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Protein

Chromatin modification-related protein MEAF6

Gene

Meaf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-3214847 HATs acetylate histones
R-MMU-6804758 Regulation of TP53 Activity through Acetylation

Names & Taxonomyi

Protein namesi
Recommended name:
Chromatin modification-related protein MEAF6
Short name:
MYST/Esa1-associated factor 6
Alternative name(s):
Esa1-associated factor 6 homolog
Short name:
Protein EAF6 homolog
Gene namesi
Name:Meaf6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1917338 Meaf6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002726102 – 191Chromatin modification-related protein MEAF6Add BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei6N6-acetyllysineCombined sources1
Modified residuei69N6-acetyllysine; alternateCombined sources1
Cross-linki69Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei74N6-acetyllysineCombined sources1
Cross-linki113Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki113Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei118PhosphoserineCombined sources1
Modified residuei120PhosphothreonineCombined sources1
Isoform 2 (identifier: Q2VPQ9-2)
Modified residuei182PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ2VPQ9
MaxQBiQ2VPQ9
PaxDbiQ2VPQ9
PeptideAtlasiQ2VPQ9
PRIDEiQ2VPQ9

PTM databases

iPTMnetiQ2VPQ9
PhosphoSitePlusiQ2VPQ9

Expressioni

Gene expression databases

BgeeiENSMUSG00000028863 Expressed in 234 organ(s), highest expression level in superior cervical ganglion
CleanExiMM_2310005N01RIK
ExpressionAtlasiQ2VPQ9 baseline and differential
GenevisibleiQ2VPQ9 MM

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5 and the subunits EP400, TRRAP, BRD8, EPC1, DMAP1, RUVBL1, RUVBL2, ING3, actin, ACTL6A, MORF4L1, MORF4L2, MRGBP, YEATS4, VPS72 and MEAF6. Component of the HBO1 complex composed at least of ING4 or ING5, MYST2/HBO1, MEAF6, and one of JADE1, JADE2 and JADE3. Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi213858, 2 interactors
ComplexPortaliCPX-794 HBO1-4.1 histone acetyltransferase complex
CPX-795 HBO1-4.2 histone acetyltransferase complex
CPX-796 HBO1-4.3 histone acetyltransferase complex
CPX-797 HBO1-5.1 histone acetyltransferase complex
CPX-798 HBO1-5.2 histone acetyltransferase complex
CPX-799 HBO1-5.3 histone acetyltransferase complex
CPX-800 MOZ1 histone acetyltransferase complex
CPX-801 MOZ2 histone acetyltransferase complex
CPX-802 MOZ3 histone acetyltransferase complex
CPX-803 MORF1 histone acetyltransferase complex
CPX-804 MORF3 histone acetyltransferase complex
CPX-805 MORF2 histone acetyltransferase complex
CPX-990 NuA4 histone acetyltransferase complex
IntActiQ2VPQ9, 1 interactor
MINTiQ2VPQ9
STRINGi10090.ENSMUSP00000053543

Structurei

3D structure databases

ProteinModelPortaliQ2VPQ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili11 – 47Sequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the EAF6 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3856 Eukaryota
ENOG4111IAX LUCA
GeneTreeiENSGT00390000015257
InParanoidiQ2VPQ9
KOiK11344
OMAiXEPGSGT
OrthoDBiEOG091G126R
TreeFamiTF324130

Family and domain databases

InterProiView protein in InterPro
IPR015418 Eaf6
PANTHERiPTHR13476 PTHR13476, 1 hit
PfamiView protein in Pfam
PF09340 NuA4, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q2VPQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAMHNKTAPP QIPDTRRELA ELVKRKQELA ETLANLERQI YAFEGSYLED
60 70 80 90 100
TQMYGNIIRG WDRYLTNQKN SNSKNDRRNR KFKEAERLFS KSSVTSAAAV
110 120 130 140 150
SALAGVQDQL IEKREPGSGT ESDTSPDFHN QENEPAQEDP EDLDGSVQGV
160 170 180 190
KPQKAASSTS SGSHHSSHKK RKNKNRHRID LKLNKKPRAD Y
Length:191
Mass (Da):21,649
Last modified:January 10, 2006 - v1
Checksum:i4B9EDC2812CFF1FD
GO
Isoform 2 (identifier: Q2VPQ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-191: IDLKLNKKPRADY → MNVSPQTGWHQLHL

