UniProtKB - Q2VYF4 (LETM2_HUMAN)
Protein
LETM1 domain-containing protein LETM2, mitochondrial
Gene
LETM2
Organism
Homo sapiens (Human)
Status
Functioni
Caution
Despite its name, it does not contain any EF-hand domains.Curated
GO - Molecular functioni
- ribosome binding Source: InterPro
GO - Biological processi
- cellular metal ion homeostasis Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q2VYF4 |
Names & Taxonomyi
Protein namesi | Recommended name: LETM1 domain-containing protein LETM2, mitochondrialAlternative name(s): LETM1 and EF-hand domain-containing protein 2 Leucine zipper-EF-hand-containing transmembrane protein 1-like |
Gene namesi | Name:LETM2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000165046.12 |
HGNCi | HGNC:14648, LETM2 |
neXtProti | NX_Q2VYF4 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Single-pass membrane protein By similarity
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 177 | Mitochondrial intermembraneSequence analysisAdd BLAST | 152 | |
Transmembranei | 178 – 198 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 199 – 491 | Mitochondrial matrixSequence analysisAdd BLAST | 293 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePathology & Biotechi
Organism-specific databases
DisGeNETi | 137994 |
OpenTargetsi | ENSG00000165046 |
PharmGKBi | PA134887111 |
Miscellaneous databases
Pharosi | Q2VYF4, Tdark |
Polymorphism and mutation databases
BioMutai | LETM2 |
DMDMi | 160013759 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 25 | MitochondrionSequence analysisAdd BLAST | 25 | |
ChainiPRO_0000307137 | 26 – 491 | LETM1 domain-containing protein LETM2, mitochondrialAdd BLAST | 466 |
Proteomic databases
jPOSTi | Q2VYF4 |
MassIVEi | Q2VYF4 |
MaxQBi | Q2VYF4 |
PaxDbi | Q2VYF4 |
PeptideAtlasi | Q2VYF4 |
PRIDEi | Q2VYF4 |
ProteomicsDBi | 61530 [Q2VYF4-1] 61531 [Q2VYF4-2] 61532 [Q2VYF4-3] 61533 [Q2VYF4-4] |
PTM databases
iPTMneti | Q2VYF4 |
PhosphoSitePlusi | Q2VYF4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000165046, Expressed in cerebellar hemisphere and 134 other tissues |
ExpressionAtlasi | Q2VYF4, baseline and differential |
Genevisiblei | Q2VYF4, HS |
Organism-specific databases
HPAi | ENSG00000165046, Tissue enhanced (blood, testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 126495, 2 interactors |
IntActi | Q2VYF4, 1 interactor |
STRINGi | 9606.ENSP00000369291 |
Miscellaneous databases
RNActi | Q2VYF4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 221 – 438 | Letm1 RBDPROSITE-ProRule annotationAdd BLAST | 218 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 208 – 235 | Sequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 382 – 385 | Poly-Leu | 4 |
Keywords - Domaini
Coiled coil, Transit peptide, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1043, Eukaryota |
GeneTreei | ENSGT00950000183167 |
HOGENOMi | CLU_008958_0_0_1 |
InParanoidi | Q2VYF4 |
OMAi | KTYMKNY |
OrthoDBi | 516860at2759 |
PhylomeDBi | Q2VYF4 |
TreeFami | TF316321 |
Family and domain databases
InterProi | View protein in InterPro IPR011685, LETM1 IPR033122, LETM1_RBD |
Pfami | View protein in Pfam PF07766, LETM1, 1 hit |
