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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosamine + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate = UDP + 2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-beta-D-glucosaminyl-(1->6)-2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi: lipid IV(A) biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (lpxA)
  2. UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Lipid-A-disaccharide synthase (lpxB)
  6. Tetraacyldisaccharide 4'-kinase (lpxK)
This subpathway is part of the pathway lipid IV(A) biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine, the pathway lipid IV(A) biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processLipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciMMAG342108:G1G2B-2575-MONOMER
UniPathwayi
UPA00359;UER00481

Protein family/group databases

CAZyiGT19 Glycosyltransferase Family 19

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:amb2484
OrganismiMagnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Taxonomic identifieri342108 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeMagnetospirillum
Proteomesi
  • UP000007058 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002551961 – 390Lipid-A-disaccharide synthaseAdd BLAST390

Interactioni

Protein-protein interaction databases

STRINGi342108.amb2484

Structurei

3D structure databases

ProteinModelPortaliQ2W4D7
SMRiQ2W4D7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D0V Bacteria
COG0763 LUCA
HOGENOMiHOG000018004
KOiK00748
OMAiPTVWAWR
OrthoDBiPOG091H01NW

Family and domain databases

HAMAPiMF_00392 LpxB, 1 hit
InterProiView protein in InterPro
IPR003835 Glyco_trans_19
PANTHERiPTHR30372 PTHR30372, 1 hit
PfamiView protein in Pfam
PF02684 LpxB, 1 hit
TIGRFAMsiTIGR00215 lpxB, 1 hit

Sequencei

Sequence statusi: Complete.

Q2W4D7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLIYLIAGEP SGDLLGGRLM AALKERLGEG VSFAGIGGES MRAEGLTSLF
60 70 80 90 100
PMTELSVMGL VEVLPRIPKI LRRVKQTISD IETKRPDALV TIDSWGFNGR
110 120 130 140 150
IQAGLKARGV PVPRIHYVAP MVWAWKSGRT KTLARVLDLL LTLLPNEPEW
160 170 180 190 200
FEKEGLKTLH VGHPVIEGAA SRGDGAAFRV RHGFAPDRKL LCVLPGSRHS
210 220 230 240 250
ETAKLLAPFG ETIALLARRF PDLAVVVPTV ETVADEVSQA VKSWALPSMV
260 270 280 290 300
VRGPEKYDAF AACDAALAAS GTVALELAMA RLPAVITYKV SPVSAFIATR
310 320 330 340 350
FLGLSLKFVT LVNILVDEAV MPELLQDDCR PDKLAAAVEH LLTDEAARAL
360 370 380 390
QAAGARRALE KLGLGGESPG KRAADAVIDF IRQGKEQRNG
Length:390
Mass (Da):41,913
Last modified:January 10, 2006 - v1
Checksum:i6654FB66F2025349
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007255 Genomic DNA Translation: BAE51288.1
RefSeqiWP_011384865.1, NC_007626.1

Genome annotation databases

EnsemblBacteriaiBAE51288; BAE51288; amb2484
KEGGimag:amb2484

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007255 Genomic DNA Translation: BAE51288.1
RefSeqiWP_011384865.1, NC_007626.1

3D structure databases

ProteinModelPortaliQ2W4D7
SMRiQ2W4D7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi342108.amb2484

Protein family/group databases

CAZyiGT19 Glycosyltransferase Family 19

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAE51288; BAE51288; amb2484
KEGGimag:amb2484

Phylogenomic databases

eggNOGiENOG4105D0V Bacteria
COG0763 LUCA
HOGENOMiHOG000018004
KOiK00748
OMAiPTVWAWR
OrthoDBiPOG091H01NW

Enzyme and pathway databases

UniPathwayi
UPA00359;UER00481

BioCyciMMAG342108:G1G2B-2575-MONOMER

Family and domain databases

HAMAPiMF_00392 LpxB, 1 hit
InterProiView protein in InterPro
IPR003835 Glyco_trans_19
PANTHERiPTHR30372 PTHR30372, 1 hit
PfamiView protein in Pfam
PF02684 LpxB, 1 hit
TIGRFAMsiTIGR00215 lpxB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLPXB_MAGSA
AccessioniPrimary (citable) accession number: Q2W4D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 10, 2006
Last modified: October 10, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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