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Protein

Complement component receptor 1-like protein

Gene

CR1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component receptor 1-like protein
Alternative name(s):
Complement C4b-binding protein CR-1-like protein
Gene namesi
Name:CR1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000197721.16
HGNCiHGNC:2335 CR1L
MIMi605886 gene
neXtProtiNX_Q2VPA4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197721
PharmGKBiPA26856

Polymorphism and mutation databases

BioMutaiCR1L
DMDMi296439386

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 32Sequence analysisAdd BLAST32
ChainiPRO_000031777633 – 569Complement component receptor 1-like proteinAdd BLAST537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 78PROSITE-ProRule annotation
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi65 ↔ 91PROSITE-ProRule annotation
Disulfide bondi96 ↔ 137PROSITE-ProRule annotation
Disulfide bondi123 ↔ 153PROSITE-ProRule annotation
Disulfide bondi158 ↔ 207PROSITE-ProRule annotation
Disulfide bondi187 ↔ 224PROSITE-ProRule annotation
Disulfide bondi230 ↔ 272PROSITE-ProRule annotation
Disulfide bondi258 ↔ 285PROSITE-ProRule annotation
Disulfide bondi289 ↔ 332PROSITE-ProRule annotation
Disulfide bondi318 ↔ 345PROSITE-ProRule annotation
Disulfide bondi350 ↔ 392PROSITE-ProRule annotation
Disulfide bondi378 ↔ 408PROSITE-ProRule annotation
Disulfide bondi413 ↔ 454PROSITE-ProRule annotation
Disulfide bondi440 ↔ 470PROSITE-ProRule annotation
Disulfide bondi504 ↔ 541PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ2VPA4
PaxDbiQ2VPA4
PeptideAtlasiQ2VPA4
PRIDEiQ2VPA4
ProteomicsDBi61514
61515 [Q2VPA4-2]
61516 [Q2VPA4-3]

PTM databases

iPTMnetiQ2VPA4
PhosphoSitePlusiQ2VPA4

Expressioni

Tissue specificityi

Expressed in fetal liver and to a lesser extent in fetal spleen and thymus. Expression appears to be limited to hematopoietic and fetal lymphoid tissue.1 Publication

Gene expression databases

BgeeiENSG00000197721 Expressed in 71 organ(s), highest expression level in bone marrow
CleanExiHS_CR1L
ExpressionAtlasiQ2VPA4 baseline and differential
GenevisibleiQ2VPA4 HS

Organism-specific databases

HPAiHPA049348

Interactioni

Subunit structurei

Interacts with iC4 (methylamine-treated C4) but not for iC3 (methylamine-treated C3).1 Publication

Protein-protein interaction databases

IntActiQ2VPA4, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ2VPA4
SMRiQ2VPA4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 93Sushi 1PROSITE-ProRule annotationAdd BLAST61
Domaini94 – 155Sushi 2PROSITE-ProRule annotationAdd BLAST62
Domaini156 – 226Sushi 3PROSITE-ProRule annotationAdd BLAST71
Domaini228 – 287Sushi 4PROSITE-ProRule annotationAdd BLAST60
Domaini287 – 347Sushi 5PROSITE-ProRule annotationAdd BLAST61
Domaini348 – 410Sushi 6PROSITE-ProRule annotationAdd BLAST63
Domaini411 – 472Sushi 7PROSITE-ProRule annotationAdd BLAST62
Domaini473 – 543Sushi 8PROSITE-ProRule annotationAdd BLAST71

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IEGQ Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00760000118803
HOGENOMiHOG000111977
HOVERGENiHBG081346
InParanoidiQ2VPA4
OMAiKCAPRNV
OrthoDBiEOG091G0051
PhylomeDBiQ2VPA4
TreeFamiTF334137

Family and domain databases

CDDicd00033 CCP, 8 hits
InterProiView protein in InterPro
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PfamiView protein in Pfam
PF00084 Sushi, 8 hits
SMARTiView protein in SMART
SM00032 CCP, 8 hits
SUPFAMiSSF57535 SSF57535, 8 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 8 hits

