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Protein

Protein kinase C-binding protein NELL1

Gene

Nell1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDifferentiation
LigandCalcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-binding protein NELL1
Alternative name(s):
NEL-like protein 1
Gene namesi
Name:Nell1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2443902 Nell1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000032264222 – 810Protein kinase C-binding protein NELL1Add BLAST789

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi40N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi83N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi224N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi294N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi372N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi395 ↔ 407By similarity
Disulfide bondi401 ↔ 416By similarity
Disulfide bondi418 ↔ 432By similarity
Disulfide bondi438 ↔ 451By similarity
Disulfide bondi445 ↔ 460By similarity
Disulfide bondi462 ↔ 474By similarity
Disulfide bondi480 ↔ 493By similarity
Disulfide bondi487 ↔ 502By similarity
Disulfide bondi504 ↔ 515By similarity
Glycosylationi511N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi519 ↔ 529By similarity
Disulfide bondi523 ↔ 535By similarity
Disulfide bondi537 ↔ 546By similarity
Disulfide bondi553 ↔ 566By similarity
Disulfide bondi560 ↔ 575By similarity
Glycosylationi562N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi577 ↔ 594By similarity
Disulfide bondi600 ↔ 613By similarity
Disulfide bondi607 ↔ 622By similarity
Glycosylationi609N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi624 ↔ 630By similarity
Glycosylationi708N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ2VWQ2
PRIDEiQ2VWQ2

Expressioni

Gene expression databases

BgeeiENSMUSG00000055409 Expressed in 138 organ(s), highest expression level in islet of Langerhans
CleanExiMM_NELL1
ExpressionAtlasiQ2VWQ2 baseline and differential
GenevisibleiQ2VWQ2 MM

Interactioni

Subunit structurei

Homotrimer. Binds to PKC beta-1. Interacts with ATRAID; the interaction promotes osteoblast cell differentiation and mineralization (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080550

Structurei

3D structure databases

ProteinModelPortaliQ2VWQ2
SMRiQ2VWQ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini57 – 227Laminin G-likePROSITE-ProRule annotationAdd BLAST171
Domaini271 – 332VWFC 1PROSITE-ProRule annotationAdd BLAST62
Domaini434 – 475EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini476 – 516EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41
Domaini517 – 547EGF-like 3PROSITE-ProRule annotationAdd BLAST31
Domaini549 – 587EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini596 – 631EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini632 – 687VWFC 2PROSITE-ProRule annotationAdd BLAST56
Domaini692 – 750VWFC 3PROSITE-ProRule annotationAdd BLAST59

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410KD9R Eukaryota
ENOG410XSZA LUCA
GeneTreeiENSGT00810000125439
HOGENOMiHOG000217920
HOVERGENiHBG004805
InParanoidiQ2VWQ2
OMAiRRNGEDW
OrthoDBiEOG091G01DI
PhylomeDBiQ2VWQ2
TreeFamiTF323325

