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UniProtKB - Q2VYF4 (LETM2_HUMAN)

Entry version 105 (02 Dec 2020)
Sequence version 2 (23 Oct 2007)
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Protein

LETM1 domain-containing protein LETM2, mitochondrial

Gene

LETM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Despite its name, it does not contain any EF-hand domains.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q2VYF4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
LETM1 domain-containing protein LETM2, mitochondrial
Alternative name(s):
LETM1 and EF-hand domain-containing protein 2
Leucine zipper-EF-hand-containing transmembrane protein 1-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LETM2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000165046.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:14648, LETM2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q2VYF4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 177Mitochondrial intermembraneSequence analysisAdd BLAST152
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Topological domaini199 – 491Mitochondrial matrixSequence analysisAdd BLAST293

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		137994

Open Targets

More...OpenTargetsi		ENSG00000165046

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134887111

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q2VYF4, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LETM2

Domain mapping of disease mutations (DMDM)

More...DMDMi		160013759

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 25MitochondrionSequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000030713726 – 491LETM1 domain-containing protein LETM2, mitochondrialAdd BLAST466

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q2VYF4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q2VYF4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q2VYF4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q2VYF4

PeptideAtlas

More...PeptideAtlasi		Q2VYF4

PRoteomics IDEntifications database

More...PRIDEi		Q2VYF4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		61530 [Q2VYF4-1]
61531 [Q2VYF4-2]
61532 [Q2VYF4-3]
61533 [Q2VYF4-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q2VYF4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q2VYF4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000165046, Expressed in cerebellar hemisphere and 134 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q2VYF4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q2VYF4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000165046, Tissue enhanced (blood, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		126495, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q2VYF4, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000369291

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q2VYF4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q2VYF4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini221 – 438Letm1 RBDPROSITE-ProRule annotationAdd BLAST218

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili208 – 235Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi382 – 385Poly-Leu4

Keywords - Domaini

Coiled coil, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1043, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183167

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008958_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q2VYF4

Identification of Orthologs from Complete Genome Data

More...OMAi		KTYMKNY

Database of Orthologous Groups

More...OrthoDBi		516860at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q2VYF4

TreeFam database of animal gene trees

More...TreeFami		TF316321

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011685, LETM1
IPR033122, LETM1_RBD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07766, LETM1, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51758, LETM1_RBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q2VYF4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFYSYNSVL AIARTRFPSH FVHPTCSSYS PSCAFLHLPD SHLNKTCMKN 
        60         70         80         90        100
YESKKYSDPS QPGNTVLHPG TRLIQKLHTS TCWLQEVPGK PQLEQATKHP 
       110        120        130        140        150
QVTSPQATKE TGMEIKEGKQ SYRQKIMDEL KYYYNGFYLL WIDAKVAARM 
       160        170        180        190        200
VWRLLHGQVL TRRERRRLLR TCVDFFRLVP FMVFLIVPFM EFLLPVFLKL 
       210        220        230        240        250
FPEMLPSTFE SESKKEEKQK KKMAVKLELA KFLQETMTEM ARRNRAKMGD 
       260        270        280        290        300
ASTQLSSYVK QVQTGHKPST KEIVRFSKLF EDQLALEHLD RPQLVALCKL 
       310        320        330        340        350
LELQTFGTNN LLRFQLLMKL KSIKADDEII AKEGVTALSV SELQAACRAR 
       360        370        380        390        400
GMRSLGLTEE QLRQQLTEWQ DLHLKENVPP SLLLLSRTFY LIDVKPKPIE 
       410        420        430        440        450
IPLSGEAPKT DILVELPTFT ESKENMVDLA PQLKGTKDED FIQPPPVTSS 
       460        470        480        490 
PITPSTPISL PKGPITSSEE PTLQAKSQMT AQNSKASSKG A
Length:491
Mass (Da):55,921
Last modified:October 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF7515E57C73237D1
GO
Isoform 2 (identifier: Q2VYF4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Show »
Length:444
Mass (Da):50,633
Checksum:i26CEFB04A32D4A42
GO
Isoform 3 (identifier: Q2VYF4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.
     168-215: Missing.

Show »
Length:396
Mass (Da):44,907
Checksum:i0E9D387A21BC5E28
GO
Isoform 4 (identifier: Q2VYF4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-214: Missing.
     215-215: K → M

Show »
Length:277
Mass (Da):30,909
Checksum:i192EC66CF62CF816
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PMA4E9PMA4_HUMAN
LETM1 domain-containing protein LET...
LETM2
443Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8K1M9A8K1M9_HUMAN
LETM1 domain-containing protein LET...
LETM2
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJN4E5RJN4_HUMAN
LETM1 domain-containing protein LET...
LETM2
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RK40E5RK40_HUMAN
LETM1 domain-containing protein LET...
LETM2
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCZ8H0YCZ8_HUMAN
LETM1 domain-containing protein LET...
LETM2
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIC7E9PIC7_HUMAN
LETM1 domain-containing protein LET...
LETM2
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PN52E9PN52_HUMAN
LETM1 domain-containing protein LET...
LETM2
142Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti448T → A in AAO49715 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0285881 – 214Missing in isoform 4. 1 PublicationAdd BLAST214
Alternative sequenceiVSP_0285891 – 47Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST47
Alternative sequenceiVSP_028590168 – 215Missing in isoform 3. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_028591215K → M in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY173945 mRNA Translation: AAO49715.1
AK058138 mRNA Translation: BAB71680.1
AC087623 Genomic DNA No translation available.
BC029541 mRNA Translation: AAH29541.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS56534.1 [Q2VYF4-2]
CCDS6106.1 [Q2VYF4-3]
CCDS69466.1 [Q2VYF4-1]

