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Protein

Malate dehydrogenase

Gene

mdh

Organism
Magnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADUniRule annotation1
Binding sitei83SubstrateUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Binding sitei96NADUniRule annotation1
Binding sitei121SubstrateUniRule annotation1
Binding sitei152SubstrateUniRule annotation1
Active sitei176Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 15NADUniRule annotation6
Nucleotide bindingi119 – 121NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

BioCyciMMAG342108:G1G2B-4082-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:amb3957
OrganismiMagnetospirillum magneticum (strain AMB-1 / ATCC 700264)
Taxonomic identifieri342108 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesRhodospirillaceaeMagnetospirillum
Proteomesi
  • UP000007058 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002419521 – 319Malate dehydrogenaseAdd BLAST319

Proteomic databases

PRIDEiQ2W064

Interactioni

Protein-protein interaction databases

STRINGi342108.amb3957

Structurei

3D structure databases

ProteinModelPortaliQ2W064
SMRiQ2W064
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213794
KOiK00024
OMAiQCTPKVE
OrthoDBiPOG091H02N6

Family and domain databases

CDDicd01339 LDH-like_MDH, 1 hit
Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00487 Malate_dehydrog_3, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR011275 Malate_DH_type3
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01763 MalateDH_bact, 1 hit

Sequencei

Sequence statusi: Complete.

Q2W064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARKKIALVG SGNIGGTLAH LIGLKELGDV VMFDIAEGIP QGKGLDILES
60 70 80 90 100
TPVEGVDCRY SGANDYSAIA GADVVIVTAG VPRKPGMSRD DLVGINLKVM
110 120 130 140 150
AAVGEGIKKN CPGAFVICIT NPLDVMVWAL QHYSGVPANM IVGMAGVLDS
160 170 180 190 200
ARFRTFLCEE FNVSVEDVTA FVLGGHGDTM VPLVRYSTVA GIPLPDLVKM
210 220 230 240 250
GWTTQEKLDQ IVQRTRDGGA EIVNLLKTGS AYYAPAASGV AMAEAFLKDK
260 270 280 290 300
KRVLPVATLV KGGTYGQPDD VFVGVPVVIG EGGVERIVEI ELNAAEQAEF
310
NKSADAVRGL VKVAKGLMG
Length:319
Mass (Da):33,429
Last modified:January 10, 2006 - v1
Checksum:i7146DB110A6CEED5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP007255 Genomic DNA Translation: BAE52761.1
RefSeqiWP_011386311.1, NC_007626.1

Genome annotation databases

EnsemblBacteriaiBAE52761; BAE52761; amb3957
KEGGimag:amb3957

Similar proteinsi

Entry informationi

Entry nameiMDH_MAGSA
AccessioniPrimary (citable) accession number: Q2W064
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: January 10, 2006
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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