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.iShow all

Isoform 1 (identifier: Q2VPA4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPPVRLERP FPSRRFPGLL LAALVLLLSS FSDQCNVPEW LPFARPTNLT
60 70 80 90 100
DDFEFPIGTY LNYECRPGYS GRPFSIICLK NSVWTSAKDK CKRKSCRNPP
110 120 130 140 150
DPVNGMAHVI KDIQFRSQIK YSCPKGYRLI GSSSATCIIS GNTVIWDNKT
160 170 180 190 200
PVCDRIICGL PPTIANGDFT SISREYFHYG SVVTYHCNLG SRGKKVFELV
210 220 230 240 250
GEPSIYCTSK DDQVGIWSGP APQCIIPNKC TPPNVENGIL VSDNRSLFSL
260 270 280 290 300
NEVVEFRCQP GFGMKGPSHV KCQALNKWEP ELPSCSRVCQ PPPDVLHAER
310 320 330 340 350
TQRDKDNFSP GQEVFYSCEP GYDLRGSTYL HCTPQGDWSP AAPRCEVKSC
360 370 380 390 400
DDFLGQLPNG HVLFPLNLQL GAKVDFVCDE GFQLKGSSAS YCVLAGMESL
410 420 430 440 450
WNSSVPVCER KSCETPPVPV NGMVHVITDI HVGSRINYSC TTGHRLIGHS
460 470 480 490 500
SAECILSGNT AHWSMKPPIC QQIFCPNPPA ILNGRHTGTP LGDIPYGKEV
510 520 530 540 550
SYTCDPHPDR GMTFNLIGES TIRRTSEPHG NGVWSSPAPR CELPVGAGSH
560
DALIVGKFYE VFAEEFCHL
Length:569
Mass (Da):62,714
Last modified:May 18, 2010 - v3
Checksum:iD49F7517E1347A5D
GO
Isoform 2 (identifier: Q2VPA4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-263: Missing.
     444-444: H → F
     445-569: Missing.

Note: No experimental confirmation available.
Show »
Length:181
Mass (Da):19,907
Checksum:iCFC9CC2E28455ED5
GO
Isoform 3 (identifier: Q2VPA4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     444-444: H → F
     445-569: Missing.

Note: No experimental confirmation available.
Show »
Length:444
Mass (Da):49,143
Checksum:i8F4AAEFF760F21F3
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGF5A0A0C4DGF5_HUMAN
Complement component receptor 1-lik...
CR1L
388Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038677116R → G. Corresponds to variant dbSNP:rs2296158Ensembl.1
Natural variantiVAR_038678139I → V. Corresponds to variant dbSNP:rs3085Ensembl.1
Natural variantiVAR_038679402N → D1 PublicationCorresponds to variant dbSNP:rs12729569Ensembl.1
Natural variantiVAR_038680455I → V1 PublicationCorresponds to variant dbSNP:rs6683902Ensembl.1
Natural variantiVAR_038681491L → P. Corresponds to variant dbSNP:rs2796257Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0311511 – 263Missing in isoform 2. 1 PublicationAdd BLAST263
Alternative sequenceiVSP_031152444H → F in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_031153445 – 569Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST125

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137789 Genomic DNA No translation available.
AL365178 Genomic DNA No translation available.
BC109190 mRNA Translation: AAI09191.1
BC109191 mRNA Translation: AAI09192.1
AY114160 mRNA Translation: AAM47024.1
CCDSiCCDS44310.1 [Q2VPA4-1]
RefSeqiNP_783641.1, NM_175710.1 [Q2VPA4-1]
UniGeneiHs.628568
Hs.655194

Genome annotation databases

EnsembliENST00000508064; ENSP00000421736; ENSG00000197721 [Q2VPA4-1]
GeneIDi1379
KEGGihsa:1379
UCSCiuc001hga.5 human [Q2VPA4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCR1L_HUMAN
AccessioniPrimary (citable) accession number: Q2VPA4
Secondary accession number(s): Q32MC9, Q8NEU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 105 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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