NCBI Reference Sequences

More...RefSeqi		NP_001186588.1, NM_001199659.2 [Q2VYF4-2]
NP_001273748.1, NM_001286819.1 [Q2VYF4-1]
NP_653253.1, NM_144652.3 [Q2VYF4-3]
XP_011542708.1, XM_011544406.1 [Q2VYF4-2]
XP_011542709.1, XM_011544407.1 [Q2VYF4-2]
XP_011542712.1, XM_011544410.2 [Q2VYF4-4]
XP_016868540.1, XM_017013051.1 [Q2VYF4-1]
XP_016868541.1, XM_017013052.1 [Q2VYF4-1]
XP_016868542.1, XM_017013053.1 [Q2VYF4-1]
XP_016868543.1, XM_017013054.1 [Q2VYF4-1]
XP_016868544.1, XM_017013055.1 [Q2VYF4-1]
XP_016868545.1, XM_017013056.1 [Q2VYF4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000297720; ENSP00000297720; ENSG00000165046 [Q2VYF4-3]
ENST00000379957; ENSP00000369291; ENSG00000165046 [Q2VYF4-1]
ENST00000523983; ENSP00000428765; ENSG00000165046 [Q2VYF4-2]
ENST00000527710; ENSP00000434867; ENSG00000165046 [Q2VYF4-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		137994

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:137994

UCSC genome browser

More...UCSCi		uc003xll.4, human [Q2VYF4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY173945 mRNA Translation: AAO49715.1
AK058138 mRNA Translation: BAB71680.1
AC087623 Genomic DNA No translation available.
BC029541 mRNA Translation: AAH29541.2
CCDSiCCDS56534.1 [Q2VYF4-2]
CCDS6106.1 [Q2VYF4-3]
CCDS69466.1 [Q2VYF4-1]
RefSeqiNP_001186588.1, NM_001199659.2 [Q2VYF4-2]
NP_001273748.1, NM_001286819.1 [Q2VYF4-1]
NP_653253.1, NM_144652.3 [Q2VYF4-3]
XP_011542708.1, XM_011544406.1 [Q2VYF4-2]
XP_011542709.1, XM_011544407.1 [Q2VYF4-2]
XP_011542712.1, XM_011544410.2 [Q2VYF4-4]
XP_016868540.1, XM_017013051.1 [Q2VYF4-1]
XP_016868541.1, XM_017013052.1 [Q2VYF4-1]
XP_016868542.1, XM_017013053.1 [Q2VYF4-1]
XP_016868543.1, XM_017013054.1 [Q2VYF4-1]
XP_016868544.1, XM_017013055.1 [Q2VYF4-1]
XP_016868545.1, XM_017013056.1 [Q2VYF4-1]

3D structure databases

SMRiQ2VYF4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126495, 2 interactors
IntActiQ2VYF4, 1 interactor
STRINGi9606.ENSP00000369291

PTM databases

iPTMnetiQ2VYF4
PhosphoSitePlusiQ2VYF4

Polymorphism and mutation databases

BioMutaiLETM2
DMDMi160013759

Proteomic databases

jPOSTiQ2VYF4
MassIVEiQ2VYF4
MaxQBiQ2VYF4
PaxDbiQ2VYF4
PeptideAtlasiQ2VYF4
PRIDEiQ2VYF4
ProteomicsDBi61530 [Q2VYF4-1]
61531 [Q2VYF4-2]
61532 [Q2VYF4-3]
61533 [Q2VYF4-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11001, 107 antibodies

The DNASU plasmid repository

More...DNASUi		137994

Genome annotation databases

EnsembliENST00000297720; ENSP00000297720; ENSG00000165046 [Q2VYF4-3]
ENST00000379957; ENSP00000369291; ENSG00000165046 [Q2VYF4-1]
ENST00000523983; ENSP00000428765; ENSG00000165046 [Q2VYF4-2]
ENST00000527710; ENSP00000434867; ENSG00000165046 [Q2VYF4-4]
GeneIDi137994
KEGGihsa:137994
UCSCiuc003xll.4, human [Q2VYF4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		137994
DisGeNETi137994
EuPathDBiHostDB:ENSG00000165046.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		LETM2
HGNCiHGNC:14648, LETM2
HPAiENSG00000165046, Tissue enhanced (blood, testis)
neXtProtiNX_Q2VYF4
OpenTargetsiENSG00000165046
PharmGKBiPA134887111

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1043, Eukaryota
GeneTreeiENSGT00950000183167
HOGENOMiCLU_008958_0_0_1
InParanoidiQ2VYF4
OMAiKTYMKNY
OrthoDBi516860at2759
PhylomeDBiQ2VYF4
TreeFamiTF316321

Enzyme and pathway databases

PathwayCommonsiQ2VYF4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		137994, 8 hits in 844 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		LETM2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		137994
PharosiQ2VYF4, Tdark

Protein Ontology

More...PROi		PR:Q2VYF4
RNActiQ2VYF4, protein

Gene expression databases

BgeeiENSG00000165046, Expressed in cerebellar hemisphere and 134 other tissues
ExpressionAtlasiQ2VYF4, baseline and differential
GenevisibleiQ2VYF4, HS

Family and domain databases

InterProiView protein in InterPro
IPR011685, LETM1
IPR033122, LETM1_RBD
PfamiView protein in Pfam
PF07766, LETM1, 1 hit
PROSITEiView protein in PROSITE
PS51758, LETM1_RBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLETM2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q2VYF4
Secondary accession number(s): A6NMG3, Q8NCR2, Q96LL1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: December 2, 2020
This is version 105 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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