Note: No experimental confirmation available.Combined sources
Show »
Length:192
Mass (Da):21,723
Checksum:i2F595123C751C0A3
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GX42V9GX42_MOUSE
Chromatin modification-related prot...
Meaf6
181Annotation score:
B1ASC8B1ASC8_MOUSE
Chromatin modification-related prot...
Meaf6
173Annotation score:
V9GXH6V9GXH6_MOUSE
Chromatin modification-related prot...
Meaf6
147Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_022452179 – 191IDLKL…PRADY → MNVSPQTGWHQLHL in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009177 mRNA Translation: BAB26123.1
AL626775 Genomic DNA No translation available.
BC108404 mRNA Translation: AAI08405.1
CCDSiCCDS18637.1 [Q2VPQ9-2]
CCDS71467.1 [Q2VPQ9-1]
RefSeqiNP_001277630.1, NM_001290701.1 [Q2VPQ9-1]
NP_081586.1, NM_027310.4 [Q2VPQ9-2]
UniGeneiMm.291214
Mm.460503

Genome annotation databases

EnsembliENSMUST00000055213; ENSMUSP00000053543; ENSMUSG00000028863 [Q2VPQ9-2]
ENSMUST00000154689; ENSMUSP00000122288; ENSMUSG00000028863 [Q2VPQ9-1]
GeneIDi70088
KEGGimmu:70088
UCSCiuc008urs.2 mouse [Q2VPQ9-2]
uc008uru.2 mouse [Q2VPQ9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK009177 mRNA Translation: BAB26123.1
AL626775 Genomic DNA No translation available.
BC108404 mRNA Translation: AAI08405.1
CCDSiCCDS18637.1 [Q2VPQ9-2]
CCDS71467.1 [Q2VPQ9-1]
RefSeqiNP_001277630.1, NM_001290701.1 [Q2VPQ9-1]
NP_081586.1, NM_027310.4 [Q2VPQ9-2]
UniGeneiMm.291214
Mm.460503

3D structure databases

ProteinModelPortaliQ2VPQ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213858, 2 interactors
ComplexPortaliCPX-794 HBO1-4.1 histone acetyltransferase complex
CPX-795 HBO1-4.2 histone acetyltransferase complex
CPX-796 HBO1-4.3 histone acetyltransferase complex
CPX-797 HBO1-5.1 histone acetyltransferase complex
CPX-798 HBO1-5.2 histone acetyltransferase complex
CPX-799 HBO1-5.3 histone acetyltransferase complex
CPX-800 MOZ1 histone acetyltransferase complex
CPX-801 MOZ2 histone acetyltransferase complex
CPX-802 MOZ3 histone acetyltransferase complex
CPX-803 MORF1 histone acetyltransferase complex
CPX-804 MORF3 histone acetyltransferase complex
CPX-805 MORF2 histone acetyltransferase complex
CPX-990 NuA4 histone acetyltransferase complex
IntActiQ2VPQ9, 1 interactor
MINTiQ2VPQ9
STRINGi10090.ENSMUSP00000053543

PTM databases

iPTMnetiQ2VPQ9
PhosphoSitePlusiQ2VPQ9

Proteomic databases

EPDiQ2VPQ9
MaxQBiQ2VPQ9
PaxDbiQ2VPQ9
PeptideAtlasiQ2VPQ9
PRIDEiQ2VPQ9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055213; ENSMUSP00000053543; ENSMUSG00000028863 [Q2VPQ9-2]
ENSMUST00000154689; ENSMUSP00000122288; ENSMUSG00000028863 [Q2VPQ9-1]
GeneIDi70088
KEGGimmu:70088
UCSCiuc008urs.2 mouse [Q2VPQ9-2]
uc008uru.2 mouse [Q2VPQ9-1]

Organism-specific databases

CTDi64769
MGIiMGI:1917338 Meaf6

Phylogenomic databases

eggNOGiKOG3856 Eukaryota
ENOG4111IAX LUCA
GeneTreeiENSGT00390000015257
InParanoidiQ2VPQ9
KOiK11344
OMAiXEPGSGT
OrthoDBiEOG091G126R
TreeFamiTF324130

Enzyme and pathway databases

ReactomeiR-MMU-3214847 HATs acetylate histones
R-MMU-6804758 Regulation of TP53 Activity through Acetylation

Miscellaneous databases

ChiTaRSiMeaf6 mouse
PROiPR:Q2VPQ9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028863 Expressed in 234 organ(s), highest expression level in superior cervical ganglion
CleanExiMM_2310005N01RIK
ExpressionAtlasiQ2VPQ9 baseline and differential
GenevisibleiQ2VPQ9 MM

Family and domain databases

InterProiView protein in InterPro
IPR015418 Eaf6
PANTHERiPTHR13476 PTHR13476, 1 hit
PfamiView protein in Pfam
PF09340 NuA4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEAF6_MOUSE
AccessioniPrimary (citable) accession number: Q2VPQ9
Secondary accession number(s): B1ASC6, Q9D7J5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: January 10, 2006
Last modified: November 7, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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