UniProtKB - Q2VPJ6 (Q2VPJ6_HUMAN)
Protein
Submitted name:
HSP90AA1 protein
Gene
HSP90AA1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATP binding Source: UniProtKB-KW
- unfolded protein binding Source: InterPro
GO - Biological processi
- protein folding Source: InterPro
Keywordsi
Molecular function | ChaperoneARBA annotation |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: HSP90AA1 proteinImported |
Gene namesi | Name:HSP90AA1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Other locations
- Melanosome ARBA annotation
Other locations
- melanosome Source: UniProtKB-SubCell
PTM / Processingi
Keywords - PTMi
AcetylationARBA annotationProteomic databases
PeptideAtlasi | Q2VPJ6 |
PRIDEi | Q2VPJ6 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 40 – 194 | HATPase_cInterPro annotationAdd BLAST | 155 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 225 – 278 | DisorderedSequence analysisAdd BLAST | 54 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 551 – 571 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 243 – 257 | PolyampholyteSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the heat shock protein 90 family.ARBA annotation
Keywords - Domaini
Coiled coilSequence analysisFamily and domain databases
Gene3Di | 1.20.120.790, 1 hit 3.30.565.10, 1 hit |
HAMAPi | MF_00505, HSP90, 1 hit |
InterProi | View protein in InterPro IPR003594, HATPase_C IPR036890, HATPase_C_sf IPR019805, Heat_shock_protein_90_CS IPR037196, HSP90_C IPR001404, Hsp90_fam IPR020575, Hsp90_N IPR020568, Ribosomal_S5_D2-typ_fold |
PANTHERi | PTHR11528, PTHR11528, 1 hit |
Pfami | View protein in Pfam PF02518, HATPase_c, 1 hit PF00183, HSP90, 1 hit |
PIRSFi | PIRSF002583, Hsp90, 1 hit |
PRINTSi | PR00775, HEATSHOCK90 |
SMARTi | View protein in SMART SM00387, HATPase_c, 1 hit |
SUPFAMi | SSF54211, SSF54211, 1 hit SSF55874, SSF55874, 1 hit |
PROSITEi | View protein in PROSITE PS00298, HSP90, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q2VPJ6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPEETQTQDQ PMEEEEVETF AFQAEIAQLM SLIINTFYSN KEIFLRELIS
60 70 80 90 100
NSSDALDKIR YESLTDPSKL DSGKELHINL IPNKQDRTLT IVDTGIGMTK
110 120 130 140 150
ADLINNLGTI AKSGTKAFME ALQAGADISM IGQFGVGFYS AYLVAEKVTV
160 170 180 190 200
ITKHNDDEQY AWESSAGGSF TVRTDTGEPM GRGTKVILHL KEDQTEYLEE
210 220 230 240 250
RRIKEIVKKH SQFIGYPITL FVEKERDKEV SDDEAEEKED KEEEKEKEEK
260 270 280 290 300
ESEDKPEIED VGSDEEEEKK DGDKKKKKKI KEKYIDQEEL NKTKPIWTRN
310 320 330 340 350
PDDITNEEYG EFYKSLTNDW EDHLAVKHFS VEGQLEFRAL LFVPRRAPFD
360 370 380 390 400
LFENRKKKNN IKLYVRRVFI MDNCEELIPE YLNFIRGVVD SEDLPLNISR
410 420 430 440 450
EMLQQSKILK VIRKNLVKKC LELFTELAED KENYKKFYEQ FSKNIKLGIH
460 470 480 490 500
EDSQNRKKLS ELLRYYTSAS GDEMVSLKDY CTRMKENQKH IYYITGETKD
510 520 530 540 550
QVANSAFVER LRKHGLEVIY MIEPIDEYCV QQLKEFEGKT LVSVTKEGLE
560 570 580
LPEDEEEKKK QEEKKTKFEN LCKIMKDILE KKKKK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 585 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC108695 mRNA Translation: AAI08696.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC108695 mRNA Translation: AAI08696.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | Q2VPJ6 |
PRIDEi | Q2VPJ6 |
Miscellaneous databases
ChiTaRSi | HSP90AA1, human |
Family and domain databases
Gene3Di | 1.20.120.790, 1 hit 3.30.565.10, 1 hit |
HAMAPi | MF_00505, HSP90, 1 hit |
InterProi | View protein in InterPro IPR003594, HATPase_C IPR036890, HATPase_C_sf IPR019805, Heat_shock_protein_90_CS IPR037196, HSP90_C IPR001404, Hsp90_fam IPR020575, Hsp90_N IPR020568, Ribosomal_S5_D2-typ_fold |
PANTHERi | PTHR11528, PTHR11528, 1 hit |
Pfami | View protein in Pfam PF02518, HATPase_c, 1 hit PF00183, HSP90, 1 hit |
PIRSFi | PIRSF002583, Hsp90, 1 hit |
PRINTSi | PR00775, HEATSHOCK90 |
SMARTi | View protein in SMART SM00387, HATPase_c, 1 hit |
SUPFAMi | SSF54211, SSF54211, 1 hit SSF55874, SSF55874, 1 hit |
PROSITEi | View protein in PROSITE PS00298, HSP90, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q2VPJ6_HUMAN | |
Accessioni | Q2VPJ6Primary (citable) accession number: Q2VPJ6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | January 10, 2006 |
Last sequence update: | January 10, 2006 | |
Last modified: | April 7, 2021 | |
This is version 88 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |