeable to zinc ions (By similarity). In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions (By similarity). Essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. Calcium channel which may play a role in metastasis suppression. May act as a spontaneously active, calcium-permeable plasma membrane channel (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by zinc ions.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-RNO-3295583, TRP channels

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily M member 1
Alternative name(s):
Melastatin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Trpm1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...RGDi		1597140, Trpm1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 875CytoplasmicCuratedAdd BLAST875
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei876 – 896HelicalSequence analysisAdd BLAST21
Topological domaini897 – 942ExtracellularCuratedAdd BLAST46
Transmembranei943 – 963HelicalSequence analysisAdd BLAST21
Topological domaini964 – 973CytoplasmicCurated10
Transmembranei974 – 994HelicalSequence analysisAdd BLAST21
Topological domaini995 – 1006ExtracellularCuratedAdd BLAST12
Transmembranei1007 – 1027HelicalSequence analysisAdd BLAST21
Topological domaini1028 – 1105CytoplasmicCuratedAdd BLAST78
Transmembranei1106 – 1126HelicalSequence analysisAdd BLAST21
Topological domaini1127 – 1156ExtracellularCuratedAdd BLAST30
Transmembranei1157 – 1177HelicalSequence analysisAdd BLAST21
Topological domaini1178 – 1628CytoplasmicCuratedAdd BLAST451

Keywords - Cellular componenti

Cell membrane, Cell projection, Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003289321 – 1628Transient receptor potential cation channel subfamily M member 1Add BLAST1628

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi1127N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q2WEA5

PRoteomics IDEntifications database

More...PRIDEi		Q2WEA5

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q2WEA5

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q2WEA5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q2WEA5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TRPM3; the interaction results in the formation of a heteromultimeric cation channel complex.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10116.ENSRNOP00000062990

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1233 – 1253Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM1 sub-subfamily. [View classification]Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3614, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q2WEA5

Database of Orthologous Groups

More...OrthoDBi		738147at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q2WEA5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.5.1010, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005821, Ion_trans_dom
IPR029588, TRPM1
IPR041491, TRPM_SLOG
IPR032415, TRPM_tetra
IPR037162, TRPM_tetra_sf

The PANTHER Classification System

More...PANTHERi		PTHR13800:SF13, PTHR13800:SF13, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00520, Ion_trans, 1 hit
PF18139, LSDAT_euk, 1 hit
PF16519, TRPM_tetra, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q2WEA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGSMRKMSSS FKRGSIKSST SGSQKGQKAW IEKTFCKREC IFVIPSTKDP 
        60         70         80         90        100
NRCCCGQLTN QHIPPLPSVT PSSTAEDTKQ GDAQSGKWSV SKHTQSYPTD 
       110        120        130        140        150
SYGILEFQGG GYSNKAMYIR VSYDTKPDSL LHLMVKDWQL ELPKLLISVH 
       160        170        180        190        200
GGLQSFEMQP KLKQVFGKGL IKAAMTTGAW IFTGGVSTGV VSHVGDALKD 
       210        220        230        240        250
HSSKSRGRLC AIGIAPWGMV ENKEDLVGKD VTRVYQTMSN PLSKLSVLNN 
       260        270        280        290        300
SHTHFILADN GTLGKYGAEV KLRRQLEKHI SLQKINTRLG QGVPVVGLVV 
       310        320        330        340        350
EGGPNVVSIV LEYLREDPPV PVVVCDGSGR ASDILSFAHK YCDEGGVINE 
       360        370        380        390        400
SLRDQLLVTI QKTFNYSKSQ SHQLFAIIME CMKKKELVTV FRMGSEGQQD 
       410        420        430        440        450
VEMAILTALL KGTNVSAPDQ LSLALAWNRV DIARSQIFVF GPHWPPLGSL 
       460        470        480        490        500
APPVDTKVAE KEKKPPTATT KGRGKGKGKK KGKVKEEVEE ETDPRKIELL 
       510        520        530        540        550
NWVNALEQAM LDALVLDRVD FVKLLIENGV NMQHFLTIPR LEELYNTRLG 
       560        570        580        590        600
PPNTLHLLVR DVKKSNLPPD YHISLIDIGL VLEYLMGGAY RCNYTRKSFR 
       610        620        630        640        650
TLYNNLFGPK RPKALKLLGM EDDEPPAKGK KKKKKKKEEE IDIDVDDPAV 
       660        670        680        690        700
SRFQYPFHEL MVWAVLMKRQ KMAVFLWQRG EECMAKALVA CKLYKAMAHE 
       710        720        730        740        750
SSESELVDDI SQDLDNNSKD FGQLAVELLD QSYKHDEQVA MKLLTYELKN 
       760        770        780        790        800
WSNSTCLKLA VAAKHRDFIA HTCSQMLLTD MWMGRLRMRK NPGLKVIMGI 
       810        820        830        840        850
LIPPTILFLE FRSYDDFSYQ TSKENEDGKE KEEENVDANA DAGSRKGDEE 
       860        870        880        890        900
NEHKKQRSIP IGTKICEFYN APIVKFWFYT ISYLGYLLLF NYVILVRMDG 
       910        920        930        940        950
WPSPQEWIVI SYIVSLALEK IREILMSEPG KLSQKIKVWL QEYWNITDLV 
       960        970        980        990       1000
AISMFMVGAI LRLQNQPYMG YGRVIYCVDI ILWYIRVLDI FGVNKYLGPY 
      1010       1020       1030       1040       1050
VMMIGKMMID MLYFVVIMLV VLMSFGVARQ AILHPEEKPS WKLARNIFYM 
      1060       1070       1080       1090       1100
PYWMIYGEVF ADQIDRKTRI HIYAMEINPP CGENLYDEEG KRLPPCIPGA 
      1110       1120       1130       1140       1150
WLTPALMACY LLVANILLVN LLIAVFNNTF FEVKSISNQV WKFQRYQLIM 
      1160       1170       1180       1190       1200
TFHDRPVLPP PMIILSHIYI IVMRLSGRCR KKREGDQEER DRGLKLFLSD 
      1210       1220       1230       1240       1250
EELKKLHEFE EQCVQEHFRE KEDEQQSSSD ERIRVTSERV ENMSMRLEEI 
      1260       1270       1280       1290       1300
NERENFMKAS LQTVDLRLSQ LEELSGRMVG ALENLAGIDR SDLIQARSRA 
      1310       1320       1330       1340       1350
SSECEATYLL RQSSINSADG YSMYRYHFNG EELLFEEPAL STSPGTVFRK 
      1360       1370       1380       1390       1400
KTCSFRVKEE DVKPHLDQPS SLHHTPGPSP PATPGRSRLA LDGPLSTELR 
      1410       1420       1430       1440       1450
PGLDPGISAG ELDPRADFKS AEVAPSLNTA NVASTQLTVE STVSHPLRES 
      1460       1470       1480       1490       1500
KLARYYPGDL NTYKTMKSRS FVYSEGRKLV RGLSNWGAEY SSIMDQTWNS 
      1510       1520       1530       1540       1550
AEWRCQVQRI TRSRSTDIPY IVSEAASQDE FEDEHRESLL APQISRSALT 
      1560       1570       1580       1590       1600
VSDRPEKENL LSVKPHQTLG FPCLRSRSLH GHPRSAKPSP SKLDRAGHAS 
      1610       1620 
STSNLAVMSD APEGQNTQQE KGNPETEC
Length:1,628
Mass (Da):184,318
Last modified:January 10, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2CFB057DF62CB102
GO
Isoform 21 Publication (identifier: Q2WEA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1066-1072: RKTRIHI → L

Show »
Length:1,622
Mass (Da):183,526
Checksum:iDD4594078C460875
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1M9X0F1M9X0_RAT
Transient receptor potential cation...
Trpm1
1,628Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0527401066 – 1072RKTRIHI → L in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ867482 mRNA Translation: CAI30141.1
AJ867483 mRNA Translation: CAI30142.1

NCBI Reference Sequences

More...RefSeqi		NP_001032822.1, NM_001037733.1 [Q2WEA5-2]
NP_001032823.1, NM_001037734.1 [Q2WEA5-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		361586

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		rno:361586

UCSC genome browser

More...UCSCi		RGD:1597140, rat [Q2WEA5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ867482 mRNA Translation: CAI30141.1
AJ867483 mRNA Translation: CAI30142.1
RefSeqiNP_001032822.1, NM_001037733.1 [Q2WEA5-2]
NP_001032823.1, NM_001037734.1 [Q2WEA5-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000062990

PTM databases

CarbonylDBiQ2WEA5
iPTMnetiQ2WEA5
PhosphoSitePlusiQ2WEA5

Proteomic databases

PaxDbiQ2WEA5
PRIDEiQ2WEA5

Genome annotation databases

GeneIDi361586
KEGGirno:361586
UCSCiRGD:1597140, rat [Q2WEA5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4308
RGDi1597140, Trpm1

Phylogenomic databases

eggNOGiKOG3614, Eukaryota
InParanoidiQ2WEA5
OrthoDBi738147at2759
PhylomeDBiQ2WEA5

Enzyme and pathway databases

ReactomeiR-RNO-3295583, TRP channels

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q2WEA5

Family and domain databases

Gene3Di1.20.5.1010, 1 hit
InterProiView protein in InterPro
IPR005821, Ion_trans_dom
IPR029588, TRPM1
IPR041491, TRPM_SLOG
IPR032415, TRPM_tetra
IPR037162, TRPM_tetra_sf
PANTHERiPTHR13800:SF13, PTHR13800:SF13, 1 hit
PfamiView protein in Pfam
PF00520, Ion_trans, 1 hit
PF18139, LSDAT_euk, 1 hit
PF16519, TRPM_tetra, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRPM1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2WEA5
Secondary accession number(s): Q2WEA4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: January 10, 2006
Last modified: February 10, 2021
This is version 93 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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