PROSITEi | View protein in PROSITE PS51758, LETM1_RBD, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q2VYF4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAFYSYNSVL AIARTRFPSH FVHPTCSSYS PSCAFLHLPD SHLNKTCMKN
60 70 80 90 100
YESKKYSDPS QPGNTVLHPG TRLIQKLHTS TCWLQEVPGK PQLEQATKHP
110 120 130 140 150
QVTSPQATKE TGMEIKEGKQ SYRQKIMDEL KYYYNGFYLL WIDAKVAARM
160 170 180 190 200
VWRLLHGQVL TRRERRRLLR TCVDFFRLVP FMVFLIVPFM EFLLPVFLKL
210 220 230 240 250
FPEMLPSTFE SESKKEEKQK KKMAVKLELA KFLQETMTEM ARRNRAKMGD
260 270 280 290 300
ASTQLSSYVK QVQTGHKPST KEIVRFSKLF EDQLALEHLD RPQLVALCKL
310 320 330 340 350
LELQTFGTNN LLRFQLLMKL KSIKADDEII AKEGVTALSV SELQAACRAR
360 370 380 390 400
GMRSLGLTEE QLRQQLTEWQ DLHLKENVPP SLLLLSRTFY LIDVKPKPIE
410 420 430 440 450
IPLSGEAPKT DILVELPTFT ESKENMVDLA PQLKGTKDED FIQPPPVTSS
460 470 480 490
PITPSTPISL PKGPITSSEE PTLQAKSQMT AQNSKASSKG A
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PMA4 | E9PMA4_HUMAN | LETM1 domain-containing protein LET... | LETM2 | 443 | Annotation score: | ||
A8K1M9 | A8K1M9_HUMAN | LETM1 domain-containing protein LET... | LETM2 | 173 | Annotation score: | ||
E5RJN4 | E5RJN4_HUMAN | LETM1 domain-containing protein LET... | LETM2 | 122 | Annotation score: | ||
E5RK40 | E5RK40_HUMAN | LETM1 domain-containing protein LET... | LETM2 | 169 | Annotation score: | ||
H0YCZ8 | H0YCZ8_HUMAN | LETM1 domain-containing protein LET... | LETM2 | 86 | Annotation score: | ||
E9PIC7 | E9PIC7_HUMAN | LETM1 domain-containing protein LET... | LETM2 | 116 | Annotation score: | ||
E9PN52 | E9PN52_HUMAN | LETM1 domain-containing protein LET... | LETM2 | 142 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 448 | T → A in AAO49715 (Ref. 1) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028588 | 1 – 214 | Missing in isoform 4. 1 PublicationAdd BLAST | 214 | |
Alternative sequenceiVSP_028589 | 1 – 47 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 47 | |
Alternative sequenceiVSP_028590 | 168 – 215 | Missing in isoform 3. 1 PublicationAdd BLAST | 48 | |
Alternative sequenceiVSP_028591 | 215 | K → M in isoform 4. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY173945 mRNA Translation: AAO49715.1 AK058138 mRNA Translation: BAB71680.1 AC087623 Genomic DNA No translation available. BC029541 mRNA Translation: AAH29541.2 |
CCDSi | CCDS56534.1 [Q2VYF4-2] CCDS6106.1 [Q2VYF4-3] CCDS69466.1 [Q2VYF4-1] |
RefSeqi | NP_001186588.1, NM_001199659.2 [Q2VYF4-2] NP_001273748.1, NM_001286819.1 [Q2VYF4-1] NP_653253.1, NM_144652.3 [Q2VYF4-3] XP_011542708.1, XM_011544406.1 [Q2VYF4-2] XP_011542709.1, XM_011544407.1 [Q2VYF4-2] XP_011542712.1, XM_011544410.2 [Q2VYF4-4] XP_016868540.1, XM_017013051.1 [Q2VYF4-1] XP_016868541.1, XM_017013052.1 [Q2VYF4-1] XP_016868542.1, XM_017013053.1 [Q2VYF4-1] XP_016868543.1, XM_017013054.1 [Q2VYF4-1] XP_016868544.1, XM_017013055.1 [Q2VYF4-1] XP_016868545.1, XM_017013056.1 [Q2VYF4-1] |
Genome annotation databases
Ensembli | ENST00000297720; ENSP00000297720; ENSG00000165046 [Q2VYF4-3] ENST00000379957; ENSP00000369291; ENSG00000165046 [Q2VYF4-1] ENST00000523983; ENSP00000428765; ENSG00000165046 [Q2VYF4-2] ENST00000527710; ENSP00000434867; ENSG00000165046 [Q2VYF4-4] |
GeneIDi | 137994 |
KEGGi | hsa:137994 |
UCSCi | uc003xll.4, human [Q2VYF4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY173945 mRNA Translation: AAO49715.1 AK058138 mRNA Translation: BAB71680.1 AC087623 Genomic DNA No translation available. BC029541 mRNA Translation: AAH29541.2 |