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024731 EGF_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G
IPR001007 VWF_dom
PfamiView protein in Pfam
PF12947 EGF_3, 1 hit
PF07645 EGF_CA, 3 hits
PF02210 Laminin_G_2, 1 hit
PF00093 VWC, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 6 hits
SM00179 EGF_CA, 5 hits
SM00282 LamG, 1 hit
SM00210 TSPN, 1 hit
SM00214 VWC, 4 hits
SM00215 VWC_out, 2 hits
SUPFAMiSSF49899 SSF49899, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 5 hits
PS01187 EGF_CA, 3 hits
PS50025 LAM_G_DOMAIN, 1 hit
PS01208 VWFC_1, 2 hits
PS50184 VWFC_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q2VWQ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPMDVILVLW FCVCTARTVL GFGMDPDLQM DIITELDLVN TTLGVTQVAG
60 70 80 90 100
LHNASKAFLF QDVQREIHSA PHVSEKLIQL FRNKSEFTFL ATVQQKPSTS
110 120 130 140 150
GVILSIRELE HSYFELESSG PREEIRYHYI HGGKPRTEAL PYRMADGQWH
160 170 180 190 200
KVALSVSASH LLLHVDCNRI YERVIDPPET NLPPGSNLWL GQRNQKHGFF
210 220 230 240 250
KGIIQDGKII FMPNGFITQC PNLNRTCPTC SDFLSLVQGI MDLQELLAKM
260 270 280 290 300
TAKLNYAETR LGQLENCHCE KTCQVSGLLY RDQDSWVDGD NCRNCTCKSG
310 320 330 340 350
AVECRRMSCP PLNCSPDSLP VHISGQCCKV CRPKCIYGGK VLAEGQRILT
360 370 380 390 400
KTCRECRGGV LVKITEACPP LNCSEKDHIL PENQCCRVCR GHNFCAEAPK
410 420 430 440 450
CGENSECKNW NTKATCECKN GYISVQGNSA YCEDIDECAA KMHYCHANTV
460 470 480 490 500
CVNLPGLYRC DCIPGYIRVD DFSCTEHDDC GSGQHNCDKN AICTNTVQGH
510 520 530 540 550
SCTCQPGYVG NGTVCKAFCE EGCRYGGTCV APNKCVCPSG FTGSHCEKDI
560 570 580 590 600
DECAEGFVEC HNHSRCVNLP GWYHCECRSG FHDDGTYSLS GESCIDIDEC
610 620 630 640 650
ALRTHTCWND SACINLAGGF DCLCPSGPSC SGDCPHEGGL KHNGQVWILR
660 670 680 690 700
EDRCSVCSCK DGKIFCRRTA CDCQNPNVDL FCCPECDTRV TSQCLDQSGQ
710 720 730 740 750
KLYRSGDNWT HSCQQCRCLE GEADCWPLAC PSLSCEYTAI FEGECCPRCV
760 770 780 790 800
SDPCLADNIA YDIRKTCLDS SGISRLSGAV WTMAGSPCTT CQCKNGRVCC
810
SVDLVCLENN
Length:810
Mass (Da):89,415
Last modified:January 10, 2006 - v1
Checksum:i3AD132E97FB83590
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YWD8D3YWD8_MOUSE
Protein kinase C-binding protein NE...
Nell1
763Annotation score:
D3YV40D3YV40_MOUSE
Protein kinase C-binding protein NE...
Nell1
379Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY622226 mRNA Translation: AAV41488.1
CCDSiCCDS21309.1
RefSeqiNP_001032995.1, NM_001037906.2
UniGeneiMm.383528

Genome annotation databases

EnsembliENSMUST00000081872; ENSMUSP00000080550; ENSMUSG00000055409
GeneIDi338352
KEGGimmu:338352
UCSCiuc009hbx.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY622226 mRNA Translation: AAV41488.1
CCDSiCCDS21309.1
RefSeqiNP_001032995.1, NM_001037906.2
UniGeneiMm.383528

3D structure databases

ProteinModelPortaliQ2VWQ2
SMRiQ2VWQ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080550

Proteomic databases

PaxDbiQ2VWQ2
PRIDEiQ2VWQ2

Protocols and materials databases

DNASUi338352
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081872; ENSMUSP00000080550; ENSMUSG00000055409
GeneIDi338352
KEGGimmu:338352
UCSCiuc009hbx.1 mouse

Organism-specific databases

CTDi4745
MGIiMGI:2443902 Nell1

Phylogenomic databases

eggNOGiENOG410KD9R Eukaryota
ENOG410XSZA LUCA
GeneTreeiENSGT00810000125439
HOGENOMiHOG000217920
HOVERGENiHBG004805
InParanoidiQ2VWQ2
OMAiRRNGEDW
OrthoDBiEOG091G01DI
PhylomeDBiQ2VWQ2
TreeFamiTF323325

Miscellaneous databases

PROiPR:Q2VWQ2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055409 Expressed in 138 organ(s), highest expression level in islet of Langerhans
CleanExiMM_NELL1
ExpressionAtlasiQ2VWQ2 baseline and differential
GenevisibleiQ2VWQ2 MM

Family and domain databases

InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024731 EGF_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR001791 Laminin_G
IPR001007 VWF_dom
PfamiView protein in Pfam
PF12947 EGF_3, 1 hit
PF07645 EGF_CA, 3 hits
PF02210 Laminin_G_2, 1 hit
PF00093 VWC, 2 hits
SMARTiView protein in SMART
SM00181 EGF, 6 hits
SM00179 EGF_CA, 5 hits
SM00282 LamG, 1 hit
SM00210 TSPN, 1 hit
SM00214 VWC, 4 hits
SM00215 VWC_out, 2 hits
SUPFAMiSSF49899 SSF49899, 1 hit
SSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 3 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 5 hits
PS01187 EGF_CA, 3 hits
PS50025 LAM_G_DOMAIN, 1 hit
PS01208 VWFC_1, 2 hits
PS50184 VWFC_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiNELL1_MOUSE
AccessioniPrimary (citable) accession number: Q2VWQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 10, 2006
Last modified: November 7, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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