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Protein

Leucine-rich repeat-containing protein 75B

Gene

LRRC75B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 75B
Alternative name(s):
Leucine-rich repeat-containing protein FAM211B
Gene namesi
Name:LRRC75B
Synonyms:C22orf36, FAM211B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000178026.12
HGNCiHGNC:33155 LRRC75B
neXtProtiNX_Q2VPJ9

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000178026
PharmGKBiPA162378982

Polymorphism and mutation databases

BioMutaiFAM211B
DMDMi118573588

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002540461 – 315Leucine-rich repeat-containing protein 75BAdd BLAST315

Proteomic databases

PaxDbiQ2VPJ9
PRIDEiQ2VPJ9
ProteomicsDBi61518
61519 [Q2VPJ9-2]

PTM databases

PhosphoSitePlusiQ2VPJ9

Expressioni

Gene expression databases

BgeeiENSG00000178026 Expressed in 181 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_C22orf36
ExpressionAtlasiQ2VPJ9 baseline and differential
GenevisibleiQ2VPJ9 HS

Organism-specific databases

HPAiHPA002540

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000320520

Structurei

3D structure databases

ProteinModelPortaliQ2VPJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati182 – 195LRR 1Add BLAST14
Repeati207 – 220LRR 2Add BLAST14

Sequence similaritiesi

Belongs to the LRRC75 family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IIWD Eukaryota
ENOG410Z0F1 LUCA
GeneTreeiENSGT00390000004841
HOGENOMiHOG000111942
HOVERGENiHBG066484
InParanoidiQ2VPJ9
OMAiIYEYTEG
OrthoDBiEOG091G0JK8
PhylomeDBiQ2VPJ9
TreeFamiTF332831

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q2VPJ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGARLGRRAG PEAGSEAGAA AGCGPAPYER RVRWLREIQS TLRERRPERA
60 70 80 90 100
RQLLRLLRQD LGLERTLLPD ILYRDVAFLN PVDPISHDLL VNLARDLQCP
110 120 130 140 150
KKDYELWKSS DKICRQLIYH LTPHSKQQQG SSLRQRKTQS CLKSSLQKTL
160 170 180 190 200
LAGETVDLSG IPLSTQDVQH ITRYLSSHGA VLAVLDLSFT GLSDELLHLL
210 220 230 240 250
LPSLWALPRL TQLLLNGNRL TRATARKLTD AIKDTTKFPA LAWVDLGNNV
260 270 280 290 300
DVASLPQPLL VGLRRRLSQR TSLPTIYEGL DLEPEGSAAG ATTPASTWDS
310
TAAGLGPEPQ ACCAR
Length:315
Mass (Da):34,740
Last modified:January 10, 2006 - v1
Checksum:i099B03832A2DD370
GO
Isoform 2 (identifier: Q2VPJ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-152: DLGLERTLLP...KSSLQKTLLA → AREGAVRPWA...AAECVRVFGV
     153-315: Missing.

Note: No experimental confirmation available.
Show »
Length:152
Mass (Da):16,640
Checksum:i5450D9C35B799B30
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WCG9F8WCG9_HUMAN
Leucine-rich repeat-containing prot...
LRRC75B
108Annotation score:
F8WCZ7F8WCZ7_HUMAN
Leucine-rich repeat-containing prot...
LRRC75B
74Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051125140S → R. Corresponds to variant dbSNP:rs743370Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02117260 – 152DLGLE…KTLLA → AREGAVRPWAGGQGGSGGLG VWEARGYGLWACIRREARRS WSLARAGGFRGRDRLQHAGS CVGERATAWSEGWVRSADRV EEGAAECVRVFGV in isoform 2. 1 PublicationAdd BLAST93
Alternative sequenceiVSP_021173153 – 315Missing in isoform 2. 1 PublicationAdd BLAST163

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097054 mRNA Translation: BAC04937.1
BC032388 mRNA Translation: AAH32388.1
BC108684 mRNA Translation: AAI08685.1
CCDSiCCDS42991.1 [Q2VPJ9-1]
RefSeqiNP_997527.2, NM_207644.2 [Q2VPJ9-1]
UniGeneiHs.113314

Genome annotation databases

EnsembliENST00000318753; ENSP00000320520; ENSG00000178026 [Q2VPJ9-1]
GeneIDi388886
KEGGihsa:388886
UCSCiuc003aaq.3 human [Q2VPJ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK097054 mRNA Translation: BAC04937.1
BC032388 mRNA Translation: AAH32388.1
BC108684 mRNA Translation: AAI08685.1
CCDSiCCDS42991.1 [Q2VPJ9-1]
RefSeqiNP_997527.2, NM_207644.2 [Q2VPJ9-1]
UniGeneiHs.113314

3D structure databases

ProteinModelPortaliQ2VPJ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000320520

PTM databases

PhosphoSitePlusiQ2VPJ9

Polymorphism and mutation databases

BioMutaiFAM211B
DMDMi118573588

Proteomic databases

PaxDbiQ2VPJ9
PRIDEiQ2VPJ9
ProteomicsDBi61518
61519 [Q2VPJ9-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318753; ENSP00000320520; ENSG00000178026 [Q2VPJ9-1]
GeneIDi388886
KEGGihsa:388886
UCSCiuc003aaq.3 human [Q2VPJ9-1]

Organism-specific databases

CTDi388886
EuPathDBiHostDB:ENSG00000178026.12
GeneCardsiLRRC75B
HGNCiHGNC:33155 LRRC75B
HPAiHPA002540
neXtProtiNX_Q2VPJ9
OpenTargetsiENSG00000178026
PharmGKBiPA162378982
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIWD Eukaryota
ENOG410Z0F1 LUCA
GeneTreeiENSGT00390000004841
HOGENOMiHOG000111942
HOVERGENiHBG066484
InParanoidiQ2VPJ9
OMAiIYEYTEG
OrthoDBiEOG091G0JK8
PhylomeDBiQ2VPJ9
TreeFamiTF332831

Miscellaneous databases

GenomeRNAii388886
PROiPR:Q2VPJ9

Gene expression databases

BgeeiENSG00000178026 Expressed in 181 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_C22orf36
ExpressionAtlasiQ2VPJ9 baseline and differential
GenevisibleiQ2VPJ9 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR032675 LRR_dom_sf
ProtoNetiSearch...

Entry informationi

Entry nameiLR75B_HUMAN
AccessioniPrimary (citable) accession number: Q2VPJ9
Secondary accession number(s): Q8N0S9, Q8N8B1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 10, 2006
Last modified: September 12, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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