CCDSi | CCDS56534.1 [Q2VYF4-2] CCDS6106.1 [Q2VYF4-3] CCDS69466.1 [Q2VYF4-1] |
RefSeqi | NP_001186588.1, NM_001199659.2 [Q2VYF4-2] NP_001273748.1, NM_001286819.1 [Q2VYF4-1] NP_653253.1, NM_144652.3 [Q2VYF4-3] XP_011542708.1, XM_011544406.1 [Q2VYF4-2] XP_011542709.1, XM_011544407.1 [Q2VYF4-2] XP_011542712.1, XM_011544410.2 [Q2VYF4-4] XP_016868540.1, XM_017013051.1 [Q2VYF4-1] XP_016868541.1, XM_017013052.1 [Q2VYF4-1] XP_016868542.1, XM_017013053.1 [Q2VYF4-1] XP_016868543.1, XM_017013054.1 [Q2VYF4-1] XP_016868544.1, XM_017013055.1 [Q2VYF4-1] XP_016868545.1, XM_017013056.1 [Q2VYF4-1] |
3D structure databases
SMRi | Q2VYF4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 126495, 2 interactors |
IntActi | Q2VYF4, 1 interactor |
STRINGi | 9606.ENSP00000369291 |
PTM databases
iPTMneti | Q2VYF4 |
PhosphoSitePlusi | Q2VYF4 |
Polymorphism and mutation databases
BioMutai | LETM2 |
DMDMi | 160013759 |
Proteomic databases
jPOSTi | Q2VYF4 |
MassIVEi | Q2VYF4 |
MaxQBi | Q2VYF4 |
PaxDbi | Q2VYF4 |
PeptideAtlasi | Q2VYF4 |
PRIDEi | Q2VYF4 |
ProteomicsDBi | 61530 [Q2VYF4-1] 61531 [Q2VYF4-2] 61532 [Q2VYF4-3] 61533 [Q2VYF4-4] |
Protocols and materials databases
Antibodypediai | 11001, 107 antibodies |
DNASUi | 137994 |
Genome annotation databases
Ensembli | ENST00000297720; ENSP00000297720; ENSG00000165046 [Q2VYF4-3] ENST00000379957; ENSP00000369291; ENSG00000165046 [Q2VYF4-1] ENST00000523983; ENSP00000428765; ENSG00000165046 [Q2VYF4-2] ENST00000527710; ENSP00000434867; ENSG00000165046 [Q2VYF4-4] |
GeneIDi | 137994 |
KEGGi | hsa:137994 |
UCSCi | uc003xll.4, human [Q2VYF4-1] |
Organism-specific databases
CTDi | 137994 |
DisGeNETi | 137994 |
EuPathDBi | HostDB:ENSG00000165046.12 |
GeneCardsi | LETM2 |
HGNCi | HGNC:14648, LETM2 |
HPAi | ENSG00000165046, Tissue enhanced (blood, testis) |
neXtProti | NX_Q2VYF4 |
OpenTargetsi | ENSG00000165046 |
PharmGKBi | PA134887111 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1043, Eukaryota |
GeneTreei | ENSGT00950000183167 |
HOGENOMi | CLU_008958_0_0_1 |
InParanoidi | Q2VYF4 |
OMAi | KTYMKNY |
OrthoDBi | 516860at2759 |
PhylomeDBi | Q2VYF4 |
TreeFami | TF316321 |
Enzyme and pathway databases
PathwayCommonsi | Q2VYF4 |
Miscellaneous databases
BioGRID-ORCSi | 137994, 8 hits in 844 CRISPR screens |
ChiTaRSi | LETM2, human |
GenomeRNAii | 137994 |
Pharosi | Q2VYF4, Tdark |
PROi | PR:Q2VYF4 |
RNActi | Q2VYF4, protein |
Gene expression databases
Bgeei | ENSG00000165046, Expressed in cerebellar hemisphere and 134 other tissues |
ExpressionAtlasi | Q2VYF4, baseline and differential |
Genevisiblei | Q2VYF4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011685, LETM1 IPR033122, LETM1_RBD |
Pfami | View protein in Pfam PF07766, LETM1, 1 hit |
PROSITEi | View protein in PROSITE PS51758, LETM1_RBD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LETM2_HUMAN | |
Accessioni | Q2VYF4Primary (citable) accession number: Q2VYF4 Secondary accession number(s): A6NMG3, Q8NCR2, Q96LL1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | October 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 105 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM